The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Identification of a Conserved Ankyrin-binding Motif in the Family of Sodium Channel α Subunits
Open accessAbstract
Interactions with ankyrinG are crucial to the localization of voltage-gated sodium channels (VGSCs) at the axon initial segment and for neurons to initiate action potentials. However, the molecular nature of these interactions remains unclear. Here we report that VGSC-alpha, but not -beta, subunits bind to ankyrinG using pull-down assays. Further dissection of this activity identifies a conserved 9-amino acid motif ((V/A)P(I/L)AXXE(S/D)D) required for ankyrinG binding. This motif is also required for the localization of chimeric neurofascin/sodium channel molecules to the initial segment of cultured hippocampal neurons. The conserved nature of this motif suggests that it functions to localize sodium channels to a variety of "excitable" membrane domains both inside and outside of the nervous system.
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Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death
Mohler, P. J., Schott, J.-J., Gramolini, A. O., Dilly, K. W., Guatimosim, S., duBell, W. H., Song, L.-S., Haurogné, K., Kyndt, F., Ali, M. E., et al. (2003) · Nature · doi:10.1038/nature01335 · Cited by 957
Sodium channel Na v 1.6 is localized at nodes of Ranvier, dendrites, and synapses
Caldwell, J. H., Schaller, K. L., Lasher, R. S., Peles, E., & Levinson, S. R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.090034797 · Cited by 649
Ankyrin-B Is Required for Intracellular Sorting of Structurally Diverse Ca2+ Homeostasis Proteins
Tuvia, S., Buhusi, M., Davis, L., Reedy, M., & Bennett, V. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.5.995 · Cited by 127
Bennett, V., & Lambert, S. (1999) · Journal of Neurocytology · doi:10.1023/a:1007005528505 · Cited by 109
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Cited by
Ogiwara, I., Miyamoto, H., Morita, N., Atapour, N., Mazaki, E., Inoue, I., Takeuchi, T., Itohara, S., Yanagawa, Y., Obata, K., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5270-06.2007 · Cited by 879
Molecular motors and mechanisms of directional transport in neurons
Hirokawa, N., & Takemura, R. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1624 · Cited by 834
Pan, Z., Kao, T., Horvath, Z., Lemos, J., Sul, J.-Y., Cranstoun, S. D., Bennett, V., Scherer, S. S., & Cooper, E. C. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4314-05.2006 · Cited by 585
The axon initial segment and the maintenance of neuronal polarity
Rasband, M. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2852 · Cited by 442
Polarized Domains of Myelinated Axons
Salzer, J. L. (2003) · Neuron · doi:10.1016/s0896-6273(03)00628-7 · Cited by 403
Metadata
- Authors
- Lemaillet, G., Walker, B., & Lambert, S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-07
- Volume
- 278
- Issue
- 30
- Pages
- 27333-27339
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2029428999
- Cited by
- 242
- References
- 4
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
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