Redox Imbalance in Cystine/Glutamate Transporter-deficient Mice

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Absence of system xc − on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis

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System Xc− inhibition blocks bone marrow-multiple myeloma exosomal crosstalk, thereby countering bortezomib resistance

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Effects of long-term zinc supplementation on plasma thiol metabolites and redox status in patients with age-related macular degeneration.

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The viability of primary hepatocytes is maintained under a low cysteine-glutathione redox state with a marked elevation in ophthalmic acid production

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Cystine/glutamate transporter, system x c − , is involved in nitric oxide production in mouse peritoneal macrophages

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Cystine/glutamate antiporter blockage induces myelin degeneration

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Catabolism of extracellular glutathione supplies cysteine to support tumours

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System xc− in microglia is a novel therapeutic target for post-septic neurological and psychiatric illness

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Heteromeric Amino Acid Transporters in Brain: from Physiology to Pathology

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Age-dependent oxidation of extracellular cysteine/cystine redox state (Eh(Cys/CySS)) in mouse lung fibroblasts is mediated by a decline in Slc7a11 expression

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RGS4 deficit in prefrontal cortex contributes to the behaviors related to schizophrenia via system xc--mediated glutamatergic dysfunction in mice

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Role of ferroptosis in Porphyromonas gingivalis- induced impairment of epithelial junction

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Leishmania panamensis infection and antimonial drugs modulate expression of macrophage drug transporters and metabolizing enzymes: impact on intracellular parasite survival

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Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B‐containing N‐methyl‐ d ‐aspartate–sensitive glutamate receptor signaling

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Advances in ferroptosis for castration-resistant prostate cancer treatment: novel drug targets and combination therapy strategies

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Cystine/glutamate antiporter xCT deficiency reduces metastasis without impairing immune system function in breast cancer mouse models

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xCT deficiency aggravates acetaminophen-induced hepatotoxicity under inhibition of the transsulfuration pathway

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Pancreatic acinar cell fate relies on system xC- to prevent ferroptosis during stress

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A Literature Review of Glutathione Therapy in Ameliorating Hepatic Dysfunction in Non-Alcoholic Fatty Liver Disease

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RNF126-mediated ubiquitination of FSP1 affects its subcellular localization and ferroptosis

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Ferroptosis in Ischemic Stroke and Related Traditional Chinese Medicines

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High-Throughput Assay Development for Cystine-Glutamate Antiporter (xc-) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells

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Identification, Expression, and Roles of the Cystine/Glutamate Antiporter in Ocular Tissues

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MPTP-induced parkinsonism in mice alters striatal and nigral xCT expression but is unaffected by the genetic loss of xCT

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Ferroptosis: An Emerging Target for Bladder Cancer Therapy

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Change of cystine/glutamate antiporter expression in ethanol-dependent rats

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Iron-mediated oxidative cell death is a potential contributor to neuronal dysfunction induced by neonatal hemolytic hyperbilirubinemia

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Development of a primary microglia screening assay and its use to characterize inhibition of system xc- by erastin and its analogs

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A Negative Correlation Between Expression Profiles of Runt-Related Transcription Factor-2 and Cystine/Glutamate Antiporter xCT Subunit in Ovariectomized Mouse Bone

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Differential Regulation of the Extracellular Cysteine/Cystine Redox State (EhCySS) by Lung Fibroblasts from Young and Old Mice

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Spermatogonial Gene Networks Selectively Couple to Glutathione and Pentose Phosphate Metabolism but Not Cysteine Biosynthesis

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Cystine–glutamate antiporter deletion accelerates motor recovery and improves histological outcomes following spinal cord injury in mice

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Plasma L-Cystine/L-Glutamate Imbalance Increases Tumor Necrosis Factor-Alpha from CD14+ Circulating Monocytes in Patients with Advanced Cirrhosis

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Cysteine Depletion-Initiated Redox Imbalance Evokes Ferroptosis and Pyroptosis for Enhanced Pancreatic Cancer Therapy

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Mutation of ataxia–telangiectasia mutated is associated with dysfunctional glutathione homeostasis in cerebellar astroglia

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Genetic and pharmacological manipulation of glial glutamate transporters does not alter infection-induced seizure activity

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Sulfasalazine decreases astrogliosis‐mediated seizure burden

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Pharmacological targets for the induction of ferroptosis: Focus on Neuroblastoma and Glioblastoma

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Decreased reproductive performance in xCT-knockout male mice

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Decreased epileptogenesis in mice lacking the System xc− transporter occurs in association with a reduction in AMPA receptor subunit GluA1

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Downregulation of Cystine Transporter xc– by Irinotecan in Human Head and Neck Cancer FaDu Xenografts

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Cystine/Glutamate antiporter system xc- deficiency impairs macrophage glutathione metabolism and cytokine production

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S-Adenosylmethionine Alleviates Amyloid-β-Induced Neural Injury by Enhancing Trans-Sulfuration Pathway Activity in Astrocytes

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The Solute Carrier Family 7 Member 11 (SLC7A11) is Regulated by LH/Androgen and Required for Cystine/Glutathione Homeostasis in Mouse Sertoli Cells

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The Role of Ferric Nitrilotriacetate in Renal Carcinogenesis and Cell Death: From Animal Models to Clinical Implications

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Implication of system xc− in neuroinflammation during the onset and maintenance of neuropathic pain

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The metabolites from traditional Chinese medicine targeting ferroptosis for cancer therapy

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Natural products targeting ferroptosis pathways in cancer therapy (Review)

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Tonic extracellular glutamate and ischaemia: glutamate antiporter system xc− regulates anoxic depolarization in hippocampus

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Localisation of novel forms of glutamate transporters and the cystine-glutamate antiporter in the choroid plexus: Implications for CSF glutamate homeostasis

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Mapping of the cystine–glutamate exchanger in the mouse eye: a role for xCT in controlling extracellular redox balance

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Overview of cysteine metabolism

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Reactive oxygen species and cancer

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Chronic Sulfasalazine Treatment in Mice Induces System xc− - Independent Adverse Effects

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Role of Transmembrane Domain 8 in Substrate Selectivity and Translocation of SteT, a Member of the l-Amino Acid Transporter (LAT) Family

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Zonisamide attenuates lactacystin-induced parkinsonism in mice without affecting system xc−

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Impact of sex, age and diet on the cysteine/cystine and glutathione/glutathione disulfide plasma redox couples in mice

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Excess cysteine drives conjugate formation and impairs proliferation of NRF2-activated cancer cells

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Importance of Autophagy in Mediating Cellular Responses to Iron Overload in Cardiomyocytes

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Hydrogen peroxide triggers an increase in cell surface expression of system xc− in cultured human glioma cells

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Low-level developmental lead exposure does not predispose to adult alcohol self-administration, but does increase the risk of relapsing to alcohol seeking in mice: Contrasting role of GLT1 and xCT brain expression

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D-Cysteine supplementation partially protects against ferroptosis induced by xCT dysfunction via increasing the availability of glutathione

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Cystathionine Is a Novel Substrate of Cystine/Glutamate Transporter

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The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond

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(4 S)-4-(3-[ 18 F]Fluoropropyl)- l-glutamate

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The cystine/cysteine cycle: a redox cycle regulating susceptibility versus resistance to cell death

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System xc− and Thioredoxin Reductase 1 Cooperatively Rescue Glutathione Deficiency

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