The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Nucleosome Assembly Protein 1 Exchanges Histone H2A-H2B Dimers and Assists Nucleosome Sliding
Open accessAbstract
Eukaryotic chromatin is highly dynamic and turns over rapidly even in the absence of DNA replication. Here we show that the acidic histone chaperone nucleosome assembly protein 1 (NAP-1) from yeast reversibly removes and replaces histone protein dimer H2A-H2B or histone variant dimers from assembled nucleosomes, resulting in active histone exchange. Transient removal of H2A-H2B dimers facilitates nucleosome sliding along the DNA to a thermodynamically favorable position. Histone exchange as well as nucleosome sliding is independent of ATP and relies on the presence of the C-terminal acidic domain of yeast NAP-1, even though this region is not required for histone binding and chromatin assembly. Our results suggest a novel role for NAP-1 (and perhaps other acidic histone chaperones) in mediating chromatin fluidity by incorporating histone variants and assisting nucleosome sliding. NAP-1 may function either untargeted (if acting alone) or may be targeted to specific regions within the genome through interactions with additional factors.
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Cites
Kinetics of Core Histones in Living Human Cells
Kimura, H., & Cook, P. R. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.7.1341 · Cited by 675
Adkins, M. W., Howar, S. R., & Tyler, J. K. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.05.016 · Cited by 294
Cited by
The Nucleosomal Surface as a Docking Station for Kaposi's Sarcoma Herpesvirus LANA
Barbera, A. J., Chodaparambil, J. V., Kelley-Clarke, B., Joukov, V., Walter, J. C., Luger, K., & Kaye, K. M. (2006) · Science · doi:10.1126/science.1120541 · Cited by 503
Self-citationHistone dynamics in living cells revealed by photobleaching
Kimura, H. (2005) · DNA Repair · doi:10.1016/j.dnarep.2005.04.012 · Cited by 109
Nap1 and Chz1 have Separate Htz1 Nuclear Import and Assembly Functions
Straube, K., Blackwell, J. S., & Pemberton, L. F. (2010) · Traffic · doi:10.1111/j.1600-0854.2009.01010.x · Cited by 53
Metadata
- Authors
- Park, Y.-J., Chodaparambil, J. V., Bao, Y., McBryant, S. J., & Luger, K.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 280
- Issue
- 3
- Pages
- 1817-1825
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2063516501
- Cited by
- 186
- References
- 2
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Park, Y.-J., Chodaparambil, J. V., Bao, Y., McBryant, S. J., & Luger, K. (2005). Nucleosome Assembly Protein 1 Exchanges Histone H2A-H2B Dimers and Assists Nucleosome Sliding. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m411347200
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