The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins
Open accessAbstract
Activation of the c-Jun NH(2)-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is mediated by a protein kinase cascade. This signaling mechanism may be coordinated by the interaction of components of the protein kinase cascade with scaffold proteins. The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates signaling by the mixed-lineage kinase (MLK)-->MAP kinase kinase 7 (MKK7)-->JNK pathway. The scaffold proteins JIP1 and JIP2 interact to form oligomeric complexes that accumulate in peripheral cytoplasmic projections extended at the cell surface. The JIP proteins function by aggregating components of a MAP kinase module (including MLK, MKK7, and JNK) and facilitate signal transmission by the protein kinase cascade.
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MAPK scaffolding proteins JIP1 and PEA-15 and substrates RSK1, MK2, and MEF2a also contain a linear KIM domain that mediates MAPK binding in the cell.
“Notably, MAPK scaffolding proteins (JNK-interacting protein, JIP1; 29 phosphoprotein enriched in astrocytes 15, PEA-15 30 ) and substrates (Ribosomal protein S6 kinase alpha-1, RSK1; 31 MAP kinase-activated protein kinase 2, MK2; 32 and myocyte enhancer factor 2A, MEF2a 33 ) also contain linear KIM domain, which mediates MAPK binding in the cell.”
From Molecular basis of MAP kinase regulation (2013) · cites this paper as [29]
JIPs display a highly polarized subcellular localization at the tips of neuronal cell processes and in extended projections from the surface of insulinoma cells.
“The JIPs display a highly polarized subcellular localization at the tips of neuronal cell processes and in extended projections from the surface of insulinoma cells (Meyer et al. 1999; Yasuda et al. 1999; Kelkar et al. 2000).”
From Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules (2001) · cites this paper as Yasuda et al. 1999
JIP-1 and JIP-2 are ∼50% identical, have a similar domain structure, and can form homodimeric and heterodimeric complexes.
“JIP-1 (also known as IB1) and JIP-2 are ∼50% identical, have a similar domain structure, and can form homodimeric and heterodimeric complexes (Yasuda et al. 1999).”
From Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules (2001) · cites this paper as Yasuda et al. 1999
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- Authors
- Yasuda, J., Whitmarsh, A. J., Cavanagh, J., Sharma, M., & Davis, R. J.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1999-10
- Volume
- 19
- Issue
- 10
- Pages
- 7245-7254
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC84717
- OpenAlex
- W2155483393
- Cited by
- 458
- References
- 36
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 15 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 10 · 2016: 6 · 2015: 5 · 2014: 11 · 2013: 6 · 2012: 10
- FWCI
- 14.70
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Molecular and Cellular Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Keywords
- JNK, c-Jun N-terminal kinase, MAPK signaling, mixed lineage kinase, MKK7, protein kinase cascades, JIP1, protein oligomerization, signal transduction, cytoplasmic projections
- MeSH terms
- Amino Acid Sequence, Carrier Proteins, Cell Compartmentation, Cloning, Molecular, Molecular Sequence Data, Protein Binding, Signal Transduction, Sequence Homology, Amino Acid, Protein Structure, Quaternary, Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase Kinases, MAP Kinase Kinase Kinases, JNK Mitogen-Activated Protein Kinases, MAP Kinase Kinase 7, Adaptor Proteins, Signal Transducing
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