Cited by 285Plant biochemistry and biosynthesisPlant Molecular Biology ResearchLipid metabolism and biosynthesis

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Contribution of the Mevalonate and Methylerythritol Phosphate Pathways to the Biosynthesis of Gibberellins inArabidopsis

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Kasahara, Hiroyuki, Hanada, Atsushi, Kuzuyama, Tomohisa, Takagi, Motoki, Kamiya, Yuji, Yamaguchi, Shinjiro·2002·Journal of Biological Chemistry

DOI 10.1074/jbc.m208659200

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Abstract

Gibberellins (GAs) are diterpene plant hormones essential for many developmental processes. Although the GA biosynthesis pathway has been well studied, our knowledge on its early stage is still limited. There are two possible routes for the biosynthesis of isoprenoids leading to GAs, the mevalonate (MVA) pathway in the cytosol and the methylerythritol phosphate (MEP) pathway in plastids. To distinguish these possibilities, metabolites from each isoprenoid pathway were selectively labeled with (13)C in Arabidopsis seedlings. Efficient (13)C-labeling was achieved by blocking the endogenous pathway chemically or genetically during the feed of a (13)C-labeled precursor specific to the MVA or MEP pathways. Gas chromatography-mass spectrometry analyses demonstrated that both MVA and MEP pathways can contribute to the biosyntheses of GAs and campesterol, a cytosolic sterol, in Arabidopsis seedlings. While GAs are predominantly synthesized through the MEP pathway, the MVA pathway plays a major role in the biosynthesis of campesterol. Consistent with some crossover between the two pathways, phenotypic defects caused by the block of the MVA and MEP pathways were partially rescued by exogenous application of the MEP and MVA precursors, respectively. We also provide evidence to suggest that the MVA pathway still contributes to GA biosynthesis when this pathway is limiting.

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Authors: Kasahara, H., Hanada, A., Kuzuyama, T., Takagi, M., Kamiya, Y., & Yamaguchi, S.
Affiliations: RIKEN (JP)
The University of Tokyo (JP)
Corresponding author: Yamaguchi, Shinjiro
ORCID: Kasahara, Hiroyuki
Kuzuyama, Tomohisa
Takagi, Motoki
Kamiya, Yuji
Yamaguchi, Shinjiro
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2002-11
Volume: 277
Issue: 47
Pages: 45188-45194
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m208659200
OpenAlex: W2024426942
Cited by: 285
References: 45
Citations by year: 2026: 12 · 2025: 10 · 2024: 15 · 2023: 6 · 2022: 17 · 2021: 16 · 2020: 13 · 2019: 8 · 2018: 10 · 2017: 10 · 2016: 11 · 2015: 4 · 2014: 10 · 2013: 16 · 2012: 20
FWCI: 3.01
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 6554 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: gibberellin biosynthesis, mevalonate pathway, methylerythritol phosphate pathway, isoprenoid biosynthesis, campesterol, Arabidopsis thaliana, 13C labeling, sterol biosynthesis
MeSH terms: Carbon Isotopes, Erythritol, Gibberellins, Lovastatin, Mevalonic Acid, Pentosephosphates, Plant Growth Regulators, Xylulose, Molecular Structure, Arabidopsis, Seedlings

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Contribution of the Mevalonate and Methylerythritol Phosphate Pathways to the Biosynthesis of Gibberellins inArabidopsis

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