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Cited by 80Sirtuins and Resveratrol in MedicineDNA Repair MechanismsPARP inhibition in cancer therapy

Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair

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Van Meter, Michael, Mao, Zhiyong, Gorbunova, Vera, Seluanov, Andrei·2011·Aging
DOI 10.18632/aging.100389PMC PMC3227448
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Abstract

The sirtuin gene family comprises an evolutionarily ancient set of NAD+ dependent protein deacetylase and mono-ADP ribosyltransferase enzymes. Found in all domains of life, sirtuins regulate a diverse array of biological processes, including DNA repair, gene silencing, apoptosis and metabolism. Studies in multiple model organisms have indicated that sirtuins may also function to extend lifespan and attenuate age-related pathologies. To date, most of these studies have focused on the deacetylase activity of sirtuins, and relatively little is known about the other biochemical activity of sirtuins, mono-ADP ribosylation. We recently reported that the mammalian sirtuin, SIRT6, mono-ADP ribosylates PARP1 to promote DNA repair in response to oxidative stress. In this research perspective we review the role of SIRT6 in DNA repair and discuss the emerging implications for sirtuin directed mono-ADP ribosylation in aging and age-related diseases.

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Cited by

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Authors
Van Meter, M., Mao, Z., Gorbunova, V., & Seluanov, A.
Affiliations
  • Department of Biology, University of Rochester, Rochester, NY 14627, USA
  • University of Rochester (US)
ORCID
Venue
Aging
Publisher
Impact Journals, LLC
Published
2011-09-22
Volume
3
Issue
9
Pages
829-835
ISSN
1945-4589 (ISSN-L)
DOI
10.18632/aging.100389
PMC
PMC3227448
OpenAlex
W2120609642
Cited by
80
References
9
Citations by year
2026: 3 · 2025: 6 · 2024: 5 · 2023: 3 · 2022: 10 · 2021: 7 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 9 · 2016: 3 · 2015: 7 · 2014: 4 · 2013: 2 · 2012: 11
FWCI
0.50
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Aging (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (F31AG041603, R01AG027237)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Keywords
SIRT6, sirtuins, mono-ADP-ribosylation, DNA repair, PARP1, oxidative stress, age-related diseases, NAD+-dependent deacetylase, lifespan extension
MeSH terms
Poly (ADP-Ribose) Polymerase-1, Adenosine Diphosphate Ribose, Animals, DNA Repair, Humans, Isoenzymes, Poly(ADP-ribose) Polymerases, ADP Ribose Transferases, Sirtuins, Genomic Instability, DNA Breaks, Double-Stranded

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