The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Necrotic Cell Death in Response to Oxidant Stress Involves the Activation of the Apoptogenic Caspase-8/Bid Pathway
Open accessAbstract
Human epithelial (A549) cells exposed to hyperoxia die by cellular necrosis. In the current study, we demonstrated the involvement of apoptogenic factors in epithelial cell necrosis in response to hyperoxia, including the formation of the Fas-related death-inducing signaling complex and initiation of mitochondria-dependent apoptotic pathways. We showed increased activation of both Bid and Bax in A549 cells subjected to hyperoxia. Bax activation involved a Bid-assisted conformational change. We discovered that the response to hyperoxia in vivo predominantly involved the activation of the Bid/caspase-8 pathway without apparent increases in Bax expression. Disruption of the Bid pathway by gene deletion protected against cell death in vivo and in vitro. Likewise, inhibition of caspase-8 by Flip also protected against cell death. Taken together, we have demonstrated the involvement of apoptogenic factors in epithelial cell responses to hyperoxia, despite a final outcome of cellular necrosis. We have, for the first time, identified a predominant role for the caspase-8/Bid pathway in signaling associated with hyperoxic lung injury and cell death in vivo and in vitro.
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“The antitumor effect of atmospheric hyperoxia may be due to oxidative stress and increased apoptosis (BCL2‐associated X [Bax]/Bcl‐2 mRNA expression rate), which is associated with the mitogen‐activated protein kinase (MAPK) pathway.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [299]
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Cites
Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
Li, H., Zhu, H., Xu, C.-J., & Yuan, J. (1998) · Cell · doi:10.1016/s0092-8674(00)81590-1 · Cited by 4,445
Molecular characterization of mitochondrial apoptosis-inducing factor
Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., et al. (1999) · Nature · doi:10.1038/17135 · Cited by 4,060
Luo, X., Budihardjo, I., Zou, H., Slaughter, C., & Wang, X. (1998) · Cell · doi:10.1016/s0092-8674(00)81589-5 · Cited by 3,626
Self-citationApoptosis, oncosis, and necrosis. An overview of cell death.
Majno, G., & Joris, I. (1995) · PubMed · Cited by 3,328
THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS
Kroemer, G., Dallaporta, B., & Resche-Rigon, M. (1998) · Annual Review of Physiology · doi:10.1146/annurev.physiol.60.1.619 · Cited by 1,975
Leist, M., Single, B., Castoldi, A. F., Kühnle, S., & Nicotera, P. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.8.1481 · Cited by 1,871
Desagher, S., Osen‐Sand, A., Nichols, A. C., Eskes, R., Montessuit, S., Lauper, S., Maundrell, K., Antonsson, B. E., & Martinou, J. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.5.891 · Cited by 1,260
Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane
Eskes, R., Desagher, S., Antonsson, B. E., & Martinou, J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.929-935.2000 · Cited by 1,212
Checkpoints of dueling dimers foil death wishes
Oltvai, Z. N. (1994) · Cell · doi:10.1016/0092-8674(94)90188-0 · Cited by 795
Finucane, D., Bossy‐Wetzel, E., Waterhouse, N. J., Cotter, T. G., & Green, D. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.2225 · Cited by 714
Research works printed but not linked: 5
- Majno, 1995, Am. J. Pathol., 146, 3
- Otterbein, 1998, Am. J. Physiol., 275, L14
- O'Reilly, 2001, Am. J. Physiol., 278, L552
- Allen, 1998, Am. J. Physiol., 274, L159
- O'Reilly, 2001, Am. J. Physiol., 281, L291
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Ryter, S. W., Alam, J., & Choi, A. M. K. (2006) · Physiological Reviews · doi:10.1152/physrev.00011.2005 · Cited by 2,342
Self-citationMechanisms of Cell Death in Oxidative Stress
Ryter, S. W., Kim, H. P., Hoetzel, A., Park, J. W., Nakahira, K., Wang, X., & Choi, A. M. K. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.9.49 · Cited by 1,286
Self-citationAmelioration of Ischemic Acute Renal Injury by Neutrophil Gelatinase-Associated Lipocalin
Mishra, J., Mori, K., Ma, Q., Kelly, C. N., Yang, J., Mitsnefes, M. M., Barasch, J. M., & Devarajan, P. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000145013.44578.45 · Cited by 536
The independence of and associations among apoptosis, autophagy, and necrosis
Chen, Q., Kang, J., & Fu, C. (2018) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-018-0018-5 · Cited by 368
Hyperoxia causes angiopoietin 2–mediated acute lung injury and necrotic cell death
Bhandari, V., Choo-Wing, R., Lee, C. G., Zhu, Z., Nedrelow, J. H., Chupp, G. L., Zhang, X., Matthay, M. A., Ware, L. B., Homer, R., et al. (2006) · Nature Medicine · doi:10.1038/nm1494 · Cited by 339
Metadata
- Authors
- Wang, X., Ryter, S. W., Dai, C., Tang, Z.-L., Watkins, S. C., Yin, X.-M., Song, R., & Choi, A. M. K.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Choi, Augustine M.K.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-08
- Volume
- 278
- Issue
- 31
- Pages
- 29184-29191
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2052913152
- Cited by
- 136
- References
- 41
- Citations by year
- 2026: 3 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 5 · 2012: 2
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (7r01ai042365-02)
- National Heart, Lung, and Blood Institute (R01HL055330, R01HL55330, R01HL60234, R01HL060234)
- National Institute of Allergy and Infectious Diseases (R01 AI-42365)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Keywords
- necrosis, hyperoxia, oxidative stress, caspase-8, Bid, Bax, mitochondrial apoptosis, A549 cells, epithelial cells, hyperoxic lung injury, c-FLIP
- MeSH terms
- Adenocarcinoma, Animals, Carrier Proteins, Cells, Cultured, Enzyme Inhibitors, Fibroblasts, Humans, Lung, Lung Neoplasms, Male, Membrane Glycoproteins, Mice, Inbred C3H, Mice, Inbred C57BL, Oxygen, Tumor Cells, Cultured, Apoptosis, Gene Deletion, Mice, Knockout, Oxidative Stress, fas Receptor, Caspases, Intracellular Signaling Peptides and Proteins, BH3 Interacting Domain Death Agonist Protein, Mice, Caspase 8, Fas Ligand Protein, CASP8 and FADD-Like Apoptosis Regulating Protein, Caspase 9, Caspase Inhibitors
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