Redox Imbalance in Cystine/Glutamate Transporter-deficient Mice

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Cystathionine Is a Novel Substrate of Cystine/Glutamate Transporter

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Cross Talk Between Ferroptosis and Cerebral Ischemia

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Double-edged roles of ferroptosis in endometriosis and endometriosis-related infertility

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xCT deficiency accelerates chemically induced tumorigenesis

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Loss of the cystine/glutamate antiporter in melanoma abrogates tumor metastasis and markedly increases survival rates of mice

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Inhibiting xCT/SLC7A11 induces ferroptosis of myofibroblastic hepatic stellate cells but exacerbates chronic liver injury

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Superoxide produced by mitochondrial complex III plays a pivotal role in the execution of ferroptosis induced by cysteine starvation

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Inhibition of SLC7A11 by Sulfasalazine Enhances Osteogenic Differentiation of Mesenchymal Stem Cells by Modulating BMP2/4 Expression and Suppresses Bone Loss in Ovariectomized Mice

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Iron homeostasis and neurodegeneration in the ageing brain: Insight into ferroptosis pathways

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Bovine herpesvirus 4-based vector delivering the full length xCT DNA efficiently protects mice from mammary cancer metastases by targeting cancer stem cells

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Immunotargeting of the xCT Cystine/Glutamate Antiporter Potentiates the Efficacy of HER2-Targeted Immunotherapies in Breast Cancer

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Behavioral characterization of system xc- mutant mice

McCullagh, E. A., & Featherstone, D. E. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.02.010 · Cited by 41

Corticostriatal dysfunction and social interaction deficits in mice lacking the cystine/glutamate antiporter

Bentea, E., Villers, A., Moore, C., Funk, A. J., O'Donovan, S. M., Verbruggen, L., Lara, O., Janssen, P., Pauw, L. D., Declerck, N. B., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0751-3 · Cited by 41

xCT modulation in gliomas: Relevance to energy metabolism and tumor microenvironment normalization

Savaskan, N. E., & Eyüpoglu, I. Y. (2010) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2010.07.003 · Cited by 41

Induction of cystine/glutamate transporter in bacterial lipopolysaccharide induced endotoxemia in mice

Taguchi, K., Tamba, M., Bannai, S., & Sato, H. (2007) · Journal of Inflammation · doi:10.1186/1476-9255-4-20 · Cited by 41

Dissection of mitogenic and neurodegenerative actions of cystine and glutamate in malignant gliomas

Savaskan, N. E., Seufert, S., Hauke, J., Tränkle, C., Eyüpoglu, I. Y., & Hahnen, E. (2010) · Oncogene · doi:10.1038/onc.2010.391 · Cited by 40

xCT increases tuberculosis susceptibility by regulating antimicrobial function and inflammation

Cai, Y., Yang, Q., Liao, M., Wang, H., Zhang, C., Nambi, S., Wang, W., Zhang, M., Wu, J., Deng, G., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9052 · Cited by 42

Amino Acid Transporters Are a Vital Focal Point in the Control of mTORC1 Signaling and Cancer

Cormerais, Y., Vučetić, M., Parks, S. K., & Pouysségur, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010023 · Cited by 45

Treatment of early brain injury after subarachnoid hemorrhage in the rat model by inhibiting p53-induced ferroptosis

Kuang, H., Wang, T., Liu, L., Tang, C., Li, T., Ming, L., Wang, T., Zhong, W., & Wang, Y. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136134 · Cited by 41

Regulation of Hippocampal Synaptic Strength by Glial xCT

Williams, L. E., & Featherstone, D. E. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1267-14.2014 · Cited by 40

5-ALA-PDT induced ferroptosis in keloid fibroblasts via ROS, accompanied by downregulation of xCT, GPX4

Zhang, J., Liu, L., Liu, L., Shen, X., Yang, G., Deng, Y., Hu, Z., Zhang, J., & Lu, Y. (2023) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2023.103612 · Cited by 41

Focus on Molecules: The cystine/glutamate exchanger (System xc−)

Lim, J. C.-H., & Donaldson, P. J. (2010) · Experimental Eye Research · doi:10.1016/j.exer.2010.05.007 · Cited by 39

Stress as an Intercellular Signal: The Emergence of Stress-Associated Molecular Patterns (SAMP)

Rubartelli, A., & Sitia, R. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2377 · Cited by 39

Neurodegeneration in the Brain Tumor Microenvironment: Glutamate in the Limelight

Savaskan, N. E., Fan, Z., Broggini, T., Buchfelder, M., & Eyüpoglu, I. Y. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150122224158 · Cited by 38

G enetic deletion of x CT attenuates peripheral and central inflammation and mitigates LPS ‐induced sickness and depressive‐like behavior in mice

Albertini, G., Deneyer, L., Ottestad‐Hansen, S., Zhou, Y., Ates, G., Walrave, L., Demuyser, T., Bentea, E., Sato, H., Bundel, D. D., et al. (2018) · Glia · doi:10.1002/glia.23343 · Cited by 37

Functional role of ferroptosis on cancers, activation and deactivation by various therapeutic candidates-an update

Nguyen, T. H. P., Mahalakshmi, B., & Velmurugan, B. K. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.108930 · Cited by 37

Amino Acid Transporters on the Guard of Cell Genome and Epigenome

Kahya, U., Köseer, A. S., & Dubrovska, A. (2021) · Cancers · doi:10.3390/cancers13010125 · Cited by 37

Antioxidant nanozyme counteracts HIV‐1 by modulating intracellular redox potential

Singh, S. T., Ghosh, S., Pal, V. K., Munshi, M., Shekar, P., Narasimhamurthy, D. T., Mugesh, G., & Singh, A. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202013314 · Cited by 37

Carnosine dipeptidase II (CNDP2) protects cells under cysteine insufficiency by hydrolyzing glutathione-related peptides

Kobayashi, S., Homma, T., Okumura, N., Han, J., Nagaoka, K., Sato, H., Konno, H., Yamada, S., Takao, T., & Fujii, J. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.07.036 · Cited by 37

Downregulation of glutaredoxin but not glutathione loss leads to mitochondrial dysfunction in female mice CNS: Implications in excitotoxicity

Diwakar, L., Kenchappa, R. S., Jayasree Annepu, B., & Ravindranath, V. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.03.008 · Cited by 37

FGF2 Alleviates Microvascular Ischemia-Reperfusion Injury by KLF2-mediated Ferroptosis Inhibition and Antioxidant Responses

Chen, F., Zhan, J., Liu, M., Mamun, A. A., Huang, S., Tao, Y., Zhao, J., Zhang, Y., Xu, Y., He, Z., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.85692 · Cited by 36

Cystathionine Is a Novel Substrate of Cystine/Glutamate Transporter

Kobayashi, S., Sato, M., Kasakoshi, T., Tsutsui, T., Sugimoto, M., Osaki, M., Okada, F., Igarashi, K., Hiratake, J., Homma, T., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.625053 · Cited by 87

The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond

Conrad, M., & Sato, H. (2011) · Amino Acids · doi:10.1007/s00726-011-0867-5 · Cited by 621

(4 S)-4-(3-[ 18 F]Fluoropropyl)- l-glutamate

Chopra, A. (2004) · Europe PMC (PubMed Central)

The cystine/cysteine cycle: a redox cycle regulating susceptibility versus resistance to cell death

Banjac, A., Perisic, T., Sato, H., Seiler, A., Bannai, S., Weiss, N., Kölle, P., Tschoep, K., Issels, R. D., Daniel, P. T., et al. (2007) · Oncogene · doi:10.1038/sj.onc.1210796 · Cited by 324

System xc− and Thioredoxin Reductase 1 Cooperatively Rescue Glutathione Deficiency

Mandal, P. K., Seiler, A., Perisic, T., Kölle, P., Banjac Canak, A., Förster, H., Weiss, N., Kremmer, E., Lieberman, M. W., Bannai, S., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.121327 · Cited by 269