NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1
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The circadian clock controls the transcription of hundreds of genes through specific chromatin-remodeling events. The histone methyltransferase mixed-lineage leukemia 1 (MLL1) coordinates recruitment of CLOCK-BMAL1 activator complexes to chromatin, an event associated with cyclic trimethylation of histone H3 Lys4 (H3K4) at circadian promoters. Remarkably, in mouse liver circadian H3K4 trimethylation is modulated by SIRT1, an NAD(+)-dependent deacetylase involved in clock control. We show that mammalian MLL1 is acetylated at two conserved residues, K1130 and K1133. Notably, MLL1 acetylation is cyclic, controlled by the clock and by SIRT1, and it affects the methyltransferase activity of MLL1. Moreover, H3K4 methylation at clock-controlled-gene promoters is influenced by pharmacological or genetic inactivation of SIRT1. Finally, levels of MLL1 acetylation and H3K4 trimethylation at circadian gene promoters depend on NAD(+) circadian levels. These findings reveal a previously unappreciated regulatory pathway between energy metabolism and histone methylation.
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SIRT1 activity is circadian and helps control circadian gene expression through interaction with circadian transcription network and an H3K4 methyltransferase.
“SIRT1 activity is circadian, and through an interaction with components of the circadian transcription regulatory network and an H3K4 methyltransferase, SIRT1 helps to control circadian gene expression patterns (Aguilar-Arnal et al., 2015; Orozco-Solis and Sassone-Corsi, 2014).”
From The Aging Epigenome (2016) · cites this paper as Aguilar-Arnal et al., 2015
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- Authors
- Aguilar-Arnal, L., Katada, S., Orozco-Solis, R., & Sassone-Corsi, P.
- Affiliations
- Inserm (FR)
- ORCID
- Katada, Sayako
- Venue
- Nature Structural & Molecular Biology
- Published
- 2015-03-09
- Volume
- 22
- Issue
- 4
- Pages
- 312-318
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- PMC
- PMC4732879
- OpenAlex
- W1966490808
- Cited by
- 117
- References
- 56
- Citations by year
- 2026: 8 · 2025: 3 · 2024: 7 · 2023: 9 · 2022: 9 · 2021: 12 · 2020: 12 · 2019: 10 · 2018: 14 · 2017: 9 · 2016: 19 · 2015: 5
- FWCI
- 8.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Structural & Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- Japan Society for the Promotion of Science (26710003)
- National Institute on Aging (R21AG041504, AG041504)
- National Institute on Drug Abuse (R21DA036408, DA036408)
- National Institute of General Medical Sciences (GM082634, R01GM081634)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- MLL1, SIRT1, H3K4 trimethylation, circadian clock, histone deacetylation, histone acetylation, NAD+, histone methyltransferase activity, clock-controlled genes, liver, energy metabolism, chromatin regulation, Clock/BMAL1
- MeSH terms
- Acetylation, Animals, Chromatin, Gene Expression Regulation, Histones, Methylation, Models, Genetic, NAD, Mice, Myeloid-Lymphoid Leukemia Protein, Sirtuin 1, Circadian Clocks
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