Cited by 315Liver physiology and pathologyMicrotubule and mitosis dynamicsChromosomal and Genetic Variations

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Liver Cell Polyploidization: A Pivotal Role for Binuclear Hepatocytes

Open access

Guidotti, Jacques-Emmanuel, Brégerie, Olivier, Robert, Aude, Debey, Pascale, Brechot, Christian, Desdouets, Chantal·2003·Journal of Biological Chemistry

DOI 10.1074/jbc.m300982200

Open this paper in CoChat — free account

Abstract

Polyploidy is a general physiological process indicative of terminal differentiation. During liver growth, this process generates the appearance of tetraploid (4n) and octoploid (8n) hepatocytes with one or two nuclei. The onset of polyploidy in the liver has been recognized for quite some time; however, the cellular mechanisms that govern it remain unknown. In this report, we observed the sequential appearance during liver growth of binuclear diploid (2 x 2n) and mononuclear 4n hepatocytes from a diploid hepatocyte population. To identify the cell cycle modifications involved in hepatocyte polyploidization, mitosis was then monitored in primary cultures of rat hepatocytes. Twenty percent of mononuclear 2n hepatocytes failed to undergo cytokinesis with no observable contractile movement of the ring. This process led to the formation of binuclear 2 x 2n hepatocytes. This tetraploid condition following cleavage failure did not activate the p53-dependent checkpoint in G1. In fact, binuclear hepatocytes were able to proceed through S phase, and the formation of a bipolar spindle during mitosis constituted the key step leading to the genesis of two mononuclear 4n hepatocytes. Finally, we studied the duplication and clustering of centrosomes in the binuclear hepatocyte. These cells exhibited two centrosomes in G1 that were duplicated during S phase and then clustered by pairs at opposite poles of the cell during metaphase. This event led only to mononuclear 4n progeny and maintaine…

Integrity signals

Registry

Crossref · 10.1074/jbc.m300982200

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Aurora‐A overexpression reveals tetraploidization as a major route to centrosome amplification in p53−/− cells
Meraldi, P., Honda, R., & Nigg, E. A. (2002) · The EMBO Journal · doi:10.1093/emboj/21.4.483 · Cited by 676
Ploidy Regulation of Gene Expression
Galitski, T., Saldanha, A. J., Styles, C. A., Lander, E. S., & Fink, G. R. (1999) · Science · doi:10.1126/science.285.5425.251 · Cited by 633
PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone
Mollinari, C., Kleman, J.-P., Jiang, W. B., Schoehn, G., Hunter, T. R., & Margolis, R. L. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200111052 · Cited by 468
Tetraploid State Induces p53-dependent Arrest of Nontransformed Mammalian Cells in G1
Andreassen, P. R., Lohez, O. D., Lacroix, F., & Margolis, R. L. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.5.1315 · Cited by 440
Role of citron kinase as a target of the small GTPase Rho in cytokinesis
Madaule, P., Eda, M., Watanabe, N., Fujisawa, K., Matsuoka, T., Bito, H., Ishizaki, T., & Narumiya, S. (1998) · Nature · doi:10.1038/28873 · Cited by 402
AIM‐1: a mammalian midbody‐associated protein required for cytokinesis
Terada, Y., Tatsuka, M., Suzuki, F., Yasuda, Y., Fujita, S., & Otsu, M. (1998) · The EMBO Journal · doi:10.1093/emboj/17.3.667 · Cited by 400
A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles
Nislow, C., Lombillo, V. A., Kuriyama, R., & McIntosh, J. R. (1992) · Nature · doi:10.1038/359543a0 · Cited by 357
Plk Is an M-Phase-Specific Protein Kinase and Interacts with a Kinesin-Like Protein, CHO1/MKLP-1
Lee, K. S., Yuan, Y.-L. O., Kuriyama, R., & Erikson, R. L. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.12.7143 · Cited by 268
Roads to polyploidy: The megakaryocyte example
Ravid, K., Lü, J., Zimmet, J. M., & Jones, M. R. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.10035 · Cited by 266
The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion
Mayor, T., Stierhof, Y., Tanaka, K., Fry, A. M., & Nigg, E. A. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.4.837 · Cited by 237

Flagged first, then by citations

Show all 35 references

Research works printed but not linked: 4

Sigal, 1999, Am. J. Physiol., 276, G1260
Gomez-Lechon, 1981, Cell. Mol. Biol., 27, 695
Minamishima, 2002, Cancer Res., 62, 995
Chassoux, 1999, Anal. Quant. Cytol. Histol., 21, 489

Sorted by citations

Items 201–300 of 315

The enigma of cancer polyploidy as deciphered by evolutionary cancer cell biology (ECCB)
Niculescu, V. F., & Niculescu, E. R. (2024) · Academia Medicine · doi:10.20935/acadmed6233 · Cited by 8
Tipping Cancer Cells Over the Edge: The Context-Dependent Cost of High Ploidy
Andor, N., Altrock, P. M., Jain, N., & Gomes, A. P. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-2794 · Cited by 7
p38α deficiency restrains liver regeneration after partial hepatectomy triggering oxidative stress and liver injury
Rius‐Pérez, S., Tormos, A. M., Pérez, S., Finamor, I., Rada, P., Valverde, Á. M., Nebreda, Á. R., Sastre, J., & Taléns‐Visconti, R. (2019) · Scientific Reports · doi:10.1038/s41598-019-39428-3 · Cited by 9
Reviews and Perspectives
Paris, J., & Patten, S. B. (2014) · The Canadian Journal of Psychiatry · doi:10.1177/070674371405900101 · Cited by 8
The development and prevalidation of an in vitro mutagenicity assay based on MutaMouse primary hepatocytes, Part I: Isolation, structural, genetic, and biochemical characterization
Cox, J. A., Zwart, E., Luijten, M., & White, P. A. (2018) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22253 · Cited by 7
Aberrant regulation of autophagy disturbs fibrotic liver regeneration after partial hepatectomy
Lian, Y., Bai, Y., Lai, J., & Huang, A.-M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1030338 · Cited by 7
Dietary supplementation with monounsaturated and long-chain polyunsaturated fatty acids influences the liver structural recovery and hepatocyte binuclearity in female Wistar rats in experimental cirrhosis induced by thioacetamide
Fernández-Lizaranzu, I., Fontana, L., Gil, Á., Ríos, A., & Torres, M. I. (2005) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2005.02.001 · Cited by 7
Mechanisms and Consequences of Centrosome Clustering in Cancer Cells
Krämer, A., Anderhub, S. J., & Maier, B. (2012) · Humana Press eBooks · doi:10.1007/978-1-62703-035-9_17 · Cited by 7
Immunological, biochemical and histopathological evaluation of histamine receptors (H1R, H2R, H3R and H4R)-antagonist in rabbit experimental model: A short term study
Tripathi, T., Khan, A. A., Shahid, M., Khan, H. M., Siddiqui, M., Khan, R. A., & Mahdi, A. A. (2010) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2010.08.018 · Cited by 7
Diploid hepatocytes drive physiological liver renewal in adult humansPreprint
Heinke, P., Rost, F., Rode, J., Welsch, T., Alkass, K., Feddema, J., Salehpour, M., Possnert, G., Druid, H., Brusch, L., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.07.230086 · Cited by 7
Metronidazole induces genotoxicity, hepato- and nephrotoxicity by triggering DNA fragmentation in Swiss albino mice (Balb/c)
Topal, T. R., Karan, M., Çavuşoğlu, K., & Yalçın, E. (2025) · Scientific Reports · doi:10.1038/s41598-025-12230-0 · Cited by 6
Characterization of Multinuclear Hepatocytes Induced in Rats by Mitemcinal (GM-611), an Erythromycin Derivative
Hayashi, S., Fujii, E., Kato, A., Kimura, K., Mizoguchi, K., Suzuki, M., Sugimoto, T., Takanashi, H., Itoh, Z., Ōmura, S., et al. (2008) · Toxicologic Pathology · doi:10.1177/0192623308322307 · Cited by 6
Inhibiting Cytokinesis in the Liver: A New Way to Reduce Tumor Development
Desdouets, C., & Avila, M. A. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.03.006 · Cited by 6
Self-citation
Ploidy in cardiovascular development and regeneration
Lan, T., Kaminsky, S., & Wu, C. C. (2025) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2025.103618 · Cited by 5
Multinucleation as a buffer against gene expression noise in syncytial myofibres
Hansson, K. (2025) · The Journal of Physiology · doi:10.1113/jp288218 · Cited by 5
Effects of Antenatal Hypoxia on the Parameters of Tissue Homeostasis in the Liver of Albino Rats
Pinaeva, O. G., Лебедько, О. А., Яковенко, Д. В., Тимошин, С. С., Pinaev, S. K., & Николаевна, С. Е. (2014) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-014-2557-2 · Cited by 5
Attenuation of binuclear hepatocytes in the paracancerous liver tissue is associated with short‐term recurrence of hepatocellular carcinoma post‐radical surgery
Zhang, Y., Wang, N., Hao, F., Chen, Y., Fei, X., & Wang, J. (2023) · The FASEB Journal · doi:10.1096/fj.202301219r · Cited by 5
Hepatic endopolyploidy as a cellular consequence of age‐specific selection for rate of development in mice
Funk‐Keenan, J., Haire, F., Woolard, S., & Atchley, W. R. (2008) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.21211 · Cited by 5
Biochemical and histopathological evaluation of histamine receptors (H1R, H2R, H3R and H4R)-agonist in rabbits
Tripathi, T., Khan, A. A., Shahid, M., Khan, H. M., Siddiqui, M., Khan, R. A., Mahdi, A. A., & Malik, A. (2011) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2011.09.004 · Cited by 5
Liver physiological polyploidization: MicroRNA-122 a key regulator
Celton-Morizur, S., & Desdouets, C. (2017) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2016.07.006 · Cited by 5
Self-citation
ESRP2–microRNA-122 axis promotes the postnatal onset of liver polyploidization and maturation
Bangru, S., Chen, J., Baker, N., Das, D., Chembazhi, U. V., Derham, J. M., Chorghade, S., Arif, W., Alencastro, F., Duncan, A. W., et al. (2025) · Genes & Development · doi:10.1101/gad.352129.124 · Cited by 4
Two types of regenerative cell populations appear in acute liver injury
Aoyagi, T., Goya, T., Imoto, K., Azuma, Y., Hioki, T., Kohjima, M., Tanaka, M., Oda, Y., & Ogawa, Y. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102503 · Cited by 5
Endomitosis: a new cell fate in the cell cycle leading to polyploidy in megakaryocytes and hepatocytes
Hua, Q.-H., Zhang, X., Tian, R., She, Z., & Huang, Z. (2025) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2400127 · Cited by 4
Whole genome duplication through mitotic slippage causes nuclear instability
Gemble, S., Budzyk, M., Simon, A. Y., Lambuta, R. A., Nanni, L., Weiss, N., Forest, A., Miroshnikova, Y. A., di Carlo, F. S., Marthiens, V., et al. (2026) · The EMBO Journal · doi:10.1038/s44318-026-00912-y · Cited by 4
Self-citation
Consequences of Numerical Centrosome Defects in Development and Disease
Gambarotto, D., & Basto, R. (2016) · Springer eBooks · doi:10.1007/978-3-7091-1903-7_5 · Cited by 4
Centrosome Clustering in the Development of Bovine Binucleate Trophoblast Giant Cells
Klisch, K., Schraner, E. M., & Boos, A. (2016) · Cells Tissues Organs · doi:10.1159/000452271 · Cited by 4
Cell–Cell Fusions and Human Endogenous Retroviruses in Cancer
Strick, R., Beckmann, M. W., & Strissel, P. L. (2010) · Springer eBooks · doi:10.1007/978-90-481-9772-9_17 · Cited by 4
Cell Therapy in Acute and Chronic Liver Disease
Paganelli, M. (2019) · Springer eBooks · doi:10.1007/978-3-319-96400-3_43 · Cited by 4
Cell Cycle Control in the Liver
Albrecht, J. H., & Mullany, L. K. (2009) · Wiley eBooks · doi:10.1002/9780470747919.ch62 · Cited by 4
Systematic analysis of the regulatory roles of microRNAs in postnatal maturation and metergasis of liver of breeder cocks
Wu, S., Guo, W., Liang, S., Lü, H., Sun, W., Ren, X., Sun, Q., & Yang, X. (2018) · Scientific Reports · doi:10.1038/s41598-017-18674-3 · Cited by 3
Hepatic histopathological and morphometric changes in male mice exposed to rosuvastatin from pre-puberty to adulthood: a possible adaptive hepatic response
Knorst, J. K., de Mello, T. F., Oltramari, A. R., da Silva, A. S., & Leite, G. A. A. (2024) · Drug and Chemical Toxicology · doi:10.1080/01480545.2024.2385609 · Cited by 3
Assessment of Hepatocyte Ploidy by Flow Cytometry
Jin, Y., Anbarchian, T., & Nusse, R. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2557-6_12 · Cited by 4
Elucidation of proliferative capability of mononuclear tetraploid cells, emerging spontaneously from diploid cells, using image cytometry and fluorescence in situ hybridization
Ito, H., Oga, A., Furuya, T., Ikemoto, K., Amakawa, G., Chochi, Y., Kawauchi, S., & Sasaki, K. (2013) · Cell Proliferation · doi:10.1111/cpr.12032 · Cited by 3
Partial Hepatectomy in Acetylation-DeficientBubR1Mice Corroborates that Chromosome Missegregation Initiates Tumorigenesis
Lee, Y.-K., Park, I., & Lee, H. (2014) · Endocrinology and Metabolism · doi:10.3803/enm.2014.29.4.561 · Cited by 3
Fluorescence based cell counting in collagen monolayer cultures of primary hepatocytes
Priesnitz, C., Sperber, S., Garg, R., Orsini, M., & Noor, F. (2014) · Cytotechnology · doi:10.1007/s10616-014-9821-1 · Cited by 3
Analysis of centromere signal patterns in breast cancer cells with chromosomal instability using image cytometry combined with centromere fluorescence in situ hybridization
Ito, H., Oga, A., Ikemoto, K., Furuya, T., Maeda, N., Yamamoto, S., Kawauchi, S., Itoh, H., Oka, M., & Sasaki, K. (2014) · Cytometry Part A · doi:10.1002/cyto.a.22502 · Cited by 3
Features of cardiomyocyte division during rat heart development.
Guo, Z., Lin, J., Chang, L., Xu, Z., & Xin-hua, C. (2011) · Pakistan Journal of Zoology · Cited by 3
Changes in Hepatocyte Ploidy During Liver Regeneration
Duncan, A. W. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420128-6.00012-9 · Cited by 3
Electrophysiological Properties of Tetraploid Cardiomyocytes Derived from Murine Pluripotent Stem Cells Generated by Fusion of Adult Somatic Cells with Embryonic Stem Cells
Xu, G., Fatima, A., Breitbach, M., Kuzmenkin, A., Fuegemann, C. J., Ivanyuk, D., Kim, K. P., Cantz, T., Pfannkuche, K., Schöler, H. R., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076546 · Cited by 3
Polyploidy in Animal Development and Disease
Bandura, J. L., & Zielke, N. (2017) · Wiley eBooks · doi:10.1002/9781118647110.ch1 · Cited by 3
Hepatocyte Cell Cycle Progression Depends on a Transcriptional Repressor Cascade Downstream of Wnt Signaling
Jin, Y., Anbarchian, T., Wu, P., Sarkar, A., Fish, M., & Nusse, R. (2021) · doi:10.1101/2021.10.15.464616 · Cited by 2
Stereo-cell deciphers the spatial and functional heterogeneity of polyploid hepatocytes
Yang, Y., Luo, J., Cai, Y., Guo, P., Guo, Q., Wu, H., Liu, L., & Hao, S. (2026) · GigaScience · doi:10.1093/gigascience/giag023 · Cited by 1
The Role of Immunomodulator Betaleukin in Recovery of Hepatocytic Ploidy Profile in Delayed Terms after Irradiation
Sycheva, L. P., & Rozhdestvenskiĭ, L. M. (2020) · Bulletin of experimental biology and medicine · doi:10.1007/s10517-020-04909-3 · Cited by 2
Raising of Anillin expression in para-cancerous hepatocytes is associated with hepatic depolyploidization and short-term recurrence of hepatocellular carcinoma after radical operation
Wang, N., Hao, F., Zhang, Y., Xu, W., Chen, Y., Fei, X., & Wang, J. (2022) · Journal of Cancer · doi:10.7150/jca.72890 · Cited by 3
Advance in the anther tapetum development and their regulatory mechanisms
ZhenXin, S. U., Que, Z. H. O. U., & Yue, L. O. U. (2024) · Scientia Sinica Vitae · doi:10.1360/ssv-2024-0051 · Cited by 2
Adult Stem Cell Plasticity Revisited
Mezey, É. (2011) · Humana Press eBooks · doi:10.1007/978-1-61779-002-7_5 · Cited by 2
Polyploïdie cellulaire dans le tissu hépatique : nouveau rôle de l’insuline
Celton-Morizur, S., & Desdouets, C. (2009) · médecine/sciences · doi:10.1051/medsci/2009256-7651 · Cited by 1
Self-citation
Centrosome and Golgi complex during differentiation of hepatocytes in early postnatal development of mice
Sysoeva, V., & Онищенко, Г. Е. (2006) · Russian Journal of Developmental Biology · doi:10.1134/s1062360406030040 · Cited by 2
High-resolution 3D fluorescent imaging of intact tissues
El‐Nachef, D., Martinson, A., Yang, X., Murry, C. E., & MacLellan, W. R. (2021) · International Journal of Cardiology and Cardiovascular Diseases · doi:10.46439/cardiology.1.001 · Cited by 2
Whole-body γ-irradiation decelerates rat hepatocyte polyploidization
Ikhtiar, A. (2015) · International Journal of Radiation Biology · doi:10.3109/09553002.2015.1027422 · Cited by 2
The Effects of Polo-like Kinase 4 on Chromosomal Stability, Cell Migration and Tumourigenesis
Rosario, C. O. (2011) · TSpace (University of Toronto) · Cited by 2
Binucleated human hepatocytes arise through loss of membrane anchorage to the midbody during endomitosisPreprint
Darmasaputra, G., Lopes, S. M. C. D. S., Clevers, H. C., & Galli, M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.13.536716 · Cited by 4
Diploid hepatocytes resist acetaminophen-induced liver injury through suppressed JNK signaling
Wilson, S. R., Delgado, E. R., Alencastro, F., Loewenstein, R. L., Leek, M. P., Peters, L. R., Kamel, K., Wilkinson, P. D., Jain, S., Locker, J. D., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08448-z · Cited by 1
A novel sorting method uncovers metabolic heterogeneity between mononucleated and binucleated tetraploid hepatocytes
Watanabe, Y. V., Sussman, J., Anami, T., Shimodaira, G., Hattori, M., Yamane, S., Nishikawa, M., Sakai, Y., & Katsuda, T. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.113324 · Cited by 1
Changes in the chick liver structure and blood plasma biochemical properties following in ovo administration of acrylamide
Wojciechowska-Puchałka, J., Drąg-Kozak, E., Kustra, K., Trela, M., & Marcin Wojciech, L. I. S. (2026) · Poultry Science · doi:10.1016/j.psj.2026.107580 · Cited by 1
Plasmodium induced by SU6656, an Src family kinase inhibitor, is accompanied by a contractile ring defect
Yoshida, K., Ono, M., Bito, H., Mikami, T., & Sawada, H. (2011) · Cell Biochemistry and Function · doi:10.1002/cbf.1814 · Cited by 1
A case of gastric adenocarcinoma with conspicuous binuclear cytologic features
Ito, H., Furuya, C., Yamanouchi, T., Ikemoto, K., Katoh, T., Onoda, M., Kondo, T., & Oga, A. (2013) · Cancer Genetics · doi:10.1016/j.cancergen.2013.08.001 · Cited by 1
The role of some donor-host cell interactions under a microenvironmental influence during regeneration processes
Shablii, V., Лукаш, Л. Л., & Лобинцева, Г. С. (2012) · Cytology and Genetics · doi:10.3103/s0095452712030097 · Cited by 1
Peculiarities of liver regeneration in Chinese hamster Cricetulus griseus
Sakuta, G. A., Baidyuk, E. V., Aa, Z., & Kudryavtsev, B. N. (2012) · Cell and Tissue Biology · doi:10.1134/s1990519x12010105 · Cited by 1
Polyploidization Without Mitosis Improves In Vivo Liver Transduction With Lentiviral Vectors
Pichard, V., Couton, D., Desdouets, C., & Ferry, N. (2012) · Human Gene Therapy · doi:10.1089/hum.2011.227 · Cited by 1
Self-citation
The Role of Mesenchymal Cells in Cancer: Contribution to Tumor Stroma and Tumorigenic Capacity
Shoshani, O., & Zipori, D. (2010) · Springer eBooks · doi:10.1007/978-90-481-9531-2_5 · Cited by 1
A High-Throughput In Situ Method for Estimation of Hepatocyte Nuclear Ploidy in Mice
Manzano‐Núñez, F., Peters, R., Burks, D. J., & Noon, L. A. (2020) · Journal of Visualized Experiments · doi:10.3791/60095 · Cited by 2
Nucleus, Nuclear Structure, and Nuclear Functions: Pathogenesis of Nuclear Abnormalities in Cancer
Zimmermann, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-26956-6_170 · Cited by 1
Histological Changes in the Cat Placenta Throughout Gestation
Castro, G. G., Hernández, R., Cristofolini, A., Portiansky, E. L., Merkis, C., Badura, E., Casas, L. A., Barbeito, C. G., & Diessler, M. E. (2025) · Veterinary Sciences · doi:10.3390/vetsci12030207 · Cited by 1
Liver Stem Cells
Manohar, R., & Lagasse, E. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-398358-9.00045-8 · Cited by 1
La polyploïdie hépatique
Donné, R., Saroul-Aïnama, M., Maillet, V., Celton‐Morizur, S., & Desdouets, C. (2019) · médecine/sciences · doi:10.1051/medsci/2019094 · Cited by 2
Self-citation
Regulation of the Liver Cell Mass
Malek, N. P., Rudolph, K. L., & Diehl, A. M. (2007) · Wiley eBooks · doi:10.1002/9780470691861.ch2e · Cited by 1
Monitoring and mathematical modeling of in vitro human megakaryocyte expansion and maturation dynamics
Leysi-Derilou, Y. (2011) · Corpus Université Laval (Université Laval) · Cited by 1
FGF signaling promotes precursor spreading for adult adipogenesis in DrosophilaPreprint
Lei, Y., Huang, Y., Yang, K. L., Cao, X., Song, Y., Martı́n-Blanco, E., & Pastor-Pareja, J. C. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.21.489019 · Cited by 1
ESRP2-microRNA-122 axis directs the postnatal onset of liver polyploidization and maturationPreprint
Bangru, S., Chen, J., Baker, N., Das, D., Chembazhi, U. V., Derham, J. M., Chorghade, S., Arif, W., Alencastro, F., Duncan, A. W., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.06.602336 · Cited by 1
The function of the BRCA2 protein and centriole mobility during cytokinesis studied with live-cell microscopy
Jonsdottir, A. B. (2010) · Skemman
Transient tetraploidy as a route to chromosomal instability
Kuznetsova, A. A. (2013) · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.16812
The link between the centrosome, TSC disease and epithelial differentiation
Baldó, L. G. (2010) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
IN VITRO HEPATOCYTE-LIKE CELLS DIFFERENTIATION OF HUMAN UMBILICAL CORD BLOOD MESENCHYMAL STEM CELLS
Ghaderi, M., Allameh, A., Soleimani, M., & Mahdi, F. M. (2012)
Centriolar and ciliary responses to DNA damage
Conroy, P. C. (2012) · Arrow@dit (Dublin Institute of Technology) · doi:10.13025/16788
Morphology and function of cultured hepatocytes isolated from rats with experimental toxic hepatitis
Baidyuk, E. V., Shiryaeva, A. P., Bezborodkina, N. N., & Sakuta, G. A. (2009) · Cell and Tissue Biology · doi:10.1134/s1990519x09060108
The Changes In Cell Cycle Of Rat Hepatocytes During Aging
Giorgadze, S., Rukhadze, R., & Dzidziguri, D. (2015)
On the Origin of Newly Made Neural Cells in the Adult Organism: Does Transdifferentiation Occur?
Mezey, É. (2003) · Springer eBooks · doi:10.1007/0-306-48356-4_6
Primary evaluation of induced pluripotent stem cells using flow cytometry
Araki, D., Kawamura, Y., Niibe, K., Suzuki, S., Morikawa, S., Mabuchi, Y., Nakagawa, T., Okano, H., & Matsuzaki, Y. (2013) · Inflammation and Regeneration · doi:10.2492/inflammregen.33.003
O avanço da idade induz alterações na organização da cromatina e na ploidia de neurônios corticais de camundongos
Rodrigues, H. (2013) · doi:10.14393/ufu.di.2013.106
Cytoskeletal defects lead to cytokinesis failure and genomic instability in cancer cells
Wu, Q. (2008) · D-Scholarship@Pitt (University of Pittsburgh)
Nucleus, Nuclear Structure, and Nuclear Functions: Pathogenesis of Nuclear Abnormalities in Cancer
Zimmermann, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-26587-2_170-1
Università degli Studi di Milano Scuola di Dottorato in Medicina Molecolare
Bòsari, S. (2012)
Single-cell analysis of ploidy and centrosomes underscores the peculiarity of normal hepatocytes Curriculum di Genomics, Proteomics e tecnologie correlate
Clerici, M., Battaglia, C., & Vezzoni, P. (2012)
Liver Stem Cells
Lagasse, E. (2007) · Elsevier eBooks · doi:10.1016/b978-012370615-7/50051-2
Регенерация печени млекопитающих: межклеточные взаимодействия
Ельчанинов, А. В., & Fatkhudinov, T. (2020) · Наука eBooks · doi:10.7868/9785020407770
The Effects of Polo-like Kinase 4 on Cancer Cell Motility
Zih, S. W. (2012) · TSpace (University of Toronto)
Faculty Opinions recommendation of Chromosome segregation fidelity in epithelia requires tissue architecture.
Zernicka‐Goetz, M., & Shahbazi, M. N. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733850856.793553197
Faculty Opinions recommendation of In Vivo Lineage Tracing of Polyploid Hepatocytes Reveals Extensive Proliferation during Liver Regeneration.
Sosa‐Pineda, B., & Martínez-Ramírez, A. S. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737111051.793583029
Data from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen
Rebacz, B., Larsen, T. O., Clausen, M. H., Rønnest, M. H., Löffler, H., Ho, A. D., & Krämer, A. (2023) · doi:10.1158/0008-5472.c.6495780
Data from Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen
Rebacz, B., Larsen, T. O., Clausen, M. H., Rønnest, M. H., Löffler, H., Ho, A. D., & Krämer, A. (2023) · doi:10.1158/0008-5472.c.6495780.v1
Ultrastructural organization of the liver of rat pups in early postnatal ontogenesis when pregnant and lactating rats are kept on a low-protein diet
Pershina, E. G., Morozova, K. N., & Bgatova, N. P. (2024) · Ultrastructural Pathology · doi:10.1080/01913123.2024.2441933
Synaptic vesicle glycoprotein 2 enables viable aneuploidy following centrosome amplification
Blackmer, J. E., Jezuit, E. A., Chakraborty, A., Yalamanchi, S. N., Montague, R. A., Dickert, E. E., Peterson, N. G., Outlaw, W., & Fox, D. T. (2025) · Genetics · doi:10.1093/genetics/iyaf148
Transcriptional repression of central spindle factors controls endomitosis in the C. elegans intestinePreprint
Barrull-Mascaró, R., Veltkamp, S., Boutaibi, S., van Rijnberk, L. M., Lippmann, R., & Galli, M. (2025) · bioRxiv · doi:10.1101/2025.08.04.668394
Low nucleus to cytoplasmic ratio compromises cytokinesis, genome stability and development in haploid embryonic cellsPreprint
Zuccaro, M., Georgieva, D., Xu, S.-Y., Dennen, M. S., Du, Q., Chia, G., Amrane, S., Grossman, L. C., Angeles, A. D. L., Prosser, R., et al. (2025) · bioRxiv · doi:10.1101/2025.08.30.673237
Optimized Protocol for Primary Rat Hepatocyte Isolation and a Model for Investigating Experimental Steatosis
Harb, A. A., Alsalem, M., & Abdalla, S. (2025) · Methods and Protocols · doi:10.3390/mps8050111
The dual role of whole-genome duplication: biological mechanisms, functional consequences, and detection advances
Song, Y., Yang, J., Wu, S., & Wu, W. (2025) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025175 · Cited by 1
Male Rat Model of Chemical Androgen Deprivation and Estrogenization from the Perspective of Anthropometric, Histological, and Biochemical Parameters
Ćosić, P., Vukojević, M., Miler, M., Filipović, B. R., Manojlović‐Stojanoski, M., & Ajdžanović, V. Z. (2025) · Medicina · doi:10.3390/medicina62010008
Mise au point d'une thérapie génique de la maladie de Crigler-Najjar de type 1 par des AAV 8 recombinants
Flageul, M. (2009)
Impact of neoadjuvant cetuximab on liver function and tumor reduction in a murine model of selective portal vein ligation
Tirado-Rodríguez, G., Montesinos, I. R., Correcher, S. I., de Gordejuela, A. G. R., Aizpiolea, P., Alconada, D. A., Garcı́a-Alonso, I., & de la Parte, B. H. (2025) · Clinical & Experimental Metastasis · doi:10.1007/s10585-025-10386-7

Authors: Guidotti, J.-E., Brégerie, O., Robert, A., Debey, P., Brechot, C., & Desdouets, C.
Affiliations: Hôpital Necker-Enfants Malades (FR)
Centre National de la Recherche Scientifique (FR)
Corresponding author: Desdouets, Chantal
ORCID: Guidotti, Jacques-Emmanuel
Robert, Aude
Desdouets, Chantal
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2003-05
Volume: 278
Issue: 21
Pages: 19095-19101
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m300982200
OpenAlex: W1979685062
Cited by: 315
References: 35
Citations by year: 2026: 10 · 2025: 15 · 2024: 10 · 2023: 11 · 2022: 13 · 2021: 11 · 2020: 13 · 2019: 11 · 2018: 17 · 2017: 14 · 2016: 17 · 2015: 15 · 2014: 12 · 2013: 19 · 2012: 22
FWCI: 7.17
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 6354 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Keywords: binuclear hepatocytes, liver growth, cytokinesis failure, mitosis, bipolar spindle, centrosome duplication, centrosome clustering, G1/S checkpoint, cell cycle
MeSH terms: Animals, Cell Division, Cell Nucleus, Cells, Cultured, DNA, Fluorescent Antibody Technique, Kinetics, Male, Microscopy, Fluorescence, Mitosis, Polyploidy, Blotting, Western, Tumor Suppressor Protein p53, G1 Phase, S Phase, Rats, Wistar, Centrosome, Microscopy, Video, Hepatocytes, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Liver Cell Polyploidization: A Pivotal Role for Binuclear Hepatocytes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks