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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

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Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

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The Sir2 Family of Protein Deacetylases

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The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors

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Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration

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Tankyrase, a Poly(ADP-Ribose) Polymerase at Human Telomeres

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Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans

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Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate.

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p53 controls choice between apoptotic and non-apoptotic death following DNA damagePreprint

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Multi-omics Characterization of Acquired Olaparib Resistance in BRCA1 and BRCA2 Mutant Breast Cancer Cell Lines

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SCFFBXO21-mediated ubiquitination and degradation of NMNAT2 regulates axon survival in nerve injury

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Need for NAD+: Focus on Striated Muscle Laminopathies

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Nmnat1 Deficiency Causes Mitoribosome Excess in Diabetic Nephropathy Mediated by Transcriptional Repressor HIC1

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NMNAT1 Is Essential for Human iPS Cell Differentiation to the Retinal Lineage

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Proteomic analysis through larval development of Solea senegalensis flatfish

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NAD+ as a Target for Cancer Treatment

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Deletion of Nmnat1 in Skeletal Muscle Leads to the Reduction of NAD+ Levels but Has No Impact on Skeletal Muscle Morphology and Fiber Types

Karim, M., Iqbal, T., Nawaz, A., Yaku, K., & Nakagawa, T. (2023) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.69.184 · Cited by 4

Niacin

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NMNAT2 in cortical glutamatergic neurons exerts both cell and non-cell autonomous influences to shape cortical development and to maintain neuronal healthPreprint

Niou, Z., Yang, S., Sri, A., Rodriquez, H., Gilley, J., Coleman, M. P., & Lu, H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.05.479195 · Cited by 3

Protein Acetylation and NAD+ Homeostasis in Aging Muscle

Ji, L. L. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-88361-3_17 · Cited by 3

DLK, NMNAT2, and SARM1: Judge, Jury, and Executioner in Axon Degeneration

Hinz, F. I., & Hoogenraad, C. C. (2026) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-051424-045840 · Cited by 3

Loss-of-function approach using mouse retinal explants showed pivotal roles of Nmnat2 in early and middle stages of retinal development

Kuribayashi, H., Katahira, M., Aihara, M., Suzuki, Y., & Watanabe, S. (2022) · Molecular Biology of the Cell · doi:10.1091/mbc.e22-03-0078 · Cited by 3

Establishment of Model Mice to Evaluate Low Niacin Nutritional Status

MIZUTANI, A., Miu, S. A. T. O., Fujigaki, H., Yamamoto, Y., Saito, K., Hatayama, S., & Fukuwatari, T. (2023) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.69.305 · Cited by 3

Decreased mitochondrial NAD+ in WRN deficient cells links to dysfunctional proliferation

Lautrup, S., Zhang, S.-Q., Funayama, S., Lirussi, L., Visnovska, T., Cheung, H., Niere, M., Tian, Y., Nilsen, H. L., Selbæk, G., et al. (2025) · Aging · doi:10.18632/aging.206236 · Cited by 3

Chemoenzymatic Preparation of 4′‐Thioribose NAD+

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The Role of NAD+ in Anti-Aging Therapies

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Identification and characterization of NMNAT1 gene mutations in an Iranian patient with Leber congenital amaurosis 9

Neissi, M., Sheikh‐Hosseini, M., Mohammadi‐Asl, M., Al‐Badran, A. I., Roghani, M., Asl, J. M., & Jorfi, K. (2024) · Clinical Case Reports · doi:10.1002/ccr3.9506 · Cited by 6

Identification and sub-cellular localization of a NAD transporter in Leishmania braziliensis (LbNDT1)

Herrera, D. S. M., Contreras-Rodríguez, L. E., Castellanos, C. C. R., & Ramírez-Hernández, M. H. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e04331 · Cited by 3

Nicotinamide adenine dinucleotide+ metabolism biomarkers in malignant gliomas

Lucena-Cacace, A., Jiménez-García, M. P., & Verdugo-Sivianes, E. (2016) · Cancer translational medicine · doi:10.4103/2395-3977.196912 · Cited by 3

Improved Yield for the Enzymatic Synthesis of Radiolabeled Nicotinamide Adenine Dinucleotide

Eller, J., Goyal, S., & Cambronne, X. A. (2023) · ACS Bio & Med Chem Au · doi:10.1021/acsbiomedchemau.2c00065 · Cited by 3

Nicotinamide Mononucleotide Reduces Iron in BV-2 Cell by Up-Regulating Ferroportin 1 via Inhibiting the IL-6/STAT3/Hepcidin Pathway

Qian, Z., Ma, H., Chen, Y.-J., & Guo, Q. (2025) · Rejuvenation Research · doi:10.1177/15491684251405189 · Cited by 2

Subcellular Redistribution of Endomembrane GPR15 Promotes NAD+-Mediated Metabolic Reprogramming and Boosts 5-FU Chemosensitivity in Colorectal Cancer

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Mechanisms of NAD+ Homeostasis in Aging and Disease

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NAD⁺ circuits in aging, tissue repair and fibrosis

Izadpanah, R., Rappaport, J., & Alt, E. U. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103305 · Cited by 5

Targeting DNA Repair Pathways for Cancer Therapy

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Nmnat1-Rbp7 Is a Conserved Fusion-Protein That Combines NAD+ Catalysis of Nmnat1 with Subcellular Localization of Rbp7

Chen, H., Babino, D., Schönbichler, S. A., Arkhipova, V., Töchterle, S., Martin, F., Huck, C. W., Lintig, J. V., & Meyer, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143825 · Cited by 2

Expression, purification, and enzymatic activity assay of nicotinamide mononucleotide adenylyltransferase: Expression, purification, and enzymatic activity assay of nicotinamide mononucleotide adenylyltransferase

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Kinetic and oligomeric study of Leishmania braziliensis nicotinate/nicotinamide mononucleotide adenylyltransferase

Contreras-Rodríguez, L. E., Ziegler, M., & Ramírez-Hernández, M. H. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03733 · Cited by 2

Epigenetic role of sirtuins in neurodegenerative brain disorders

Khanna, A., Anamika, A., & Trigun, S. K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-814118-2.00009-4 · Cited by 3

Metabolic Regulation of Lysine Acetylation: Implications in Cancer

Singh, S., Senapati, P., & Kundu, T. K. (2022) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-07634-3_12 · Cited by 2

A Novel Coenzyme A Analogue in the Anaerobic, Sulfate‐Reducing, Marine Bacterium Desulfobacula toluolica Tol2T

Bruns, S., Cakić, N., Mitschke, N., Kopke, B., Rabus, R., & Wilkes, H. (2022) · ChemBioChem · doi:10.1002/cbic.202200584 · Cited by 2

Pharmacological Approaches for Modulating Sirtuins

Kane, A. E., & Sinclair, D. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813499-3.00006-x · Cited by 2

Structural insights into Plasmodium falciparum nicotinamide mononucleotide adenylyltransferase: oligomeric assembly

Contreras-Rodríguez, L. E., Marin-Mogollon, C. Y., Sánchez-Mejía, L. M., & Ramírez-Hernández, M. H. (2018) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/0074-02760180073 · Cited by 2

Targeted deletion of Nmnat1 in mouse retina leads to early severe retinal dystrophyPreprint

Wang, X., Yu, F. H. Z., Liao, R., & Wang, T. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/210757 · Cited by 2

NAD + repletion rescues female fertility during reproductive ageingPreprint

Bertoldo, M. J., Listijono, D. R., Ho, W.-H. J., Riepsamen, A. H., Jin, X. L., Selesniemi, K. L., Goss, D. M., Mahbub, S. B., Campbell, J. M., Habibalahi, A., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/721985 · Cited by 2

The role of nicotinamide adenine dinucleotide salvage enzymes in cardioprotection

Kibria, F., DAS, S. K., & Arefin, M. S. (2024) · Polish Journal of Cardio-Thoracic Surgery · doi:10.5114/kitp.2024.141145 · Cited by 1

The Roles of Moonlighting Nicotinamide Mononucleotide Adenylyl Transferases in Cell Physiology

Lee, Y., & Lin, S.-J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26189098 · Cited by 2

Mitochondrial NMNAT3 reduces amyloid aggregates in Drosophila and alters the amyloid processing in the 3xTgAD mouse

Yi, Z., Juvvadi, N., Zhai, R. G., Moraes, C. T., & Pinto, M. (2026) · Mitochondrial Communications · doi:10.1016/j.mitoco.2026.01.001 · Cited by 2

Localization and phosphorylation of Plasmodium falciparum nicotinamide/nicotinate mononucleotide adenylyltransferase (PfNMNAT) in intraerythrocytic stages

Nieto‐Clavijo, C., Sánchez, L. M. V., Sánchez-Lancheros, D. M., Díaz, G. J., & Ramírez, M. H. (2018) · Malaria Journal · doi:10.1186/s12936-018-2307-4 · Cited by 1

Nicotinamide Mononucleotide Adenylyl Transferase 2 Inhibition Aggravates Neurological Damage after Traumatic Brain Injury in a Rat Model

Gu, X., Ni, H., Kan, X., Chen, C., Zhou, Z., Ding, Z., Li, D., & Liu, B. (2022) · Journal of Korean Neurosurgical Society · doi:10.3340/jkns.2022.0115 · Cited by 1

Nmnat3 deficiency in hemolytic anemia exacerbates malaria infection

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Inhibiting HSD17B8 suppresses the cell proliferation caused by PTEN failure

Zhao, W., Huang, R., Ran, D., Zhang, Y., Qu, Z., & Zheng, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-63052-5 · Cited by 1

Synthesis, Biological, and Computational Evaluations of Conformationally Restricted NAD-Mimics as Discriminant Inhibitors of Human NMN-Adenylyltransferase Isozymes

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Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD + , Suppresses Glycolysis, TCA Cycle and Cell GrowthPreprint

Liu, Y., Luo, C., Li, T., Zhang, W., Zong, Z., Liu, X., & Deng, H. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.03.366427 · Cited by 1

NAD homeostasis maintained by NMNAT2 supports vesicular glycolysis and fuels fast axonal transport in distal axons of cortical glutamatergic neurons in micePreprint

Yang, S., Niou, Z., Enriquez, A., LaMar, J., Huang, J.-Y., Ling, K., Jafar‐Nejad, P., Gilley, J., Coleman, M. P., Tennessen, J. M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.06.479307 · Cited by 2

Newcastle disease virus elevates its replication by instigating oxidative stress-driven Sirtuin 7 productionPreprint

Shokeen, K., & Kumar, S. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.10.511685 · Cited by 1

NAD+ biosynthesis as a collateral lethality target for precision oncologyPreprint

Müller, F. L., Deng, P., Lin, Y.-H., Satani, N., Hammoudi, N., Mohapatra, G., Asara, J. M., & DePinho, R. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.13.518967 · Cited by 1

NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transportPreprint

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NMNAT1 Binding at Promoters and Enhancers Couples NAD + Synthesis to RNA Polymerase II EngagementPreprint

Cedeno, Y. C., Taylor, S. J., Gamble, M. J., Steidl, U. G., & Coleman, R. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.30.651499 · Cited by 1

Sirtuins as Potential Drug Targets for Metabolic Diseases

Tong, Q. (2011) · Wiley eBooks · doi:10.1002/9780470910016.ch15

Functions and Regulation of eukaryotic NAD kinase - an essential enzyme for NADP biosynthesis

Pollak, N. (2008) · NORA - Norwegian Open Research Archives

Modulation of the Poly(ADP-ribosyl)ation Reaction via the Arabidopsis ADP-Ribose/NADH Pyrophosphohydrolase, AtNUDX7, Is Involved

Ishikawa, K., Ogawa, T., Hirosue, E., Nakayama, Y., Harada, K., Fukusaki, E., Yoshimura, K., & Shigeoka, S. (2009)

NicotinamideMononucleotideAdenylyltransferase ExpressioninMitochondrialMatrixDelaysWallerian Degeneration

Araki, T. (2009)

Significance of Mechanism-Oriented Research Toward Neuronal Protection Therapy Against Neurodegenerative Disorders ~ ZNRF1 E3 Ubiquitin Ligase as a Critical Mediator for Wallerian Degeneration and Neuronal Apoptosis

Wakatsuki, S., & Araki, T. (2015) · Springer eBooks · doi:10.1007/978-4-431-54541-5_8

THE P53-NMNAT2 FEEDBACK REGULATORY LOOP: MECHANISMS UNDERLYING P53 ACTIVATION

Pan, L.-Z. (2012) · Library and Archives Canada (Government of Canada)

Heterochromatin effects in Friedreich's ataxia and sexual dimorphism

Yandım, C. (2012) · Spiral (Imperial College London) · doi:10.25560/9644

Regulation of Regenerative and Degenerative Responses to Axonal Injury

Hao, Y. (2017) · Deep Blue (University of Michigan)

The Metabolomics Study of the Shexiang Baoxin Pill

Jiang, P., Liu, R., & Zhang, W. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812744-5.00011-4

Diurnal Rhythms of Tyrosine Hydroxylase Expression are Regulated by NAD Cellular Redox and SIRT1Preprint

Logan, R. W., Parekh, P. K., Williams, W. P., Kaplan, G. N., Becker‐Krail, D. D., Yamaguchi, S., Yoshino, J., Shelton, M. A., Zhu, X., Zhang, H., et al. (2018) · SSRN Electronic Journal · doi:10.2139/ssrn.3155572

NAD + Modulation

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The Investigation of Cell Adhesion Molecules in the Lung Tissues of Cattle with Cystic Echinococcosis

YAVUZ, O., Dinçel, G. Ç., GÖKPINAR, S., & Haydardedeoğlu, A. E. (2019) · Etlik Veteriner Mikrobiyoloji Dergisi · doi:10.35864/evmd.586538

Axon pathology in mouse models of Huntington's disease

Marangoni, M. (2014) · Nottingham ePrints (University of Nottingham)

Study of the effects of macroautophagy deficiency on mitochondrial function, energy metabolism and cell fate

Sedlackova, L. (2020)

Role of SIRT3 and Mitochondrial Dysfunction in Neurodegeneration

Hor, J., Santosa, M. M., & Ng, S. (2021) · Neuromethods · doi:10.1007/978-1-0716-1712-0_5

"Clickable" chain terminator NAD + analogs for labeling substrate proteins of poly(ADP-ribose) polymerases

Grzywa, M. (2015)

Regulation of Chromatin Structure and Function by PARP-1 and ADP-Ribosylation

Liu, Z., & Kraus, W. L. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8624-4_7

Faculty Opinions recommendation of Boosting NAD+ with a small molecule that activates NAMPT.

Imai, S., & Johnson, S. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736227685.793563661

Sirtuin Activators

Kane, A. E., & Sinclair, D. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.62135-9

Faculty Opinions recommendation of NAD+ cellular redox and SIRT1 regulate the diurnal rhythms of tyrosine hydroxylase and conditioned cocaine reward.

Karatsoreos, I. N. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733181688.793564070

Faculty Opinions recommendation of Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import.

Stieger, B. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.739132008.793581107

Nutraceuticals for targeting NAD+ to restore mitochondrial function

Garten, A., & Lavery, G. G. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90256-4.00019-9

Impact of the NAD+ salvage pathway on the motor system and bioenergetics

Lundt, S. (2023) · MOspace Institutional Repository (University of Missouri) · doi:10.32469/10355/96990

Metabolism and Receptor Mechanisms of Niacin Action

Boronovskiy, S. E., Сергеевна, К. В., & Nartsissov, Y. R. (2023) · Tsitologiya · doi:10.31857/s0041377123060032

The Fluorinated NAD Precursors Enhance FK866 Cytotoxicity by Activating SARM1 in Glioblastoma Cells

He, W. M., Yang, J. Y., Zhao, Z. Y., Xiao, W., Li, W. H., & Zhao, Y. J. (2024) · Biology · doi:10.3390/biology13090649

Proteomic analysis of synergetic neuroprotective effect of adenosine, thiamine, niacin and cyanocobalamin in pathophysiology of diabetic polyneuropathy

Громова, О. А., Torshin, I. Y., & Мойсеенок, А. Г. (2024) · FARMAKOEKONOMIKA Modern Pharmacoeconomics and Pharmacoepidemiology · doi:10.17749/2070-4909/farmakoekonomika.2024.285

Nuclear NAD+ synthase nicotinamide mononucleotide adenylyltransferase 1 contributes to nuclear atypia and promotes glioma growth

Liu, J., Zhu, Y., Canic, T., Diaz-Perez, Z., Gultekin, S. H., & Zhai, R. G. (2025) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdaf029

Identification, Source, and Intracellular Distribution of Nicotinamide Coenzyme I

Shen, J., Li, S., Liu, N., Huang, Q., Rui, Y., & Wang, Y. (2025) · Springer eBooks · doi:10.1007/978-981-97-9877-3_3

Nicotinamide Adenine Dinucleotide and Heart Disease

Zhao, K., Zhu, J., & Sheng, R. (2025) · Springer eBooks · doi:10.1007/978-981-97-9877-3_23

Estrogens protect bone mass by inhibiting NAD + metabolism in osteoclastsPreprint

Marques-Carvalho, A., Adam, G. O., Chalke, A., Resende-Coelho, A., Reyes‐Castro, O., Warren, A., Grilo, L. F., Chini, C. C. S., Stronach, B., Alturkmani, F., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.11.664289

Meclizine rescues cardiac function and mitochondrial ultrastructure by ATP- and glycolysis-independent mechanisms in a genetic model of mitochondrial energy dysfunctionPreprint

Ghazal, N., Huang, B. X., Shoemaker, L. J., Faúndez, V., & Kwong, J. Q. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.03.674000

SARM1, the executioner of axon degeneration, is an ADP-ribosyl transferase and autoMARylation negatively regulates its activationPreprint

Icso, J. D., DeOrsey, L., Barasa, L., Kelch, B. A., & Thompson, P. R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.12.675907

NAD+ as a Target for Cancer Treatment

Helman, T. J., & Braidy, N. (2025) · Springer eBooks · doi:10.1007/978-3-032-00771-1_269

The combination of Anoectochilus roxburghii and Danggui-Niantong decoction ameliorates hyperuricemia by regulating NAD+ metabolism and urate transport in rats

Li, D., Tao, Z., Xu, H., Chen, R., Lei, S., Lei, M., Zhou, H., Mo, Y., Fu, C., & Yu, L. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.157822

Potent Neuronal Nicotinamide Adenine Dinucleotide-Boosting Tetrahydroquinoxalines: Structure–Activity Relationships and Early Drug Metabolism and Pharmacokinetics Evaluation

Cuřínová, P., Jöe, M., Cesar, F., Nicol, A., Schwan, K., Kohout, M., Varricchio, C., Saleh, A., Wheelock, C. E., Jóhannesson, G., et al. (2026) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.6c00058

Sirt3, une déacetylase mitochondriale NAD+dépendante, est impliquée dans la regulation de la différenciation des myoblastes

Khalek, W. A. (2013) · theses.fr (ABES) · doi:10.70675/2220373aza5dez4b8dzb213z149fa4a9b9a6

Activité ambivalente du nicotinamide chez le parasite Leishmania : adjuvant thérapeutique dans le traitement des leishmanioses et précurseur majeur du NAD+ chez le parasite.

Gazanion, É. (2010) · theses.fr (ABES) · doi:10.70675/5d636192z8a90z4ee8z89d1ze397f3b1e02d

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Involvement of eIF2 in cardiomyocytes response to endoplasmic reticulum stress

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Rôles du NAD dans la plasticité cellulaire cancéreuse

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NMNAT2-SARM1 Axis Drives Redox Failure and Disrupts APP Processing in NeuronsPreprint

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NMNAT2 Functional Landscape and Localization in Programmed Axon Degeneration

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