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Cited by 158

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Arabidopsis Histone Acetyltransferase AtGCN5 Regulates the Floral Meristem Activity through the WUSCHEL/AGAMOUS Pathway

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Bertrand, Claire, Bergounioux, Catherine, Domenichini, Séverine, Delarue, Marianne, Zhou, Dao-Xiu·2003·Journal of Biological Chemistry

Abstract

Histone acetyltransferases, which are able to acetylate histone and non-histone proteins, play important roles in gene regulation. Many histone acetyltransferases are related to yeast Gcn5, a component of two transcription regulatory complexes SAGA and ADA. In this work, by characterizing a mutation in the Arabidopsis GCN5 gene (AtGCN5) we studied the regulatory function of this gene in controlling floral meristem activity. We show that in addition to pleiotropic effects on plant development, this mutation also leads to the production of terminal flowers. The flowers show homeotic transformations of petals into stamens and sepals into filamentous structures and produce ectopic carpels. The phenotypes correlate to an expansion of the expression domains within floral meristems of the key regulatory genes WUSCHEL (WUS) and AGAMOUS (AG). These results suggest that AtGCN5 is required to regulate the floral meristem activity through the WUS/AG pathway. This study brings new elements on the elucidation of specific developmental pathways regulated by AtGCN5 and on the control mechanism of meristem regulatory gene expression.

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Metadata

Authors
Bertrand, C., Bergounioux, C., Domenichini, S., Delarue, M., & Zhou, D.-X.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2003-07
Volume
278
Issue
30
Pages
28246-28251
ISSN
0021-9258 (ISSN-L)
OpenAlex
W2167355607
Cited by
158
References
2
FWCI
6.88
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Arabidopsis Histone Acetyltransferase AtGCN5 Regulates the Floral Meristem Activity through the WUSCHEL/AGAMOUS Pathway. https://app.cochat.ai/papers/10.1074/jbc.m302787200
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Bertrand, C., Bergounioux, C., Domenichini, S., Delarue, M., & Zhou, D.-X. (2003). Arabidopsis Histone Acetyltransferase AtGCN5 Regulates the Floral Meristem Activity through the WUSCHEL/AGAMOUS Pathway. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m302787200

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