Cited by 131FOXO transcription factor regulationProstate Cancer Treatment and ResearchPI3K/AKT/mTOR signaling in cancer

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Induction of Androgen Receptor Expression by Phosphatidylinositol 3-Kinase/Akt Downstream Substrate, FOXO3a, and Their Roles in Apoptosis of LNCaP Prostate Cancer Cells

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Yang, Lin, Xie, Shaozhen, Jamaluddin, Md. Saha, Altuwaijri, Saleh, Ni, Jing, Kim, Eungseok, Chen, Yei-Tsung, Hu, Yueh-Chiang, Wang, Liang, Chuang, Kuang-Hsiang, Wu, Chun-Te, Chang, Chawnshang·2005·Journal of Biological Chemistry

DOI 10.1074/jbc.m504461200

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Abstract

The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays important roles for prostate cancer cell survival, and the androgen receptor (AR) plays essential roles for prostate cancer cell proliferation. How these two signals cooperate to control cell growth and death, however, remains unclear and debated. Here we provide the first linkage by the identification of Forkhead transcription factor FOXO3a, the PI3K/Akt downstream substrate, as a positive regulator for the induction of AR gene expression. Both Western blot and real time PCR assays demonstrate that FOXO3a can induce AR expression at the protein and mRNA levels, and gel shift and chromatin immunoprecipitation assays further demonstrate that FOXO3a can induce 5' AR promoter activity via binding to the consensus DNA-binding sequence in the AR 5' promoter -1290 to -1297 (5'-TTGTTTCA-3'). Under normal growth conditions, blocking PI3K/Akt signals by LY294002 causes LNCaP cell arrest in G1 phase rather than apoptosis. However, further blocking of AR functions by AR small interfering RNA leads to dramatic LNCaP cell death, suggesting that AR may play important protective roles when the PI3K/Akt signal pathway is blocked by LY294002. Together, our data provide the first model to explain how PI3K/Akt and AR can cooperate to control LNCaP cell growth and death under normal conditions.

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The development of androgen-independent prostate cancer.
Feldman, B. J., & Feldman, D. (2001) · Nature reviews. Cancer · doi:10.1038/35094009 · Cited by 2,326
Androgen Receptor in Prostate Cancer
Heinlein, C. A., & Chang, C. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0032 · Cited by 1,780
Self-citation
Untitled work
(2004) · doi:10.1016/s0092-8674(04)00452-0 · Cited by 1,356
Molecular Cloning of Human and Rat Complementary DNA Encoding Androgen Receptors
Chang, C. S., Kokontis, J. M., & Liao, S. (1988) · Science · doi:10.1126/science.3353726 · Cited by 891
Self-citation
Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues
Furuyama, T., Nakazawa, T., Nakano, I., & Mori, N. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3490629 · Cited by 672
Cell cycle and death control: long live Forkheads
Burgering, B. M. T., & Kops, G. J. P. L. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02113-8 · Cited by 642
cell cycle and death control: long live Forkheads
Burgering, B. M. T., Medema, R. H., & Kops, G. J. P. L. (2002) · GBM Annual Fall meeting Halle 2002 · doi:10.1240/sav_gbm_2002_h_000075 · Cited by 584
The Roles of Androgen Receptors and Androgen-Binding Proteins in Nongenomic Androgen Actions
Heinlein, C. A., & Chang, C. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0070 · Cited by 568
Self-citation
Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues
Furuyama, T., Nakazawa, T., Nakano, I., et al. (2000) · Biochemical Journal · doi:10.1042/bj3490629 · Cited by 505
HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway.
Wen, Y., Hu, M. C. ‐., Makino, K., Spohn, B., Bartholomeusz, G. A., Yan, D., & Hung, M. (2000) · PubMed · Cited by 461

Show all 42 references

Research works printed but not linked: 7

Lin, 1999, Cancer Res., 59, 2891
Altuwaijri, 2003, Cancer Res., 63, 7106
Wen, 2000, Cancer Res., 60, 6841
Truica, 2000, Cancer Res., 60, 4709
Malik, 2002, Clin. Cancer Res., 8, 1168
Zegarra-Moro, 2002, Cancer Res., 62, 1008
Mizokami, 1994, Mol. Endocrinol., 8, 77

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Differential retention of α‐vitamin E is correlated with its transporter gene expression and growth inhibition efficacy in prostate cancer cells
Ni, J., Pang, S., & Yeh, S. (2007) · The Prostate · doi:10.1002/pros.20517 · Cited by 35
Self-citation
Classic and Novel Sex Hormone Binding Globulin Effects on the Cardiovascular System in Men
Basualto-Alarcón, C., Llanos, P., García‐Rivas, G., Troncoso, M. F., Lagos, D., Barrientos, G. C., & Estrada, M. (2021) · International Journal of Endocrinology · doi:10.1155/2021/5527973 · Cited by 35
GCP‐mediated growth inhibition and apoptosis of prostate cancer cells via androgen receptor‐dependent and ‐independent mechanisms
Tepper, C. G., Vinall, R. L., Wee, C. B., Xue, L., Shi, X.-B., Burich, R. A., Mack, P. C., & White, R. D. (2007) · The Prostate · doi:10.1002/pros.20548 · Cited by 34
Regulation of PSA secretion and survival signaling by calcium‐independent phopholipase A 2 β in prostate cancer cells
Nicotera, T. M., Schuster, D. P., Bourhim, M., Chadha, K. C., Klaich, G. M., & Corral, D. A. (2009) · The Prostate · doi:10.1002/pros.20968 · Cited by 33
Role of targeted therapy in the treatment of advanced prostate cancer
Fizazi, K. S., Sternberg, C. N., Fitzpatrick, J. M., Watson, R. W. G., & Tabesh, M. (2010) · British Journal of Urology · doi:10.1111/j.1464-410x.2010.09236.x · Cited by 32
FOXO3a mediates the cytotoxic effects of cisplatin in lung cancer cells
Liu, H., Yin, J., Wang, C., Gu, Y., Deng, M., & He, Z. (2014) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000000117 · Cited by 30
Improved survival of mesenchymal stem cells by macrophage migration inhibitory factor
Xia, W., Xie, C., Jiang, M., & Hou, M. (2015) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-015-2361-y · Cited by 29
Circulating IGF-1 promotes prostate adenocarcinoma via FOXO3A/BIM signaling in a double-transgenic mouse model
Wang, S., Wang, N., Yu, B., Cao, M., Wang, Y., Guo, Y., Zhang, Y., Zhang, P., Yu, X., Wang, S., et al. (2019) · Oncogene · doi:10.1038/s41388-019-0880-9 · Cited by 29
Androgen Receptor Dependence
Chaturvedi, A. P., & Dehm, S. M. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-32656-2_15 · Cited by 32
FOXO3, estrogen receptor alpha, and androgen receptor impact tumor growth rate and infiltration of dendritic cell subsets differentially between male and female mice
Thompson, M. G., Peiffer, D. S., Larson, M., Navarro, F. C., & Watkins, S. K. (2017) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-017-1972-4 · Cited by 28
Induction of Cancer Cell Death by Apigenin: A Review on Different Cell Death Pathways
Amini, P., Moazamiyanfar, R., Dakkali, M. S., Jafarzadeh, E., Ganjizadeh, M., Rastegar‐Pouyani, N., Moloudi, K., Khodamoradi, E., Taeb, S., & Najafi, M. (2023) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557523666230119110744 · Cited by 29
Co-Depletion of Cathepsin B and uPAR Induces G0/G1 Arrest in Glioma via FOXO3a Mediated p27Kip1 Upregulation
Gopinath, S., Malla, R. R., Gondi, C. S., Alapati, K., Fassett, D. R., Klopfenstein, J. D., Dinh, D. H., Gujrati, M., & Rao, J. S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011668 · Cited by 27
Retracted
FOXO Transcription Factors and their Role in Disorders of the Female Reproductive Tract
Christian, M., Lam, E. W. ‐., Wilson, M., & Brosens, J. J. (2011) · Current Drug Targets · doi:10.2174/138945011796150253 · Cited by 26
Clinical and biological significance of forkhead class box O 3a expression in glioma: mediation of glioma malignancy by transcriptional regulation of p27kip1
Shi, J., Zhang, L., Shen, A., Zhang, J., Wang, Y., Zhao, Y., Zou, L., Ke, Q., He, F., Wang, P., et al. (2009) · Journal of Neuro-Oncology · doi:10.1007/s11060-009-0045-8 · Cited by 27
Oxidative Stress Stimulates Testicular Orphan Receptor 4 through Forkhead Transcription Factor Forkhead Box O3a
Li, G., Lee, Y., Liu, S., Cai, Y., Xie, S., Liu, N.-C., Bao, B., Chen, Z.-D., & Chang, C. (2008) · Endocrinology · doi:10.1210/en.2008-0121 · Cited by 23
Self-citation
Non-nuclear AR Signaling in Prostate Cancer
Zamagni, A., Cortesi, M., Zanoni, M., & Tesei, A. (2019) · Frontiers in Chemistry · doi:10.3389/fchem.2019.00651 · Cited by 26
Blocking hyperactive androgen receptor signaling ameliorates cardiac and renal hypertrophy in Fabry mice
Shen, J.-S., Meng, X., Wight‐Carter, M., Day, T. S., Goetsch, S. C., Forni, S., Schneider, J. W., Liu, Z.-P., & Schiffmann, R. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv070 · Cited by 20
Significance of Nuclear Accumulation of Foxo3a in Esophageal Squamous Cell Carcinoma
Chen, M., Fang, F.-M., Lu, C.-H., Lu, M., Chen, W., Lee, K., & Lin, P.-Y. (2008) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2008.02.077 · Cited by 20
Sex differences in cancer and immunotherapy outcomes: the role of androgen receptor
Zhao, J., Wang, Q., Tan, A. F., Loh, C. J. L., & Toh, H. C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1416941 · Cited by 19
Increased Acetylation in the DNA-binding Domain of TR4 Nuclear Receptor by the Coregulator ARA55 Leads to Suppression of TR4 Transactivation
Xie, S., Ni, J., Lee, Y., Liu, S., Li, G., Shyr, C., & Chang, C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.208181 · Cited by 19
Self-citation
β‐arrestin1‐medieated inhibition of FOXO3a contributes to prostate cancer cell growth in vitro and in vivo
Kong, Z., Deng, T., Zhang, M., Zhao, Z., Liu, Y., Luo, L., Cai, C., Wu, W., & Duan, X. (2018) · Cancer Science · doi:10.1111/cas.13619 · Cited by 20
Inhibition of mTORC1 Kinase Activates Smads 1 and 5 but Not Smad8 in Human Prostate Cancer Cells, Mediating Cytostatic Response to Rapamycin
Wahdan-Alaswad, R. S., Bane, K. L., Song, K. W., Shola, D. T. N., Garcia, J. A., & Danielpour, D. (2012) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0615 · Cited by 18
Retracted
Molecular Regulation of Androgen Receptors in Major Female Reproductive System Cancers
Wu, S. V., Yu, K., Lian, Z., & Deng, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147556 · Cited by 18
5α‐androstane‐3α,17β‐diol supports human prostate cancer cell survival and proliferation through androgen receptor‐independent signaling pathways: Implication of androgen‐independent prostate cancer progression
Yang, Q., Titus, M. A., Fung, K., & Lin, H. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21731 · Cited by 18
Combined Anti-Cancer Effects of Platycodin D and Sorafenib on Androgen-Independent and PTEN-Deficient Prostate Cancer
Lu, Z., Song, W., Zhang, Y., Wu, C.-P., Zhu, M., He, W., Li, N., Zhou, Y., & Xu, H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.648985 · Cited by 16
Self-citation
Foxo3
Dobson, M., & Tzivion, G. (2011) · AfCS-Nature Molecule Pages · doi:10.1038/mp.a000945.01 · Cited by 14

Authors: Yang, L., Xie, S., Jamaluddin, M. S., Altuwaijri, S., Ni, J., Kim, E., Chen, Y.-T., Hu, Y.-C., Wang, L., Chuang, K.-H., Wu, C.-T., & Chang, C.
Affiliations: The University of Texas MD Anderson Cancer Center (US)
University of Rochester Medicine (US)
Baylor College of Medicine (US)
Chang Gung University (TW)
Corresponding author: Chang, Chawnshang
ORCID: Yang, Lin
Altuwaijri, Saleh
Ni, Jing
Kim, Eungseok
Chen, Yei-Tsung
Hu, Yueh-Chiang
Wang, Liang
Wu, Chun-Te
Chang, Chawnshang
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2005-09
Volume: 280
Issue: 39
Pages: 33558-33565
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m504461200
OpenAlex: W2158889317
Cited by: 131
References: 42
Citations by year: 2025: 1 · 2024: 5 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 9 · 2014: 6 · 2013: 5 · 2012: 8
FWCI: 3.64
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 5511 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r29ca071870-05)
National Cancer Institute (CA55639, CA-71870)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 60948, R01DK067686, DK67686, R01DK060948)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › FOXO transcription factor regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: androgen receptor, FOXO3, PI3K/Akt signaling, prostate cancer, apoptosis, LNCaP cells, transcriptional regulation, G1 cell cycle arrest, LY294002
MeSH terms: Forkhead Box Protein O3, Phosphoinositide-3 Kinase Inhibitors, Chromones, Enzyme Inhibitors, Humans, Male, Models, Biological, Morpholines, Promoter Regions, Genetic, Prostatic Neoplasms, Receptors, Androgen, RNA, Messenger, Gene Expression Regulation, Neoplastic, Apoptosis, Prostate-Specific Antigen, Phosphatidylinositol 3-Kinases, RNA, Small Interfering, Cell Line, Tumor, Chromatin Immunoprecipitation, Forkhead Transcription Factors, Androgen Receptor Antagonists

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Induction of Androgen Receptor Expression by Phosphatidylinositol 3-Kinase/Akt Downstream Substrate, FOXO3a, and Their Roles in Apoptosis of LNCaP Prostate Cancer Cells

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