The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Nod1 Participates in the Innate Immune Response to Pseudomonas aeruginosa
Open accessAbstract
The mammalian innate immune system recognizes pathogen-associated molecular patterns through pathogen recognition receptors. Nod1 has been described recently as a cytosolic receptor that detects specifically diaminopimelate-containing muropeptides from Gram-negative bacteria peptidoglycan. In the present study we investigated the potential role of Nod1 in the innate immune response against the opportunistic pathogen Pseudomonas aeruginosa. We demonstrate that Nod1 detects the P. aeruginosa peptidoglycan leading to NF-kappaB activation and that this activity is diminished in epithelial cells expressing a dominant-negative Nod1 construct or in mouse embryonic fibroblasts from Nod1 knock-out mice infected with P. aeruginosa. Finally, we demonstrate that the cytokine secretion kinetics and bacterial killing are altered in Nod1-deficient cells infected with P. aeruginosa in the early stages of infection.
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Citations
Cites
Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-κB
Inohara, N., Koseki, T., del Peso, L., Hu, Y., Yee, C., Chen, S., Carrio, R., Merino, J., Liu, D., Ni, J., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.14560 · Cited by 742
Cited by
Travassos, L. H., Carneiro, L. A. M., Ramjeet, M., Hussey, S., Kim, Y.-G., Magalhães, J. G., Yuan, L., Soares, F., Chea, E., Le Bourhis, L., et al. (2010) · Nature Immunology · doi:10.1038/ni.1823 · Cited by 1,306
Self-citationNod-like proteins in immunity, inflammation and disease
Fritz, J. H., Ferrero, R. L., Philpott, D. J., & Girardin, S. E. (2006) · Nature Immunology · doi:10.1038/ni1412 · Cited by 892
Self-citationNOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease
Caruso, R., Warner, N., Inohara, N., & Núñez, G. (2014) · Immunity · doi:10.1016/j.immuni.2014.12.010 · Cited by 830
NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease
Chen, G., Shaw, M. H., Kim, Y.-G., & Nuñez, G. (2009) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092239 · Cited by 772
Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells
Kaparakis, M., Turnbull, L., Carneiro, L., Firth, S., Coleman, H. A., Parkington, H. C., Le Bourhis, L., Karrar, A., Viala, J., Mak, J., et al. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2009.01404.x · Cited by 451
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Metadata
- Authors
- Travassos, L. H., Carneiro, L. A. M., Girardin, S. E., Boneca, I. G., Lemos, R., Bozza, M. T., Domingues, R. C. P., Coyle, A. J., Bertin, J., Philpott, D. J., & Plotkowski, M. C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-11
- Volume
- 280
- Issue
- 44
- Pages
- 36714-36718
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2138494261
- Cited by
- 166
- References
- 1
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Travassos, L. H., Carneiro, L. A. M., Girardin, S. E., Boneca, I. G., Lemos, R., Bozza, M. T., Domingues, R. C. P., Coyle, A. J., Bertin, J., Philpott, D. J., & Plotkowski, M. C. (2005). Nod1 Participates in the Innate Immune Response to Pseudomonas aeruginosa. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m501649200
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