MEK Is a Key Modulator for TLR5-induced Interleukin-8 and MIP3α Gene Expression in Non-transformed Human Colonic Epithelial Cells

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. J. (1997) · Nature · doi:10.1038/41131 · Cited by 6,137 · see citing works

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605 · see citing works

Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine

Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202 · see citing works

Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression

Gewirtz, A. T., Navas, T. A., Lyons, S., Godowski, P. J., & Madara, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.1882 · Cited by 1,345 · see citing works

Mucosal flora in inflammatory bowel disease

Swidsinski, A. V., Ladhoff, A., Pernthaler, A., Swidsinski, S., Loening-Baucke, V. A., Ortner, M., Weber, J., Hoffmann, U., Schreiber, S., Dietel, M., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.30294 · Cited by 1,344 · see citing works

TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway

Yamamoto, M., Sato, S., Hemmi, H., Uematsu, S., Hoshino, K., Kaisho, T., Takeuchi, O., Takeda, K., & Akira, S. (2003) · Nature Immunology · doi:10.1038/ni986 · Cited by 1,052 · see citing works

Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility

Smith, K. D., Andersen‐Nissen, E., Hayashi, F., Strobe, K. L., Bergman, M. A., Barrett, S. L. R., Cookson, B. T., & Aderem, A. A. (2003) · Nature Immunology · doi:10.1038/ni1011 · Cited by 808 · see citing works

Toll-like receptors: key mediators of microbe detection

Underhill, D. M., & Ozinsky, A. (2002) · Current Opinion in Immunology · doi:10.1016/s0952-7915(01)00304-1 · Cited by 684 · see citing works

Distinct molecular mechanism for initiating TRAF6 signalling

Ye, H., Arron, J. R., Lamothe, B., Cirilli, M., Kobayashi, T., Shevde, N. K., Segal, D., Dzivenu, O. K., Vologodskaia, M., Yim, M., et al. (2002) · Nature · doi:10.1038/nature00888 · Cited by 665 · see citing works

The Toll–IL-1 receptor adaptor family grows to five members

O'Neill, L. A. J., Fitzgerald, K. A., & Bowie, A. G. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00115-7 · Cited by 492 · see citing works

Identification of TRAF6, a Novel Tumor Necrosis Factor Receptor-associated Factor Protein That Mediates Signaling from an Amino-terminal Domain of the CD40 Cytoplasmic Region

Ishida, T., Mizushima, S., Azuma, S., Kobayashi, N., Tojo, T., Suzuki, K., Aizawa, S., Watanabe, T., Mosialos, G., Kieff, E. D., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.46.28745 · Cited by 472 · see citing works

Segregation of TRAF6‐mediated signaling pathways clarifies its role in osteoclastogenesis

Kobayashi, N., Kadono, Y., Naito, A., Matsumoto, K., Yamamoto, T. S., Tanaka, S., & Inoue, J. (2001) · The EMBO Journal · doi:10.1093/emboj/20.6.1271 · Cited by 467 · see citing works

Regulation of Interleukin-8 Gene Expression

Roebuck, K. A. (1999) · Journal of Interferon & Cytokine Research · doi:10.1089/107999099313866 · Cited by 415 · see citing works

Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor α expression by inducing Elk-1 phosphorylation and Egr-1 expression

Guha, M., O'Connell, M. A., Pawliński, R., Hollis, A., McGovern, P., Yan, S.-F., Stern, D. M., & Mackman, N. (2001) · Blood · doi:10.1182/blood.v98.5.1429 · Cited by 374 · see citing works

Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells

Sierro, F., Dubois, B., Coste, A., Kaiserlian, D., Kraehenbuhl, J.-P., & Sirard, J.-C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241308598 · Cited by 368 · see citing works

Chemokine expression in IBD. Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn's disease

Banks, C., Bateman, A. C., Payne, R. F., Johnson, P., & Sheron, N. (2002) · The Journal of Pathology · doi:10.1002/path.1245 · Cited by 345 · see citing works

ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway

Kopp, E., Medzhitov, R., Carothers, J., Xiao, C., Douglas, I., Janeway, C. A., & Ghosh, S. (1999) · Genes & Development · doi:10.1101/gad.13.16.2059 · Cited by 334 · see citing works

NF-kappa B is a central regulator of the intestinal epithelial cell innate immune response induced by infection with enteroinvasive bacteria.

Elewaut, D. S., DiDonato, J. A., Kim, J. M., Truong, F., Eckmann, L., & Kagnoff, M. F. (1999) · PubMed · Cited by 332 · see citing works

NF-κB Is a Central Regulator of the Intestinal Epithelial Cell Innate Immune Response Induced by Infection with Enteroinvasive Bacteria

Elewaut, D. S., DiDonato, J. A., Kim, J. M., Truong, F., Eckmann, L., & Kagnoff, M. F. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.3.1457 · Cited by 285 · see citing works

Interleukin-1 (IL-1) Receptor-Associated Kinase-Dependent IL-1-Induced Signaling Complexes Phosphorylate TAK1 and TAB2 at the Plasma Membrane and Activate TAK1 in the Cytosol

Jiang, Z., Ninomiya‐Tsuji, J., Qian, Y., Matsumoto, K., & Li, X. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.20.7158-7167.2002 · Cited by 284 · see citing works

Signal Transduction Pathways Activated by the IL-1 Receptor/Toll-Like Receptor Superfamily

O'Neill, L. A. J. (2002) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-59430-4_3 · Cited by 282 · see citing works

Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3

Huang, Q., Yang, J., Lin, Y., Walker, C., Cheng, J., Liu, Z.-G., & Su, B. (2003) · Nature Immunology · doi:10.1038/ni1014 · Cited by 266 · see citing works

Murine TOLL-like Receptor 4 Confers Lipopolysaccharide Responsiveness as Determined by Activation of NFκB and Expression of the Inducible Cyclooxygenase

Rhee, S. H., & Hwang, D. H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007386200 · Cited by 247 · see citing works

NCM460, a normal human colon mucosal epithelial cell line

Moyer, M. P., Manzano, L. A., Merriman, R. L., Stauffer, J. S., & Tanzer, L. R. (1996) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/bf02722955 · Cited by 239 · see citing works

The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria

Stagg, A. J., Hart, A. L., Knight, S. C., & Kamm, M. A. (2003) · Gut · doi:10.1136/gut.52.10.1522 · Cited by 231 · see citing works

Interleukin-1 (IL-1) Receptor-Associated Kinase Leads to Activation of TAK1 by Inducing TAB2 Translocation in the IL-1 Signaling Pathway

Takaesu, G., Ninomiya‐Tsuji, J., Kishida, S., Li, X., Stark, G. R., & Matsumoto, K. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.7.2475-2484.2001 · Cited by 197 · see citing works

Intestinal bacteria and ulcerative colitis.

Cummings, J. H., Macfarlane, G. T., & Macfarlane, S. (2003) · PubMed · Cited by 164 · see citing works

Colonic epithelial cells are a major site of macrophage inflammatory protein 3α (MIP-3α) production in normal colon and inflammatory bowel disease

Kwon, J. H., Keates, S. E., Bassani, L., Mayer, L. F., & Keates, A. C. (2002) · Gut · doi:10.1136/gut.51.6.818 · Cited by 149 · see citing works

Flagellin of EnteropathogenicEscherichia coliStimulates Interleukin-8 Production in T84 Cells

Zhou, X., Girón, J. A., Torres, A. G., Crawford, J. A., Negrete, E., Vogel, S. N., & Kaper, J. B. (2003) · Infection and Immunity · doi:10.1128/iai.71.4.2120-2129.2003 · Cited by 137 · see citing works

Toll-like Receptors 2 and 4 Activate STAT1 Serine Phosphorylation by Distinct Mechanisms in Macrophages

Rhee, S. H., Jones, B. W., Toshchakov, V. Y., Vogel, S. N., & Fenton, M. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208633200 · Cited by 115 · see citing works

Helicobacter pylori induced transactivation of SRE and AP-1 through the ERK signalling pathway in gastric cancer cells

Mitsuno, Y., Yoshida, H., Maeda, S., Ogura, K., Hirata, Y., Kawabe, T., Shiratori, Y., & Omata, M. (2001) · Gut · doi:10.1136/gut.49.1.18 · Cited by 115 · see citing works

Signal Transduction Pathways Mediating Neurotensin-stimulated Interleukin-8 Expression in Human Colonocytes

Zhao, D., Keates, A. C., Kuhnt-Moore, S., Moyer, M. P., Kelly, C. P., & Pothoulakis, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104942200 · Cited by 111 · see citing works

Use of Probiotics in the Treatment of Inflammatory Bowel Disease

Hart, A. L., Stagg, A. J., & Kamm, M. A. (2003) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200302000-00005 · Cited by 102 · see citing works

Connexin 43 suppresses human glioblastoma cell growth by down-regulation of monocyte chemotactic protein 1, as discovered using protein array technology.

Huang, R., Lin, Y., Wang, C. C., Gano, J. J., Lin, B., Shi, Q., Boynton, A. L., Burke, J. F., & Huang, R. (2002) · PubMed · Cited by 96 · see citing works

The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk‐1 phosphorylation from MAP kinase activation

Sugimoto, T., Stewart, S., Han, M., & Guan, K. (1998) · The EMBO Journal · doi:10.1093/emboj/17.6.1717 · Cited by 91 · see citing works

Function of the Rho Family GTPases in Ras-stimulated Raf Activation

Li, W., Kopera, H. C., & Guan, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103496200 · Cited by 77 · see citing works

Ras Participates in CpG Oligodeoxynucleotide Signaling through Association with Toll-like Receptor 9 and Promotion of Interleukin-1 Receptor-associated Kinase/Tumor Necrosis Factor Receptor-associated Factor 6 Complex Formation in Macrophages

Xu, H., An, H., Yu, Y., Zhang, M., Qi, R., & Cao, X. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305698200 · Cited by 64 · see citing works

ESE-1, an Enterocyte-specific Ets Transcription Factor, Regulates MIP-3α Gene Expression in Caco-2 Human Colonic Epithelial Cells

Kwon, J. H., Keates, S. E., Simeonidis, S., Grall, F. T., Libermann, T. A., & Keates, A. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208241200 · Cited by 59 · see citing works

Signaling via Toll-Like Receptor 5 Can Initiate Inflammatory Mediator Production by Murine Osteoblasts

Madrazo, D. R., Tranguch, S. L., & Marriott, I. (2003) · Infection and Immunity · doi:10.1128/iai.71.9.5418-5421.2003 · Cited by 44 · see citing works

Nitric Oxide Suppresses IL-8 Transcription by Inhibiting C-Jun N-Terminal Kinase-Induced AP-1 Activation

Natarajan, R., Gupta, S., Fisher, B. J., Ghosh, S., & Fowler, A. A. (2001) · Experimental Cell Research · doi:10.1006/excr.2001.5218 · Cited by 36 · see citing works

Cl− transport in an immortalized human epithelial cell line (NCM460) derived from the normal transverse colon

Sahi, J., Nataraja, S. G., Layden, T. J., Goldstein, J. L., Moyer, M. P., & Rao, M. C. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.275.4.c1048 · Cited by 22 · see citing works

Interferon-γ induces C/EBPβ expression and activity through MEK/ERK and p38 in T84 colon epithelial cells

Salmenperä, P., Hämäläinen, S., Hukkanen, M., & Kankuri, E. M. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00293.2002 · Cited by 19 · see citing works

Principles and clinical implications of the brain-gut-enteric microbiota axis

Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342 · see citing works

TLR Signaling in the Gut in Health and Disease

Abreu, M. T., Fukata, M., & Arditi, M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4453 · Cited by 577 · see citing works

Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction

Sáez-Rodríguez, J., Alexopoulos, L. G., Epperlein, J. P., Samaga, R., Lauffenburger, D. A., Klamt, S., & Sorger, P. K. (2009) · Molecular Systems Biology · doi:10.1038/msb.2009.87 · Cited by 347 · see citing works

<scp>GABA</scp> ‐producing <i>Bifidobacterium dentium</i> modulates visceral sensitivity in the intestine

Pokusaeva, K., Johnson, C., Luk, B., Uribe, G., Fu, Y., Oezguen, N., Matsunami, R. K., Lugo, M., Major, A., Mori‐Akiyama, Y., et al. (2017) · Neurogastroenterology &amp; Motility · doi:10.1111/nmo.12904 · Cited by 337 · see citing works

Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation

Rhee, S. H., Im, E., Riegler, M., Kokkotou, E., O'Brien, M., & Pothoulakis, C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502174102 · Cited by 229 · see citing works

Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease

Kawada, M. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i42.5581 · Cited by 226 · see citing works

Urinary tract infection: Pathogenicity, antibiotic resistance and development of effective vaccines against Uropathogenic Escherichia coli

Karam, M. R. A., Habibi, M., & Bouzari, S. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.02.007 · Cited by 219 · see citing works

Activation of Toll-like Receptor 5 on Breast Cancer Cells by Flagellin Suppresses Cell Proliferation and Tumor Growth

Cai, Z., Sanchez, A., Shi, Z., Zhang, T., Liu, M., & Zhang, D. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-1993 · Cited by 216 · see citing works

Toll-Like Receptor 5 Engagement Modulates Tumor Development and Growth in a Mouse Xenograft Model of Human Colon Cancer

Rhee, S. H., Im, E., & Pothoulakis, C. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.022 · Cited by 183 · see citing works

Effects of Flagellin on Innate and Adaptive Immunity

Honko, A. N., & Mizel, S. B. (2005) · Immunologic Research · doi:10.1385/ir:33:1:083 · Cited by 171 · see citing works

The anticancer effect of probiotic Bacillus polyfermenticus on human colon cancer cells is mediated through ErbB2 and ErbB3 inhibition

Ma, E. L., Choi, Y. J., Choi, J., Pothoulakis, C., Rhee, S. H., & Im, E. (2009) · International Journal of Cancer · doi:10.1002/ijc.25011 · Cited by 162 · see citing works

TLRs Regulate the Gatekeeping Functions of the Intestinal Follicle-Associated Epithelium

Chabot, S., Wagner, J. S., Farrant, S. A., & Neutra, M. R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.4275 · Cited by 158 · see citing works

Age‐associated elevation in TLR5 leads to increased inflammatory responses in the elderly

Qian, F., Wang, X., Zhang, L., Chen, S., Piecychna, M., Allore, H., Bockenstedt, L., Malawista, S., Bucala, R., Shaw, A. C., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2011.00759.x · Cited by 154 · see citing works

CCL20/CCR6-mediated migration of regulatory T cells to the Helicobacter pylori -infected human gastric mucosa

Cook, K., Letley, D. P., Ingram, R. J. M., Staples, E., Skjoldmose, H., Atherton, J. C., & Robinson, K. (2014) · Gut · doi:10.1136/gutjnl-2013-306253 · Cited by 153 · see citing works

A Functional Role for Interleukin-21 in Promoting the Synthesis of the T-Cell Chemoattractant, MIP-3α, by Gut Epithelial Cells

Caruso, R., Fina, D., Peluso, I., Stolfi, C., Fantini, M. C., Gioia, V., Caprioli, F., Blanco, G. D. V., Paoluzi, O. A., MacDonald, T. T., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.09.053 · Cited by 150 · see citing works

Activation of TLR3 and TLR5 in channel catfish exposed to virulent

Bilodeau, A. L., & Waldbieser, G. C. (2004) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2004.12.002 · Cited by 142 · see citing works

Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation

Podechard, N., Lecureur, V., Ferrec, E. L., Guénon, I., Sparfel, L., Gilot, D., Gordon, J., Lagente, V., & Fardel, O. (2008) · Toxicology Letters · doi:10.1016/j.toxlet.2008.01.006 · Cited by 141 · see citing works

Intestinal Inflammation Increases the Expression of the P2Y6 Receptor on Epithelial Cells and the Release of CXC Chemokine Ligand 8 by UDP

Grbic, D. M., Degagné, É., Langlois, C., Dupuis, A.-A., & Gendron, F. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2659 · Cited by 130 · see citing works

Training Signaling Pathway Maps to Biochemical Data with Constrained Fuzzy Logic: Quantitative Analysis of Liver Cell Responses to Inflammatory Stimuli

Morris, M. K., Sáez-Rodríguez, J., Clarke, D. C., Sorger, P. K., & Lauffenburger, D. A. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1001099 · Cited by 123 · see citing works

Pathobiology of Neutrophil Transepithelial Migration: Implications in Mediating Epithelial Injury

Chin, A. C., & Parkos, C. A. (2006) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.2.010506.091944 · Cited by 113 · see citing works

Role of MyD88 in Phosphatidylinositol 3-Kinase Activation by Flagellin/Toll-like Receptor 5 Engagement in Colonic Epithelial Cells

Rhee, S. H., Kim, H., Moyer, M. P., & Pothoulakis, C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513861200 · Cited by 103 · see citing works

The role of post-transcriptional regulation in chemokine gene expression in inflammation and allergy

Fan, J., Heller, N. M., Gorospe, M., Atasoy, U., & Stellato, C. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00120204 · Cited by 103 · see citing works

Broad-Spectrum G Protein–Coupled Receptor Antagonist, [D-Arg1,D-Trp5,7,9,Leu11]SP: A Dual Inhibitor of Growth and Angiogenesis in Pancreatic Cancer

Guha, S., Eibl, G., Kisfalvi, K., Fan, R. S., Burdick, M. D., Reber, H. A., Hines, O. J., Strieter, R. M., & Rozengurt, E. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3197 · Cited by 102 · see citing works

Enhanced IL-10 Production by TLR4- and TLR2-Primed Dendritic Cells upon TLR Restimulation

Yanagawa, Y., & Onoé, K. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.10.6173 · Cited by 96 · see citing works

TRIF Mediates Toll-like Receptor 5-induced Signaling in Intestinal Epithelial Cells

Choi, Y. J., Im, E., Chung, H. K., Pothoulakis, C., & Rhee, S. H. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.158394 · Cited by 97 · see citing works

Corticotropin-Releasing Hormone Receptor 2-Deficient Mice Have Reduced Intestinal Inflammatory Responses

Kokkotou, E. G., Torres, D., Moss, A. C., O’Brien, M. J., Grigoriadis, D. E., Karalis, K. P., & Pothoulakis, C. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.5.3355 · Cited by 95 · see citing works

Mucosal interplay among commensal and pathogenic bacteria: Lessons from flagellin and Toll‐like receptor 5

Rumbo, M., Nempont, C., Kraehenbühl, J.-P., & Sirard, J. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.04.036 · Cited by 75 · see citing works

AsialoGM1 and TLR5 Cooperate in Flagellin-Induced Nucleotide Signaling to Activate Erk1/2

McNamara, N. A., Gallup, M., Sucher, A., Maltseva, I., McKemy, D. D., & Basbaum, C. B. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2005-0441oc · Cited by 73 · see citing works

Enhanced Dendritic Cell Antigen Uptake via α2 Adrenoceptor-Mediated PI3K Activation Following Brief Exposure to Noradrenaline

Yanagawa, Y., Matsumoto, M., & Togashi, H. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001899 · Cited by 68 · see citing works

Increase of CCL20 expression by human gingival fibroblasts upon stimulation with cytokines and bacterial endotoxin

Hosokawa, Y., Hosokawa, I., Ozaki, K., Nakae, H., & Matsuo, T. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02912.x · Cited by 67 · see citing works

Urocortin II mediates pro-inflammatory effects in human colonocytes via corticotropin-releasing hormone receptor 2α

Moss, A. C., Anton, P. M., Savidge, T., Newman, P., Cheifetz, A. S., Gay, J., Paraschos, S., Winter, M. W., Moyer, M. P., Karalis, K. P., et al. (2007) · Gut · doi:10.1136/gut.2006.110668 · Cited by 64 · see citing works

CCL20 Is Increased in Hypercholesterolemic Subjects and Is Upregulated By LDL in Vascular Smooth Muscle Cells

Calvayrac, O., Rodríguez‐Calvo, R., Alonso, J., Orbe, J., Martı́n-Ventura, J. L., Guadall, A., Gentile, M., Juan‐Babot, O., Egido, J., Beloqui, Ó., et al. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.235721 · Cited by 64 · see citing works

Neutrophil-derived JAML inhibits repair of intestinal epithelial injury during acute inflammation

Weber, D. A., Sumagin, R., McCall, I. C., Leoni, G., Neumann, P. A., Andargachew, R., Brazil, J. C., Contreras, O. M., Denning, T. L., Nusrat, A., et al. (2014) · Mucosal Immunology · doi:10.1038/mi.2014.12 · Cited by 63 · see citing works

Stimulation by TLR5 Modulates Osteoclast Differentiation through STAT1/IFN-β1

Ha, H., Lee, J.-H., Kim, H.-N., Kwak, H., Kim, H.-M., Lee, S.-E., Rhee, J., Kim, H.-H., & Lee, Z. (2008) · Journal of Immunology · doi:10.4049/jimmunol.180.3.1382 · Cited by 63 · see citing works

Phosphoinositide 3-kinase is activated by MUC1 but not responsible for MUC1-induced suppression of Toll-like receptor 5 signaling

Kato, K., Lu, W., Kai, H., & Kim, K. C. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00423.2006 · Cited by 52 · see citing works

Tissue expression of Toll-like receptors 2 and 4 in sporadic human colorectal cancer

Nihonyanagi, Y., Terai, K., Murano, T., Matsumoto, T., & Okazumi, S. (2011) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-011-1085-4 · Cited by 52 · see citing works

Blocking of the TLR5 Activation Domain Hampers Protective Potential of Flagellin DNA Vaccine

Saha, S., Takeshita, F., Matsuda, T., Jounai, N., Kobiyama, K., Matsumoto, T., Sasaki, S., Yoshida, A., Xin, K.-Q., Klinman, D. M., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.1147 · Cited by 50 · see citing works

Interleukin-34 Induces Cc-chemokine Ligand 20 in Gut Epithelial Cells

Franzè, E., Marafini, I., Simone, V. D., Monteleone, I., Caprioli, F., Colantoni, A., Ortenzi, A., Crescenzi, F., Izzo, R., Sica, G. S., et al. (2015) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjv181 · Cited by 50 · see citing works

Protein Kinase D Interaction with TLR5 Is Required for Inflammatory Signaling in Response to Bacterial Flagellin

Ivison, S. M., Graham, N. R., Bernales, C. Q., Kifayet, A., Ng, N., Shobab, L. A., & Steiner, T. S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.9.5735 · Cited by 49 · see citing works

Effects of substance P on osteoblastic differentiation and heme oxygenase‐1 in human periodontal ligament cells

Kook, Y., Lee, S., Son, D., Kim, Y., Kang, K., Cho, J., Kim, S., Kim, Y. S., Lee, H., Lee, S., et al. (2009) · Cell Biology International · doi:10.1016/j.cellbi.2008.12.007 · Cited by 46 · see citing works

TLR2 activation by proteosomes promotes uptake of particulate vaccines at mucosal surfaces

Chabot, S. M., Chernin, T. S., Shawi, M., Wagner, J. S., Farrant, S. A., Burt, D. S., Cyr, S. L., & Neutra, M. R. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.05.029 · Cited by 46 · see citing works

Toll-like receptors and renal bacterial infections.

Vandewalle, A. (2008) · PubMed · Cited by 46 · see citing works

Src family kinase tyrosine phosphorylates Toll-like receptor 4 to dissociate MyD88 and Mal/Tirap, suppressing LPS-induced inflammatory responses

Mitchell, J., Kim, S. J., Seelmann, A., Veit, B., Shepard, B. D., Im, E., & Rhee, S. H. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.11.015 · Cited by 45 · see citing works

Intestinal Immune Imbalance is an Alarm in the Development of IBD

Hu, C. C., Liao, S., Lv, L., Li, C., & Mei, Z. (2023) · Mediators of Inflammation · doi:10.1155/2023/1073984 · Cited by 42 · see citing works

Basic and Translational Understandings of Microbial Recognition by Toll-Like Receptors in the Intestine

Rhee, S. H. (2011) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2011.17.1.28 · Cited by 41 · see citing works

PTEN regulates TLR5‐induced intestinal inflammation by controlling Mal/TIRAP recruitment

Choi, Y. J., Jung, J., Chung, H. K., Im, E., & Rhee, S. H. (2012) · The FASEB Journal · doi:10.1096/fj.12-217596 · Cited by 41 · see citing works

Toll-Like Receptor 5 Engagement Induces Interleukin-17C Expression in Intestinal Epithelial Cells

Im, E., Jung, J., & Rhee, S. H. (2012) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2012.0053 · Cited by 40 · see citing works

TLR1-induced chemokine production is critical for mucosal immunity against Yersinia enterocolitica

Sugiura, Y., Kamdar, K., Khakpour, S., Young, G., Karpus, W. J., & DePaolo, R. W. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.5 · Cited by 40 · see citing works

MUC1 expression by human airway epithelial cells mediates pseudomonas aeruginosa adhesion

Kim, K. C. (2010) · Frontiers in Bioscience-Elite · doi:10.2741/e67 · Cited by 40 · see citing works

TRIF Modulates TLR5-dependent Responses by Inducing Proteolytic Degradation of TLR5

Choi, Y. J., Im, E., Pothoulakis, C., & Rhee, S. H. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.115022 · Cited by 39 · see citing works

Expression and Regulation of the CC‐Chemokine Ligand 20 During Human Tuberculosis

Lee, J., Lee, J. ‐., Son, J. W., Oh, J. ‐., Shin, D. ‐., Yuk, J., Song, C., Paik, T.-H., & Jo, E. (2007) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2007.02040.x · Cited by 38 · see citing works

Substance P regulates macrophage inflammatory protein 3α/chemokine C-C ligand 20 (CCL20) with heme oxygenase-1 in human periodontal ligament cells

Lee, S.-K., Pi, S., Kim, S.-H., Min, K.-S., Lee, H.-J., Chang, H.-S., Kang, K.-H., Kim, H.-R., Shin, H.-I., Lee, S.-K., et al. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2007.03514.x · Cited by 36 · see citing works

Physiological TLR5 expression in the intestine is regulated by differential DNA binding of Sp1/Sp3 through simultaneous Sp1 dephosphorylation and Sp3 phosphorylation by two different PKC isoforms

Thakur, B. K., Dasgupta, N., Ta, A., & Das, S. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw189 · Cited by 35 · see citing works

The angiogenic effect of probioticBacillus polyfermenticuson human intestinal microvascular endothelial cells is mediated by IL-8

Im, E., Choi, Y. J., Kim, C. H., Fiocchi, C., Pothoulakis, C., & Rhee, S. H. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00204.2009 · Cited by 35 · see citing works

Allyl methyl disulfide inhibits IL-8 and IP-10 secretion in intestinal epithelial cells via the NF-кB signaling pathway.

Zhang, Y., Wang, Y., Zhang, F., Wang, K.-M., Liu, G., Yang, M., Luan, Y., Zhao, Z.-X., Zhang, J., Cao, X.-K., et al. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.05.013 · Cited by 30 · see citing works

Bacillus polyfermenticus Ameliorates Colonic Inflammation by Promoting Cytoprotective Effects in Colitic Mice ,

Im, E., Choi, Y. J., Pothoulakis, C., & Rhee, S. H. (2009) · Journal of Nutrition · doi:10.3945/jn.109.108613 · Cited by 30 · see citing works

Mechanisms of Inflammasome Signaling, microRNA Induction and Resolution of Inflammation by Helicobacter pylori

Pachathundikandi, S. K., Blaser, N., & Backert, S. (2019) · Current topics in microbiology and immunology · doi:10.1007/978-3-030-15138-6_11 · Cited by 29 · see citing works

Flagellin produced in plants is a potent adjuvant for oral immunization

Girard, A., Saron, W. A. A., Bergeron-Sandoval, L.-P., Sarhan, F., & Archambault, D. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.06.092 · Cited by 22 · see citing works

Tissue Eosinophilia in a Mouse Model of Colitis Is Highly Dependent on TLR2 and Independent of Mast Cells

Albert, E. J., Duplisea, J. J., Dawicki, W., Haidl, I. D., & Marshall, J. S. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.11.041 · Cited by 21 · see citing works

Many Roles of CCL20: Emphasis on Breast Cancer

Osuala, K. O., & Sloane, B. F. (2014) · Postdoc Journal · doi:10.14304/surya.jpr.v2n3.2 · Cited by 19 · see citing works

Corticotropin Releasing Hormone and Urocortin 3 Stimulate Vascular Endothelial Growth Factor Expression through the cAMP/CREB Pathway

Rhee, S. H., Ma, E. L., Lee, Y., Taché, Y., Pothoulakis, C., & Im, E. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.678979 · Cited by 19 · see citing works

c‐Jun N‐terminal kinase in pancreatic tumor stroma augments tumor development in mice

Sato, T. A., Shibata, W., Hikiba, Y., Kaneta, Y., Suzuki, N., Ihara, S., Ishii, Y., Sue, S., Kameta, E., Sugimori, M., et al. (2017) · Cancer Science · doi:10.1111/cas.13382 · Cited by 17 · see citing works

Flagellin expression enhances Salmonella accumulation in TLR5-positive macrophages

Metcalfe, H. J., Best, A., Kanellos, T., Ragione, R. M. L., & Werling, D. (2010) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2010.02.008 · Cited by 17 · see citing works

AsialoGM1-Mediated IL-8 Release by Human Corneal Epithelial Cells Requires Coexpression of TLR5

Du, J. W., Zhang, F., Capó‐Aponte, J. E., Tachado, S. D., Zhang, J., Yu, F. X., Sack, R. A., Koziel, H., & Reinach, P. S. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0250 · Cited by 17 · see citing works

The vaccine adjuvant MPLA activates glycolytic metabolism in mouse mDC by a JNK-dependent activation of mTOR-signaling

Blanco‐Pérez, F., Goretzki, A., Wolfheimer, S., & Schülke, S. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2018.12.029 · Cited by 16 · see citing works

TLR5 Activation through NF-κB Is a Neuroprotective Mechanism of Postconditioning after Cerebral Ischemia in Mice

Jeong, J., Kim, S., Lim, D.-S., Kim, S.-H., Doh, H., Kim, S., & Song, Y. S. (2017) · Experimental Neurobiology · doi:10.5607/en.2017.26.4.213 · Cited by 13 · see citing works

Microbial cell components induced tolerance to flagellin-stimulated inflammation through Toll-like receptor pathways in intestinal epithelial cells

Li, N., Quidgley, M. C., Kobeissy, F. H., Joseph, J., & Neu, J. (2012) · Cytokine · doi:10.1016/j.cyto.2012.08.003 · Cited by 12 · see citing works

Chemokine-Mediated B Cell Trafficking during Early Rabbit GALT Development

Zhai, S.-K., Volgina, V. V., Sethupathi, P., Knight, K. L., & Lanning, D. K. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302575 · Cited by 10 · see citing works

Flagellin in Fusion with Human Rotavirus Structural Proteins Exerts an Adjuvant Effect When Delivered with Replicating but Non-Disseminating Adenovectors Through the Intrarectal Route

Girard, A., Roques, É., Bernard Massie, B., & Archambault, D. (2013) · Molecular Biotechnology · doi:10.1007/s12033-013-9723-z · Cited by 8 · see citing works

Identification of a novel TLR5 agonist derived from the P97 protein of Mycoplasma hyopneumoniae

Gauthier, L., Babych, M., Segura, M., Bourgault, S., & Archambault, D. (2020) · Immunobiology · doi:10.1016/j.imbio.2020.151962 · Cited by 8 · see citing works

TNFα induces tolerant production of CXC chemokines in colorectal cancer HCT116 cells via A20 inhibition of ERK signaling

Zhou, X., Dong-jian, A., Liu, X., Jiang, M., Yuan, C., & Hu, J. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.11.027 · Cited by 7 · see citing works

Innate Immunity

Eckmann, L. (2006) · Elsevier eBooks · doi:10.1016/b978-012088394-3/50045-3 · Cited by 6 · see citing works

Are there effective new strategies for the treatment of acute and chronic GvHD?

Chao, N. J. A. (2008) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2007.11.012 · Cited by 6 · see citing works

Toll like receptor 5 ligand induces monocyte chemoattractant protein-1 in mouse osteoblastic cells

Nakamura, K., Deyama, Y., Yoshimura, Y., Suzuki, K., & Morita, M. (2012) · Biomedical Research · doi:10.2220/biomedres.33.39 · Cited by 5 · see citing works

Protein denature extracts of Lactobacillus crispatus KT‐11 strain promote interleukin 12p40 production via Toll‐like receptor 2 in J774.1 cell culture

Tobita, K., Hoshi, F., Ohki, T., & Watanabe, I. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13599 · Cited by 4 · see citing works

Irritable bowel syndrome and the gut microbiota

Heenan, P. E., Keenan, J. I., Bayer, S. B., Simon, M., & Gearry, R. B. (2019) · Journal of the Royal Society of New Zealand · doi:10.1080/03036758.2019.1695635 · Cited by 4 · see citing works

Inferring Intracellular Signal Transduction Circuitry from Molecular Perturbation Experiments

Wynn, M. L., Egbert, M. E., Consul, N., Chang, J., Wu, Z.-F., Meravjer, S. D., & Schnell, S. D. (2017) · Bulletin of Mathematical Biology · doi:10.1007/s11538-017-0270-9 · Cited by 3 · see citing works

Characterising the immune response to Salmonella and Salmonella surface antigens during a systemic infection

Bobat, S. (2011) · University of Birmingham Institutional Research Archive (University of Birmingham) · Cited by 1 · see citing works

SERIES ''SIGNALLING AND TRANSCRIPTIONAL REGULATION IN INFLAMMATORY AND IMMUNE CELLS: IMPORTANCE IN LUNG BIOLOGY AND DISEASE'' Edited by K.F. Chung and I.M. Adcock Number 1 in this Series The role of post-transcriptional regulation in chemokine gene expression in inflammation and allergy

Fan, J., Gorospe, M., Atasoy, U., & Stellato, C. (2005)

Pathobiology of Neutrophil Transepithelial Migration: Implications in Mediating

Chin, A. C., & Parkos, C. A. (2007)

Interleukin-21 controls inflammatory pathways in IBD

Fina, D. (2009) · Cineca Institutional Research Information System (Tor Vergata University) · doi:10.58015/fina-daniele_phd2009-02-03

TLR5-mediated activation of p38 MAPK regulates epithelial IL-8 expression via a post-transcriptional mechanism

Yu, Y., Zeng, H., Lyons, S., Carlson, A., Merlin, D., Neish, A. S., & Gewirtz, A. T. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)82441-1 · Cited by 14 · see citing works

TRIF Mediates Toll-like Receptor 5-induced Signaling in Intestinal Epithelial Cells

Choi, Y. J., Im, E., Chung, H. K., Pothoulakis, C., & Rhee, S. H. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.158394 · Cited by 97 · see citing works

TLR5-mediated activation of p38 MAPK regulates epithelial IL-8 expression via posttranscriptional mechanism

Yu, Y., Zeng, H., Lyons, S., Carlson, A., Merlin, D., Neish, A. S., & Gewirtz, A. T. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00503.2002 · Cited by 142 · see citing works

Role of MyD88 in Phosphatidylinositol 3-Kinase Activation by Flagellin/Toll-like Receptor 5 Engagement in Colonic Epithelial Cells

Rhee, S. H., Kim, H., Moyer, M. P., & Pothoulakis, C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513861200 · Cited by 103 · see citing works

GIV003 Helicobacter pylori flagellins have very low intrinsic activity to stimulate human gastric epithelial cells via TLR5

(2003) · International Journal of Medical Microbiology Supplements · doi:10.1016/s1433-1128(03)80624-1