The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
BIRB796 Inhibits All p38 MAPK Isoforms in Vitro and in Vivo
Open accessAbstract
The compound BIRB796 inhibits the stress-activated protein kinases p38alpha and p38beta and is undergoing clinical trials for the treatment of inflammatory diseases. Here we report that BIRB796 also inhibits the activity and the activation of SAPK3/p38gamma. This occurs at higher concentrations of BIRB796 than those that inhibit p38alpha and p38beta and at lower concentrations than those that inhibit the activation of JNK isoforms. We also show that at these concentrations, BIRB796 blocks the stress-induced phosphorylation of the scaffold protein SAP97, further establishing that this is a physiological substrate of SAPK3/p38gamma. Our results demonstrate that BIRB796, in combination with SB203580, a compound that inhibits p38alpha and p38beta, but not the other p38 isoforms, can be used to identify physiological substrates of SAPK3/p38gamma as well as those of p38alpha and p38beta.
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Cited by
Roussel, L., Houle, F., Chan, C., Yao, Y., Bérubé, J., Olivenstein, R., Martin, J. G., Huot, J., Hamid, Q., Ferri, L., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903162 · Cited by 272
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Senescent fibroblast-derived Chemerin promotes squamous cell carcinoma migration
Farsam, V., Basu, A., Gatzka, M., Treiber, N., Schneider, L. A., Mulaw, M. A., Lucas, T., Kochanek, S., Dummer, R., Levesque, M. P., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13446 · Cited by 59
Gardiner, L.-J., Carrieri, A. P., Bingham, K., Macluskie, G., Bunton, D., McNeil, M., & Pyzer-Knapp, E. O. (2022) · PLOS ONE · doi:10.1371/journal.pone.0263248 · Cited by 36
Metadata
- Authors
- Kuma, Y., Sabio, G., Bain, J., Shpiro, N., Márquez, R., & Cuenda, A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 280
- Issue
- 20
- Pages
- 19472-19479
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2147510335
- Cited by
- 304
- References
- 24
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
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