Cited by 391Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsNF-κB Signaling Pathways

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Tumor Necrosis Factor-α, Interleukin-1β, and Interferon-γ Stimulate γ-Secretase-mediated Cleavage of Amyloid Precursor Protein through a JNK-dependent MAPK Pathway

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Liao, Yung-Feng, Wang, Bo-Jeng, Cheng, Hui-Ting, Kuo, Lan-Hsin, Wolfe, Michael S.·2004·Journal of Biological Chemistry

DOI 10.1074/jbc.m402034200

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Abstract

The deposition of the amyloid beta (Abeta) peptide in neuritic plaques plays a critical role in the pathogenesis of Alzheimer's disease (AD). Abeta is generated through the proteolysis of amyloid precursor protein (APP) by the sequential actions of beta- and gamma-secretases. Although recent evidence has unveiled much about the biochemical identity and characteristics of gamma-secretase, the mechanism regulating endogenous gamma-secretase activity remains elusive. To identify possible extracellular signals and associated signaling cascades that could regulate APP proteolysis by gamma-secretase activity, we have developed a cell-based reporter gene assay by stably cotransfecting HEK293 cells with the Gal4-driven luciferase reporter gene and the Gal4/VP16-tagged C-terminal fragment of APP (C99-GV), the immediate substrate of gamma-secretase. The cleavage of C99-GV by gamma-secretase releases the transcription factor that activates luciferase expression, providing a quantitative measurement of gamma-secretase activity. Using this reporter assay, we have demonstrated that interferon-gamma, interleukin-1beta, and tumor necrosis factor-alpha can specifically stimulate gamma-secretase activity, concomitant with increased production of Abeta and the intracellular domain of APP (AICD). The gamma-secretase-dependent cleavage of Notch is also enhanced upon the stimulation of these cytokines. The cytokine-enhanced gamma-secretase activity can be suppressed by a potent inhibitor of c-Jun N-terminal kinase (JNK). Furthermore, cells transfected with dominant-positive MEKK1, one of the most potent activators of the JNK cascade, exhibit increased gamma-secretase activity, suggesting that the JNK-dependent mitogen-activated protein kinase pathway could mediate the cytokine-elicited regulation of gamma-secretase. Our studies provide direct evidence that cytokine-elicited signaling cascades control Abeta production by modulating gamma-secretase activity.

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Authors: Liao, Y.-F., Wang, B.-J., Cheng, H.-T., Kuo, L.-H., & Wolfe, M. S.
Affiliations: Academia Sinica (TW)
Brigham and Women's Hospital (US)
Corresponding author: Liao, Yung-Feng
ORCID: Liao, Yung-Feng
Wolfe, Michael S.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2004-11
Volume: 279
Issue: 47
Pages: 49523-49532
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m402034200
OpenAlex: W1992680479
Cited by: 389
References: 57
Citations by year: 2026: 12 · 2025: 16 · 2024: 29 · 2023: 28 · 2022: 25 · 2021: 21 · 2020: 22 · 2019: 16 · 2018: 14 · 2017: 12 · 2016: 13 · 2015: 13 · 2014: 15 · 2013: 25 · 2012: 14
FWCI: 9.04
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 5833 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: Alzheimer's Association
National Science Council
Academia Sinica
National Institutes of Health
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: gamma-secretase, amyloid precursor protein, amyloid-beta, Alzheimer's disease, TNF-α, IL-1β, interferon-gamma, JNK, MAPK signaling, MEKK1, Notch cleavage, APP intracellular domain, cytokine signaling
MeSH terms: Animals, Cell Line, DNA, Dose-Response Relationship, Drug, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Genes, Dominant, Humans, Interferon-gamma, Interleukin-1, Luciferases, Membrane Proteins, Mutation, Endopeptidases, Transfection, Tumor Necrosis Factor-alpha, Blotting, Western, Signal Transduction, Aspartic Acid Endopeptidases, Amyloid beta-Protein Precursor, Culture Media, Serum-Free, Protein Structure, Tertiary, Genes, Reporter, COS Cells, Mitogen-Activated Protein Kinase Kinases, MAP Kinase Signaling System, JNK Mitogen-Activated Protein Kinases, MAP Kinase Kinase 4, Receptors, Notch, Amyloid Precursor Protein Secretases

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Tumor Necrosis Factor-α, Interleukin-1β, and Interferon-γ Stimulate γ-Secretase-mediated Cleavage of Amyloid Precursor Protein through a JNK-dependent MAPK Pathway

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