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Connexin-related signaling in cell death: to live or let die?

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P2X7 Interactions and Signaling – Making Head or Tail of It

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A His-155 to Tyr Polymorphism Confers Gain-of-Function to the Human P2X7 Receptor of Human Leukemic Lymphocytes

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The P2X7 Receptor Channel Pore Dilates under Physiological Ion Conditions

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The nucleotide receptor P2X7 mediates actin reorganization and membrane blebbing in RAW 264.7 macrophages via p38 MAP kinase and Rho

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Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages

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Glu496 to Ala Polymorphism in the P2X7 Receptor Impairs ATP-Induced IL-1β Release from Human Monocytes

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The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition

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Palmitoylation of the P2X7 receptor, an ATP‐gated channel, controls its expression and association with lipid rafts

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Experimental Characterization and Mathematical Modeling of P2X7 Receptor Channel Gating

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Exacerbation of Experimental Autoimmune Encephalomyelitis in P2X7R−/− Mice: Evidence for Loss of Apoptotic Activity in Lymphocytes

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Interleukin-1β has trophic effects in microglia and its release is mediated by P2X7R pore

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C terminus of the P2X7 receptor: treasure hunting

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Inhibitory Effects of Chloride on the Activation of Caspase-1, IL-1β Secretion, and Cytolysis by the P2X7 Receptor

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Are second messengers crucial for opening the pore associated with P2X7 receptor?

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Expression, assembly and function of novel C‐terminal truncated variants of the mouse P2X7 receptor: re‐evaluation of P2X7 knockouts

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Patch–clamp coordinated spectroscopy shows P2X 2 receptor permeability dynamics require cytosolic domain rearrangements but not Panx-1 channels

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Purinergic receptor P2X7: A novel target for anti-inflammatory therapy

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P2X7 Receptor: A Potential Therapeutic Target for Depression?

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P2X7 receptor activates extracellular signal-regulated kinases ERK1 and ERK2 independently of Ca2+ influx

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P2RX7 Purinoceptor as a Therapeutic Target—The Second Coming?

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The Role of Purinergic P2X7 Receptor in Inflammation and Cancer: Novel Molecular Insights and Clinical Applications

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Expression of P2X7 in human hematopoietic cell lines and leukemia patients

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The Pro-451 to Leu Polymorphism within the C-terminal Tail of P2X7 Receptor Impairs Cell Death but Not Phospholipase D Activation in Murine Thymocytes

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A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90

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Inherent P2X7 Receptors Regulate Macrophage Functions during Inflammatory Diseases

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Functional expression of P2X7 receptors in non-neuronal cells of rat dorsal root ganglia

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The P2X7 receptor: Shifting from a low- to a high-conductance channel — An enigmatic phenomenon?

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P2X7 and NRAMP1/SLC11 A1 gene polymorphisms in Mexican mestizo patients with pulmonary tuberculosis

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Mutation of a Dibasic Amino Acid Motif Within the C Terminus of the P2X7 Nucleotide Receptor Results in Trafficking Defects and Impaired Function

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Regulation of P2X7 receptor expression and function in the brain

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C-terminal Calmodulin-binding Motif Differentially Controls Human and Rat P2X7 Receptor Current Facilitation

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The trafficking and targeting of P2X receptors

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Emerging role of P2X7 receptors in CNS health and disease

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Influence of Extracellular Monovalent Cations on Pore and Gating Properties of P2X7 Receptor-Operated Single-Channel Currents

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Splice-variants of the P2X7 receptor reveal differential agonist-dependence and functional coupling with pannexin-1

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Kinetics of P2X7 Receptor-Operated Single Channels Currents

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A Role for Mitogen-activated Protein KinaseErk1/2 Activation and Non-selective Pore Formation in P2X7 Receptor-mediated Thymocyte Death

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The P2X7 Carboxyl Tail Is a Regulatory Module of P2X7 Receptor Channel Activity

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P2X7 receptor positively regulates MyD88-dependent NF-κB activation

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Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions

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Contribution of Transmembrane Regions to ATP-gated P2X2 Channel Permeability Dynamics

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Regulation by P2X 7 : Epithelial Migration and Stromal Organization in the Cornea

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Coupling of two pools of P2X7 receptors to distinct intracellular signaling pathways in rat submandibular gland

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Gene Dosage Determines the Negative Effects of Polymorphic Alleles of the P2X7Receptor on Adenosine Triphosphate–Mediated Killing of Mycobacteria by Human Macrophages

Fernando, S. L., Saunders, B. M., Sluyter, R., Skarratt, K. K., Wiley, J. S., & Britton, W. J. (2005) · The Journal of Infectious Diseases · doi:10.1086/430622 · Cited by 61 · see citing works

Astrocytic and Oligodendrocytic P2X7 Receptors Determine Neuronal Functions in the CNS

Zhao, Y., Tang, Y., & Illés, P. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.641570 · Cited by 59 · see citing works

P2X4 receptor channels form large noncytolytic pores in resting and activated microglia

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Cell signaling via the P2X7 nucleotide receptor: linkage to ROS production, gene transcription, and receptor trafficking

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Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection

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Fluoroquinolone Eye Drop–Induced Cytotoxicity: Role of Preservative in P2X7 Cell Death Receptor Activation and Apoptosis

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Time-Resolved Measurement of State-Specific P2X2Ion Channel Cytosolic Gating Motions

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Expression and function of the P2X7 purinergic receptor in patients with systemic lupus erythematosus and rheumatoid arthritis

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P2X7 receptor activation leads to increased cell death in a radiosensitive human glioma cell line

Gehring, M. P., Pereira, T. C. B., Zanin, R. F., Borges, M. C., Filho, A. B., Battastini, A. M. O., Bogo, M. R., Lenz, G., Campos, M. M., & Morrone, F. B. (2012) · Purinergic Signalling · doi:10.1007/s11302-012-9319-2 · Cited by 57 · see citing works

P2X7 Receptor at the Crossroads of T Cell Fate

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P2X7 and phospholipid signalling: The search of the “missing link” in epithelial cells

Garcia‐Marcos, M., Pochet, S., Marino, A., & Dehaye, J. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.05.008 · Cited by 56 · see citing works

Activation of P2X7 receptors causes isoform-specific translocation of protein kinase C in osteoclasts

Armstrong, S., Pereverzev, A., Dixon, S. J., & Sims, S. M. (2008) · Journal of Cell Science · doi:10.1242/jcs.031534 · Cited by 56 · see citing works

Assembly and trafficking of P2X purinergic receptors (Review)

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Non-Synonymous Single Nucleotide Polymorphisms in the P2X Receptor Genes: Association with Diseases, Impact on Receptor Functions and Potential Use as Diagnosis Biomarkers

Caseley, E. A., Muench, S. P., Roger, S., Mao, H., Baldwin, S. A., & Jiang, L. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150813344 · Cited by 51 · see citing works

P2X7 Receptor is Involved in Mitochondrial Dysfunction Induced by Extracellular Alpha Synuclein in Neuroblastoma SH-SY5Y Cells

Wilkaniec, A., Cieślik, M., Murawska, E., Babiec, L., Gąssowska-Dobrowolska, M., Pałasz, E., Jęśko, H. M., & Adamczyk, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113959 · Cited by 50 · see citing works

Requirement of Xk and Vps13a for the P2X7-mediated phospholipid scrambling and cell lysis in mouse T cells

Ryoden, Y., Segawa, K., & Nagata, S. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2119286119 · Cited by 49 · see citing works

Human P2X7 Pore Function Predicts Allele Linkage Disequilibrium

Denlinger, L. C., Coursin, D. B., Schell, K. A., Angelini, G., Green, D. N., Guadarrama, A. G., Halsey, J., Prabhu, U., Hogan, K. J., & Bertics, P. J. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2005.065425 · Cited by 49 · see citing works

Detection of Human P2X7 Nucleotide Receptor Polymorphisms by a Novel Monocyte Pore Assay Predictive of Alterations in Lipopolysaccharide-Induced Cytokine Production

Denlinger, L. C., Angelini, G., Schell, K. A., Green, D. N., Guadarrama, A. G., Prabhu, U., Coursin, D. B., Bertics, P. J., & Hogan, K. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.7.4424 · Cited by 48 · see citing works

The role of P2X7 receptors in tissue fibrosis: a brief review

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Preservation of Differentiation and Clonogenic Potential of Human Hematopoietic Stem and Progenitor Cells during Lyophilization and Ambient Storage

Buchanan, S. S., Pyatt, D. W., & Carpenter, J. F. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012518 · Cited by 46 · see citing works

ATP downregulates P2X7 and inhibits osteoclast formation in RAW cells

Hiken, J., & Steinberg, T. H. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00361.2003 · Cited by 45 · see citing works

P2X7 receptor gene polymorphism analysis in rheumatoid arthritis

Al-Shukaili, A. K., Alkaabi, J., Hassan, B., Al‐Araimi, T., Tobi, M. A., Al-Kindi, M., Al-Maniri, A., Al-Gheilani, A., & Al-Ansari, A. (2011) · International Journal of Immunogenetics · doi:10.1111/j.1744-313x.2011.01019.x · Cited by 43 · see citing works

P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2

Adamczyk, M., Griffiths, R., Dewitt, S., Knäuper, V., & Aeschlimann, D. P. (2015) · Journal of Cell Science · doi:10.1242/jcs.175968 · Cited by 42 · see citing works

Alternative splicing of P2RX7 pre-messenger RNA in health and diseases: Myth or reality?

Benzaquen, J., Heeke, S., Hreich, S. J. D., Douguet, L., Marquette, C., Hofman, P. M., & Vouret‐Craviari, V. (2019) · Biomedical Journal · doi:10.1016/j.bj.2019.05.007 · Cited by 42 · see citing works

HIV-1 gp120 Promotes Lysosomal Exocytosis in Human Schwann Cells

Datta, G., Miller, N. M., Afghah, Z., Geiger, J., & Chen, X.-S. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00329 · Cited by 39 · see citing works

Loss of Function of P2X7 Receptor Scavenger Activity in Aging Mice

Vessey, K. A., Gu, B. J., Jobling, A. I., Phipps, J. A., Greferath, U., Tran, M. X., Dixon, M., Baird, P. N., Guymer, R. H., Wiley, J. S., et al. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.04.016 · Cited by 42 · see citing works

P2X7 receptor in cardiovascular disease: The heart side

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Activation of the P2X7 ion channel by soluble and covalently bound ligands

Schwarz, N., Fliegert, R., Adriouch, S., Séman, M., Guse, A. H., Haag, F., & Koch‐Nolte, F. (2009) · Purinergic Signalling · doi:10.1007/s11302-009-9135-5 · Cited by 38 · see citing works

P2RX7B is a new theranostic marker for lung adenocarcinoma patients

Benzaquen, J., Hreich, S. J. D., Heeke, S., Juhel, T., Lalvée, S., Bauwens, S., Saccani, S., Lenormand, P., Hofman, V., Butori, M., et al. (2020) · Theranostics · doi:10.7150/thno.48229 · Cited by 37 · see citing works

The Second Transmembrane Domain of P2X7 Contributes to Dilated Pore Formation

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Effects of toxic cellular stresses and divalent cations on the human P2X7 cell death receptor.

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Different properties of P2X7 receptor in hippocampal and cortical astrocytes

Bianco, F., Colombo, A. V., Saglietti, L., Lecca, D., Abbracchio, M. P., Matteoli, M., & Verderio, C. (2009) · Purinergic Signalling · doi:10.1007/s11302-009-9137-3 · Cited by 36 · see citing works

The P2X7 purinergic receptor: a potential therapeutic target for lung cancer

Li, Q., Zhu, X., Song, W., Peng, X., & Zhao, R. (2020) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-020-03379-4 · Cited by 36 · see citing works

Conserved ectodomain cysteines are essential for rat P2X7 receptor trafficking

Jindřichová, M., Kuzyk, P., Li, S., Stojilković, S. S., & Zemkova, H. W. (2012) · Purinergic Signalling · doi:10.1007/s11302-012-9291-x · Cited by 15 · see citing works

Mutation of a Dibasic Amino Acid Motif Within the C Terminus of the P2X7 Nucleotide Receptor Results in Trafficking Defects and Impaired Function

Denlinger, L. C., Sommer, J. A., Parker, K., Gudipaty, L., Fisette, P. L., Watters, J. J., Proctor, R. A., Dubyak, G., & Bertics, P. J. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.3.1304 · Cited by 78 · see citing works

C terminus of the P2X7 receptor: treasure hunting

Costa‐Junior, H. M., Vieira, F. S., & Coutinho‐Silva, R. (2011) · Purinergic Signalling · doi:10.1007/s11302-011-9215-1 · Cited by 128 · see citing works

Electrophysiological and Biochemical Characterization of the Human P2X7B Receptor Inxenopus Laevisoocytes

Yakoob, S. H., Schmalzing, G., & Markwárdt, F. (2021) · Biophysical Journal · doi:10.1016/j.bpj.2020.11.1423

Funktionelle Bedeutung der C-terminalen Domäne des humanen P2X7-Rezeptors

Becker, D. (2010) · Digitalen Hochschulbibliothek Sachsen-Anhalt (Universitäts- und Landesbibliothek Sachsen-Anhalt) · doi:10.25673/176