Mouse Sir2 Homolog SIRT6 Is a Nuclear ADP-ribosyltransferase

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Items 101–200 of 553

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2. Neuronal protection by sirtuins in Alzheimer's disease
   Thimmappa S. Anekonda, P. Hemachandra Reddy · 2005 · Journal of Neurochemistry
3. Calorie Restriction and Dietary Restriction Mimetics: A Strategy for Improving Healthy Aging and Longevity
   Gabriella Testa, Fiorella Biasi, Giuseppe Poli, Elena Chiarpotto · 2014 · Current Pharmaceutical Design
4. SIRT6 in DNA repair, metabolism and ageing
   David B. Lombard, Bjoern Schwer, Frederick W. Alt, Raúl Mostoslavsky · 2008 · Journal of Internal Medicine
5. Biological and Potential Therapeutic Roles of Sirtuin Deacetylases
   D. M. Taylor, M. M. Maxwell, Ruth Luthi‐Carter, Aleksey G. Kazantsev · 2008 · Cellular and Molecular Life Sciences
6. Differential expression of sirtuins in the aging rat brain
   Nady Braidy, Anne Poljak, Ross Grant, Tharusha Jayasena, Hussein Mansour, Tailoi Chan‐Ling, George A. Smythe, Perminder Singh Sachdev, Gilles J. Guillemin · 2015 · Frontiers in Cellular Neuroscience · Retracted
7. SIRT6 is a DNA double-strand break sensor
   Lior Onn, Miguel Portillo, Stefan Ilic, Gal Cleitman, Daniel Stein, Shai Kaluski, Ido Shirat, Zeev Slobodnik, Monica Einav, Fabian Erdel et al. · 2020 · eLife
8. Sirtuins and Insulin Resistance
   Shuang Zhou, Xiaoqiang Tang, Hou‐Zao Chen · 2018 · Frontiers in Endocrinology
9. The Poly(ADP-ribose) Polymerase PARP-1 Is Required for Oxidative Stress-induced TRPM2 Activation in Lymphocytes
   Ben D. Buelow, Yumei Song, Andrew M. Scharenberg · 2008 · Journal of Biological Chemistry
10. Insights into the Sirtuin Mechanism from Ternary Complexes Containing NAD+ and Acetylated Peptide
    Kevin G. Hoff, José L. Avalos‬, Kristin L. Sens, Cynthia Wolberger · 2006 · Structure
11. Regulation of Sirtuin Function by Posttranslational Modifications
    Franziska Flick, Bernhard Lüscher · 2012 · Frontiers in Pharmacology
12. Acetyl-lysine Analog Peptides as Mechanistic Probes of Protein Deacetylases
    Brian C. Smith, John M. Denu · 2007 · Journal of Biological Chemistry
13. The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repair
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14. SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells
    Michael Van Meter, Zhiyong Mao, Vera A. Gorbunova, Andrei Seluanov · 2011 · Cell Cycle
15. SIRT2 as a Therapeutic Target for Age-Related Disorders
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16. Mechanisms and Molecular Probes of Sirtuins
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17. Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells.
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18. A review of the sirtuin system, its clinical implications, and the potential role of dietary activators like resveratrol: part 1.
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19. Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair
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20. Functional dissection of SIRT6: Identification of domains that regulate histone deacetylase activity and chromatin localization
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21. JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks
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22. The role of linker histone H1 modifications in the regulation of gene expression and chromatin dynamics
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23. Small molecule regulation of Sir2 protein deacetylases
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24. The Role of SIRT6 Protein in Aging and Reprogramming of Human Induced Pluripotent Stem Cells
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25. Pathways for Ischemic Cytoprotection: Role of Sirtuins in Caloric Restriction, Resveratrol, and Ischemic Preconditioning
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26. Intracellular distribution of human SIRT 7 and mapping of the nuclear/nucleolar localization signal
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27. Chroman-4-one- and Chromone-Based Sirtuin 2 Inhibitors with Antiproliferative Properties in Cancer Cells
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28. A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation
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29. Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease
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30. Mediterranean diet and cardioprotection: The role of nitrite, polyunsaturated fatty acids, and polyphenols
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31. The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update
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32. Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells
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33. The Current State of NAD+‐Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets
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34. The Role of Sirt6 in Obesity and Diabetes
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35. Overexpression of Sirtuin 6 Suppresses Inflammatory Responses and Bone Destruction in Mice With Collagen‐Induced Arthritis
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36. Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics
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37. Therapeutic role of sirtuins in neurodegenerative disease
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38. Nicotinamidase activity is important for germination
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39. Sirtuins and Their Relevance to the Kidney
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40. A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD + -Dependent Enzymes
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41. NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1
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42. Function and metabolism of sirtuin metabolite O-acetyl-ADP-ribose
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43. Potential Modulation of Sirtuins by Oxidative Stress
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44. Calorie restriction-induced SIRT6 activation delays aging by suppressing NF-κB signaling
    Nannan Zhang, Zhongchi Li, Wei Mu, Liyuan Li, Yaru Liang, Maoyang Lu, Zhuoran Wang, Ying Qiu, Zhao Wang · 2016 · Cell Cycle
45. Sirtuin 6: linking longevity with genome and epigenome stability
    Anatoly Korotkov, Andrei Seluanov, Vera A. Gorbunova · 2021 · Trends in Cell Biology
46. NAD+ as a Signaling Molecule Modulating Metabolism
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47. Interplay between compartmentalized NAD + synthesis and consumption: a focus on the PARP family
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48. Combining affinity purification by ADP-ribose-binding macro domains with mass spectrometry to define the mammalian ADP-ribosyl proteome
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49. Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation
    Ann-Katrin Hopp, Patrick Grüter, Michael O. Hottiger · 2019 · Cells
50. The taming of PARP1 and its impact on NAD+ metabolism
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51. Sirtuins in vascular diseases: Emerging roles and therapeutic potential
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52. Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases
    Milena Vitiello, Alberto Zullo, Luigi Servillo, Francesco Paolo Mancini, Adriana Borriello, Alfonso Giovane, Fulvio Della Ragione, Nunzia D’Onofrio, Maria Luisa Balestrieri · 2016 · Ageing Research Reviews
53. Sirtuins' control of autophagy and mitophagy in cancer
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54. Chemical and structural biology of protein lysine deacetylases
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55. Plasmodium falciparum Sir2: an Unusual Sirtuin with Dual Histone Deacetylase and ADP-Ribosyltransferase Activity
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56. Sir2 Protein Deacetylases: Evidence for Chemical Intermediates and Functions of a Conserved Histidine
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57. SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity
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58. Interplay between SIRT proteins and tumour suppressor transcription factors in chemotherapeutic resistance of cancer.
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59. Intracellular Mono-ADP-Ribosylation in Signaling and Disease
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60. The role of sirtuins in modulating redox stressors
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61. Targeting sirtuins for cancer therapy: epigenetics modifications and beyond
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62. SIRT1: Linking Adaptive Cellular Responses to Aging-Associated Changes in Organismal Physiology
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63. SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism
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64. Emerging Therapeutic Potential of SIRT6 Modulators
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65. Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology
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66. The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5)
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67. Structure and function of the ARH family of ADP-ribosyl-acceptor hydrolases
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68. Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway
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69. Sirtuin 6: a review of biological effects and potential therapeutic properties
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70. SIRT1: roles in aging and cancer
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71. Metabolic and Neuropsychiatric Effects of Calorie Restriction and Sirtuins
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72. The CD38 glycohydrolase and the NAD sink: implications for pathological conditions
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73. Identifying the functional contribution of the defatty-acylase activity of SIRT6
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74. SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in ob/ob mice
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75. Sirtuin inhibitors
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76. SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation
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77. Who watches the watchmen? Regulation of the expression and activity of sirtuins
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78. SIRT6, a protein with many faces
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79. Synthesis and Characterization of SIRT6 Protein Coated Magnetic Beads: Identification of a Novel Inhibitor of SIRT6 Deacetylase from Medicinal Plant Extracts
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80. Alcohol-induced protein hyperacetylation: Mechanisms and consequences
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81. ADP-Ribosyltransferases and Poly ADP-Ribosylation
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82. Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators
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83. Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming
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84. Nicotinamide adenine dinucleotide: beyond a redox coenzyme
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85. Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair
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86. The Expanding Constellation of Histone Post-Translational Modifications in the Epigenetic Landscape
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87. Sirtuins and Cancer: Role in the Epithelial‐Mesenchymal Transition
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88. Nicotinamide Adenine Dinucleotide Metabolism and Neurodegeneration
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89. Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model
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90. Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells
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91. Sirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism
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92. Expanding functions of intracellular resident mono‐ ADP ‐ribosylation in cell physiology
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93. The Role of Sirtuins in Kidney Diseases
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94. Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal damage
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95. β-nicotinamide mononucleotide (NMN) production in Escherichia coli
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96. Role of Sirtuins and Calorie Restriction in Neuroprotection: Implications in Alzheimers and Parkinsons Diseases
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97. SIRT6 deacetylase activity regulates NAMPT activity and NAD(P)(H) pools in cancer cells
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98. Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors
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99. The Role of SIRT3 in the Brain Under Physiological and Pathological Conditions
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100. SIRT6 transcriptionally regulates global protein synthesis through transcription factor Sp1 independent of its deacetylase activity
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