The DOI matches its Crossref record; 229 of the 229 references it cites were found in a registry or an index.
Aurora A kinase (AURKA) in normal and pathological cell division
Open accessAbstract
Temporally and spatially controlled activation of the Aurora A kinase (AURKA) regulates centrosome maturation, entry into mitosis, formation and function of the bipolar spindle, and cytokinesis. Genetic amplification and mRNA and protein overexpression of Aurora A are common in many types of solid tumor, and associated with aneuploidy, supernumerary centrosomes, defective mitotic spindles, and resistance to apoptosis. These properties have led Aurora A to be considered a high-value target for development of cancer therapeutics, with multiple agents currently in early-phase clinical trials. More recently, identification of additional, non-mitotic functions and means of activation of Aurora A during interphase neurite elongation and ciliary resorption have significantly expanded our understanding of its function, and may offer insights into the clinical performance of Aurora A inhibitors. Here we review the mitotic and non-mitotic functions of Aurora A, discuss Aurora A regulation in the context of protein structural information, and evaluate progress in understanding and inhibiting Aurora A in cancer.
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1 retracted
BRCA1 Phosphorylation by Aurora-A in the Regulation of G2 to M Transition
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RetractedCytoscape 2.8: new features for data integration and network visualization
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Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
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A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers
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Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets
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HEF1-Dependent Aurora A Activation Induces Disassembly of the Primary Cilium
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Self-citationMutations in aurora prevent centrosome separation leading to the formation of monopolar spindles
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Dalby, M. J., Gadegaard, N., & Oreffo, R. O. C. (2014) · Nature Materials · doi:10.1038/nmat3980 · Cited by 1,082
Sannerud, R., Esselens, C., Ejsmont, P., Mattera, R., Rochin, L., Tharkeshwar, A. K., De Baets, G., De Wever, V., Habets, R., Baert, V., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.020 · Cited by 299
Shah, K. N., Bhatt, R., Rotow, J., Rohrberg, J., Olivas, V., Wang, V. E., Hemmati, G., Martins, M. M., Maynard, A., Kuhn, J., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0264-7 · Cited by 286
Melichar, B., Adenis, A., Lockhart, A. C., Bennouna, J., Dees, E. C., Kayaleh, O., Obermannova, R., DeMichele, A., Zatloukal, P., Zhang, B., et al. (2015) · The Lancet Oncology · doi:10.1016/s1470-2045(15)70051-3 · Cited by 254
Lineage specificity of primary cilia in the mouse embryo
Bangs, F. K., Schrode, N., Hadjantonakis, A.-K., & Anderson, K. V. (2015) · Nature Cell Biology · doi:10.1038/ncb3091 · Cited by 174
Metadata
- Authors
- Nikonova, A. S., Astsaturov, I., Serebriiskii, I. G., Dunbrack, R. L., & Golemis, E. A.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2012-08-03
- Volume
- 70
- Issue
- 4
- Pages
- 661-687
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- OpenAlex
- W2083352151
- Cited by
- 448
- References
- 229
- FWCI
- 11.15
- Type
- journal article
- Language
- en
- Open access
- green
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- Nikonova, A. S., Astsaturov, I., Serebriiskii, I. G., Dunbrack, R. L., & Golemis, E. A. (2013). Aurora A kinase (AURKA) in normal and pathological cell division. Cellular and Molecular Life Sciences. https://doi.org/10.1007/s00018-012-1073-7
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