A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2

Knowles, Lynn M.; Axelrod, Fumiko; Browne, Cecille D.; Smith, Jeffrey W.

doi:10.1074/jbc.m405061200

Cited by 151Cancer, Lipids, and MetabolismLipid metabolism and biosynthesisSphingolipid Metabolism and Signaling

A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2

Open access

Knowles, Lynn M., Axelrod, Fumiko, Browne, Cecille D., Smith, Jeffrey W.·2004·Journal of Biological Chemistry

DOI 10.1074/jbc.m405061200

Open this paper in CoChat — free account

Abstract

In eukaryotes, fatty acid synthase (FAS) is the enzyme responsible for synthesis of palmitate, the precursor of long-chain nonessential fatty acids. FAS is up-regulated in a wide range of cancers and has been suggested as a relevant drug target. Here, two independent approaches are taken toward knocking down FAS and then probing its connection to tumor cell proliferation. In one approach, Orlistat, a drug approved for treating obesity, is used as a potent inhibitor of the thioesterase function of FAS. In a separate strategy, the expression of FAS is suppressed by targeted knock-down with small interfering RNA. In both circumstances, the ablation of FAS activity causes a dramatic down-regulation of Skp2, a component of the E3 ubiquitin ligase that controls the turnover of p27Kip1. These effects ultimately tie into the retinoblastoma protein pathway and lead to a cell-cycle arrest at the G1/S boundary. Altogether, the findings of the study reveal unappreciated links between fatty acid synthase and ubiquitin-dependent proteolysis of cell-cycle regulatory proteins.

Integrity signals

Registry

Crossref · 10.1074/jbc.m405061200

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

FASN can promote cancer progression and contribute to therapy resistance by sustaining mitogenic signaling, facilitating the G1/S transition, and supplying lipid resources necessary for biomass accumulation and evasion of cell cycle checkpoints.
“FASN can promote cancer progression and contribute to therapy resistance by sustaining mitogenic signaling, facilitating the G1/S transition, and supplying lipid resources necessary for biomass accumulation and evasion of cell cycle checkpoints [30,48].”
From Inhibition of fatty acid synthase enhances therapeutic efficacy and delays acquired resistance to BRAF-targeted therapy in colorectal cancer (2026) · cites this paper as [48]

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
Carrano, A. C., Eytan, E., Hershko, A., & Pagano, M. (1999) · Nature Cell Biology · doi:10.1038/12013 · Cited by 1,544 · see citing works
Activity-based protein profiling: The serine hydrolases
Liu, Y., Patricelli, M. P., & Cravatt, B. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14694 · Cited by 1,133 · see citing works
Annual Report to the Nation on the Status of Cancer, 1975-2000, Featuring the Uses of Surveillance Data for Cancer Prevention and Control
Weir, H. K. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djg040 · Cited by 864 · see citing works
Fatty acid synthesis: a potential selective target for antineoplastic therapy
Kuhajda, F. P., Jenner, K., Wood, F. D., Hennigar, R. A., Jacobs, L. B., Dick, J. D., & Pasternack, G. R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.14.6379 · Cited by 705 · see citing works
Insights into SCF ubiquitin ligases from the structure of the Skp1–Skp2 complex
Schulman, B. A., Carrano, A. C., Jeffrey, P. D., Bowen, Z., Kinnucan, E., Finnin, M. S., Elledge, S. J., Harper, J. W., Pagano, M., & Pavletich, N. P. (2000) · Nature · doi:10.1038/35042620 · Cited by 610 · see citing works
Orlistat Is a Novel Inhibitor of Fatty Acid Synthase with Antitumor Activity
Kridel, S. J., Axelrod, F. T., Rozenkrantz, N., & Smith, J. W. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3645 · Cited by 610 · see citing works
Self-citation
Synthesis and antitumor activity of an inhibitor of fatty acid synthase
Kuhajda, F. P., Pizer, E. S., Li, J. N., Mani, N. S., Frehywot, G. L., & Townsend, C. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3450 · Cited by 568 · see citing works
Profiling Serine Hydrolase Activities in Complex Proteomes
Kidd, D., Liu, Y., & Cravatt, B. F. (2001) · Biochemistry · doi:10.1021/bi002579j · Cited by 369 · see citing works
Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma.
Milgraum, L. Z., Witters, L. A., Pasternack, G. R., & Kuhajda, F. P. (1997) · PubMed · Cited by 333 · see citing works
Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells.
Pizer, E. S., Jackisch, C., Wood, F. D., Pasternack, G. R., Davidson, N. E., & Kuhajda, F. P. (1996) · PubMed · Cited by 291 · see citing works
The lipase inhibitor tetrahydrolipstatin binds covalently to the putative active site serine of pancreatic lipase
Hadváry, P., Sidler, W., Meister, W., Vetter, W., & Wolfer, H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52203-1 · Cited by 281 · see citing works
C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity
Thupari, J. N., Landree, L. E., Ronnett, G. V., & Kuhajda, F. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132128899 · Cited by 262 · see citing works
Fibronectin's cell-adhesive domain and an amino-terminal matrix assembly domain participate in its assembly into fibroblast pericellular matrix.
McDonald, J. A., Quade, B. J., Broekelmann, T. J., Lachance, R. M., Forsman, K., Hasegawa, E., & Akiyama, S. K. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61453-x · Cited by 256 · see citing works
Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines.
Pizer, E. S., Chrest, F. J., DiGiuseppe, J. A., & Han, W. F. (1998) · PubMed · Cited by 250 · see citing works
Relationship between 5-fluorouracil (5-FU) dose intensity and therapeutic response in patients with advanced colorectal cancer receiving infusional therapy containing 5-FU
Gamelin, E. C., Danquechin‐Dorval, E., Dumesnil, Y., Maillart, P., Goudier, M.-J., Burtin, P. C., Delva, R., Lortholary, A. H., Gesta, P., & Larra, F. (1996) · Cancer · doi:10.1002/(sici)1097-0142(19960201)77:3 · Cited by 217 · see citing works
Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival.
Yang, G., Ayala, G., Marzo, A. D., Tian, W., Frolov, A., Wheeler, T. M., Thompson, T. C., & Harper, J. W. (2002) · PubMed · Cited by 203 · see citing works
Structure of the Complex between the Antibiotic Cerulenin and Its Target, β-Ketoacyl-Acyl Carrier Protein Synthase
Moche, M., Schneider, G., Edwards, P. C., Dehesh, K., & Lindqvist, Y. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6031 · Cited by 200 · see citing works
Initial studies in humans with the novel gastrointestinal lipase inhibitor Ro 18–0647 (tetrahydrolipstatin)
Hauptman, J., Jeunet, F., & Hartmann, D. (1992) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/55.1.309s · Cited by 182 · see citing works
Proteomic analysis of Fasciola hepatica excretory-secretory products
Jefferies, J. R., Campbell, A. M., van Rossum, A. J., Barrett, J., & Brophy, P. M. (2001) · PROTEOMICS · doi:10.1002/1615-9861(200109)1:9 · Cited by 171 · see citing works
Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53.
Li, J. N., Gorospe, M., Chrest, F. J., Kumaravel, T. S., Evans, M. K., Han, W. F., & Pizer, E. S. (2001) · PubMed · Cited by 166 · see citing works
Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells.
Pizer, E. S., Wood, F. D., Pasternack, G. R., & Kuhajda, F. P. (1996) · PubMed · Cited by 132 · see citing works
Fatty Acid Synthase (Fas) Predictive Strength in Poorly Differentiated Early Breast Carcinomas
Alò, P., Visca, P., Trombetta, G., Mangoni, A., Lenti, L., Monaco, S., Botti, C., Serpieri, D. E., & Tondo, U. D. (1999) · Tumori Journal · doi:10.1177/030089169908500108 · Cited by 129 · see citing works
Cumulative Effect of Phosphorylation of pRB on Regulation of E2F Activity
Brown, V. D., Phillips, R. A., & Gallie, B. L. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3246 · Cited by 116 · see citing works
Fatty acid synthase (FAS) expression in human breast cancer cell culture supernatants and in breast cancer patients
Wang, Y. (., Kuhajda, F. P., Li, J. N., Pizer, E. S., Han, W. F., Sokoll, L. J., & Chan, D. W. (2001) · Cancer Letters · doi:10.1016/s0304-3835(01)00464-5 · Cited by 116 · see citing works
Structure−Activity Studies of Cerulenin Analogues as Protein Palmitoylation Inhibitors
Lawrence, D. S., Zilfou, J. T., & Smith, C. D. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm980591s · Cited by 96 · see citing works
Human fatty acid synthase: Role of interdomain in the formation of catalytically active synthase dimer
Chirala, S. S., Jayakumar, A., Gu, Z.-W., & Wakil, S. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051635998 · Cited by 94 · see citing works
A Method for Application of Samples to Matrix-Assisted Laser Desorption Ionization Time-of-Flight Targets That Enhances Peptide Detection
Landry, F., Lombardo, C. R., & Smith, J. W. (2000) · Analytical Biochemistry · doi:10.1006/abio.1999.4468 · Cited by 94 · see citing works
Self-citation
The architecture of the animal fatty acid synthetase complex. IV. Mapping of active centers and model for the mechanism of action.
Tsukamoto, Y., Wong, H., Mattick, J. S., & Wakil, S. J. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43808-7 · Cited by 91 · see citing works
Immunohistochemical Expression of Human Erythrocyte Glucose Transporter and Fatty Acid Synthase in Infiltrating Breast Carcinomas and Adjacent Typical/Atypical Hyperplastic or Normal Breast Tissue
Alò, P., Visca, P., Botti, C., Galati, G. M., Sebastiani, V., Andreano, T., Tondo, U. D., & Pizer, E. S. (2001) · American Journal of Clinical Pathology · doi:10.1309/5y2l-cdck-yb55-kdk6 · Cited by 79 · see citing works
Mapping the Functional Topology of the Animal Fatty Acid Synthase by Mutant Complementation in Vitro
Rangan, V. S., Joshi, A. K., & Smith, S. (2001) · Biochemistry · doi:10.1021/bi015535z · Cited by 71 · see citing works
Apoptosis of androgen-independent prostate cell line induced by inhibition of fatty acid synthesis.
Furuya, Y., Akimoto, S., Yasuda, K., & Ito, H. (1997) · PubMed · Cited by 64 · see citing works
Mapping of Functional Interactions between Domains of the Animal Fatty Acid Synthase by Mutant Complementation in vitro
Joshi, A. K., Witkowski, A., & Smith, S. (1997) · Biochemistry · doi:10.1021/bi9626968 · Cited by 61 · see citing works
Key role of mitochondria in cerulenin-mediated apoptosis
Heiligtag, S., Bredehorst, R., & David, K. A. (2002) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401055 · Cited by 59 · see citing works
The architecture of the animal fatty acid synthetase. II. Separation of the core and thioesterase functions and determination of the N-C orientation of the subunit.
Mattick, J. S., Nickless, J., Mizugaki, M., Yang, C., Uchiyama, S., & Wakil, S. J. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43806-3 · Cited by 55 · see citing works
Cyclin E dependent kinase activity in human breast cancer in relation to cyclin E, p27 and p21 expression and retinoblastoma protein phosphorylation
Lodén, M., Nielsen, N. H., Roos, G., Emdin, S. O., & Landberg, G. (1999) · Oncogene · doi:10.1038/sj.onc.1202488 · Cited by 45 · see citing works
Insights into a plasma membrane signature
Harvey, S., ZHANG, Y., Landry, F., Miller, C. M., & Smith, J. W. (2001) · Physiological Genomics · doi:10.1152/physiolgenomics.2001.5.3.129 · Cited by 36 · see citing works
Self-citation
The N-Terminal Domains of Cyclin-Dependent Kinase Inhibitory Proteins Block the Phosphorylation of cdk2/Cyclin E by the CDK-Activating Kinase
Rank, K. B., EVANS, D. B., & Sharma, S. K. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2648 · Cited by 30 · see citing works
Cellular pharmacology of cerulenin analogs that inhibit protein palmitoylation11Abbreviations: FT-IR, Fourier transform infrared; THF, tetrahydrofuran; FBS, fetal bovine serum; FPTase, farnesyl protein transferase; PPTase, protein palmitoyltransferase; FTI, farnesyl transferase inhibitor; DTT, dithiothreitol.
Vos, M. L. D., Lawrence, D. S., & Smith, C. D. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00739-0 · Cited by 29 · see citing works

Flagged first, then by citations

Sorted by citations

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Menendez, J. A., & Lupu, R. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2222 · Cited by 2,941 · see citing works
Targeting cellular metabolism to improve cancer therapeutics
Zhao, Y., Butler, E. B., & Tan, M. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.60 · Cited by 994 · see citing works
Fatty Acid Synthase As a Potential Therapeutic Target in Cancer
Flavin, R., Peluso, S., Nguyen, P. L., & Loda, M. F. (2010) · Future Oncology · doi:10.2217/fon.10.11 · Cited by 545 · see citing works
Disruption of Hepatic Adipogenesis Is Associated With Impaired Liver Regeneration in Mice
Shteyer, E., Liao, Y., Muglia, L. J., Hruz, P. W., & Rudnick, D. A. (2004) · Hepatology · doi:10.1002/hep.20462 · Cited by 234 · see citing works
Activity-Based Proteome Profiling of Potential Cellular Targets of Orlistat − An FDA-Approved Drug with Anti-Tumor Activities
Yang, P., Liu, K., Ngai, M. H., Lear, M. J., Wenk, M. R., & Yao, S. Q. (2009) · Journal of the American Chemical Society · doi:10.1021/ja907716f · Cited by 230 · see citing works
Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer
Świerczyński, J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i9.2279 · Cited by 201 · see citing works
Inhibition of StearoylCoA Desaturase Activity Blocks Cell Cycle Progression and Induces Programmed Cell Death in Lung Cancer Cells
Hess, D., Chisholm, J. W., & Igal, R. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011394 · Cited by 195 · see citing works
In vivo Incorporation of Unnatural Amino Acids to Probe Structure, Dynamics, and Ligand Binding in a Large Protein by Nuclear Magnetic Resonance Spectroscopy
Cellitti, S. E., Jones, D. H., Lagpacan, L., Hao, X., Zhang, Q., Hu, H., Brittain, S. M., Brinker, A., Caldwell, J. S., Bursulaya, B. D., et al. (2008) · Journal of the American Chemical Society · doi:10.1021/ja801602q · Cited by 191 · see citing works
Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non‐small cell lung cancer
Ali, A., Levantini, E., Teo, J. T., Goggi, J., Clohessy, J. G., Wu, C., Chen, L., Yang, H. H., Krishnan, I., Kocher, O. N., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201708313 · Cited by 187 · see citing works
Inhibition of Fatty Acid Synthase Induces Endoplasmic Reticulum Stress in Tumor Cells
Little, J. L., Wheeler, F. B., Fels, D. R., Koumenis, C., & Kridel, S. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-1794 · Cited by 181 · see citing works
Antitumoral actions of the anti-obesity drug orlistat (Xenical™) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene
Menéndez, J. A., Vellón, L., & Lupu, R. (2005) · Annals of Oncology · doi:10.1093/annonc/mdi239 · Cited by 180 · see citing works
Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model
Carvalho, M. A., Zecchin, K. G., Seguin, F., Bastos, D. C., Agostini, M., Rangel, A. L. C. A., Veiga, S. S., Raposo, H. F., Oliveira, H. C. F., Loda, M. F., et al. (2008) · International Journal of Cancer · doi:10.1002/ijc.23835 · Cited by 171 · see citing works
Mechanism of Apoptosis Induced by the Inhibition of Fatty Acid Synthase in Breast Cancer Cells
Bandyopadhyay, S., Zhan, R., Wang, Y., Pai, S. K., Hirota, S., Hosobe, S., Takano, Y., Saito, K., Furuta, E., Iiizumi, M., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3197 · Cited by 165 · see citing works
Stearoyl CoA desaturase-1: New insights into a central regulator of cancer metabolism
Igal, R. A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.09.009 · Cited by 159 · see citing works
The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas
Seguin, F., Carvalho, M. A., Bastos, D. C., Agostini, M., Zecchin, K. G., Flores, M. P. A., Chudzinski-Tavassi, A. M., Coletta, R. D., & Graner, E. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.355 · Cited by 154 · see citing works
The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer
Sadowski, M. C., Pouwer, R. H., Gunter, J. H., Lubik, A. A., Quinn, R. J., & Nelson, C. C. (2014) · Oncotarget · doi:10.18632/oncotarget.2433 · Cited by 144 · see citing works
Biochemistry, molecular biology, and pharmacology of fatty acid synthase, an emerging therapeutic target and diagnosis/prognosis marker.
Liu, H., Liu, J., Wu, X., & Zhang, J. (2010) · PubMed Central · Cited by 141 · see citing works
Orlistat as a FASN inhibitor and multitargeted agent for cancer therapy
Schcolnik‐Cabrera, A., Chávez-Blanco, A. D., Domínguez-Gómez, G., Taja‐Chayeb, L., Morales‐Bárcenas, R., Trejo‐Becerril, C., Pérez‐Cárdenas, E., González‐Fierro, A., & Dueñas‐González, A. (2018) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2018.1471132 · Cited by 141 · see citing works
Inhibition of fatty acid synthase prevents preadipocyte differentiation
Schmid, B., Rippmann, J. F., Tadayyon, M., & Hamilton, B. S. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.01.067 · Cited by 139 · see citing works
The Fatty Acid Synthase Inhibitor Orlistat Reduces the Growth and Metastasis of Orthotopic Tongue Oral Squamous Cell Carcinomas
Agostini, M., Almeida, L. Y., Bastos, D. C., Ortega, R. M., Moreira, F. S., Seguin, F., Zecchin, K. G., Raposo, H. F., Oliveira, H. C. F., Amoêdo, N. D., et al. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-1136 · Cited by 131 · see citing works
The effect of FASN inhibition on the growth and metabolism of a cisplatin‐resistant ovarian carcinoma model
Papaevangelou, E., de Almeida, G. S., Box, C., deSouza, N. M., & Chung, Y. (2018) · International Journal of Cancer · doi:10.1002/ijc.31392 · Cited by 119 · see citing works
Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis
Birsoy, K., Berry, R., Wang, T., Ceyhan, O., Tavazoie, S., Friedman, J. M., & Rodeheffer, M. S. (2011) · Development · doi:10.1242/dev.067710 · Cited by 109 · see citing works
Role of fatty acid synthase in gemcitabine and radiation resistance of pancreatic cancers.
Yang, Y., Liu, H., Li, Z., Zhao, Z., Yip-Schneider, M., Fan, Q., Schmidt, C. M., Chiorean, E. G., Xie, J., Liang Cheng, C., et al. (2011) · PubMed Central · Cited by 109 · see citing works
Inhibition of Fatty-acid Synthase Induces Caspase-8-mediated Tumor Cell Apoptosis by Up-regulating DDIT4
Knowles, L. M., Chen, Y., Osterman, A. L., & Smith, J. W. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803384200 · Cited by 98 · see citing works
Self-citation
Fatty acid synthase inhibitors: new directions for oncology
Kridel, S. J., Lowther, W. T., & Pemble, C. W., IV (2007) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.16.11.1817 · Cited by 90 · see citing works
Application of a Flexible Synthesis of (5R)-Thiolactomycin To Develop New Inhibitors of Type I Fatty Acid Synthase
McFadden, J. M., Medghalchi, S. M., Thupari, J. N., Pinn, M. L., Vadlamudi, A., Miller, K. I., Kuhajda, F. P., & Townsend, C. A. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm049389h · Cited by 89 · see citing works
Modulation of Fatty Acid Synthase Enzyme Activity and Expression during Hepatitis C Virus Replication
Nasheri, N., Joyce, M., Rouleau, Y., Yang, P., Yao, S. Q., Tyrrell, D. L., & Pezacki, J. P. (2013) · Chemistry & Biology · doi:10.1016/j.chembiol.2013.03.014 · Cited by 88 · see citing works
Lipases or Esterases: Does It Really Matter? Toward a New Bio-Physico-Chemical Classification
Ali, Y. B., Verger, R., & Abousalham, A. (2012) · Methods in molecular biology · doi:10.1007/978-1-61779-600-5_2 · Cited by 88 · see citing works
Uncovering the metabolomic fingerprint of breast cancer
Oakman, C. A., Tenori, L., Biganzoli, L., Santarpia, L., Cappadona, S., Luchinat, C., & Leo, A. D. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.05.001 · Cited by 85 · see citing works
Rutin and orlistat produce antitumor effects via antioxidant and apoptotic actions
Saleh, A. A., El‐Fayoumi, H. M., Youns, M., & Barakat, W. (2018) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-018-1579-0 · Cited by 83 · see citing works
Fatty Acid Synthase Inhibition by Amentoflavone Induces Apoptosis and Antiproliferation in Human Breast Cancer Cells
Lee, J., Lee, M. S., Oh, W. K., & Sul, J. Y. (2009) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.32.1427 · Cited by 83 · see citing works
Polyunsaturated fatty acid metabolism in prostate cancer
Berquin, I. M., Edwards, I. J., Kridel, S. J., & Chen, Y. Q. (2011) · Cancer and Metastasis Reviews · doi:10.1007/s10555-011-9299-7 · Cited by 81 · see citing works
Prognostic impact of Skp2 and p27 in human breast cancer
Traub, F., Mengel, M., Lück, H. J., Kreipe, H. H., & von Wasielewski, R. (2006) · Breast Cancer Research and Treatment · doi:10.1007/s10549-006-9202-3 · Cited by 80 · see citing works
Practical, Catalytic, Asymmetric Synthesis of β-Lactones via a Sequential Ketene Dimerization/Hydrogenation Process: Inhibitors of the Thioesterase Domain of Fatty Acid Synthase
Purohit, V. C., Richardson, R. D., Smith, J. W., & Romo, D. (2006) · The Journal of Organic Chemistry · doi:10.1021/jo060392d · Cited by 80 · see citing works
Self-citation
Loss of Hepatocyte Nuclear Factor 1α Function in Human Hepatocellular Adenomas Leads to Aberrant Activation of Signaling Pathways Involved in Tumorigenesis
Pelletier, L., Rebouissou, S., Paris, A., Rathahao, E., Perdu-Durand, E., Bioulac‐Sage, P., Imbeaud, S., & Zucman‐Rossi, J. (2009) · Hepatology · doi:10.1002/hep.23362 · Cited by 78 · see citing works
Inhibition of fatty acid synthase in melanoma cells activates the intrinsic pathway of apoptosis
Zecchin, K. G., Rossato, F. A., Raposo, H. F., de Melo, D. R., Alberici, L. C., Oliveira, H. C. F., Castilho, R. F., Coletta, R. D., Vercesi, A. E., & Graner, E. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.157 · Cited by 76 · see citing works
MicroRNAs and oncogenic transcriptional regulatory networks controlling metabolic reprogramming in cancers
Pinweha, P., Rattanapornsompong, K., Charoensawan, V., & Jitrapakdee, S. (2016) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2016.05.005 · Cited by 75 · see citing works
Total Synthesis and Comparative Analysis of Orlistat, Valilactone, and a Transposed Orlistat Derivative: Inhibitors of Fatty Acid Synthase
Ma, G., Zancanella, M. A., Oyola, Y., Richardson, R. D., Smith, J. W., & Romo, D. (2006) · Organic Letters · doi:10.1021/ol061651o · Cited by 75 · see citing works
Self-citation
Catalytic Asymmetric Synthesis of trans‐Configured β‐Lactones: Cooperation of Lewis Acid and Ion Pair Catalysis
Kull, T., Cabrera, J., & Peters, R. (2010) · Chemistry - A European Journal · doi:10.1002/chem.201000840 · Cited by 74 · see citing works
Fatty acid synthase causes drug resistance by inhibiting TNF-α and ceramide production
Liu, H., Wu, X., Dong, Z., Luo, Z., Zhao, Z., Xu, Y., & Zhang, J. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m033811 · Cited by 75 · see citing works
Identification and structural characterization of an unusual mycobacterial monomeromycolyl‐diacylglycerol
Kremer, L., de Chastellier, C., Dobson, G., Gibson, K. J. C., Bifani, P. J., Balor, S., Gorvel, J., Locht, C., Minnikin, D. E., & Besra, G. S. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04717.x · Cited by 71 · see citing works
Inhibition of Fatty Acid Synthase by Orlistat Accelerates Gastric Tumor Cell Apoptosis in Culture and Increases Survival Rates in Gastric Tumor Bearing Mice In Vivo
Dowling, S. C., Cox, J., & Cenedella, R. J. (2009) · Lipids · doi:10.1007/s11745-009-3298-2 · Cited by 67 · see citing works
Inhibition of fatty acid synthase by amentoflavone reduces coxsackievirus B3 replication
Wilsky, S., Sobotta, K., Wiesener, N., Pilas, J., Althof, N., Münder, T., Wutzler, P., & Henke, A. (2011) · Archives of Virology · doi:10.1007/s00705-011-1164-z · Cited by 63 · see citing works
Gerosuppressant Metformin: less is more
Menéndez, J. A., Cufí, S., Oliveras‐Ferraros, C., Vellón, L., Joven, J., & Vázquez‐Martín, A. (2011) · Aging · doi:10.18632/aging.100316 · Cited by 57 · see citing works
Discrepant NOXA (PMAIP1) transcript and NOXA protein levels: a potential Achilles’ heel in mantle cell lymphoma
Dengler, M. A., Weilbacher, A., Gutekunst, M., Staiger, A. M., Vöhringer, M. C., Horn, H., Ott, G., Aulitzky, W. E., & van der Kuip, H. (2014) · Cell Death and Disease · doi:10.1038/cddis.2013.552 · Cited by 55 · see citing works
Click-based synthesis and proteomic profiling of lipstatin analogues
Ngai, M. H., Yang, P., Liu, K., Shen, Y., Wenk, M. R., Yao, S. Q., & Lear, M. J. (2010) · Chemical Communications · doi:10.1039/c0cc01276a · Cited by 55 · see citing works
Cooperative Al(Salen)-Pyridinium Catalysts for the Asymmetric Synthesis of trans-Configured β-Lactones by [2+2]-Cyclocondensation of Acylbromides and Aldehydes: Investigation of Pyridinium Substituent Effects
Meier, P., Broghammer, F., Latendorf, K., Rauhut, G., & Peters, R. (2012) · Molecules · doi:10.3390/molecules17067121 · Cited by 55 · see citing works
Inhibition of human pancreatic lipase by tetrahydrolipstatin: Further kinetic studies showing its reversibility
Tiss, A., Lengsfeld, H., Carrière, F., & Verger, R. (2008) · Journal of Molecular Catalysis B Enzymatic · doi:10.1016/j.molcatb.2008.11.003 · Cited by 55 · see citing works
3-Aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase inhibitors
Rivkin, A., Kim, Y. R., Goulet, M. T., Bays, N. W., Hill, A. D., Kariv, I., Krauss, S., Ginanni, N., Strack, P. R., Kohl, N. E., et al. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.06.014 · Cited by 55 · see citing works
Gastrointestinal stromal tumours overexpress fatty acid synthase
Rossi, S., Ou, W., Tang, D., Bhattacharya, N., Tos, A. P. D., Fletcher, J. A., & Loda, M. F. (2006) · The Journal of Pathology · doi:10.1002/path.1983 · Cited by 54 · see citing works
Lipid Biosynthesis and its Coordination with Cell Cycle Progression
Kwok, A. C. M., & Wong, J. T. Y. (2005) · Plant and Cell Physiology · doi:10.1093/pcp/pci213 · Cited by 53 · see citing works
Proton pump inhibitors suppress DNA damage repair and sensitize treatment resistance in breast cancer by targeting fatty acid synthase
Wang, C. J., Li, D., Danielson, J. A., Zhang, E. H., Dong, Z., Miller, K. D., Li, L., Zhang, J.-T., & Liu, J.-Y. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.03.026 · Cited by 51 · see citing works
A Mutant of Hepatitis B Virus X Protein (HBxΔ127) Promotes Cell Growth through A Positive Feedback Loop Involving 5-Lipoxygenase and Fatty Acid Synthase
Wang, Q., Zhang, W., Liu, Q., Zhang, X., Lv, N., Ye, L., & Zhang, X. (2010) · Neoplasia · doi:10.1593/neo.91298 · Cited by 51 · see citing works
Antioxidant and lipase inhibitory activities and essential oil composition of pomegranate peel extracts
Hadrich, F., Cher, S., Gargouri, Y. T., & Adel, S. (2014) · Journal of Oleo Science · doi:10.5650/jos.ess13163 · Cited by 49 · see citing works
Effects of fatty acid synthase inhibitors on lymphatic vessels: an in vitro and in vivo study in a melanoma model
Bastos, D. C., Paupert, J., Maillard, C., Seguin, F., Carvalho, M. A., Agostini, M., Coletta, R. D., Noël, A., & Graner, E. (2016) · Laboratory Investigation · doi:10.1038/labinvest.2016.125 · Cited by 49 · see citing works
Synthesis of Novel β-Lactone Inhibitors of Fatty Acid Synthase
Richardson, R. D., Ma, G., Oyola, Y., Zancanella, M. A., Knowles, L. M., Cieplak, P., Romo, D., & Smith, J. W. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm800321h · Cited by 49 · see citing works
Self-citation
Mollugin inhibits proliferation and induces apoptosis by suppressing fatty acid synthase in HER2‐overexpressing cancer cells
Truong, M., Hwang, Y. P., Kim, H. G., Na, M., & Jeong, H. G. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24258 · Cited by 48 · see citing works
Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer
Knowles, L. M., & Smith, J. W. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-168 · Cited by 47 · see citing works
Self-citation
PI3K/Akt signaling regulates p27kip1 expression via Skp2 in PC3 and DU145 prostate cancer cells, but is not a major factor in p27kip1 regulation in LNCaP and PC346 cells
van Duijn, P. W., & Trapman, J. (2006) · The Prostate · doi:10.1002/pros.20398 · Cited by 46 · see citing works
Fatty acid synthase inhibitor orlistat induces apoptosis in T cell lymphoma: Role of cell survival regulatory molecules
Kant, S., Kumar, A., & Singh, S. M. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.07.010 · Cited by 44 · see citing works
High Prevalence of Fatty Acid Synthase Expression in Colorectal Cancers in Middle Eastern Patients and Its Potential Role as a Therapeutic Target
Shahab Uddin, M. S., Hussain, A. R., Ahmed, M., Abubaker, J. A., Al-Sanea, N. A., Abduljabbar, A. S., Ashari, L. H. S., Alhomoud, S. J., Al‐Dayel, F., Bavi, P. P., et al. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.230 · Cited by 43 · see citing works
Fatty acid synthase overexpression confers an independent prognosticator and associates with radiation resistance in nasopharyngeal carcinoma
Kao, Y., Lee, S., Lin, L.-C., Chen, L., Hsing, C., Hsu, H.-P., Huang, H.-Y., Shiue, Y.-L., Chen, T.-J., & Li, C. (2012) · Tumor Biology · doi:10.1007/s13277-012-0605-y · Cited by 43 · see citing works
Link between obesity and cancer: role of triglyceride/free fatty acid cycling.
Gong, Y., Lj, D., & Liang, J. (2014) · PubMed · Cited by 43 · see citing works
Fatty acid synthase inhibition results in a magnetic resonance–detectable drop in phosphocholine
Ross, J. R., Najjar, A. M., Sankaranarayanapillai, M., Tong, W. P., Kaluarachchi, K., & Ronen, S. M. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0015 · Cited by 43 · see citing works
Fatty Acid Synthase Inhibitors Induce Apoptosis in Non-Tumorigenic Melan-A Cells Associated with Inhibition of Mitochondrial Respiration
Rossato, F. A., Zecchin, K. G., Guardia, P. G. L., Ortega, R. M., Alberici, L. C., Costa, R. A. P. E., Catharino, R. R., Graner, E., Castilho, R. F., & Vercesi, A. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101060 · Cited by 43 · see citing works
Fatty Acid Synthase Activity in Tumor Cells
Little, J. L., & Kridel, S. J. (2008) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-1-4020-8831-5_7 · Cited by 42 · see citing works
Profiling of central metabolism in human cancer cells by two-dimensional NMR, GC-MS analysis, and isotopomer modeling
Chen, Y., Richardson, A. D., Osterman, A. L., & Smith, J. W. (2007) · Metabolomics · doi:10.1007/s11306-007-0094-y · Cited by 41 · see citing works
Self-citation
Structure–Activity Relationship of Polyphenols That Inhibit Fatty Acid Synthase
Li, B.-H., Ma, X., Wang, Y., & Tian, W. (2005) · The Journal of Biochemistry · doi:10.1093/jb/mvi171 · Cited by 40 · see citing works
Protocatechuic Acid Inhibits Oleic Acid-Induced Vascular Smooth Muscle Cell Proliferation through Activation of AMP-Activated Protein Kinase and Cell Cycle Arrest in G0/G1 Phase
Lin, M., Ou, T., Chang, C.-H., Chan, K., & Wang, C. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf505303s · Cited by 40 · see citing works
Diallyl Sulfide Promotes Cell-Cycle Arrest Through the p53 Expression and Triggers Induction of Apoptosis Via Caspase- and Mitochondria-Dependent Signaling Pathways in Human Cervical Cancer Ca Ski Cells
Chiu, T.-H., Lan, K.-Y., Yang, M., Lin, J., Hsia, T., Wu, C.-T., Yang, J., Chueh, F., & Chung, J. (2013) · Nutrition and Cancer · doi:10.1080/01635581.2012.725503 · Cited by 39 · see citing works
Cacalol, a natural sesquiterpene, induces apoptosis in breast cancer cells by modulating Akt-SREBP-FAS signaling pathway
Liu, W., Furuta, E., Shindo, K., Watabe, M., Xing, F., Pandey, P. R., Okuda, H., Pai, S. K., Murphy, L. L., Cao, D., et al. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1076-8 · Cited by 39 · see citing works
Artesunate Activates the Intrinsic Apoptosis of HCT116 Cells through the Suppression of Fatty Acid Synthesis and the NF-κB Pathway
Chen, X., Wong, Y., Lim, T. K., Lim, W., Lin, Q., Wang, J., & Hua, Z. (2017) · Molecules · doi:10.3390/molecules22081272 · Cited by 38 · see citing works
Orlistat: From Antiobesity Drug to Anticancer Agent in Her-2/neu (erbB-2)-Overexpressing Gastrointestinal Tumors?
Menéndez, J., Vellon, L., & Lupu, R. (2005) · Experimental biology and medicine · doi:10.1177/153537020523000301 · Cited by 28 · see citing works
Mechanistic Investigations of the ZnCl 2 -Mediated Tandem Mukaiyama Aldol Lactonization: Evidence for Asynchronous, Concerted Transition States and Discovery of 2-Oxopyridyl Ketene Acetal Variants
Zhao, C., Mitchell, T. A., Vallakati, R., Pérez, L. M., & Romo, D. (2011) · Journal of the American Chemical Society · doi:10.1021/ja209163w · Cited by 33 · see citing works
Mechanism of Orlistat Hydrolysis by the Thioesterase of Human Fatty Acid Synthase
Fako, V. E., Zhang, J., & Liu, J. (2014) · ACS Catalysis · doi:10.1021/cs500956m · Cited by 32 · see citing works
Fatty acid synthase inhibitor orlistat impairs cell growth and down-regulates PD-L1 expression of a human T-cell leukemia line
Cioccoloni, G., Aquino, A., Notarnicola, M., Caruso, M. G., Bonmassar, E., Zonfrillo, M., Caporali, S., Faraoni, I., Villivà, C., Fuggetta, M. P., et al. (2019) · Journal of Chemotherapy · doi:10.1080/1120009x.2019.1694761 · Cited by 32 · see citing works
Novel antagonists of the thioesterase domain of human fatty acid synthase
Richardson, R. D., & Smith, J. W. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0187 · Cited by 27 · see citing works
Self-citation
The peculiarities of cancer cell metabolism: A route to metastasization and a target for therapy
Carvalho, T. M. A., Cardoso, H. J., Figueira, M. I., Vaz, C. V., & Socorro, S. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.03.053 · Cited by 27 · see citing works
Acyl Carrier Protein-specific 4′-Phosphopantetheinyl Transferase Activates 10-Formyltetrahydrofolate Dehydrogenase
Strickland, K. C., Hoeferlin, L. A., Oleinik, N. V., Krupenko, N. I., & Krupenko, S. A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.080556 · Cited by 26 · see citing works
Crystal Structure of the Human Fatty Acid Synthase Enoyl-Acyl Carrier Protein-Reductase Domain Complexed with Triclosan Reveals Allosteric Protein-Protein Interface Inhibition
Sippel, K. H., Vyas, N. K., Zhang, W., Sankaran, B., & Quiocho, F. A. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.608547 · Cited by 25 · see citing works
Orlistat, a novel potent antitumor agent for ovarian cancer: proteomic analysis of ovarian cancer cells treated with Orlistat
Huang, H., Tang, J. P., Zhou, S., Yi, T., Peng, H., Shen, G., Xie, N., Huang, K., Yang, T., Wu, J., et al. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1465 · Cited by 25 · see citing works
The anti-obesity drug orlistat promotes sensitivity to TRAIL by two different pathways in hormone-refractory prostate cancer cells
Sowa, Y. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1353 · Cited by 25 · see citing works
Enantioselective total synthesis of (−)-tetrahydrolipstatin using Oppolzer’s sultam directed aldol reaction
Kumaraswamy, G., & Markondaiah, B. (2007) · Tetrahedron Letters · doi:10.1016/j.tetlet.2007.11.051 · Cited by 25 · see citing works
Aberrant Lipid Metabolism in Cancer: Current Status and Emerging Therapeutic Perspectives
Irshad, R., Tabassum, S., & Husain, M. (2023) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026623666230522103321 · Cited by 24 · see citing works
Synthesis and biological investigation of the β-thiolactone and β-lactam analogs of tetrahydrolipstatin
Aubry, S., Aubert, G., Cresteil, T., & Crich, D. (2012) · Organic & Biomolecular Chemistry · doi:10.1039/c2ob06976h · Cited by 24 · see citing works
Targeting Cancer Metabolism and Current Anti-Cancer Drugs
Sukjoi, W., Ngamkham, J., Attwood, P. V., & Jitrapakdee, S. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-55035-6_2 · Cited by 23 · see citing works
β-Lactam congeners of orlistat as inhibitors of fatty acid synthase
Zhang, W., Richardson, R. D., Chamni, S., Smith, J. W., & Romo, D. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.02.043 · Cited by 23 · see citing works
Self-citation
FASN inhibition sensitizes metastatic OSCC cells to cisplatin and paclitaxel by downregulating cyclin B1
Almeida, L. Y., MOREIRA, F. D. S., dos Santos, G. A., Zelaya, F. J. M. C., Rojas, C. A. O., Agostini, M., Mariano, F. S., Bastos, D. C., Nicolau, U. R., Kowalski, L. P., et al. (2021) · Oral Diseases · doi:10.1111/odi.14017 · Cited by 21 · see citing works
FASN deficiency induces a cytosol-to-mitochondria citrate flux to mitigate detachment-induced oxidative stress
Dai, W., Wang, Z., Wang, G., Wang, Q. A., DeBerardinis, R. J., & Jiang, L. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112971 · Cited by 19 · see citing works
Trophoblastic Neoplasms Express Fatty Acid Synthase, Which May Be a Therapeutic Target via Its Inhibitor C93
Ueda, S. M., Mao, T., Kuhajda, F. P., Vasoontara, C., Giuntoli, R. L., Bristow, R. E., Kurman, R. J., & Shih, I. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.081162 · Cited by 20 · see citing works
Fatty Acid Synthase Inhibition Induces Differential Expression of Genes Involved in Apoptosis and Cell Proliferation in Ocular Cancer Cells
Deepa, P. R., Vandhana, S., & Krishnakumar, S. (2013) · Nutrition and Cancer · doi:10.1080/01635581.2013.748923 · Cited by 20 · see citing works
Disruption of crosstalk between the fatty acid synthesis and proteasome pathways enhances unfolded protein response signaling and cell death
Little, J. L., Wheeler, F. B., Koumenis, C., & Kridel, S. J. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0558 · Cited by 20 · see citing works
Cut the fat: targeting cholesterol and lipid metabolism in glioblastoma
Zekanovic, S., Sing, P. A., Leenstra, S., & Lamfers, M. L. M. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07993-3 · Cited by 16 · see citing works
The antimetastatic activity of orlistat is accompanied by an antitumoral immune response in mouse melanoma
Almeida, L. Y., Mariano, F. S., Bastos, D. C., Cavassani, K. A., Raphelson, J. R., Mariano, V. S., Agostini, M., Moreira, F. S., Coletta, R. D., Mattos‐Graner, R. O., et al. (2019) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-019-04010-1 · Cited by 17 · see citing works
Global Gene Deregulations in FASN Silenced Retinoblastoma Cancer Cells: Molecular and Clinico‐Pathological Correlations
Sangeetha, M., Deepa, P. R., Rishi, P., Khetan, V., & Krishnakumar, S. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25217 · Cited by 17 · see citing works
A fast-acting lipid checkpoint in G1 prevents mitotic defects
Köberlin, M. S., Fan, Y., Liu, C., Chung, M., Pinto, A. F. M., Jackson, P. K., Saghatelian, A., & Meyer, T. (2024) · Nature Communications · doi:10.1038/s41467-024-46696-9 · Cited by 15 · see citing works
Orlistat treatment induces apoptosis and arrests cell cycle in HSC-3 oral cancer cells
Xiao, X., Liu, H., & Li, X. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2017.09.001 · Cited by 15 · see citing works
Obesity, fatty acid synthase, and cancer: serendipity or forgotten causal linkage?
Menéndez, J. A., Colomer, R., & Lupu, R. (2004) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2004.10.007 · Cited by 15 · see citing works
Fatty acid synthase as a potential new therapeutic target for cervical cancer
Nascimento, J., Mariot, C. D. S., Vianna, D. R. B., Kliemann, L. M., Chaves, P., Loda, M. F., Buffon, A., Beck, R. C. R., & Pilger, D. A. (2022) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765202220210670 · Cited by 14 · see citing works
Revealing protein networks and gene-drug connectivity in cancer from direct information
Jiang, X., Martínez-Ledesma, E., & Morcos, F. (2017) · Scientific Reports · doi:10.1038/s41598-017-04001-3 · Cited by 14 · see citing works

Metabolic signaling pathways asociated with fatty acid synthase activity
Kridel, S. J., & Little, J. L. (2005) · Cancer Research
Fatty acid synthase inhibition induces apoptosis independent of lipid metabolism
Knowles, L. M., Yang, C., & Smith, J. W. (2006) · The FASEB Journal · doi:10.1096/fasebj.20.4.a488-a · Cited by 1 · see citing works
Self-citation
Inhibition of fatty acid synthase activates the unfolded protein response in tumor cells
Kridel, S. J. (2008) · The FASEB Journal · doi:10.1096/fasebj.22.1_supplement.1034.4
Inhibition of Fatty Acid Synthase in Prostate Cancer by Orlistat, a Novel Therapeutic
Kridel, S. J. (2007) · Defense Technical Information Center (DTIC)
Inhibition of Fatty-acid Synthase Induces Caspase-8-mediated Tumor Cell Apoptosis by Up-regulating DDIT4
Knowles, L. M., Chen, Y., Osterman, A. L., & Smith, J. W. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803384200 · Cited by 98 · see citing works
Self-citation

Authors: Knowles, L. M., Axelrod, F., Browne, C. D., & Smith, J. W.
Affiliations: Sanford Burnham Prebys Medical Discovery Institute (US)
Corresponding author: Smith, Jeffrey W.
ORCID: Knowles, Lynn M.
Smith, Jeffrey W.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2004-07
Volume: 279
Issue: 29
Pages: 30540-30545
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m405061200
OpenAlex: W2115307821
Cited by: 146
References: 38
Citations by year: 2026: 3 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 2 · 2021: 4 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 4 · 2015: 5 · 2014: 12 · 2013: 6 · 2012: 13
FWCI: 3.48
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 5946 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Cancer Institute (CA30199, CA-69306, R01CA069306, CA6982713, P30CA030199)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
Keywords: fatty acid synthase, Skp2, orlistat, cell cycle arrest, G1/S checkpoint, p27, ubiquitin-mediated proteolysis, E3 ubiquitin ligase, tumor cell proliferation, siRNA knockdown, cancer drug targets
MeSH terms: Orlistat, Avidin, Biotin, Cell Cycle, Cell Division, Cell Line, Dose-Response Relationship, Drug, Epithelial Cells, Fatty Acids, Humans, Lactones, Lipase, Obesity, Serine Endopeptidases, Time Factors, Blotting, Western, Down-Regulation, Retinoblastoma Protein, G1 Phase, S Phase, Cell Cycle Proteins, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Palmitic Acid, Tumor Suppressor Proteins, Ubiquitin, RNA, Small Interfering, Ubiquitin-Protein Ligases, S-Phase Kinase-Associated Proteins, Cell Line, Tumor, Cyclin-Dependent Kinase Inhibitor p27, Fatty Acid Synthases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks