The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Aurora-A Abrogation of p53 DNA Binding and Transactivation Activity by Phosphorylation of Serine 215
Open accessAbstract
The tumor suppressor p53 is important in the decision to either arrest cell cycle progression or induce apoptosis in response to a variety of stimuli. p53 posttranslational modifications and association with other proteins have been implicated in the regulation of its stability and transactivation activity. Here we show that p53 is phosphorylated by the mitotic kinase Aurora-A at serine 215. Unlike most identified phosphorylation sites of p53 that positively associate with p53 function (Brooks, C. L., and Gu, W. (2003) Curr. Opin. Cell Biol. 15, 164-171), the phosphorylation of p53 by Aurora-A at Ser-215 abrogates p53 DNA binding and transactivation activity. Downstream target genes of p53, such as p21Cip/WAF1 and PTEN, were inhibited by Aurora-A in a Ser-215 phosphorylation-dependent manner (i.e. phosphomimic p53-S215D lost and non-phosphorylatable p53-S215A retained normal p53 function). As a result, Aurora-A overrides the apoptosis and cell cycle arrest induced by cisplatin and gamma-irradiation, respectively. However, the effect of Aurora-A on p53 DNA binding and transactivation activity was not affected by phosphorylation of Ser-315, a recently identified Aurora-A phosphorylation site of p53 (Katayama, H., Sasai, K., Kawai, H., Yuan, Z. M., Bondaruk, J., Suzuki, F., Fujii, S., Arlinghaus, R. B., Czerniak, B. A., and Sen, S. (2004) Nat. Genet. 36, 55-62). Our data indicate that phosphorylation of p53 at Ser-215 by Aurora-A is a major mechanism to inactivate p53 and can provide a molecular insight for Aurora-A function.
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3 retracted
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Self-citationRetractedPositive Feedback Regulation between Akt2 and MyoD during Muscle Differentiation
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Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53
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Cited by
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Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy
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Aurora A kinase (AURKA) in normal and pathological cell division
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The Aurora kinase family in cell division and cancer
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Aurora kinases: novel therapy targets in cancers
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Metadata
- Authors
- Liu, Q., Kaneko, S., Yang, L., Feldman, R. I., Nicosia, S. V., Chen, J., & Cheng, J. Q.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2004-12
- Volume
- 279
- Issue
- 50
- Pages
- 52175-52182
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2091312754
- Cited by
- 334
- References
- 38
- FWCI
- 7.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Liu, Q., Kaneko, S., Yang, L., Feldman, R. I., Nicosia, S. V., Chen, J., & Cheng, J. Q. (2004). Aurora-A Abrogation of p53 DNA Binding and Transactivation Activity by Phosphorylation of Serine 215. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m406802200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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