The P2X7 Receptor

Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

Bauernfeind, F. G., Horvath, G. L., Stutz, A., Alnemri, E. S., MacDonald, K. L., Speert, D. P., Fernandes‐Alnemri, T., Wu, J., Monks, B. G., Fitzgerald, K. A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901363 · Cited by 3,006 · see citing works

The Cytolytic P _2Z Receptor for Extracellular ATP Identified as a P _2X Receptor (P2X ₇ )

Surprenant, A., Rassendren, F., Kawashima, E., North, R. A., & Buell, G. (1996) · Science · doi:10.1126/science.272.5262.735 · Cited by 1,739 · see citing works

Extracellular ATP: effects, sources and fate

Gordon, J. L. (1986) · Biochemical Journal · doi:10.1042/bj2330309 · Cited by 1,668 · see citing works

Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor

Pelegrı́n, P., & Surprenant, A. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601378 · Cited by 1,428 · see citing works

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

Chekeni, F. B., Elliott, M. R., Sandilos, J. K., Walk, S. F., Kinchen, J. M., Lazarowski, E. R., Armstrong, A. J., Penuela, S., Laird, D. W., Salvesen, G. S., et al. (2010) · Nature · doi:10.1038/nature09413 · Cited by 1,120 · see citing works

Altered Cytokine Production in Mice Lacking P2X7Receptors

Solle, M., Labasi, J. M., Perregaux, D. G., Stam, E. J., Petrushova, N., Koller, B. H., Griffiths, R., & Gabel, C. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006781200 · Cited by 924 · see citing works

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

Chessell, I. P., Hatcher, J. P., Bountra, C., Michel, A. D., Hughes, J. P., Green, P., Egerton, J., Murfin, M., Richardson, J. C., Peck, W. L., et al. (2005) · Pain · doi:10.1016/j.pain.2005.01.002 · Cited by 790 · see citing works

Crystal structure of the ATP-gated P2X4 ion channel in the closed state

Kawate, T., Michel, J. J. C., Birdsong, W. T., & Gouaux, E. (2009) · Nature · doi:10.1038/nature08198 · Cited by 739 · see citing works

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock

Yang, D., He, Y., Muñoz-Planillo, R., Liu, Q., & Núñez, G. (2015) · Immunity · doi:10.1016/j.immuni.2015.10.009 · Cited by 604 · see citing works

Molecular mechanism of ATP binding and ion channel activation in P2X receptors

Hattori, M., & Gouaux, E. (2012) · Nature · doi:10.1038/nature11010 · Cited by 554 · see citing works

The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes

Silverman, W. R., Vaccari, J. P. D. R., Locovei, S., Qiu, F., Carlsson, S. K., Scemes, E., Keane, R. W., & Dahl, G. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.004804 · Cited by 534 · see citing works

P2X7 receptor inhibition improves recovery after spinal cord injury

Wang, X., Arcuino, G., Takano, T., Lin, J. H.-C., Peng, W. G., Wan, P., Li, P., Xu, Q., Liu, Q. S., Goldman, S. A., et al. (2004) · Nature Medicine · doi:10.1038/nm1082 · Cited by 495 · see citing works

Tissue distribution of the P2X7 receptor

Collo, G., Neidhart, S., Kawashima, E. H., Kosco‐Vilbois, M. H., North, R. A., & Buell, G. N. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00140-8 · Cited by 493 · see citing works

The Permeabilizing ATP Receptor, P2X7

Rassendren, F., Buell, G. N., Virginio, C., Collo, G., North, R. A., & Surprenant, A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.9.5482 · Cited by 479 · see citing works

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

Bábelová, A., Moreth, K., Tsalastra, W., Zeng-Brouwers, J., Eickelberg, O., Young, M. F., Brückner, P., Pfeilschifter, J. M., Schaefer, R. M., Gröne, H., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.014266 · Cited by 474 · see citing works

Pannexin1 is part of the pore forming unit of the P2X7 receptor death complex

Locovei, S., Scemes, E., Qiu, F., Spray, D. C., & Dahl, G. (2007) · FEBS Letters · doi:10.1016/j.febslet.2006.12.056 · Cited by 434 · see citing works

Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury

Peng, W., Cotrina, M. L., Han, X., Yu, H., Bekar, L. K., Blum, L., Takano, T., Tian, G.-F., Goldman, S. A., & Nedergaard, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902531106 · Cited by 425 · see citing works

A Novel P2X7 Receptor Activator, the Human Cathelicidin-Derived Peptide LL37, Induces IL-1β Processing and Release

Elssner, A., Duncan, M., Gavrilin, M. A., & Wewers, M. D. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.8.4987 · Cited by 425 · see citing works

A-740003 [N-(1-{[(Cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X7 Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat

Honoré, P., Donnelly‐Roberts, D. L., Namovic, M. T., Hsieh, G. C., Zhu, C., Mikusa, J. P., Hernandez, G., Zhong, C., Gauvin, D. M., Chandran, P., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.111559 · Cited by 418 · see citing works

Pore dilation of neuronal P2X receptor channels

Virginio, C., MacKenzie, A., Rassendren, F. A., North, R. A., & Surprenant, A. (1999) · Nature Neuroscience · doi:10.1038/7225 · Cited by 414 · see citing works

Hetero-oligomeric Assembly of P2X Receptor Subunits

Torres, G. E., Egan, T. M., & Voigt, M. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6653 · Cited by 414 · see citing works

Brilliant Blue G Selectively Blocks ATP-Gated Rat P2X7Receptors

Jiang, L., Mackenzie, A. B., North, R. A., & Surprenant, A. (2000) · Molecular Pharmacology · doi:10.1124/mol.58.1.82 · Cited by 401 · see citing works

The P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease

Bartlett, R., Stokes, L., & Sluyter, R. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008003 · Cited by 395 · see citing works

ATP-Induced Killing of Mycobacteria by Human Macrophages Is Mediated by Purinergic P2Z(P2X7) Receptors

Lammas, D. A., Stober, C. B., Harvey, C. J., Kendrick, N., Panchalingam, S., & Kumararatne, D. S. (1997) · Immunity · doi:10.1016/s1074-7613(00)80364-7 · Cited by 393 · see citing works

P2X7 receptor: an emerging target in central nervous system diseases

Sperlágh, B., & Illes, P. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.08.002 · Cited by 390 · see citing works

Proteomic and functional evidence for a P2X7 receptor signalling complex

Kim, M., Jiang, L., Wilson, H. L., North, R. A., & Surprenant, A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.22.6347 · Cited by 379 · see citing works

Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds

Khakh, B. S., Bao, X. R., Labarca, C. G., & Lester, H. A. (1999) · Nature Neuroscience · doi:10.1038/7233 · Cited by 365 · see citing works

Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation

Qu, Y., Misaghi, S., Newton, K., Gilmour, L. L., Louie, S., Cupp, J. E., Dubyak, G., Hackos, D. H., & Dixit, V. M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100478 · Cited by 365 · see citing works

Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity

Sorge, R. E., Trang, T., Dorfman, R., Smith, S. B., Beggs, S., Ritchie, J., Austin, J., Zaykin, D. V., Meulen, H. V., Costigan, M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2710 · Cited by 360 · see citing works

NAD-Induced T Cell Death

Séman, M., Adriouch, S., Scheuplein, F., Krebs, C. F., Freese, D., Glowacki, G., Deterre, P., Haag, F., & Koch‐Nolte, F. (2003) · Immunity · doi:10.1016/s1074-7613(03)00266-8 · Cited by 336 · see citing works

Pharmacological characterization of recombinant human and rat P2X receptor subtypes

Bianchi, B. R., Lynch, K. J., Touma, E., Niforatos, W., Burgard, E. C., Alexander, K. M., Park, H. S., Yu, H., Metzger, R. E., Kowaluk, E. A., et al. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00350-7 · Cited by 331 · see citing works

P2X7 receptor-Pannexin1 complex: pharmacology and signaling

Iglesias, R., Locovei, S., Roque, A., Alberto, A. P., Dahl, G., Spray, D. C., & Scemes, E. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00228.2008 · Cited by 331 · see citing works

Human astrocytes express a novel NLRP2 inflammasome

Minkiewicz, J., Vaccari, J. P. D. R., & Keane, R. W. (2013) · Glia · doi:10.1002/glia.22499 · Cited by 328 · see citing works

Clinical evaluation of the efficacy of the P2X7 purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine

Keystone, E. C., Wang, M. M., Layton, M., Hollis, S., & McInnes, I. B. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-143578 · Cited by 318 · see citing works

Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2x purinoceptors).

Evans, R. J., Lewis, C. J., Buell, G. N., Valera, S., North, R. A., & Surprenant, A. (1995) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10232-0 · Cited by 316 · see citing works

A Glu-496 to Ala Polymorphism Leads to Loss of Function of the Human P2X7 Receptor

Gu, B. J., Zhang, W., Worthington, R. A., Sluyter, R., Dao‐Ung, P., Petrou, S., Barden, J. A., & Wiley, J. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010353200 · Cited by 314 · see citing works

Structural basis for subtype-specific inhibition of the P2X7 receptor

Karasawa, A., & Kawate, T. (2016) · eLife · doi:10.7554/elife.22153 · Cited by 308 · see citing works

Pannexin 1, an ATP Release Channel, Is Activated by Caspase Cleavage of Its Pore-associated C-terminal Autoinhibitory Region

Sandilos, J. K., Chiu, Y., Chekeni, F. B., Armstrong, A. J., Walk, S. F., Ravichandran, K. S., & Bayliss, D. A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.323378 · Cited by 304 · see citing works

Purinergic Signaling and Blood Vessels in Health and Disease

Burnstock, G., & Ralevic, V. (2013) · Pharmacological Reviews · doi:10.1124/pr.113.008029 · Cited by 303 · see citing works

Pannexin-1 Couples to Maitotoxin- and Nigericin-induced Interleukin-1β Release through a Dye Uptake-independent Pathway

Pelegrı́n, P., & Surprenant, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m610351200 · Cited by 301 · see citing works

Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors

Kurashima, Y., Amiya, T., Nochi, T., Fujisawa, K., Haraguchi, T., Iba, H., Tsutsui, H., Sato, S., Nakajima, S., Iijima, H., et al. (2012) · Nature Communications · doi:10.1038/ncomms2023 · Cited by 286 · see citing works

A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP

Qiu, F., & Dahl, G. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00433.2008 · Cited by 275 · see citing works

Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors

Donnelly‐Roberts, D. L., Namovic, M. T., Han, P., & Jarvis, M. F. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00233.x · Cited by 271 · see citing works

X-ray structures define human P2X3 receptor gating cycle and antagonist action

Mansoor, S., Lü, W., Oosterheert, W., Shekhar, M., Tajkhorshid, E., & Gouaux, E. (2016) · Nature · doi:10.1038/nature19367 · Cited by 259 · see citing works

ATP-stimulated Release of Interleukin (IL)-1β and IL-18 Requires Priming by Lipopolysaccharide and Is Independent of Caspase-1 Cleavage

Mehta, V. B., Hart, J., & Wewers, M. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006814200 · Cited by 255 · see citing works

Trophic activity of a naturally occurring truncated isoform of the P2X7 receptor

Adinolfi, E., Cirillo, M., Woltersdorf, R., Falzoni, S., Chiozzi, P., Pellegatti, P., Callegari, M. G., Sandonà, D., Markwárdt, F., Schmalzing, G., et al. (2010) · The FASEB Journal · doi:10.1096/fj.09-153601 · Cited by 254 · see citing works

ATP induces nucleotide permeability in rat mast cells

Cockcroft, S., & Gomperts, B. D. (1979) · Nature · doi:10.1038/279541a0 · Cited by 253 · see citing works

Efficacy and Safety of CE-224,535, an Antagonist of P2X 7 Receptor, in Treatment of Patients with Rheumatoid Arthritis Inadequately Controlled by Methotrexate

Stock, T. C., Bloom, B. J., Wei, N., Ishaq, S., Park, W., WANG, X., Gupta, P. K., & MEBUS, C. A. (2012) · The Journal of Rheumatology · doi:10.3899/jrheum.110874 · Cited by 246 · see citing works

Toward an understanding of the protein interaction network of the human liver

Wang, J., Huo, K., Ma, L., Tang, L., Li, D., Huang, X., Yuan, Y., Li, C., Wang, W., Guan, W., et al. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.67 · Cited by 243 · see citing works

Long noncoding RNA (lincRNA), a new paradigm in gene expression control

Deniz, E., & Erman, B. (2016) · Functional & Integrative Genomics · doi:10.1007/s10142-016-0524-x · Cited by 243 · see citing works

Evidence for Functional P2X4/P2X7 Heteromeric Receptors

Guo, C. Y., Masin, M., Qureshi, O. S., & Murrell‐Lagnado, R. D. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.035980 · Cited by 239 · see citing works

ATP-Mediated Killing of Intracellular Mycobacteria by Macrophages Is a P2X7-Dependent Process Inducing Bacterial Death by Phagosome-Lysosome Fusion

Fairbairn, I. P., Stober, C. B., Kumararatne, D. S., & Lammas, D. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.6.3300 · Cited by 234 · see citing works

Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses

Jacob, F., Perez-Novo, C. A., Bachert, C., & Crombruggen, K. V. (2013) · Purinergic Signalling · doi:10.1007/s11302-013-9357-4 · Cited by 232 · see citing works

The ATP4- receptor of rat mast cells

Cockcroft, S., & Gomperts, B. D. (1980) · Biochemical Journal · doi:10.1042/bj1880789 · Cited by 225 · see citing works

The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein

Franceschini, A., Capece, M., Chiozzi, P., Falzoni, S., Sanz, J. M., Sarti, A. C., Bonora, M., Pinton, P., & Di Virgilio, F. (2015) · The FASEB Journal · doi:10.1096/fj.14-268714 · Cited by 225 · see citing works

Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: Relevance for neuropsychiatric disorders

Basso, A. M., Bratcher, N. A., Harris, R. R., Jarvis, M. F., Decker, M. W., & Rueter, L. E. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.10.018 · Cited by 224 · see citing works

The microglial ATP‐gated ion channel P2X7 as a CNS drug target

Bhattacharya, A., & Biber, K. (2016) · Glia · doi:10.1002/glia.23001 · Cited by 221 · see citing works

P2X Receptors in Health and Disease

Burnstock, G., & Kennedy, C. (2011) · Advances in Pharmacology · doi:10.1016/b978-0-12-385526-8.00011-4 · Cited by 213 · see citing works

DISTRIBUTION OF P2X RECEPTORS IN THE URINARY BLADDER AND THE URETER OF THE RAT

Lee, H. Y., Bardini, M., & Burnstock, G. (2000) · The Journal of Urology · doi:10.1016/s0022-5347(05)67618-5 · Cited by 210 · see citing works

Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons

Anderson, C. M., & Nedergaard, M. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.03.003 · Cited by 207 · see citing works

Identification and characterization of splice variants of the human P2X7 ATP channel

Cheewatrakoolpong, B., Gilchrest, H., Anthes, J. C., & Greenfeder, S. A. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.04.087 · Cited by 207 · see citing works

Expression of P2X7 purinoceptors on human lymphocytes and monocytes: evidence for nonfunctional P2X7 receptors

Gu, B. J., Zhang, W. Y., Bendall, L. J., Chessell, I. P., Buell, G. N., & Wiley, J. S. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.4.c1189 · Cited by 204 · see citing works

Blockade of Human P2X7 Receptor Function With a Monoclonal Antibody

Buell, G. N., Chessell, I. P., Michel, A. D., Collo, G., Salazzo, M., Herren, S., Gretener, D., Grahames, C., Kaur, R., Kosco‐Vilbois, M. H., et al. (1998) · Blood · doi:10.1182/blood.v92.10.3521 · Cited by 201 · see citing works

Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ ‐47965567

Bhattacharya, A., Wang, Q., Ao, H., Shoblock, J. R., Lord, B., Aluisio, L. E., Fraser, I. C., Nepomuceno, D. H., Neff, R. A., Welty, N., et al. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12314 · Cited by 200 · see citing works

Cutting Edge: A Natural P451L Mutation in the Cytoplasmic Domain Impairs the Function of the Mouse P2X7 Receptor

Adriouch, S., Dox, C., Welge, V., Séman, M., Koch‐Nolte, F., & Haag, F. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.8.4108 · Cited by 196 · see citing works

P2X receptors

North, R. A. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0427 · Cited by 191 · see citing works

P2X7 receptor regulation of non-classical secretion from immune effector cells

Dubyak, G. (2012) · Cellular Microbiology · doi:10.1111/cmi.12001 · Cited by 189 · see citing works

A Functional P2X7 Splice Variant with an Alternative Transmembrane Domain 1 Escapes Gene Inactivation in P2X7 Knock-out Mice

Nicke, A., Kuan, Y., Masin, M., Rettinger, J., Marquez-Klaka, B., Bender, O., Górecki, D. C., Murrell‐Lagnado, R. D., & Soto, F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.033134 · Cited by 187 · see citing works

Cutting Edge: The Nucleotide Receptor P2X7 Contains Multiple Protein- and Lipid-Interaction Motifs Including a Potential Binding Site for Bacterial Lipopolysaccharide

Denlinger, L. C., Fisette, P. L., Sommer, J. A., Watters, J. J., Prabhu, U., Dubyak, G., Proctor, R. A., & Bertics, P. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.1871 · Cited by 182 · see citing works

Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation

Danquah, W., Meyer‐Schwesinger, C., Rissiek, B., Pinto, C., Prat, A. S., Amadi, M., Iacenda, D., Knop, J., Hammel, A., Bergmann, P., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf8463 · Cited by 182 · see citing works

Epithelial Membrane Proteins Induce Membrane Blebbing and Interact with the P2X7 Receptor C Terminus

Wilson, H. L., Wilson, S. A., Surprenant, A., & North, R. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205120200 · Cited by 181 · see citing works

A Protein Kinase C Site Highly Conserved in P2X Subunits Controls the Desensitization Kinetics of P2X2 ATP-gated Channels

Boué‐Grabot, É., Archambault, V., & Séguéla, P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.14.10190 · Cited by 175 · see citing works

Two haplotypes of the P2X 7 receptor containing the Ala‐348 to Thr polymorphism exhibit a gain‐of‐function effect and enhanced interleukin‐1β secretion

Stokes, L., Fuller, S. J., Sluyter, R., Skarratt, K. K., Gu, B. J., & Wiley, J. S. (2010) · The FASEB Journal · doi:10.1096/fj.09-150862 · Cited by 174 · see citing works

P2X4 Assembles with P2X7 and Pannexin-1 in Gingival Epithelial Cells and Modulates ATP-induced Reactive Oxygen Species Production and Inflammasome Activation

Hung, S.-C., Choi, C. H., Sadier, N. S., Johnson, L., Atanasova, K. R., Sellami, H., Yilmaz, Ö., & Ojcius, D. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070210 · Cited by 171 · see citing works

P2X7 receptor cell surface expression and cytolytic pore formation are regulated by a distal C-terminal region

Smart, M. L., Gu, B., Panchal, R. G., Wiley, J., Cromer, B., Williams, D. A., & Petrou, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211094200 · Cited by 170 · see citing works

P2X7 receptor signaling contributes to tissue factor–dependent thrombosis in mice

Furlan-Freguia, C., Marchese, P., Gruber, A., Ruggeri, Z. M., & Ruf, W. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46129 · Cited by 169 · see citing works

An Ile-568 to Asn Polymorphism Prevents Normal Trafficking and Function of the Human P2X7 Receptor

Wiley, J. S., Dao‐Ung, L., Li, C., Shemon, A. N., Gu, B. J., Smart, M. L., Fuller, S. J., Barden, J. A., Petrou, S., & Sluyter, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212759200 · Cited by 166 · see citing works

The P2X7 Receptor-Interleukin-1 Liaison

Giuliani, A. L., Sarti, A. C., Falzoni, S., & Di Virgilio, F. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00123 · Cited by 166 · see citing works

A His-155 to Tyr Polymorphism Confers Gain-of-Function to the Human P2X7 Receptor of Human Leukemic Lymphocytes

Cabrini, G., Falzoni, S., Forchap, S., Pellegatti, P., Balboni, A., Agostini, P., Cuneo, A., Castoldi, G., Baricordi, O. R., & Virgilio, F. D. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.82 · Cited by 164 · see citing works

The P2X7 Receptor Channel Pore Dilates under Physiological Ion Conditions

Yan, Z., Li, S., Liang, Z., Tomić, M., & Stojilković, S. S. (2008) · The Journal of General Physiology · doi:10.1085/jgp.200810059 · Cited by 164 · see citing works

Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptor

Gu, B. J., & Wiley, J. S. (2006) · Blood · doi:10.1182/blood-2005-07-2994 · Cited by 160 · see citing works

ADP and AMP Induce Interleukin-1β Release from Microglial Cells through Activation of ATP-Primed P2X7 Receptor Channels

Chakfe, Y., Seguin, R. M., Antel, J. P., Morissette, C., Malo, D., Henderson, D. J., & Séguéla, P. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03061.2002 · Cited by 158 · see citing works

The Human Cathelicidin LL-37 Modulates the Activities of the P2X7 Receptor in a Structure-dependent Manner

Tomasinsig, L., Pizzirani, C., Skerlavaj, B., Pellegatti, P., Gulinelli, S., Tossi, A., Virgilio, F. D., & Zanetti, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802185200 · Cited by 158 · see citing works

ATP-induced autophagy is associated with rapid killing of intracellular mycobacteria within human monocytes/macrophages

Biswas, D., Qureshi, O. S., Lee, W.-Y. J., Croudace, J. E., Mura, M., & Lammas, D. A. (2008) · BMC Immunology · doi:10.1186/1471-2172-9-35 · Cited by 156 · see citing works

Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages

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Nitration of Hsp90 induces cell death

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Lipopolysaccharide Induces Alveolar Macrophage Necrosis via CD14 and the P2X7 Receptor Leading to Interleukin-1α Release

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miR-150 Promotes Human Breast Cancer Growth and Malignant Behavior by Targeting the Pro-Apoptotic Purinergic P2X7 Receptor

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LncRNA NONRATT021972 siRNA regulates neuropathic pain behaviors in type 2 diabetic rats through the P2X7 receptor in dorsal root ganglia

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N-methyl- d -glucamine and propidium dyes utilize different permeation pathways at rat P2X7 receptors

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ADP‐ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site

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MicroRNA-150 protects the mouse heart from ischaemic injury by regulating cell death

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Spinal cord pathology is ameliorated by P2X7 antagonism in SOD1-G93A mouse model of amyotrophic lateral sclerosis

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T follicular helper cells promote a beneficial gut ecosystem for host metabolic homeostasis by sensing microbiota-derived extracellular ATP

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Tyrosine Phosphorylation of HSP90 within the P2X7 Receptor Complex Negatively Regulates P2X7 Receptors

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A phase I clinical trial demonstrates that nfP2X7 -targeted antibodies provide a novel, safe and tolerable topical therapy for basal cell carcinoma

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Activation of the NLRP3/caspase-1 inflammasome in human dental pulp tissue and human dental pulp fibroblasts

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microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus

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Differential role of extracellular histidines in copper, zinc, magnesium and proton modulation of the P2X7 purinergic receptor

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Plasma Membrane Cholesterol as a Regulator of Human and Rodent P2X7 Receptor Activation and Sensitization

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Probenecid Blocks Human P2X7 Receptor-Induced Dye Uptake via a Pannexin-1 Independent Mechanism

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The sixth sense: hematopoietic stem cells detect danger through purinergic signaling

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Involvement of P2X4 receptor in P2X7 receptor-dependent cell death of mouse macrophages

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The enzyme Cyp26b1 mediates inhibition of mast cell activation by fibroblasts to maintain skin-barrier homeostasis.

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The ATP4− receptor-operated ion channel of human lymphocytes: Inhibition of ion fluxes by amiloride analogs and by extracellular sodium ions

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Mutation of a Dibasic Amino Acid Motif Within the C Terminus of the P2X7 Nucleotide Receptor Results in Trafficking Defects and Impaired Function

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Structural Insights into Divalent Cation Modulations of ATP-Gated P2X Receptor Channels

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Clemastine Potentiates the Human P2X7 Receptor by Sensitizing It to Lower ATP Concentrations

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A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age‐related macular degeneration

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P2X7 receptors: role in bone cell formation and function

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Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development—Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus

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C-terminal Calmodulin-binding Motif Differentially Controls Human and Rat P2X7 Receptor Current Facilitation

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P2X2 and P2X5 Subunits Define a New Heteromeric Receptor with P2X7-Like Properties

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Influence of external ATP on permeability and metabolism of dog red blood cells

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P2X7 Receptor–Pannexin 1 Hemichannel Association: Effect of Extracellular Calcium on Membrane Permeabilization

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Emerging role of P2X7 receptors in CNS health and disease

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Stimulation of rat erythrocyte P2X7receptor induces the release of epoxyeicosatrienoic acids

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A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis

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Caveolin‐1 influences P2X7 receptor expression and localization in mouse lung alveolar epithelial cells

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Loss of P2X7 nucleotide receptor function leads to abnormal fat distribution in mice

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Complexities of Measuring Antagonist Potency at P2X7Receptor Orthologs

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PI3K/Akt signaling pathway triggers P2X7 receptor expression as a pro-survival factor of neuroblastoma cells under limiting growth conditions

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Splice-variants of the P2X7 receptor reveal differential agonist-dependence and functional coupling with pannexin-1

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Transient P2X7 Receptor Activation Triggers Macrophage Death Independent of Toll-like Receptors 2 and 4, Caspase-1, and Pannexin-1 Proteins

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P2X4 receptors interact with both P2X2 and P2X7 receptors in the form of homotrimers

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Negative and positive allosteric modulators of the P2X 7 receptor

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P2X7 receptor activation induces inflammatory responses in salivary gland epithelium

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The P2X7/P2X4 interaction shapes the purinergic response in murine macrophages

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P2X7 receptor positively regulates MyD88-dependent NF-κB activation

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The ATP Receptors P2X7 and P2X4 Modulate High Glucose and Palmitate-Induced Inflammatory Responses in Endothelial Cells

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Antidepressant- and anticompulsive-like effects of purinergic receptor blockade: Involvement of nitric oxide

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Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions

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The P2X7 Receptor Supports Both Life and Death in Fibrogenic Pancreatic Stellate Cells

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Identification of regions of the P2X7receptor that contribute to human and rat species differences in antagonist effects

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ATP stimulates GRK-3 phosphorylation and β-arrestin-2-dependent internalization of P2X7 receptor

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Differential Regulation of P2X7 Receptor Activation by Extracellular Nicotinamide Adenine Dinucleotide and Ecto-ADP-Ribosyltransferases in Murine Macrophages and T Cells

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Role of neuroinflammation in neurodegeneration development

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Extracellular ATP and P2 purinergic signalling in the tumour microenvironment

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The P2X7 receptor: A main player in inflammation

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Update of P2X receptor properties and their pharmacology: IUPHAR Review 30

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The Elusive P2X7 Macropore

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P2X7 receptor and the NLRP3 inflammasome: Partners in crime

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ATP in the tumour microenvironment drives expression of nfP2X7, a key mediator of cancer cell survival

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The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies

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The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition

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Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology

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P2X7 Receptors Amplify CNS Damage in Neurodegenerative Diseases

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P2X7 Receptor Signaling in Stress and Depression

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Endothelial Dysfunction: Redox Imbalance, NLRP3 Inflammasome, and Inflammatory Responses in Cardiovascular Diseases

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A central role for P2X7 receptors in human microglia

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18 F-JNJ-64413739, a Novel PET Ligand for the P2X7 Ion Channel: Radiation Dosimetry, Kinetic Modeling, Test-Retest Variability, and Occupancy of the P2X7 Antagonist JNJ-54175446

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Modulation of innate and adaptive immunity by P2X ion channels

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Non-nucleotide Agonists Triggering P2X7 Receptor Activation and Pore Formation

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AMPK-dependent and independent actions of P2X7 in regulation of mitochondrial and lysosomal functions in microglia

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Moderate-intensity exercise alleviates pyroptosis by promoting autophagy in osteoarthritis via the P2X7/AMPK/mTOR axis

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Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder

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The role and pharmacological properties of the P2X7 receptor in neuropathic pain

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P2X7 Variants in Oncogenesis

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PI3K/Akt/GSK-3β signal pathway is involved in P2X7 receptor-induced proliferation and EMT of colorectal cancer cells

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Structural and Functional Basis for Understanding the Biological Significance of P2X7 Receptor

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Characterisation of the pharmacodynamic effects of the P2X7 receptor antagonist JNJ-54175446 using an oral dexamphetamine challenge model in healthy males in a randomised, double-blind, placebo-controlled, multiple ascending dose trial

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Dihydromyricetin Alleviates Diabetic Neuropathic Pain and Depression Comorbidity Symptoms by Inhibiting P2X7 Receptor

Guan, S., Shen, Y., Ge, H., Xiong, W., He, L., Liu, L., Yin, C., Wei, X., & Gao, Y. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00770 · Cited by 60 · see citing works

Puerarin Inhibits NLRP3-Caspase-1-GSDMD-Mediated Pyroptosis via P2X7 Receptor in Cardiomyocytes and Macrophages

Sun, S., Gong, D., Liu, R., Wang, R., Chen, D., Yuan, T., Wang, S., Xing, C., Lv, Y., Du, G., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713169 · Cited by 60 · see citing works

Structure, function and techniques of investigation of the P2X7 receptor (P2X7R) in mammalian cells

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Effect of P2X7 receptor on tumorigenesis and its pharmacological properties

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P2X7 Receptor–Mediated Inflammation in Cardiovascular Disease

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P2X7 receptor in inflammation and pain

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Inflammatory Response During Myocardial Infarction

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The P2X7 Receptor as Regulator of T Cell Development and Function

Grassi, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01179 · Cited by 40 · see citing works

Adult mesenchymal stem cells: is there a role for purine receptors in their osteogenic differentiation?

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New Insights Into Permeation of Large Cations Through ATP-Gated P2X Receptors

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Antidepressant-like effect induced by P2X7 receptor blockade in FSL rats is associated with BDNF signalling activation

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Rosacea pathogenesis and therapeutics: current treatments and a look at future targets

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P2X7 receptor: a critical regulator and potential target for breast cancer

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Alternative splicing of P2RX7 pre-messenger RNA in health and diseases: Myth or reality?

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The P2X7 Receptor in Osteoarthritis

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Membrane Transport Proteins in Osteoclasts: The Ins and Outs

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P2X7 receptor in cardiovascular disease: The heart side

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Role and therapeutic targets of P2X7 receptors in neurodegenerative diseases

Zheng, H., Liu, Q., Zhou, S., Luo, H., & Zhang, W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1345625 · Cited by 40 · see citing works

Purinergic signaling and tumor microenvironment in cervical Cancer

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Diabetes and hypertension: Pivotal involvement of purinergic signaling

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Purinergic receptors in cognitive disturbances

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The P2X7 purinergic receptor: a potential therapeutic target for lung cancer

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Contribution of non-selective membrane channels and receptors in epilepsy

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The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1G93A mice

Ly, D., Dongol, A., Cuthbertson, P., Guy, T. V., Geraghty, N. J., Sophocleous, R. A., Sin, L., Turner, B. J., Watson, D., Yerbury, J. J., et al. (2020) · Purinergic Signalling · doi:10.1007/s11302-020-09692-4 · Cited by 36 · see citing works

The P2X7 Receptor Stimulates IL-6 Release from Pancreatic Stellate Cells and Tocilizumab Prevents Activation of STAT3 in Pancreatic Cancer Cells

Magni, L., Bouazzi, R., Olmedilla, H. H., Petersen, P. S. S., Tozzi, M., & Novak, I. (2021) · Cells · doi:10.3390/cells10081928 · Cited by 35 · see citing works

Regulation and functions of the NLRP3 inflammasome in RNA virus infection

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The P2X7 receptor and pannexin-1 are involved in glucose-induced autocrine regulation in β-cells

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Purinergic Receptors in Basal Ganglia Diseases: Shared Molecular Mechanisms between Huntington’s and Parkinson’s Disease

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The role of extracellular vesicles in traumatic brain injury-induced acute lung injury

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Enteric nervous system and inflammatory bowel diseases: Correlated impacts and therapeutic approaches through the P2X7 receptor

Magalhães, H. I. R., & Castelucci, P. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i46.7909 · Cited by 33 · see citing works

The mechanosensory and mechanotransductive processes mediated by ion channels and the impact on bone metabolism: A systematic review

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Development and clinical translation of P2X7 receptor antagonists: A potential therapeutic target in coronary artery disease?

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Alcohol and e-cigarette damage alveolar-epithelial barrier by activation of P2X7r and provoke brain endothelial injury via extracellular vesicles

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Implication of lncRNA MSTRG.81401 in Hippocampal Pyroptosis Induced by P2X7 Receptor in Type 2 Diabetic Rats with Neuropathic Pain Combined with Depression

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P2RX7 at the Host-Pathogen Interface of Infectious Diseases

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P2X7 receptor antagonism increases regulatory T cells and reduces clinical and histological graft-versus-host disease in a humanised mouse model

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Modulation of Microglial Function by ATP-Gated P2X7 Receptors: Studies in Rat, Mice and Human

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Mapping a novel positive allosteric modulator binding site in the central vestibule region of human P2X7

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P2 Receptors as Therapeutic Targets in the Salivary Gland: From Physiology to Dysfunction

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The P2X7 Receptor as a Mechanistic Biomarker for Epilepsy

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P2X7 receptor antagonists for the treatment of systemic inflammatory disorders

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Structure-Activity Relationships and Therapeutic Potential of Purinergic P2X7 Receptor Antagonists

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Attenuating Diabetic Vascular and Neuronal Defects by Targeting P2rx7

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20S-Protopanaxatriol Ameliorates Hepatic Fibrosis, Potentially Involving FXR-Mediated Inflammatory Signaling Cascades

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The role of P2X7 receptor in infection and metabolism: Based on inflammation and immunity

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Animal Models for the Investigation of P2X7 Receptors

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Unveiling the P2X7 receptor: Exploring its mechanisms, pathogenic role in ocular diseases, and emerging therapeutic potential

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Long-term treatment with the P2X7 receptor antagonist Brilliant Blue G reduces liver inflammation in a humanized mouse model of graft-versus-host disease

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Functional roles of lncRNAs and its potential mechanisms in neuropathic pain

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Beyond Seizure Control: Treating Comorbidities in Epilepsy via Targeting of the P2X7 Receptor

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Application of nanotechnology in the treatment of glomerulonephritis: current status and future perspectives

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P2X7 receptor as the regulator of T-cell function in intestinal barrier disruption

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P2X7 Variants in Pathophysiology

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Involvement of P2X7 Receptors in the Osteogenic Differentiation of Mesenchymal Stromal/Stem Cells Derived from Human Subcutaneous Adipose Tissue

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Role of TRPV4-P2X7 Pathway in Neuropathic Pain in Rats with Chronic Compression of the Dorsal Root Ganglion

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P2X7R Mediates the Synergistic Effect of ATP and MSU Crystals to Induce Acute Gouty Arthritis

Li, X., Wan, A., Liu, Y., Li, M., Zhu, Z., Luo, C., & Tao, J. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/3317307 · Cited by 24 · see citing works

P2X7 receptor promotes migration and invasion of non-small cell lung cancer A549 cells through the PI3K/Akt pathways

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Ca2+ flux through splice variants of the ATP-gated ionotropic receptor P2X7 is regulated by its cytoplasmic N terminus

Liang, X., Samways, D. S. K., Cox, J. A., & Egan, T. M. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009666 · Cited by 24 · see citing works

Purinergic Signaling in Pancreas—From Physiology to Therapeutic Strategies in Pancreatic Cancer

Novak, I., Yu, H., Magni, L., & Deshar, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228781 · Cited by 24 · see citing works

P2X7 receptor activation impairs antitumour activity of natural killer cells

Baroja‐Mazo, A., Peñín‐Franch, A., Lucas‐Ruiz, F., de Torre‐Minguela, C., Alarcón‐Vila, C., Hernández‐Caselles, T., & Pelegrı́n, P. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15951 · Cited by 22 · see citing works

The P2X7 Receptor 489C>T Gain of Function Polymorphism Favors HHV-6A Infection and Associates With Female Idiopathic Infertility

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Purinergic P2X7 receptor as a potential therapeutic target in depression

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Overview of the role of purinergic signaling and insights into its role in cancer therapy

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The Coming of Age of the P2X7 Receptor in Diagnostic Medicine

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Radioligands targeting purinergic P2X7 receptor

Zheng, Q. (2020) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2020.127169 · Cited by 22 · see citing works

Altered donor P2X7 activity in human leukocytes correlates with P2RX7 genotype but does not affect the development of graft-versus-host disease in humanised mice

Adhikary, S. R., Geraghty, N. J., Cuthbertson, P., Sluyter, R., & Watson, D. (2019) · Purinergic Signalling · doi:10.1007/s11302-019-09651-8 · Cited by 22 · see citing works

P2X7 Receptor-Related Genetic Mouse Models – Tools for Translational Research in Psychiatry

Urbina-Treviño, L., von Mücke-Heim, I.-A., & Deussing, J. M. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2022.876304 · Cited by 22 · see citing works

P2X7R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes

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Research Progress of Pyroptosis in Diabetic Kidney Disease

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P2Y2 and P2X4 Receptors Mediate Ca2+ Mobilization in DH82 Canine Macrophage Cells

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A Possible Causal Involvement of Neuroinflammatory, Purinergic P2X7 Receptors in Psychiatric Disorders

Tang, Y., Illes, P., Zhang, Y., Yin, H.-Y., & Rubini, P. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220302152400 · Cited by 20 · see citing works

P2X7 Is Involved in the Mouse Retinal Degeneration via the Coordinated Actions in Different Retinal Cell Types

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The P2X7 receptor in mood disorders: Emerging target in immunopsychiatry, from bench to bedside

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A comprehensive toxicological analysis of trans-fatty acids (TFAs) reveals a pro-apoptotic action specific to industrial TFAs counteracted by polyunsaturated FAs

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P2X7 receptors from the perspective of NLRP3 inflammasome pathway in depression: Potential role of cannabidiol

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Structural and Functional Basis for Understanding the Biological Significance of P2X7 Receptor

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Significance of P2X7 Receptor Variants to Human Health and Disease

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Pharmacological Targeting of P2x7 Receptors: Inflammation, Cancer, And Beyond

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The P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease

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