Desdouets, Chantal

Liver Cell Polyploidization: A Pivotal Role for Binuclear Hepatocytes

Guidotti, J.-E., Brégerie, O., Robert, A., Debey, P., Brechot, C., & Desdouets, C. (2003) · Journal of Biological Chemistry

Liver physiology and pathologyMicrotubule and mitosis dynamics

Cited by 315

Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease

Gentric, G., Maillet, V., Paradis, V., Couton, D., L’Hermitte, A., Panasyuk, G., Fromenty, B., Celton-Morizur, S., & Desdouets, C. (2015) · Journal of Clinical Investigation

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 240

Polyploidization in Liver Tissue

Gentric, G., & Desdouets, C. (2014) · The American Journal of Pathology

Liver physiology and pathologyChromosomal and Genetic Variations

Cited by 192

Polyploidy in liver development, homeostasis and disease

Donne, R., Saroul-Aïnama, M., Cordier, P., Celton-Morizur, S., & Desdouets, C. (2020) · Nature Reviews Gastroenterology & Hepatology

Liver physiology and pathologyChromosomal and Genetic Variations

Cited by 188

Liver tetraploidization is controlled by a new process of incomplete cytokinesis

Margall-Ducos, G., Celton-Morizur, S., Couton, D., Brégerie, O., & Desdouets, C. (2007) · Journal of Cell Science

Microtubule and mitosis dynamicsLiver physiology and pathology

Cited by 170

The insulin/Akt pathway controls a specific cell division program that leads to generation of binucleated tetraploid liver cells in rodents

Celton-Morizur, S., Merlen, G., Couton, D., Margall-Ducos, G., & Desdouets, C. (2009) · Journal of Clinical Investigation

Liver physiology and pathologyMetabolism, Diabetes, and Cancer

Cited by 145

Changes to hepatocyte ploidy and binuclearity profiles during human chronic viral hepatitis

Toyoda, H., Bregerie, O., Vallet, A., Nalpas, B., Pivert, G., Brechot, C., & Desdouets, C. (2005) · Gut

Liver physiology and pathologyHepatitis B Virus Studies

Cited by 105

Reactive cholangiocytes differentiate into proliferative hepatocytes with efficient DNA repair in mice with chronic liver injury

Manco, R., Clerbaux, L.-A., Verhulst, S., Bou Nader, M., Sempoux, C., Ambroise, J., Bearzatto, B., Gala, J. L., Horsmans, Y., van Grunsven, L., et al. (2019) · Journal of Hepatology

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 92

Cdc42-mediated MTOC polarization in dendritic cells controls targeted delivery of cytokines at the immune synapse

Pulecio, J., Petrovic, J., Prete, F., Chiaruttini, G., Lennon-Dumenil, A.-M., Desdouets, C., Gasman, S., Burrone, O. R., & Benvenuti, F. (2010) · Journal of Experimental Medicine

Immunotherapy and Immune ResponsesT-cell and B-cell Immunology

Cited by 91

Polyploidy and liver proliferation: Central role of insulin signaling

Celton-Morizur, S., Merlen, G., Couton, D., & Desdouets, C. (2010) · Cell Cycle

Liver physiology and pathologyMicrotubule and mitosis dynamics

Cited by 75

Polyploidy and liver proliferation

Gentric, G., Celton-Morizur, S., & Desdouets, C. (2012) · Clinics and Research in Hepatology and Gastroenterology

Liver physiology and pathologyOrgan Transplantation Techniques and Outcomes

Cited by 73

Hepatitis B virus X protein promotes DNA damage propagation through disruption of liver polyploidization and enhances hepatocellular carcinoma initiation

Ahodantin, J., Bou-Nader, M., Cordier, C., Mégret, J., Soussan, P., Desdouets, C., & Kremsdorf, D. (2019) · Oncogene

Hepatitis B Virus StudiesLiver physiology and pathology

Cited by 46

Liver physiological polyploidization: MicroRNA-122 a key regulator

Celton-Morizur, S., & Desdouets, C. (2017) · Clinics and Research in Hepatology and Gastroenterology

Liver physiology and pathologyMicroRNA in disease regulation

Cited by 5