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K+-dependent Cerebellar Granule Neuron Apoptosis
Open accessAbstract
Rat mature cerebellar granule, unlike hippocampal neurons, die by apoptosis when cultured in a medium containing a physiological concentration of K+ but survive under high external K+ concentrations. Cell death in physiological K+ parallels the developmental expression of the TASK-1 and TASK-3 subunits that encode the pH-sensitive standing outward K+ current IKso. Genetic transfer of the TASK subunits in hippocampal neurons, lacking IKso, induces cell death, while their genetic inactivation protects cerebellar granule neurons. Neuronal death of cultured rat granule neurons is also prevented by conditions that specifically reduce K+ efflux through the TASK-3 channels such as extracellular acidosis and ruthenium red. TASK leak K+ channels thus play an important role in K+-dependent apoptosis of cerebellar granule neurons in culture.
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Citations
Cited by
Molecular Background of Leak K+Currents: Two-Pore Domain Potassium Channels
Enyedi, P., & Czirják, G. (2010) · Physiological Reviews · doi:10.1152/physrev.00029.2009 · Cited by 868
The roles of K+ channels in cancer
Pardo, L. A., & Stühmer, W. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3635 · Cited by 477
Roles of K + channels in regulating tumour cell proliferation and apoptosis
Wang, Z. (2004) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/s00424-004-1258-5 · Cited by 280
Davis, M. J., Earley, S., Li, Y.-S., & Chien, S. (2023) · Physiological Reviews · doi:10.1152/physrev.00053.2021 · Cited by 273
The TREK K2P channels and their role in general anaesthesia and neuroprotection
Franks, N. P., & Honoré, E. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.09.003 · Cited by 214
Metadata
- Authors
- Lauritzen, I., Zanzouri, M., Honoré, E., Duprat, F., Ehrengruber, M. U., Lazdunski, M., & Patel, A. J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-08
- Volume
- 278
- Issue
- 34
- Pages
- 32068-32076
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2029299513
- Cited by
- 193
- References
- 0
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lauritzen, I., Zanzouri, M., Honoré, E., Duprat, F., Ehrengruber, M. U., Lazdunski, M., & Patel, A. J. (2003). K+-dependent Cerebellar Granule Neuron Apoptosis. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m302631200
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