The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Adiponectin Stimulates Angiogenesis in Response to Tissue Ischemia through Stimulation of AMP-activated Protein Kinase Signaling
Open accessAbstract
Obesity is a risk factor for the development of cardiovascular diseases that are associated with impaired angiogenesis. Adiponectin is an adipocyte-specific adipocytokine with anti-atherogenic and anti-diabetic properties, and its plasma levels are reduced in association with obesity-linked diseases. Here, we investigated whether adiponectin regulates angiogenesis in response to tissue ischemia using adiponectin knock-out (KO) mice. Angiogenic repair of ischemic hind limbs was impaired in adiponectin-KO mice compared with wild-type (WT) mice as evaluated by laser Doppler flow method and capillary density analyses. Adenovirus-mediated supplement of adiponectin accelerated angiogenic repair in both adiponectin-KO and WT mice. Intramuscular injection of an adenovirus encoding dominant-negative AMP-activated kinase diminished the improvement in limb perfusion seen in WT mice and abolished the adiponectin-induced enhancement of perfusion. These data indicate that adiponectin can function to stimulate angiogenesis in response to ischemic stress by promoting AMP-activated kinase signaling. Therefore, adiponectin may be useful in the treatment for obesity-related vascular deficiency diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In addition to authentic angiogenic factors, AT secretes several important adipokines and endogenous angiogenesis inhibitors to modulate the balance of new blood vessel formation, including adiponectin (36,37), leptin (34), resistin (38), visfatin/thrombospondin 1 (39), and plasminogen activator inhibitor (40).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [37]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133
Self-citationNovel Modulator for Endothelial Adhesion Molecules
Ouchi, N., Kihara, S., Arita, Y., Maeda, K., Kuriyama, H., Okamoto, Y., Hotta, K., Nishida, M., Takahashi, M., Nakamura, T., et al. (1999) · Circulation · doi:10.1161/01.cir.100.25.2473 · Cited by 2,158
Self-citationDiet-induced insulin resistance in mice lacking adiponectin/ACRP30
Maeda, N., Shimomura, I., Kishida, K., Nishizawa, H., Matsuda, M., Nagaretani, H., Furuyama, N., Kondo, H., Takahashi, M., Arita, Y., et al. (2002) · Nature Medicine · doi:10.1038/nm724 · Cited by 2,114
Self-citationAssociation of Hypoadiponectinemia With Coronary Artery Disease in Men
Kumada, M., Kihara, S., Sumitsuji, S., Kawamoto, T., Matsumoto, S., Ouchi, N., Arita, Y., Okamoto, Y., Shimomura, I., Hiraoka, H., et al. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000048856.22331.50 · Cited by 1,419
Self-citationOuchi, N., Kihara, S., Arita, Y., Nishida, M., Matsuyama, A., Okamoto, Y., Ishigami, M., Kuriyama, H., Kishida, K., Nishizawa, H., et al. (2001) · Circulation · doi:10.1161/01.cir.103.8.1057 · Cited by 1,281
Self-citationAdiponectin and Metabolic Syndrome
Matsuzawa, Y., Funahashi, T., Kihara, S., & Shimomura, I. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000099786.99623.ef · Cited by 1,203
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Grundy, 2004, Arterioscler. Thromb. Vasc. Biol., 24, E13
Cited by
Sorted by citations
Items 101–200 of 336
Adiponectin Deficiency Limits Tumor Vascularization in the MMTV-PyV-mT Mouse Model of Mammary Cancer
Denzel, M. S., Hebbard, L., Shostak, G., Shapiro, L. S., Cardiff, R. D., & Ranscht, B. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2661 · Cited by 84
Ding, M., Xie, Y., Wagner, R. J., Yu, J. H., Carrao, A. C. R., Kohn, L. L., Guzman, A. K., Powell, R. J., Hwa, J., Rzucidlo, E. M., et al. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.216804 · Cited by 82
Gonon, A. T., Widegren, U., Bulhak, A., Salehzadeh, F., Persson, J., Sjöquist, P.-O. B., & Pernow, J. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn017 · Cited by 82
“Adiponectin stimulates AMPK signalling in isolated cardiomyocytes(27) and in the ischaemic hindlimb.(28) Furthermore, adiponectin protects the murine heart against ischaemia and reperfusion injury via an AMPK-dependent pathway.”
BackgroundPerivascular Adipose Tissue: the Sixth Man of the Cardiovascular System
Cheng, C. K., Bakar, H. A., Gollasch, M., & Huang, Y. (2018) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-018-6820-z · Cited by 84
Calcitonin gene-related peptide promotes angiogenesis via AMP-activated protein kinase
Zheng, S., Li, W., Xu, M., Bai, X., Zhou, Z., Han, J., Shyy, J. Y.-J., & Wang, X. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00173.2010 · Cited by 79
“AMPK has been shown to promote angiogenesis (22), especially under hypoxic and/or ischemic stresses (27).”
BackgroundAngiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis
An, Y., Sun, K., Joffin, N., Zhang, F., Deng, Y., Donzé, O., Kusminski, C. M., & Scherer, P. E. (2017) · eLife · doi:10.7554/elife.24071 · Cited by 77
Adiponectin and Vulnerable Atherosclerotic Plaques
Barseghian, A., Gawande, D., & Bajaj, M. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.11.011 · Cited by 77
Higuchi, A., Ohashi, K., Kihara, S., Walsh, K., & Ouchi, N. (2009) · Circulation Research · doi:10.1161/circresaha.109.194506 · Cited by 76
Self-citationObesity and inflammation: A new look at an old problem
Mehta, S., & Farmer, J. A. (2007) · Current Atherosclerosis Reports · doi:10.1007/s11883-007-0009-4 · Cited by 75
Maternal serum adiponectin multimers in preeclampsia
Mazaki‐Tovi, S., Romero, R. J., Vaisbuch, E., Kusanovic, J. P., Erez, O., Gotsch, F., Chaiworapongsa, T., Than, N. G., Kim, S. K., Nhan‐Chang, C., et al. (2009) · Journal of Perinatal Medicine · doi:10.1515/jpm.2009.085 · Cited by 75
Reynolds, H. R., Buyon, J. P., Kim, M., Rivera, T. L., Izmirly, P., Tunick, P. A., & Clancy, R. M. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.12.007 · Cited by 72
Physiological role of adiponectin in different tissues: a review
Esmaili, S., Hemmati, M., & Karamian, M. (2018) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2018.1493606 · Cited by 73
“Adiponectin supporters are shown to stimulate the growth of blood vessels in the rat models (Ouchi et al. 2004, Shibata et al. 2004).”
BackgroundPotential impact of carbohydrate and fat intake on pathological left ventricular hypertrophy
SHARMA, N., Okere, I. C., Duda, M. K., Chess, D. J., O’Shea, K. M., & Stanley, W. C. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.11.007 · Cited by 69
Advancements in therapeutic drugs targeting of senescence
Zhu, M., Meng, P., Ling, X., & Zhou, L. (2020) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622320964125 · Cited by 68
Adipocytokines and obesity-linked disorders.
Ouchi, N., Ohashi, K., Shibata, R., & Murohara, T. (2012) · PubMed Central · doi:10.18999/nagjms.74.1-2.19 · Cited by 67
Self-citationAdiponectin in severe preeclampsia
Nien, J. K., Mazaki‐Tovi, S., Romero, R. J., Erez, O., Kusanovic, J. P., Gotsch, F., Pineles, B. L., Gómez, R., Edwin, S. S., Mazor, M., et al. (2007) · Journal of Perinatal Medicine · doi:10.1515/jpm.2007.121 · Cited by 69
Cardiometabolic effects of adiponectin
Parker, J., & Walsh, K. X. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.09.001 · Cited by 64
Self-citationAdiponectin and cardiovascular inflammatory responses
Takemura, Y., Walsh, K. X., & Ouchi, N. (2007) · Current Atherosclerosis Reports · doi:10.1007/s11883-007-0025-4 · Cited by 63
“APN-KO mice display an impaired angiogenic response to chronic hind-limb ischemia [ 10 ].”
BackgroundSelf-citationiPS cell sheets created by a novel magnetite tissue engineering method for reparative angiogenesis
Kito, T., Shibata, R., Ishii, M., Suzuki, H., Himeno, T., Kataoka, Y., Yamamura, Y., Yamamoto, T., Nishio, N., Ito, S., et al. (2013) · Scientific Reports · doi:10.1038/srep01418 · Cited by 63
Self-citationAdya, R., Tan, B. K., Chen, J., & Randeva, H. S. (2012) · Journal of Vascular Research · doi:10.1159/000338279 · Cited by 62
Adiponectin--an adipokine with unique metabolic properties
Wiecek, A., Adamczak, M., & Chudek, J. T. (2007) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfl814 · Cited by 63
“In this context, it is of interest that adiponectin stimulates angiogenesis in response to tissue ischaemia [36].”
BackgroundMethodInfluentialIshii, M., Shibata, R., Kondo, K., Kambara, T., Shimizu, Y., Tanigawa, T., Bando, Y., Nishimura, M., Ouchi, N., & Murohara, T. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.557835 · Cited by 61
“Adiponectin is an adipocytokine that is downregulated in obesity-linked diseases and exerts protective actions on a variety of metabolic and cardiovascular disorders (30,34-36).”
BackgroundSelf-citationAssessment of Endothelial Dysfunction in Childhood Obesity and Clinical Use
Bruyndonckx, L., Hoymans, V. Y., Craenenbroeck, A. H. V., Vissers, D. K., Vrints, C. J., Ramet, J., & Conraads, V. M. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/174782 · Cited by 66
“Recent human data show that adiponectin stimulates the migratory capacity of circulating angiogenic cells [62], thereby supporting animal experiments that suggested angiogenesis-stimulating effects [63] and the promotion of neovascularization [64].”
BackgroundBack to the heart: The protective role of adiponectin
Caselli, C., D’Amico, A., Cabiati, M., Prescimone, T., Ry, S. D., & Giannessi, D. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.03.003 · Cited by 61
The Clinical Implications of Blood Adiponectin in Cardiometabolic Disorders
Chang, L., Huang, K., Wu, Y., Kao, H., Chen, C., Lai, L., Hwang, J., & Yang, W. (2009) · Journal of the Formosan Medical Association · doi:10.1016/s0929-6646(09)60079-6 · Cited by 60
Urano, T., Ito, Y., Akao, M., Sawa, T., Miyata, K., Tabata, M., Morisada, T., Hato, T., Yano, M., Kadomatsu, T., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.149674 · Cited by 59
Self-citationRen, J. T., Xu, X., Wang, Q., Ren, S. Y., Dong, M., & Zhang, Y. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.02.002 · Cited by 61
The infrapatellar fat pad in inflammaging, knee joint health, and osteoarthritis
Wang, M. G., Seale, P., & Furman, D. (2024) · npj Aging · doi:10.1038/s41514-024-00159-z · Cited by 64
Ikeda, Y., Ohashi, K., Shibata, R., Pimentel, D. R., Kihara, S., Ouchi, N., & Walsh, K. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.03.002 · Cited by 58
“The method of protein extraction from mice hearts was previously described in detail [17].”
MethodSelf-citationYi, W., Sun, Y., Gao, E., Wei, X., Lau, W. B., Zheng, Q., Wang, Y., Yuan, Y., Wang, X., Tao, L., et al. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3722 · Cited by 57
“The majority of APN’s metabolic regulatory function occurs via the AMPK/ACC signaling axis (28), whereas its inhibition of the inflammatory response and elicitation of vasodilatation/vasculoprotection occurs largely through the AMPK/eNOS axis (6, 23).”
Ohashi, K., Enomoto, T., Joki, Y., Shibata, R., Ogura, Y., Kataoka, Y., Shimizu, Y., Kambara, T., Uemura, Y., Yuasa, D., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.555789 · Cited by 53
“Ad- -gal at 4 10(7) pfu or AdNDNF at 4 10(7) pfu or 1 10(8) pfu was injected into five different sites of the adductor muscle in the left limb 3 days prior to the surgery, as described previously (18, 22).”
MethodSelf-citationAdiponectin promotes migration activities of endothelial progenitor cells via Cdc42/Rac1
Nakamura, N., Naruse, K., Matsuki, T., Hamada, Y., Nakashima, E., Kamiya, H., Matsubara, T., Enomoto, A., Takahashi, M., Oiso, Y., et al. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.07.011 · Cited by 55
“Moreover, adiponectin was found to be capable of stimulating angiogenesis [11].”
BackgroundNatarajan, R., Salloum, F. N., Fisher, B. J., Kukreja, R. C., & Fowler, A. A. (2008) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31815f248d · Cited by 55
“Adiponectin-knockout (APN-KO) mice have diet-induced insulin resistance(47) and impaired angiogenic responses to ischemia.(48) On the other hand, adiponectin overexpression promotes insulin sensitivity and angiogenesis, and it inhibits cardiac hypertrophy.”
BackgroundArakawa, H., Jinnin, M., Muchemwa, F. C., Makino, T., Kajihara, I., Makino, K., Honda, N., Sakai, K., Fukushima, S., & Ihn, H. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2011.01310.x · Cited by 54
Chen, X., & Wang, Y. (2010) · Medical Oncology · doi:10.1007/s12032-010-9617-x · Cited by 55
“VECs into capillary-like structures and induces blood vessel growth in mouse and rabbit models of angiogenesis [65], which is mediated by the promotion of AMPK signaling in ischemic stress model [ 66 ].”
BackgroundSummer, R. S., Walsh, K. X., & Medoff, B. D. (2011) · Pulmonary Circulation · doi:10.4103/2045-8932.93542 · Cited by 52
Self-citationAdiponectin‐Mediated Modulation of Lymphatic Vessel Formation and Lymphedema
Shimizu, Y., Shibata, R., Ishii, M., Ohashi, K., Kambara, T., Uemura, Y., Yuasa, D., Kataoka, Y., Kihara, S., Murohara, T., et al. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000438 · Cited by 56
“Furthermore, we have shown that the disruption of adiponectin contributes to impaired revascularization in response to tissue ischemia and exacerbation of endothelial dysfunction.(15,20)”
Self-citationWang, Y., Xu, L. Y., Lam, K. S. L., Lü, G., Cooper, G. J. S., & Xu, A. (2006) · PROTEOMICS · doi:10.1002/pmic.200500840 · Cited by 53
Jakubiak, G. K., Pawlas, N., Cieślar, G., & Stanek, A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17249339 · Cited by 53
“It had been described previously that adiponectin stimulated angiogenesis in response to tissue ischemia [100].”
BackgroundAssociation between Risk Factors for Vascular Dementia and Adiponectin
Song, J., Lee, W. T., Park, K. A., & Lee, J. E. (2014) · BioMed Research International · doi:10.1155/2014/261672 · Cited by 58
“It is an effective insulin sensitizer [64, 71, 72], and it promotes peripheral insulin sensitivity [14] and inhibits liver gluconeogenesis [73].”
BackgroundAdiponectin multimers in maternal plasma
Mazaki‐Tovi, S., Romero, R. J., Kusanovic, J. P., Erez, O., Vaisbuch, E., Gotsch, F., Mittal, P., Than, N. G., Nhan-Chang, C. L., Chaiworapongsa, T., et al. (2008) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050802266881 · Cited by 53
“Adiponectin has an important role in the pathophysiology of insulin resistance and diabetes [115–122], atherosclerosis [77– 79,123,124], hypertension [80,125,126], dyslipidemia [127–129], and angiogenesis [130,131].”
BackgroundThe role of adiponectin in cardiovascular disease
Peng, J., Chen, Q., & Wu, C. (2023) · Cardiovascular Pathology · doi:10.1016/j.carpath.2022.107514 · Cited by 56
Wei, L., Chai, S., Chen, Y., Zhang, H., Li, J., & Qin, N. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01331-2 · Cited by 54
Takahashi, N. K., Shibata, R., Ouchi, N., Sugimoto, M., Murohara, T., & Komori, K. (2014) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2013.09.061 · Cited by 51
“We employed a mouse model of neovascularization by surgically removing the entire left femoral artery and under anesthesia with sodium pentobarbital (50 mg/kg intraperitoneally) as previously described.(23,27,28) Mice were randomly assigned to one of three groups.”
BackgroundMethodInfluentialSelf-citationPositive correlations between circulating adiponectin and MMP2 in preeclampsia pregnant
Eleuterio, N. M., Palei, A. C., Machado, J. D. S. R., Tanus-Santos, J. E., Cavalli, R. D. C., & Sandrim, V. C. (2015) · Pregnancy Hypertension · doi:10.1016/j.preghy.2015.03.001 · Cited by 50
“Some reports have described the roles of leptin [4] and adiponectin [5,9,10] in trophoblastic invasion and migration during pregnancy, which are mediated by the activity of metalloproteinases (MMPs) and their inhibitors [11–16].”
BackgroundAdiponectin Deficiency Promotes Tumor Growth in Mice by Reducing Macrophage Infiltration
Sun, Y., & Lodish, H. F. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011987 · Cited by 50
“One group, employing in vitro cell culture systems and other angiogenesis models, showed that adiponectin can stimulate angiogenesis [5,6].”
BackgroundKawai, K., Kageyama, A., Tsumano, T., Nishimoto, S., Fukuda, K., Yokoyama, S., Oguma, T., Fujita, K., Yoshimoto, S., Yanai, A., et al. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.07.045 · Cited by 50
Essential Role of Caveolin-3 in Adiponectin Signalsome Formation and Adiponectin Cardioprotection
Wang, Y., Wang, X., Jasmin, J.-F., Lau, W. B., Li, R., Yuan, Y., Yi, W., Chuprun, K. J., Lisanti, M. P., Koch, W. J., et al. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.242164 · Cited by 46
Cao, T., Gao, Z. L., Gu, L., Chen, M., Yang, B., Cao, K., Huang, H., & Li, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103793 · Cited by 47
“Through stimulation of AMP-activated protein kinase signaling, adiponectin has been demonstrated to modulate the angiogenesis process in vivo in a mouse model of ischemiainduced angiogenesis [11].”
BackgroundZhu, Z., Fu, C., Li, X., Song, Y., Li, C., Zou, M., Guan, Y., & Zhu, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023554 · Cited by 48
“AMP-activated protein kinase (AMPK), a heteroteimeric serine/threonine protein kinase, which is activated in many cell types by increased intracellular concentrations of AMP, plays an important role in angiogenesis when activated by vascular endothelial growth factor (VEGF) [7,8,9], basic fibroblast growth factor [10]…”
BackgroundAndo, Y., Inaba, M., Sakaguchi, Y., Tsuda, M., Quan, G. K., Omae, M., Okazaki, K., & Ikehara, S. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20382 · Cited by 48
Wang, Y., Tao, L., Yuan, Y., Lau, W. B., Li, R., Lopez, B. L., Christopher, T. A., Tian, R., & Ma, X.-L. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90975.2008 · Cited by 47
“Specifically, pharmacological inhibition of AMPK activity or genetic inhibition of AMPK expression virtually abolishes the metabolic (3, 38), anti-inflammatory (17), and vasculoprotective (24, 29) effects of adiponectin.”
Multifaceted roles of adiponectin in rheumatoid arthritis
Liu, D., Luo, S., & Li, Z. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.08.013 · Cited by 48
Reihill, J. A., Ewart, M., & Salt, I. P. (2011) · Vascular Cell · doi:10.1186/2045-824x-3-9 · Cited by 47
“Such findings are consistent with previous observations demonstrating AMPK-mediated angiogenesis in response to both adiponectin [22] and hypoxia [15].”
Kuwashiro, T., Ago, T., Kamouchi, M., Matsuo, R., Hata, J., Kuroda, J., Fukuda, K., Sugimori, H., Fukuhara, M., Awano, H., et al. (2014) · Metabolism · doi:10.1016/j.metabol.2014.04.012 · Cited by 47
Parker, J., Nakamura, K., Silver, M., Zuriaga, M. A., MacLauchlan, S., Aprahamian, T. R., & Walsh, K. X. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.548115 · Cited by 46
Self-citationAdiponectin and Long-Term Mortality in Coronary Artery Disease Participants and Controls
Hascoët, S., Elbaz, M., Bongard, V., Bouisset, F., Verdier, C., Vindis, C., Genoux, A., Taraszkiewicz, D., Perret, B., Galinier, M., et al. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300079 · Cited by 45
Suzuki, H., Shibata, R., Kito, T., Ishii, M., Li, P., Yoshikai, T., Nishio, N., Ito, S., Numaguchi, Y., Yamashita, J. K., et al. (2010) · BMC Cell Biology · doi:10.1186/1471-2121-11-72 · Cited by 44
“To avoid data variations due to ambient light and temperature, hindlimb blood flow was expressed as the ratio of left (ischemic) to right (nonischemic) LDBF in a same mouse according to previous studies [26,29-33].”
MethodSelf-citationThe role of adiponectin in placentation and preeclampsia
Adu‐Gyamfi, E. A., Fondjo, L. A., Owiredu, W. K. B. A., Czika, A., Nelson, W., Lamptey, J., Wang, Y., & Ding, Y. (2019) · Cell Biochemistry and Function · doi:10.1002/cbf.3458 · Cited by 44
Miao, J., Shen, L., Tang, Y., Wang, Y., Tao, M., Jin, K., Zhao, Y., & Yang, G. (2013) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12198 · Cited by 42
Kaarniranta, K., Paananen, J., Nevalainen, T., Sorri, I., Seitsonen, S., Immonen, I. J. R., Salminen, A., Pulkkinen, L., & Uusitupa, M. I. J. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.02.050 · Cited by 42
Enomoto, T., Ohashi, K., Shibata, R., Kambara, T., Uemura, Y., Yuasa, D., Kataoka, Y., Miyabe, M., Matsuo, K., Joki, Y., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083183 · Cited by 44
“Construction of adenoviral vectors The adenovirus (Ad) vectors expressing b-galactosidase (Ad-(gal), Flag-tagged KLF9 (Ad-KLF9) and Flag-tagged KLF15 (AdKLF15) were constructed under the control of CMV promoter [25,26].”
BackgroundSelf-citationThe contribution of dynamic stromal remodeling during mammary development to breast carcinogenesis
McCready, J., Arendt, L. M., Rudnick, J. A., & Kuperwasser, C. (2010) · Breast Cancer Research · doi:10.1186/bcr2578 · Cited by 46
Craven, K. E., Gore, J., Wilson, J. L., & Korc, M. (2015) · Oncotarget · doi:10.18632/oncotarget.6345 · Cited by 42
“For example, ADIPOQ which rescues impaired angiogenesis in ADIPOQ-null mice [68, 69] and stimulates endothelial migration and tube formation [70] was increased by ~11-fold, whereas pro-angiogenic GHSR and NLRP3 [71–74] were increased by ~4.8-and ~4-fold, respectively.”
InfluentialJasinski‐Bergner, S., Büttner, M., Quandt, D., Seliger, B., & Kielstein, H. (2017) · Obesity Facts · doi:10.1159/000481732 · Cited by 42
Cai, L., Xu, S., Piao, C., Qiu, S., Li, H., & Du, J. (2015) · Molecular Carcinogenesis · doi:10.1002/mc.22428 · Cited by 41
“However, several contradictory studies have suggested that adiponectin promotes angiogenesis in vitro cell culture systems and other angiogenesis models by activation of AMPK and PI3K/Akt signaling pathways [18,19].”
BackgroundLKB1 Deficiency in Tie2-Cre-expressing Cells Impairs Ischemia-induced Angiogenesis
Ohashi, K., Ouchi, N., Higuchi, A., Shaw, R. J., & Walsh, K. X. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.123794 · Cited by 43
Self-citationAdiponectin Provides Cardiovascular Protection in Metabolic Syndrome
Okamoto, Y. (2011) · Cardiology Research and Practice · doi:10.4061/2011/313179 · Cited by 40
“In a mouse hindlimb ischemia model, APN deficiency impairs revascularization, whereas adenovirus-mediated APN administration recovers angiogenesis [46].”
BackgroundKLF15 promotes transcription of KLF3 gene in bovine adipocytes
Guo, H., Khan, R., Raza, S. H. A., Ning, Y., Wei, D., Wu, S., Hosseini, S. M., Ullah, I., Garcia, M., & Zan, L. (2018) · Gene · doi:10.1016/j.gene.2018.03.049 · Cited by 40
Mazaki‐Tovi, S., Romero, R. J., Vaisbuch, E., Kusanovic, J. P., Erez, O., Mittal, P., Gotsch, F., Chaiworapongsa, T., Than, N. G., Kim, S. K., et al. (2010) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767050903026481 · Cited by 40
“Adiponectin, identified independently by four groups [80–83] took position as an important adipocytokine with a wide range of biological actions including insulin-sensitizing [84], anti-atherogenic [85], and angiogenic [86] properties.”
Pravastatin accelerates ischemia-induced angiogenesis through AMP-activated protein kinase
Izumi, Y., Shiota, M., Kusakabe, H., Hikita, Y., Nakao, T., Nakamura, Y., Muro, T., Miura, K., Yoshiyama, M., & Iwao, H. (2009) · Hypertension Research · doi:10.1038/hr.2009.77 · Cited by 39
Role of hormones in bone remodeling in the craniofacial complex: A review
Tunheim, E. G., Skallevold, H. E., & Rokaya, D. (2023) · Journal of Oral Biology and Craniofacial Research · doi:10.1016/j.jobcr.2023.01.009 · Cited by 38
Adiponectin deficiency exacerbates age-related hearing impairment
Tanigawa, T., Shibata, R., Ouchi, N., Kondo, K., Ishii, M., Katahira, N., Kambara, T., Inoue, Y., Takahashi, R., Ikeda, N., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.140 · Cited by 38
“APN-KO mice exhibit impaired angiogenesis in response to hindlimb ischemia, whereas overexpression of APN promotes ischemia-mediated angiogenesis.(17) APN supplementation has also been shown to stimulate blood vessel growth in both rabbit corneal angiogenesis and mouse Matrigel plug implantation models.”
BackgroundInfluentialSelf-citationSiegel, A. B., Goyal, A., Salomao, M. A., Wang, S., Lee, V., Hsu, C. C.-S., Rodriguez, R., Hershman, D. L., Brown, R. S., Neugut, A. I., et al. (2014) · Oncology · doi:10.1159/000367971 · Cited by 38
Adiponectin and sporadic Alzheimer’s disease: Clinical and molecular links
Letra, L., Rodrigues, T., Matafome, P. N., Santana, I. J., & Seiça, R. M. F. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.10.002 · Cited by 38
“, 2008) and regulates angiogenesis (Ouchi et al., 2004; Shibata et al., 2004) potentially protecting the brain against β–induced vascular impairment.”
Metformin inhibits ALK1-mediated angiogenesis via activation of AMPK
Ying, Y., Ueta, T., Jiang, S., Lin, H., Wang, Y., Vavvas, D. G., Wen, R., Chen, Y., & Luo, Z. (2017) · Oncotarget · doi:10.18632/oncotarget.15825 · Cited by 36
Age-related cardiovascular disease and the beneficial effects of calorie restriction
Sung, M. M. Y., & Dyck, J. R. B. (2011) · Heart Failure Reviews · doi:10.1007/s10741-011-9293-8 · Cited by 38
Systemic Adiponectin Malfunction as a Risk Factor for Cardiovascular Disease
Lau, W. B., Tao, L., Wang, Y., Li, R., & Ma, X. L. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3743 · Cited by 36
“Either pharmacological inhibition of AMPK activity or genetic suppression of AMPK expression virtually abolishes Ad’s antiinflammatory (21), and vasculoprotective (44, 55) effects.”
Induction of angiogenesis by murine resistin: putative role of PI3-kinase and NO-dependent pathways
Robertson, S. A., Rae, C. J., & Graham, A. (2009) · Regulatory Peptides · doi:10.1016/j.regpep.2008.07.008 · Cited by 35
The impact of adipokines on vascular networks in adipose tissue
Vliora, M., Ravelli, C., Grillo, E., Corsini, M., Flouris, A. D., & Mitola, S. M. F. (2022) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2022.07.008 · Cited by 37
Shen, L., Miao, J., Yuan, F., Zhao, Y., Tang, Y., Wang, Y., Zhao, Y., & Yang, G. (2012) · Gene Therapy · doi:10.1038/gt.2012.7 · Cited by 35
Adiponectin, Insulin Sensitivity and Diabetic Retinopathy in Latinos With Type 2 Diabetes
Kuo, J. Z.-C., Guo, X., Klein, R., Klein, B. E. K., Genter, P. M., Roll, K., Hai, Y., Goodarzi, M. O., Rotter, J. I., Chen, Y.-D. I., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-1221 · Cited by 34
Jiang, X., Song, D., Ye, B., Wang, X., Song, G., Yang, S.-K., & Hu, J. (2011) · Journal of Orthopaedic Research® · doi:10.1002/jor.21355 · Cited by 34
“Adiponectin was proven to promote pro-angiogenic cellular responses in endothelial cells under ischemic state.(11) Ouchi et al.”
BackgroundTargeting adiponectin for cardioprotection
Ouchi, N., Shibata, R., & Walsh, K. X. (2006) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.10.4.573 · Cited by 33
“APN-KO mice exhibit impaired angiogenic repair in response to hindlimb ischaemia, whereas adenovirus-mediated overexpression of adiponectin promotes neovascularisation [52].”
BackgroundSelf-citationObesity, Insulin Resistance, and Capillary Recruitment
Rattigan, S., Bussey, C. T., Ross, R. M., & Richards, S. M. (2007) · Microcirculation · doi:10.1080/10739680701282796 · Cited by 34
“Adiponectin inhibits apoptosis in HUVECs [36] and promotes angiogenesis both in vivo [62] and in vitro [48].”
BackgroundLi, J., Li, C., Huang, Y., Guan, P., Huang, D., Yu, H., Yang, X., & Liu, L. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03822-9 · Cited by 33
“APN is an adipokine secreted by fat cells and has a variety of functions, including promoting blood vessel formation [145] and endothelial cell inflammatory responses [146].”
BackgroundXiong, J., Wang, Z., Bai, J., Cheng, K., Liu, Q., & Ni, J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1184766 · Cited by 36
“, 2003), especially under hypoxic and/or ischemic stress (Shibata et al., 2004).”
BackgroundThe Therapeutic Potential of the Adiponectin Pathway
Gu, W., & Li, Y. (2011) · BioDrugs · doi:10.2165/11594790-000000000-00000 · Cited by 32
Intricate role of oxidative stress in the progression of obesity
Nijhawan, P., Arora, S., & Behl, T. (2019) · Obesity Medicine · doi:10.1016/j.obmed.2019.100125 · Cited by 35
Geloneze, B., Pereira, J. A., Pareja, J. C., Lima, M. M. D. O., Lazarin, M. A. C. T., de Souza, I. C. P., Tambascia, M. A., Chaim, É. A., & Muscelli, E. (2009) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302009000200022 · Cited by 31
Adiponectin modulates the function of endothelial progenitor cells via AMPK/eNOS signaling pathway
Wang, S., Miao, J., Qu, M., Yang, G., & Shen, L. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.09.073 · Cited by 30
Rohrbach, S., Aslam, M., Niemann, B., & Schulz, R. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12650 · Cited by 31
“Activation of the AMPK pathway by adiponectin mediates antihypertrophic effects in cardiomyocytes (Chan et al., 2004; Shibata et al., 2004a) and also plays an important role in the improved functional LV recovery and reduction of infarct size after I/R in mice (Shibata et al., 2005; Shinmura et…”
BackgroundInfluentialLindgren, A., Levin, M. C., Blomqvist, S. R., Wikström, J., Ahnmark, A., Mogensen, C., Böttcher, G., Bohlooly‐Y, M., Borén, J., Gan, L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080330 · Cited by 30
“Interestingly, adiponectin has been shown to stimulate angiogenesis both in vitro and in vivo [30,31], and it would be of interest for future studies to explore the contribution of the two adiponectin receptors in this process.”
BackgroundBin-Jumah, M. N. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/6290143 · Cited by 30
“Adiponectin protected against cerebral ischemia-reperfusion [16] and atherosclerotic plaque formation [17] and improved revascularization of ischemic limbs [18].”
BackgroundObesity Inhibits Angiogenesis Through TWIST1-SLIT2 Signaling
Hunyenyiwa, T., Hendee, K., Matus, K., Kyi, P., Mammoto, T., & Mammoto, A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.693410 · Cited by 30
Obesity-Induced Immunological Effects on the Skin
Palanivel, J. A., & Millington, G. W. M. (2023) · Skin Health and Disease · doi:10.1002/ski2.160 · Cited by 30
“50 For example, in adiponectin knock‐out mice, the angiogenic repair of the ischaemic hind limb is impaired.(51) Similarly, wound closure is delayed in adiponectin‐ deficient mice compared to wild‐type mice, as the keratinocyte migration and proliferation was impaired.”
BackgroundModulation of Lupus Phenotype by Adiponectin Deficiency in Autoimmune Mouse Models
Duffen, J., Menn‐Josephy, H., Laskow, B., Takemura, Y., & Aprahamian, T. R. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9486-2 · Cited by 28
“Adiponectin-deficient mice are more prone to injury in surgical models of myocardial ischemiareperfusion injury, myocardial infarction, hypertrophic cardiomyopathy, and peripheral artery disease [17–20].”
Cilostazol Stimulates Revascularisation in Response to Ischaemia via an eNOS-Dependent Mechanism
Hori, A., Shibata, R., Morisaki, K., Murohara, T., & Komori, K. (2011) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2011.07.015 · Cited by 28
Self-citationFenofibrate promotes ischemia-induced revascularization through the adiponectin-dependent pathway
Li, P., Shibata, R., Maruyama, S., Kondo, M., Ohashi, K., Ouchi, N., & Murohara, T. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00284.2010 · Cited by 28
“Experimental studies have shown that adiponectin displays favorable effects on the vascular function by directly acting on the vascular component cells (7, 24, 25, 33, 34).”
BackgroundMethodResultInfluentialSelf-citationMaternal serum adiponectin multimers in patients with a small-for-gestational-age newborn
Mazaki‐Tovi, S., Romero, R. J., Vaisbuch, E., Erez, O., Mittal, P., Chaiworapongsa, T., Kim, S. K., Pacora, P., Yeo, L., Gotsch, F., et al. (2009) · Journal of Perinatal Medicine · doi:10.1515/jpm.2009.128 · Cited by 28
Metadata
- Authors
- Shibata, R., Ouchi, N., Kihara, S., Sato, K., Funahashi, T., & Walsh, K.
- Affiliations
- Boston University (US)
- The University of Osaka (JP)
- Corresponding author
- Walsh, Kenneth
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2004-07
- Volume
- 279
- Issue
- 27
- Pages
- 28670-28674
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1990840335
- Cited by
- 336
- References
- 35
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 10 · 2023: 10 · 2022: 7 · 2021: 7 · 2020: 13 · 2019: 7 · 2018: 6 · 2017: 16 · 2016: 5 · 2015: 13 · 2014: 21 · 2013: 19 · 2012: 23
- FWCI
- 13.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (HD23681, AG15052)
- U.S. Public Health Service (HE 23641)
- National Institute on Aging (AG17241, AG15052, R01AG017241)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-40197, R01AR040197)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- adiponectin, angiogenesis, tissue ischemia, AMPK, AMPK signaling, hindlimb ischemia, limb perfusion, adiponectin knockout mice, adenoviral gene transfer, obesity, adipokines
- MeSH terms
- Adenoviridae, Animals, Antibodies, Monoclonal, Capillaries, Genes, Dominant, Ischemia, Mice, Inbred C57BL, Multienzyme Complexes, Neovascularization, Pathologic, Obesity, Proteins, Time Factors, Blotting, Western, Signal Transduction, Protein Serine-Threonine Kinases, Adipocytes, Gene Transfer Techniques, Mice, Knockout, Platelet Endothelial Cell Adhesion Molecule-1, Intercellular Signaling Peptides and Proteins, Mice, Adiponectin, AMP-Activated Protein Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
