Advancements in therapeutic drugs targeting of senescence

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652 · see citing works

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057 · see citing works

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796 · see citing works

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · see citing works

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

Souers, A. J., Leverson, J. D., Boghaert, E. R., Ackler, S. L., Catron, N. D., Chen, J., Dayton, B. D., Ding, H., Enschede, S. H., Fairbrother, W. J., et al. (2013) · Nature Medicine · doi:10.1038/nm.3048 · Cited by 3,058 · see citing works

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., A. Saltness, R., Jeganathan, K. B., Verzosa, G. C., Pezeshki, A., et al. (2016) · Nature · doi:10.1038/nature16932 · Cited by 2,891 · see citing works

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell · doi:10.1111/acel.12344 · Cited by 2,562 · see citing works

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0092-9 · Cited by 2,287 · see citing works

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.11.012 · Cited by 2,045 · see citing works

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

Tse, C., Shoemaker, A. R., Adickes, J., Anderson, M. G., Chen, J., Jin, S., Johnson, E. F., Marsh, K. C., Mitten, M. J., Nimmer, P., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5836 · Cited by 1,992 · see citing works

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

Chang, J., Wang, Y., Shao, L., Laberge, R.-M., Demaria, M., Campisi, J., Janakiraman, K., Sharpless, N. E., Ding, S., Feng, W., et al. (2016) · Nature Medicine · doi:10.1038/nm.4010 · Cited by 1,819 · see citing works

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

Taipale, M., Jarosz, D. F., & Lindquist, S. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2918 · Cited by 1,818 · see citing works

Induction of autophagy by spermidine promotes longevity

Eisenberg, T., Knauer, H., Schauer, A., Büttner, S., Ruckenstuhl, C., Carmona-Gutierrez, D., Ring, J., Schroeder, S., Magnes, C., Antonacci, L., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1975 · Cited by 1,680 · see citing works

Targeting the dynamic HSP90 complex in cancer

Trepel, J. B., Mollapour, M., Giaccone, G., & Neckers, L. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2887 · Cited by 1,523 · see citing works

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

Jeon, O. H., Kim, C., Laberge, R.-M., Demaria, M., Rathod, S., Vasserot, A. P., Chung, J. W., Kim, D. H., Poon, Y., David, N., et al. (2017) · Nature Medicine · doi:10.1038/nm.4324 · Cited by 1,515 · see citing works

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

Baar, M. P., Brandt, R. M. C., Putavet, D. A., Klein, J. D. D., Derks, K. W. J., Bourgeois, B. R. M., Stryeck, S., Rijksen, Y., van Willigenburg, H., Feijtel, D. A., et al. (2017) · Cell · doi:10.1016/j.cell.2017.02.031 · Cited by 1,454 · see citing works

Metformin improves healthspan and lifespan in mice

Martin-Montalvo, A., Mercken, E. M., Mitchell, S. J., Palacios, H. H., Mote, P. L., Scheibye-Knudsen, M., Gomes, A. P., Ward, T. M., Minor, R. K., Blouin, M.-J., et al. (2013) · Nature Communications · doi:10.1038/ncomms3192 · Cited by 1,445 · see citing works

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

Hickson, L. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.08.069 · Cited by 1,383 · see citing works

Cellular senescence promotes adverse effects of chemotherapy and cancer relapse

Demaria, M., O'Leary, M. N., Chang, J., Shao, L., Liu, S., Alimirah, F., Koenig, K., Le, C., Mitin, N., Deal, A. M., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0241 · Cited by 1,338 · see citing works

Senescent cells: an emerging target for diseases of ageing

Childs, B. G., Gluscevic, M., Baker, D. J., Laberge, R.-M., Marquess, D., Dananberg, J., & van Deursen, J. M. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.116 · Cited by 1,284 · see citing works

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

Justice, J. N., Nambiar, A. M., Tchkonia, T., LeBrasseur, N. K., Pascual, R., Hashmi, S. K., Prata, L., Masternak, M. M., Kritchevsky, S. B., Musi, N., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2018.12.052 · Cited by 1,261 · see citing works

CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior

Silverstein, R. L., & Febbraio, M. (2009) · Science Signaling · doi:10.1126/scisignal.272re3 · Cited by 1,247 · see citing works

Senescence and aging: Causes, consequences, and therapeutic avenues

McHugh, D., & Gil, J. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201708092 · Cited by 1,233 · see citing works

Cardioprotection and lifespan extension by the natural polyamine spermidine

Eisenberg, T., Abdellatif, M., Schroeder, S., Primessnig, U., Stekovic, S., Pendl, T., Harger, A., Schipke, J., Zimmermann, A., Schmidt, A., et al. (2016) · Nature Medicine · doi:10.1038/nm.4222 · Cited by 1,168 · see citing works

Spermidine in health and disease

Madeo, F., Eisenberg, T., Pietrocola, F., & Kroemer, G. (2018) · Science · doi:10.1126/science.aan2788 · Cited by 1,154 · see citing works

Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors

Zhu, Y., Tchkonia, T., Fuhrmann‐Stroissnigg, H., Dai, H. M., Ling, Y. Y., Stout, M. B., Pirtskhalava, T., Giorgadze, N., Johnson, K. O., Giles, C. B., et al. (2016) · Aging Cell · doi:10.1111/acel.12445 · Cited by 1,148 · see citing works

Exogenous Antioxidants—Double‐Edged Swords in Cellular Redox State: Health Beneficial Effects at Physiologic Doses versus Deleterious Effects at High Doses

Bouayed, J., & Bohn, T. (2010) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.3.4.12858 · Cited by 1,095 · see citing works

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

Kim, D., Nguyen, M. D., Dobbin, M. M., Fischer, A., Sananbenesi, F., Rodgers, J. T., Delalle, I., Baur, J. A., Sui, G., Armour, S. M., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601758 · Cited by 1,074 · see citing works

Fisetin is a senotherapeutic that extends health and lifespan

Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.09.015 · Cited by 1,032 · see citing works

Cellular senescence: a translational perspective

Kirkland, J. L., & Tchkonia, T. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.04.013 · Cited by 1,013 · see citing works

Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status

Hardie, D. G. (2003) · Endocrinology · doi:10.1210/en.2003-0982 · Cited by 994 · see citing works

Modulation of Akt kinase activity by binding to Hsp90

Sato, S., Fujita, N., & Tsuruo, T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.170276797 · Cited by 967 · see citing works

Melatonin: an ancient molecule that makes oxygen metabolically tolerable

Manchester, L. C., Coto‐Montes, A. M., Boga, J. A., Andersen, L. P. H., Zhou, Z., Galano, A., Vriend, J. P., Tan, D. X., & Reiter, R. J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12267 · Cited by 954 · see citing works

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

Xu, M., Tchkonia, T., Ding, H., Ogrodnik, M., Lubbers, E. R., Pirtskhalava, T., White, T. A., Johnson, K. O., Stout, M. B., Mezera, V., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515386112 · Cited by 915 · see citing works

Senescence and apoptosis: dueling or complementary cell fates?

Childs, B. G., Baker, D. J., Kirkland, J. L., Campisi, J., & van Deursen, J. M. (2014) · The EMBO Reports · doi:10.15252/embr.201439245 · Cited by 915 · see citing works

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

Miller, R. A., Harrison, D. E., Astle, C. M., Baur, J. A., Boyd, A. R., de Cabo, R., Fernandez, E., Flurkey, K., Javors, M. A., Nelson, J. F., et al. (2011) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glq178 · Cited by 896 · see citing works

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

Caccamo, A., Majumder, S., Richardson, A., Strong, R., & Oddo, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.100420 · Cited by 881 · see citing works

New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

Zhu, Y., Doornebal, E. J., Pirtskhalava, T., Giorgadze, N., Wentworth, M., Fuhrmann-Stroissnigg, H., Niedernhofer, L. J., Robbins, P. D., Tchkonia, T., & Kirkland, J. L. (2017) · Aging · doi:10.18632/aging.101202 · Cited by 757 · see citing works

A senescent cell bystander effect: senescence‐induced senescence

Nelson, G., Wordsworth, J., Wang, C., Jurk, D., Lawless, C., Martin‐Ruiz, C., & von Zglinicki, T. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00795.x · Cited by 755 · see citing works

Augmented Wnt signaling in a mammalian model of accelerated aging

Liu, H., Fergusson, M. M., Castilho, R. M., Liu, J., Cao, L., Chen, J., Malide, D., Rovira, I. I., Schimel, D., Kuo, C. J., et al. (2007) · Science · doi:10.1126/science.1143578 · Cited by 755 · see citing works

The Role of Catechins in Cellular Responses to Oxidative Stress

Bernatonienė, J., & Kopustinskienė, D. M. (2018) · Molecules · doi:10.3390/molecules23040965 · Cited by 704 · see citing works

Identification of HSP90 inhibitors as a novel class of senolytics

Fuhrmann-Stroissnigg, H., Ling, Y. Y., Zhao, J., McGowan, S. J., Zhu, Y., Brooks, R. W., Grassi, D., Gregg, S. Q., Stripay, J. L., Dorronsoro, A., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00314-z · Cited by 701 · see citing works

Rapamycin slows aging in mice

Wilkinson, J. E., Burmeister, L., Brooks, S. V., Chan, C., Friedline, S., Harrison, D. E., Hejtmancik, J. F., Nadon, N. L., Strong, R., Wood, L. K., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00832.x · Cited by 682 · see citing works

Targeting senescent cells alleviates obesity-induced metabolic dysfunction

Palmer, A. K., Xu, M., Zhu, Y., Pirtskhalava, T., Weivoda, M. M., Hachfeld, C. M., Prata, L. G., van Dijk, T. H., Verkade, E., Casaclang‐Verzosa, G., et al. (2019) · Aging Cell · doi:10.1111/acel.12950 · Cited by 658 · see citing works

Metformin inhibits the senescence‐associated secretory phenotype by interfering with <scp>IKK</scp>/<scp>NF</scp>‐κ<scp>B</scp> activation

Moiseeva, O., Deschênes‐Simard, X., St‐Germain, E., Igelmann, S., Huot, G., Cadar, A. E., Bourdeau, V., Pollak, M. N., & Ferbeyre, G. (2013) · Aging Cell · doi:10.1111/acel.12075 · Cited by 654 · see citing works

Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae

Yuan, J., Peng, J., Yin, K., & Wang, J. (2011) · Molecular Nutrition &amp; Food Research · doi:10.1002/mnfr.201000414 · Cited by 649 · see citing works

Melatonin: Physiological effects in humans

Claustrat, B., & Leston, J. (2015) · Neurochirurgie · doi:10.1016/j.neuchi.2015.03.002 · Cited by 629 · see citing works

Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?

He, Y., Yue, Y., Zheng, X., Zhang, K., Chen, S., & Du, Z. (2015) · Molecules · doi:10.3390/molecules20059183 · Cited by 611 · see citing works

Age and immunity: What is “immunosenescence”?

Pawelec, G. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2017.10.024 · Cited by 606 · see citing works

Targeting senescent cells enhances adipogenesis and metabolic function in old age

Xu, M., Palmer, A. K., Ding, H., Weivoda, M. M., Pirtskhalava, T., White, T. A., Sepe, A., Johnson, K. O., Stout, M. B., Giorgadze, N., et al. (2015) · eLife · doi:10.7554/elife.12997 · Cited by 604 · see citing works

The senescence-associated secretory phenotype and its regulation

Lopes-Paciencia, S., Saint-Germain, E., Rowell, M.-C., Ruiz, A. F., Kalegari, P., & Ferbeyre, G. (2019) · Cytokine · doi:10.1016/j.cyto.2019.01.013 · Cited by 601 · see citing works

Towards a comprehensive public health response to population ageing

Beard, J., & Bloom, D. E. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61461-6 · Cited by 578 · see citing works

Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

Lee, J. H., Budanov, A. V., Park, E. J., Birse, R., Kim, T. E., Perkins, G. A., Ocorr, K., Ellisman, M. H., Bodmer, R., Bier, E., et al. (2010) · Science · doi:10.1126/science.1182228 · Cited by 570 · see citing works

The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1

Xiao, L., Xu, X., Zhang, F., Wang, M., Xu, Y., Tang, D., Wang, J., Qin, Y., Liu, Y., Tang, C., et al. (2016) · Redox Biology · doi:10.1016/j.redox.2016.12.022 · Cited by 568 · see citing works

Animal and human studies with the mitochondria‐targeted antioxidant MitoQ

Smith, R. A. J., & Murphy, M. P. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05627.x · Cited by 553 · see citing works

The role of cellular senescence in ageing and endocrine disease

Khosla, S., Farr, J. N., Tchkonia, T., & Kirkland, J. L. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0335-y · Cited by 523 · see citing works

Methods to Detect Biomarkers of Cellular Senescence

Itahana, K., Campisi, J., & Dimri, G. P. (2007) · Methods in molecular biology · doi:10.1007/978-1-59745-361-5_3 · Cited by 516 · see citing works

Fisetin: A Dietary Antioxidant for Health Promotion

Khan, N., Syed, D. N., Ahmad, N., & Mukhtar, H. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4901 · Cited by 512 · see citing works

Therapeutic potential of quercetin as a cardiovascular agent

Patel, R. V., Mistry, B. M., Shinde, S. K., Syed, R., Singh, V., & Shin, H. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.06.053 · Cited by 506 · see citing works

Redox regulation of SIRT1 in inflammation and cellular senescence

Hwang, J.-W., Yao, H., Caito, S., Sundar, I. K., & Rahman, I. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.03.015 · Cited by 503 · see citing works

The Mitochondrial-Targeted Compound SS-31 Re-Energizes Ischemic Mitochondria by Interacting with Cardiolipin

Birk, A. V., Liu, S., Soong, Y., Mills, W., Singh, P. K., Warren, J. D., Seshan, S. V., Pardee, J. D., & Szeto, H. H. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012121216 · Cited by 486 · see citing works

Mitochondrial oxidative stress in aging and healthspan

Dai, D., Chiao, Y. A., Marcinek, D. J., Szeto, H. H., & Rabinovitch, P. S. (2014) · Longevity & Healthspan · doi:10.1186/2046-2395-3-6 · Cited by 481 · see citing works

Sirtuins, a promising target in slowing down the ageing process

Grabowska, W., Sikora, E., & Bielak-Zmijewska, A. (2017) · Biogerontology · doi:10.1007/s10522-017-9685-9 · Cited by 470 · see citing works

HDAC and HDAC Inhibitor: From Cancer to Cardiovascular Diseases

Yoon, S., & Eom, G. H. (2016) · Chonnam Medical Journal · doi:10.4068/cmj.2016.52.1.1 · Cited by 469 · see citing works

The quest to slow ageing through drug discovery

Partridge, L., Fuentealba, M., & Kennedy, B. K. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0067-7 · Cited by 468 · see citing works

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older Adults

Rossman, M. J., Santos-Parker, J. R., Steward, C. A. C., Bispham, N. Z., Cuevas, L. M., Rosenberg, H. L., Woodward, K. A., Chonchol, M., Gioscia-Ryan, R. A., Murphy, M. P., et al. (2018) · Hypertension · doi:10.1161/hypertensionaha.117.10787 · Cited by 456 · see citing works

Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults

Witte, A. V., Kerti, L., Margulies, D. S., & Floel, A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0385-14.2014 · Cited by 455 · see citing works

Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty

Burgering, B. M. T., & Medema, R. H. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.1202629 · Cited by 443 · see citing works

An Attempt to Prevent Senescence: A Mitochondrial Approach

Skulachev, V. P., Anisimov, V. N., Antonenko, Y. N., Bakeeva, L. E., Chernyak, B. V., Erichev, V. P., Filenko, O. F., Kalinina, N. I., Kapelko, V. I., Kolosova, N. G., et al. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.12.008 · Cited by 430 · see citing works

Equol: a bacterial metabolite from the daidzein isoflavone and its presumed beneficial health effects

Mayo, B., Vázquez, L., & Flórez, A. B. (2019) · Nutrients · doi:10.3390/nu11092231 · Cited by 416 · see citing works

Senescence-associated inflammatory responses: aging and cancer perspectives

Lasry, A., & Ben-Neriah, Y. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.02.009 · Cited by 408 · see citing works

Mitochondria: Central Organelles for Melatonin′s Antioxidant and Anti-Aging Actions

Reiter, R., Tan, D., Rosales-Corral, S., Galano, A., Zhou, X., & Xu, B. (2018) · Molecules · doi:10.3390/molecules23020509 · Cited by 393 · see citing works

Klotho deficiency is an early biomarker of renal ischemia–reperfusion injury and its replacement is protective

Hu, M. C., Shi, M., Zhang, J., Quiñones, H., Kuro‐o, M., & Moe, O. W. (2010) · Kidney International · doi:10.1038/ki.2010.328 · Cited by 380 · see citing works

DNA damage responses and p53 in the aging process

Ou, H.-L., & Schumacher, B. (2018) · Blood · doi:10.1182/blood-2017-07-746396 · Cited by 377 · see citing works

Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/β-Catenin Signaling

Zhou, L., Li, Y., Zhou, D. F., Tan, R. J., & Liu, Y. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012080865 · Cited by 374 · see citing works

mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging

Castilho, R. M., Squarize, C. H., Chodosh, L. A., Williams, B. O., & Gutkind, J. S. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.06.017 · Cited by 371 · see citing works

Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population

Cox, K. H., Pipingas, A., & Scholey, A. B. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881114552744 · Cited by 368 · see citing works

Curcumin as a functional food-derived factor: degradation products, metabolites, bioactivity, and future perspectives

Tsuda, T. (2017) · Food & Function · doi:10.1039/c7fo01242j · Cited by 368 · see citing works

Dissociation of Bcl-2–Beclin1 Complex by Activated AMPK Enhances Cardiac Autophagy and Protects Against Cardiomyocyte Apoptosis in Diabetes

He, C., Zhu, H., Li, H., Zou, M., & Xie, Z. (2012) · Diabetes · doi:10.2337/db12-0533 · Cited by 366 · see citing works

Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism

Wang, R., Yu, Z., Sunchu, B., Shoaf, J., Dang, I., Zhao, S., Caples, K., Bradley, L., Beaver, L. M., Ho, E., et al. (2017) · Aging Cell · doi:10.1111/acel.12587 · Cited by 360 · see citing works

Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls

Bannister, C. A., Holden, S. E., Jenkins‐Jones, S., Morgan, C. L., Halcox, J. P., Schernthaner, G., Mukherjee, J., & Currie, C. J. (2014) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12354 · Cited by 356 · see citing works

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice

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Quercetin Mitigates Oxidative Stress-Induced Premature Senescence in SH-SY5Y Neuronal-like Cells

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Clearance of defective muscle stem cells by senolytics reduces the expression of senescence-associated secretory phenotype and restores myogenesis in myotonic dystrophy type 1Preprint

Conte, T. C., Duran-Bishop, G., Orfi, Z., Mokhtari, I., Deprez, A., Roussel, M., Côté, I., Pellerito, O., Maggiorani, D., Benabdallah, B., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.22.497227 · Cited by 1 · see citing works

Cellular Senescence in Vascular Dementia (VaD)

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Deciphering the emerging interrelationship between cellular senescence and extracellular vesicles: Implications for therapy and diagnosis

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Chronic low-grade inflammatory phenotype: clinical significance, causal factors and approaches to therapy

Айтбаев, К. А., Murkamilov, I., Fomin, V. V., Abdurakhmanov, I. U., Yusupova, T. F., Yusupov, F. A., Solizhonov, J. I., Boymurodov, Y., Duisheeva, G. K., Khakimov, S., et al. (2026) · Clinical Medicine (Russian Journal) · doi:10.30629/0023-2149-2025-103-12-877-884

Impact des interférons de type I sur le phénotype et la fonction des mélanocytes au cours du vitiligo

Merhi, R. (2024) · doi:10.70675/9f7d00cdz3de4z4cd5z9784za5bd3ee702e0

Lithium as a Potential Senostatic Agent in Central Nervous System Aging and Bipolar Disorder

RYBAKOWSKI, J. K., Mydlak, C., Klimek, N., & Książek, K. (2026) · Pharmaceuticals · doi:10.3390/ph19091378

Bifidobacterium pseudocatenulatum AL44 ameliorates D-galactose-induced cognitive impairment by modulating the gut-brain axis

Li, S., Wang, L., Ren, X., Song, S., & Ai, C. (2026) · Food Research International · doi:10.1016/j.foodres.2026.120048

Natural products targeting cytokine-regulated SASP inflammation networks in Ovarian cancer: Implications on immune escape and molecular resistance

Paul, B. M., Kannan, G., Arunachalam, K., & Thangaraj, P. (2026) · Inflammopharmacology · doi:10.1007/s10787-026-02346-8

Harnessing autophagy and its transcriptional regulation in tumorigenesis and neurodegeneration: Potential and existing therapeutic strategies

Suri, P., Daartey, A. B., Khan, D. M. I. O., Rayana, N. P., Chilamakuri, R., Godugu, D., Azad, M. G., Reeb, K. L., & Richardson, D. R. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100158

Skin Aging: From Molecular Mechanisms to Therapeutic and Technological Innovations

Chen, S., Yang, Y., Pan, X., Pan, Y., & Cai, S. (2026) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.71357

Senotherapeutics: Emerging pharmacological strategies to target cellular senescence

Nagy, D., Brunner, E., Ekambaram, S., Nagaraja, R. Y., Kordestan, K. V., Patai, R., Kristóf, R., Nagykaldi, M., Chandragiri, S. S., Shanmugarama, S., et al. (2026) · Advances in Translational Research · doi:10.1556/1661.2026.00015 · Cited by 1 · see citing works

Targeting Cellular Senescence: Therapeutic Advances in Senolytic and Senomorphic Interventions for Age-Related Pathologies

Pandurangan, S., Dhunmati, K., Arunkumar, R., & Nagarajan, N. C. (2026) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266429797251229062111 · Cited by 3 · see citing works

Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span

Robbins, P. D., Jurk, D., Khosla, S., Kirkland, J. L., LeBrasseur, N. K., Miller, J. D., Passos, J. F., Pignolo, R. J., Tchkonia, T., & Niedernhofer, L. J. (2021) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-050120-105018 · Cited by 339 · see citing works

Senotherapeutics in Aging and Age-Associated Disorders

Zameer, S., & Vohora, D. (2026) · CRC Press eBooks · doi:10.1201/9781003493969-5

Senolytics Target Senescent Cells and Improve Aging and Age-Related Diseases

Buffard, T., & Ferbeyre, G. (2020) · Healthy ageing and longevity · doi:10.1007/978-3-030-44903-2_4 · Cited by 2 · see citing works