The DOI matches its Crossref record; 56 of the 57 references it cites were found in a registry or an index.
Tumor Necrosis Factor-α, Interleukin-1β, and Interferon-γ Stimulate γ-Secretase-mediated Cleavage of Amyloid Precursor Protein through a JNK-dependent MAPK Pathway
Open accessAbstract
The deposition of the amyloid beta (Abeta) peptide in neuritic plaques plays a critical role in the pathogenesis of Alzheimer's disease (AD). Abeta is generated through the proteolysis of amyloid precursor protein (APP) by the sequential actions of beta- and gamma-secretases. Although recent evidence has unveiled much about the biochemical identity and characteristics of gamma-secretase, the mechanism regulating endogenous gamma-secretase activity remains elusive. To identify possible extracellular signals and associated signaling cascades that could regulate APP proteolysis by gamma-secretase activity, we have developed a cell-based reporter gene assay by stably cotransfecting HEK293 cells with the Gal4-driven luciferase reporter gene and the Gal4/VP16-tagged C-terminal fragment of APP (C99-GV), the immediate substrate of gamma-secretase. The cleavage of C99-GV by gamma-secretase releases the transcription factor that activates luciferase expression, providing a quantitative measurement of gamma-secretase activity. Using this reporter assay, we have demonstrated that interferon-gamma, interleukin-1beta, and tumor necrosis factor-alpha can specifically stimulate gamma-secretase activity, concomitant with increased production of Abeta and the intracellular domain of APP (AICD). The gamma-secretase-dependent cleavage of Notch is also enhanced upon the stimulation of these cytokines. The cytokine-enhanced gamma-secretase activity can be suppressed by a potent inhibitor of c-Jun N-terminal kinase (JNK). Furthermore, cells transfected with dominant-positive MEKK1, one of the most potent activators of the JNK cascade, exhibit increased gamma-secretase activity, suggesting that the JNK-dependent mitogen-activated protein kinase pathway could mediate the cytokine-elicited regulation of gamma-secretase. Our studies provide direct evidence that cytokine-elicited signaling cascades control Abeta production by modulating gamma-secretase activity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“B94 (GenBank M92357) is a TNF-α-inducible proinflammatory element (Colangelo et al., 2002; Liao et al., 2004).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Liao et al., 2004
In the citing paper
“IL-1β directly stimulates γ-secretase-mediated cleavage of βAPP into Aβ peptides through a JNK-dependent MAPK pathway (Liao et al., 2004).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Liao et al., 2004
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Alzheimer's Disease: Genes, Proteins, and Therapy
Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063
Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases
Barnes, P. J., & Karin, M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704103361506 · Cited by 4,622
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
Bennett, B. L., Sasaki, D. T., Murray, B. W., O'Leary, E. C., Sakata, S. T., Xu, W., Leisten, J. C., Motiwala, A., Pierce, S., Satoh, Y., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251194298 · Cited by 2,558
Signal transduction by tumor necrosis factor and its relatives.
Baud, V., & Karin, M. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02064-5 · Cited by 1,741
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
Schroeter, E. H., Kisslinger, J. A., & Kopan, R. (1998) · Nature · doi:10.1038/30756 · Cited by 1,624
Amyloid, the presenilins and Alzheimer’s disease
Hardy, J. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01030-2 · Cited by 1,370
The Molecular Cell Biology of Interferon-Gamma and Its Receptor
Farrar, M. A., & Schreiber, R. D. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.003035 · Cited by 1,353
Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK
Minden, A., Lin, A., McMahon, M., Lange, C. A., Dérijard, B., Davis, R. J., Johnson, G. L., & Karin, M. (1994) · Science · doi:10.1126/science.7992057 · Cited by 1,069
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing
Yu, G., Nishimura, M., Arawaka, S., Levitan, D. J., Zhang, L., Tandon, A., Song, Y., Rogaeva, E. A., Chen, F., Kawarai, T., et al. (2000) · Nature · doi:10.1038/35024009 · Cited by 929
Flagged first, then by citations
1 of the 57 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 201–300 of 391
Piwi reduction in the aged niche eliminates germline stem cells via Toll-GSK3 signaling
Lin, K., Wang, W., Lin, C., Rastegari, E., Su, Y., Chang, Y.-T., Liao, Y., Chang, Y.-C., Pi, H., Yu, B.-Y., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16858-6 · Cited by 30
Self-citationNeutrophil to lymphocyte ratio in Alzheimer’s disease: A systematic review and meta-analysis
Mohammadi, A., Mohammadi, M., Almasi‐Dooghaee, M., & Mirmosayyeb, O. (2024) · PLoS ONE · doi:10.1371/journal.pone.0305322 · Cited by 30
Astrocytes: From the Physiology to the Disease
Trujillo‐Estrada, L., Gómez-Arboledas, Á., Forner, S., Martini, A. C., Gutiérrez, A., Baglietto‐Vargas, D., & LaFerla, F. M. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190830110152 · Cited by 30
Inflammation Drives Alzheimer's Disease: Emphasis on 5-lipoxygenase Pathways
Siddiqui, A., Akhtar, S., Shah, Z., Othman, I., & Kumari, Y. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200924122732 · Cited by 30
Li, Y., Fan, H., Ni, M., Zhang, W., Fang, F., Sun, J., Lyu, P., & Ma, P. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.11.001 · Cited by 30
Jain, S., Singh, R., Paliwal, S., & Sharma, S. K. (2023) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557523666230511122435 · Cited by 35
Ma, G., Chen, S., Wang, X., Ba, M., Yang, H., & Lü, G. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20515 · Cited by 30
Whiten, D. R., Brownjohn, P. W., Moore, S., De, S., Strano, A., Zuo, Y., Haneklaus, M., Klenerman, D., & Livesey, F. J. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa146 · Cited by 28
McManus, R. M., Finucane, O. M., Wilk, M. M., Mills, K. H. G., & Lynch, M. A. (2017) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-017-9753-6 · Cited by 28
Martínez‐Mármol, R., Mohannak, N., Qian, L., Wang, T., Gormal, R. S., Ruitenberg, M. J., Vanhaesebroeck, B., Coulson, E. J., & Meunier, F. A. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0674-19.2019 · Cited by 27
Cognitive resilience in Alzheimer’s disease: Mechanism and potential clinical intervention
Jia, B., Xu, Y., & Zhu, X. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102711 · Cited by 30
He, G., Luo, Z., Shen, T., Li, P., Yang, J., Luo, X. G., Chen, C., Gao, P., & Yang, X. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0762-9 · Cited by 27
Hsu, Y., Chang, P., Tung, C., Shih, Y., Ni, W.-C., Li, Y., Uto, T., Shoyama, Y., Ho, C., & Lin, C. (2020) · Cells · doi:10.3390/cells9010125 · Cited by 27
Yu, X., Yu, W., Wu, L., Yang, W., & Lü, Y. (2021) · Neuroscience Research · doi:10.1016/j.neures.2021.05.014 · Cited by 27
Exosomes: A missing link between chronic systemic inflammation and Alzheimer’s disease?
Ozansoy, M., Mikati, H., Velioğlu, H. A., & Yuluğ, B. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114161 · Cited by 30
Mutti, V., Carini, G., Filippini, A., Castrezzati, S., Giugno, L., Gennarelli, M., & Russo, I. (2023) · Cells · doi:10.3390/cells12131799 · Cited by 28
Manipulation of the diet–microbiota–brain axis in Alzheimer’s disease
Lee, D. D., Lee, V. M. ‐., & Hur, S. K. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1042865 · Cited by 27
Shared Genetic Risk Factors for Late-Life Depression and Alzheimer’s Disease
Ye, Q., Bai, F., & Zhang, Z. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-151129 · Cited by 26
Russell, A. E., Jun, S., Sarkar, S., Geldenhuys, W. J., Lewis, S. E., Rellick, S. L., & Simpkins, J. W. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00051 · Cited by 27
Alabed, S. T., Zhou, H., Sariyer, I. K., & Chang, S. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094781 · Cited by 25
Liao, Y.-F., Wang, B., Hsu, W., Lee, H., Liao, C.-Y., Wu, S.-Y., Cheng, H.-T., & Hu, M. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.024299 · Cited by 25
Self-citationRole of Insulin Metabolism Disturbances in the Development of Alzheimer Disease: Mini Review
Sabayan, B., Foroughinia, F., Mowla, A., & Borhani‐Haghighi, A. (2008) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317507312623 · Cited by 24
Intranasal nerve growth factor for prevention and recovery of the outcomes of traumatic brain injury
Manni, L., Conti, G., Chiaretti, A., & Soligo, M. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.354513 · Cited by 24
Inhibition of Early Upstream Events in Prodromal Alzheimer’s Disease by Use of Targeted Antioxidants
Prasad, K. N., & Bondy, S. C. (2014) · Current Aging Science · doi:10.2174/1874609807666140804115633 · Cited by 24
Li, X., Huang, L., Kong, L., Su, Y., Zhou, H., Ji, P., Sun, R., Wang, C., Li, W., & Li, W. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12893 · Cited by 25
Alkaloids as drug leads in Alzheimer's treatment: Mechanistic and therapeutic insights
Islam, M. R., Akash, S., Islam, M. M., Sarkar, N., Kumer, A., Chakraborty, S., Dhama, K., Al‐Shaeri, M., Anwar, Y., Wilairatana, P., et al. (2024) · Brain Research · doi:10.1016/j.brainres.2024.148886 · Cited by 27
Toral-Ríos, D., Franco-Bocanegra, D., Rosas‐Carrasco, Ó., Mena‐Barranco, F., Carvajal-García, R., Meraz‐Ríos, M. A., & Campos‐Peña, V. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00148 · Cited by 22
Zhang, J., Jia, J., Qin, W., & Wang, S. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.03.007 · Cited by 22
Treatment implications of the altered cytokine-insulin axis in neurodegenerative disease
Clark, I. A., & Vissel, B. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.07.030 · Cited by 23
Enogieru, A. B., & Momodu, O. I. (2021) · The Botanical Review · doi:10.1007/s12229-021-09246-2 · Cited by 23
Bakshi, P., Jin, C., Broutin, P., Berhane, B. T., Reed, J. M., & MULLAN, M. J. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.09.051 · Cited by 22
Wang, P., Guan, P.-P., Yu, X., Zhang, L., Su, Y.-N., & Wang, Z. (2016) · Scientific Reports · doi:10.1038/srep20879 · Cited by 21
Brain Damage - Bridging Between Basic Research and Clinics
González-Quevedo, A. (2012) · InTech eBooks · doi:10.5772/2174 · Cited by 21
Contreras, J. A., Aslanyan, V., Albrecht, D., Mack, W. J., Initiative, A. D. N., & Pa, J. (2022) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12346 · Cited by 20
Szumiel, I., & Foray, N. (2011) · Acta Biochimica Polonica · doi:10.18388/abp.2011_2279 · Cited by 20
Ullah, R., Ali, G., Baseer, A., Khan, S. I., Akram, M., Khan, S., Ahmad, N., Farooq, U., Nawaz, N. K., Shaheen, S., et al. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108970 · Cited by 20
Involvement of inflammasomes in the pathogenesis of Alzheimer's disease
Beder, N., Belkhelfa, M., & Leklou, H. (2024) · Journal of Alzheimer s Disease · doi:10.1177/13872877241283677 · Cited by 20
Yadav, V., Mythri, C., & Kumarasamy, M. (2024) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2024.100048 · Cited by 22
Daily, K. P., Badr, A., Eltobgy, M. M., Estfanous, S. Z. K., Whitham, O. D., Tan, M. H., Carafice, C., Krause, K., McNamara, A. J., Hamilton, K., et al. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01390-2 · Cited by 24
Florean, C., Zampese, E., Zanese, M., Brunello, L., Ichas, F., Giorgi, F. D., & Pizzo, P. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.03.012 · Cited by 19
Cheon, J., Kwon, S.-Y., & Kim, M. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14432 · Cited by 20
The Development of an in vivo γ-Secretase Assay using Zebrafish Embryos
Wilson, L., & Lardelli, M. T. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130332 · Cited by 18
Alasmari, F. F., Ashby, C. R., Hall, F. S., Sari, Y., & Tiwari, A. K. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00658 · Cited by 18
Distinct brain regional proteome changes in the rTg‐DI rat model of cerebral amyloid angiopathy
Schrader, J. M., Xu, F., & Nostrand, W. E. V. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15463 · Cited by 18
Hu, M., Liao, Y.-F., Chen, J.-F., Wang, B., Tung, Y.-T., Lin, H., & Lee, K. (2007) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2007.10.101 · Cited by 18
Self-citationLin, K., Lin, W., Guo, Z., Chen, C., Liang, C., & Cai, X. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1545690 · Cited by 19
Tsai, Y., Kao, S.-T., & Cheng, C.-Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911311 · Cited by 20
Wu, Z., Huang, Y., Wang, T.-Y., Deng, C.-Y., Xu, Z.-R., & Tang, C. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1110087 · Cited by 18
Li, X., Cudaback, E., Keene, C. D., BREYER, R. M., & Montine, T. J. (2011) · Glia · doi:10.1002/glia.21125 · Cited by 17
Novel 7‐secretase inhibitors uncover a common nucleotide‐binding site in JAK3, SIRT2, and PS1
Wu, F., Schweizer, C., Rudinskiy, N., Taylor, D. M., Kazantsev, A. G., Luthi‐Carter, R., & Fraering, P. C. (2010) · The FASEB Journal · doi:10.1096/fj.09-148031 · Cited by 17
Camacho, R. C., Alabed, S. T., Zhou, H., & Chang, S. L. (2021) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-021-10012-9 · Cited by 18
Region-specific distribution of β-amyloid peptide and cytokine expression in TgCRND8 mice
Ma, K., Mount, H. T. J., & McLaurin, J. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.01.035 · Cited by 17
Block, J. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.02.044 · Cited by 16
Hooper, C., Barreto, P. D. S., Cantet, C., Cesari, M., Payoux, P., Salabert, A., & Vellas, B. J. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.04.014 · Cited by 19
Kalovyrna, N., Apokotou, O., Boulekou, S., Paouri, E., Boutou, A., & Georgopoulos, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-65378-2 · Cited by 16
The Role of Immunity in Alzheimer's Disease
McManus, R. M. (2022) · Advanced Biology · doi:10.1002/adbi.202101166 · Cited by 16
Cadmium induces N-cadherin cleavage via ERK-mediated γ-secretase activation in C6 astroglia cells
Jo, C., & Koh, Y. H. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.07.015 · Cited by 16
Stahl, T., Reimers, C., Johne, R., Schliebs, R., & Seeger, J. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05069.x · Cited by 16
Fertan, E., Hung, C., Danial, J. S. H., Lam, J. Y. L., Preman, P., Albertini, G., English, E. A., Böken, D., Livesey, F. J., Strooper, B. D., et al. (2024) · Brain Communications · doi:10.1093/braincomms/fcae454 · Cited by 16
Chae, S. S., Yoo, C. B., Jo, C., Yun, S., Jo, S. A., & Koh, Y. H. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22356 · Cited by 15
Anti-Inflammatory Agents: An Approach to Prevent Cognitive Decline in Alzheimer’s Disease
Brod, S. A. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-215125 · Cited by 16
Rioux, G., Turgeon, F., Le‐Bel, G., Grenier, C., Guérin, S. L., & Pouliot, R. (2022) · Cells · doi:10.3390/cells11182904 · Cited by 15
Kumar, M., Swanson, N., Ray, S., Buch, S. J., Saraswathi, V., & Sil, S. (2024) · Cells · doi:10.3390/cells13141173 · Cited by 15
Wu, W., Huang, J., Han, P., Zhang, J., Wang, Y., Jin, F., & Zhou, Y. (2023) · Molecules · doi:10.3390/molecules28227631 · Cited by 15
Verma, A., Azhar, G., Patyal, P., Zhang, X., & Wei, J. Y. (2025) · Cells · doi:10.3390/cells14110804 · Cited by 14
McKee, T. D., Loureiro, R. M. B., Dumin, J. A., Zarayskiy, V. V., & Tate, B. A. (2012) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2012.11.011 · Cited by 14
Presenilin-1 Regulates the Expression of p62 to Govern p62-dependent Tau Degradation
Tung, Y.-T., Wang, B.-J., Hsu, W., Hu, M., Her, G. M., Huang, W., & Liao, Y. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8482-y · Cited by 14
Self-citationLiu, Y., Zhao, H., Li, Q., Cui, H.-W., & Huang, G. (2022) · Aging and Disease · doi:10.14336/ad.2022.1211 · Cited by 15
Microglial clearance of Alzheimer's amyloid-beta obstructed by nanoplastics
Wang, Y., Huang, G., Liang, X., Andrikopoulos, N., Tang, H., Ding, F., Ke, P. C., & Li, Y. (2025) · Environmental Science Nano · doi:10.1039/d5en00291e · Cited by 19
Liu, C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.927256 · Cited by 13
LRRK2 Kinase Inhibition Attenuates Astrocytic Activation in Response to Amyloid β1-42 Fibrils
Filippini, A., Salvi, V., Dattilo, V., Magri, C., Castrezzati, S., Veerhuis, R., Bosisio, D., Gennarelli, M., & Russo, I. (2023) · Biomolecules · doi:10.3390/biom13020307 · Cited by 13
Lai, W. B., Wang, B. J., Hu, M., Hsu, W., Her, G. M., & Liao, Y. F. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8580-x · Cited by 15
Self-citationCavanagh, C., Colby-Milley, J., Farso, M. C., Krantic, S. M., & Quirion, R. (2011) · Future Neurology · doi:10.2217/fnl.11.50 · Cited by 15
Topalis, V., Voros, C., & Ziaka, M. (2025) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/08919887251361578 · Cited by 14
Łuc, M., Woźniak, M., Helemejko, M., & Rymaszewska, J. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.05.039 · Cited by 12
Majd, S., Rastegar, K., Zarifkar, A., & Takhshid, M. A. (2007) · Brain Research · doi:10.1016/j.brainres.2007.09.033 · Cited by 12
Huang, Z. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221042 · Cited by 12
Perdaens, O., & Pesch, V. V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312637 · Cited by 12
Wang, Q., Yuan, S., Wang, C., Huang, D., Zhang, M., Zhan, Y., Gao, F., Shi, J., Levey, A. I., & Shen, Y. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01644-z · Cited by 12
Song, G., Liang, H., Song, H., Ding, X., Wang, D., Zhang, X., & Sun, T. (2022) · Journal of Immunology Research · doi:10.1155/2022/3218452 · Cited by 13
Tweedie, D., Brossi, A. R., Chen, D., Ge, Y., Bailey, J. A., Yu, Q.-S., Kamal, M. A., Sambamurti, K., Lahiri, D. K., & Greig, N. H. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-10102 · Cited by 11
Cognitive Impairment Among Older Individuals with HIV Infection
Saylor, D. R., & Sacktor, N. C. (2016) · Current Geriatrics Reports · doi:10.1007/s13670-016-0165-x · Cited by 11
Xu, P., Cui, D., Jin, M., & Sun, L. (2024) · Journal of Neurorestoratology · doi:10.1016/j.jnrt.2024.100094 · Cited by 12
Consequences of Amyloid‐β Deficiency for the Liver
Buniatian, G. H., Schwinghammer, U., Tremmel, R., Cynis, H., Weiß, T. S., Weiskirchen, R., Lauschke, V. M., Youhanna, S. C., Ramos, I., Valcárcel, M., et al. (2024) · Advanced Science · doi:10.1002/advs.202307734 · Cited by 9
Eid, F., Boushehri, M., Boucher, C., Rajkanth, N., Sa, A. F., Alhoutan, T., Vavetsi, K., Dibart, S., & Ma, Y. (2025) · The FASEB Journal · doi:10.1096/fj.202403117rr · Cited by 10
Liu, Y., Dong, Y., Cao, Z., Ji, Y., Cheng, X., & Zheng, X. (2025) · Nutrients · doi:10.3390/nu17213451 · Cited by 12
Houacine, J., Bolmont, T., Aeschbach, L., Oulad‐Abdelghani, M., & Fraering, P. C. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.12.033 · Cited by 10
Du, Y., Liu, G., Chen, D., Yang, J., Wang, J., Sun, Y., Zhang, Q., & Liu, Y. (2023) · Brain and Behavior · doi:10.1002/brb3.2917 · Cited by 9
Ponvilawan, B., Charoenngam, N., Rittiphairoj, T., & Ungprasert, P. (2020) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.13920 · Cited by 12
He, Y., Li, H., Zhang, F., Zhang, G., Tang, X., Zhu, T., Huang, N., & Li, X. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.08.025 · Cited by 8
Cucoș, C. A., Milanesi, E., Dobre, M., Musat, I. A., Manda, G., & Cuadrado, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105799 · Cited by 8
Wei, Z.-H., Koya, J., Acharekar, N., Trejos, J., Dong, X.-D., Schanne, F. A. X., Ashby, C. R., & Reznik, S. E. (2023) · Scientific Reports · doi:10.1038/s41598-023-34355-w · Cited by 7
Panda, S. S., Lee, C., Geevimaan, K., Chen, K.-C., Yang, S., Shen, C., HuangFu, W., & Wu, H. (2024) · Journal of Biomedical Science · doi:10.1186/s12929-024-01057-y · Cited by 8
Kazemi, M., Sadeh, R. N., Khaniani, M. S., Rezazadeh, M., Derakhshan, S. M., & Ghafouri‐Fard, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-82490-9 · Cited by 9
Tumor Necrosis Factor-Alpha Alters Electrophysiological Properties of Rabbit Hippocampal Neurons
Wang, D. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190043 · Cited by 7
Lu, Z., Li, Y., Samuvel, D. J., Jin, J., Zhang, X., Lopes-Virella, M. F., & Huang, Y. Q. (2013) · Immunology · doi:10.1111/imm.12138 · Cited by 7
Minopoli, G., Passaro, F., Aloia, L., Carlomagno, F., Melillo, R. M., Santoro, M. M., Forzati, F., Zambrano, N., & Russo, T. (2007) · Neurodegenerative Diseases · doi:10.1159/000101833 · Cited by 7
The influence of tumour necrosis factor- α (TNF-α) on amyloid-β (Aβ)-degrading enzymes in vitro.
Culpan, D., Palmer, J. C., Miners, J. S., Love, S., & Kehoe, P. G. (2011) · PubMed Central · Cited by 7
Progressive Hippocampal Neuroarchitecture Changes in the 5×FAD Alzheimer’s Disease Mouse Model
Jang, H., Lee, S., Kim, Y.-J., Lee, J., Kim, S.-W., Son, Y., Kim, J., Park, J., Youn, B., & Moon, C. (2025) · Journal of Integrative Neuroscience · doi:10.31083/jin40831 · Cited by 5
From Infection to Inoculation: Expanding the Microbial Hypothesis of Alzheimer’s Disease
Dorszewska, J., Hurła, M., Banaszek, N., Kobylarek, D., Piekut, T., & Kozubski, W. P. (2023) · Current Alzheimer Research · doi:10.2174/1567205020666230202155404 · Cited by 6
Metadata
- Authors
- Liao, Y.-F., Wang, B.-J., Cheng, H.-T., Kuo, L.-H., & Wolfe, M. S.
- Affiliations
- Academia Sinica (TW)
- Brigham and Women's Hospital (US)
- Corresponding author
- Liao, Yung-Feng
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2004-11
- Volume
- 279
- Issue
- 47
- Pages
- 49523-49532
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1992680479
- Cited by
- 389
- References
- 57
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 29 · 2023: 28 · 2022: 25 · 2021: 21 · 2020: 22 · 2019: 16 · 2018: 14 · 2017: 12 · 2016: 13 · 2015: 13 · 2014: 15 · 2013: 25 · 2012: 14
- FWCI
- 9.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Alzheimer's Association
- National Science Council
- Academia Sinica
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- gamma-secretase, amyloid precursor protein, amyloid-beta, Alzheimer's disease, TNF-α, IL-1β, interferon-gamma, JNK, MAPK signaling, MEKK1, Notch cleavage, APP intracellular domain, cytokine signaling
- MeSH terms
- Animals, Cell Line, DNA, Dose-Response Relationship, Drug, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Genes, Dominant, Humans, Interferon-gamma, Interleukin-1, Luciferases, Membrane Proteins, Mutation, Endopeptidases, Transfection, Tumor Necrosis Factor-alpha, Blotting, Western, Signal Transduction, Aspartic Acid Endopeptidases, Amyloid beta-Protein Precursor, Culture Media, Serum-Free, Protein Structure, Tertiary, Genes, Reporter, COS Cells, Mitogen-Activated Protein Kinase Kinases, MAP Kinase Signaling System, JNK Mitogen-Activated Protein Kinases, MAP Kinase Kinase 4, Receptors, Notch, Amyloid Precursor Protein Secretases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review