The TREK K2P channels and their role in general anaesthesia and neuroprotection
Abstract
Two-pore-domain K+ (K(2P)) channels are a diverse and highly regulated superfamily of channels that are thought to provide baseline regulation of membrane excitability. Of these, the TREK channels are expressed highly in the human CNS, and can be activated by temperature, membrane stretch and internal acidosis. In addition, TREK channels are sensitively activated by certain polyunsaturated fatty acids that have been shown to have neuroprotective activity and by volatile and gaseous general anaesthetics. New data derived from studies of knockout animals suggest that TREK-1 might have an important role in the general anaesthetic properties of volatile agents, such as halothane, and provide an explanation for the neuroprotective properties of polyunsaturated fatty acids.
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The K2P family includes mammalian homologues activated by anesthetics and others inhibited by anesthetics.
“Subsequent work led to the discovery of the tandem pore potassium channel (K2P) family, which contains mammalian homologues that are activated by anesthetics [48]) as well as those that are inhibited by anesthetics [49, 50].”
From The Biology of General Anesthesia from Paramecium to Primate (2019) · cites this paper as [49]
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- Authors
- Franks, N. P., & Honoré, E.
- Affiliations
- Imperial College London (GB)
- Corresponding author
- Franks, Nicholas P.
- ORCID
- Franks, Nicholas P.
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2004-11
- Volume
- 25
- Issue
- 11
- Pages
- 601-608
- ISSN
- 0165-6147 (ISSN-L)
- OpenAlex
- W2070021885
- Cited by
- 214
- References
- 64
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 2 · 2020: 8 · 2019: 12 · 2018: 9 · 2017: 8 · 2016: 8 · 2015: 8 · 2014: 12 · 2013: 5 · 2012: 20
- FWCI
- 5.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Pharmacological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
- Keywords
- TREK channels, two-pore domain potassium channels, general anesthesia, neuroprotection, volatile anesthetics, halothane, polyunsaturated fatty acids, TREK-1, thermal activation, membrane stretching, acidosis, knockout animals, central nervous system
- MeSH terms
- Anesthesia, General, Animals, Humans, Ion Channel Gating, Anesthetics, General, Neuroprotective Agents, Potassium Channels, Tandem Pore Domain
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