Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration

Global analysis of protein localization in budding yeast

Huh, W.-K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., & O'Shea, E. K. (2003) · Nature · doi:10.1038/nature02026 · Cited by 4,248 · see citing works

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796 · see citing works

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510 · see citing works

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253 · see citing works

Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

Luo, J., Nikolaev, A. Y., Imai, S.-I., Chen, D., Su, F., Shiloh, A., Guarente, L., & Gu, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00524-4 · Cited by 2,081 · see citing works

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

Tissenbaum, H. A., & Guarente, L. (2001) · Nature · doi:10.1038/35065638 · Cited by 1,918 · see citing works

The Human Sir2 Ortholog, SIRT2, Is an NAD+-Dependent Tubulin Deacetylase

North, B. J., Marshall, B. L., Borra, M. T., Denu, J. M., & Verdin, E. M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00038-8 · Cited by 1,542 · see citing works

Axonal Self-Destruction and Neurodegeneration

Raff, M., Whitmore, A., & Finn, J. (2002) · Science · doi:10.1126/science.1068613 · Cited by 670 · see citing works

Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve

Lunn, E. R., Perry, V. H., Brown, M. C., Rosen, H., & Gordon, S. (1989) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1989.tb00771.x · Cited by 646 · see citing works

Calorie restriction extends yeast life span by lowering the level of NADH

Lin, S.-J., Ford, E., Haigis, M., Liszt, G., & Guarente, L. (2004) · Genes & Development · doi:10.1101/gad.1164804 · Cited by 632 · see citing works

DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite.

Szabó, C., Zingarelli, B., O’Connor, M. P., & Salzman, A. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.5.1753 · Cited by 622 · see citing works

Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene

Mack, T. G. A., Reiner, M., Beirowski, B., Mi, W., Emanuelli, M., Wagner, D., Thomson, D., Gillingwater, T., Court, F., Conforti, L., et al. (2001) · Nature Neuroscience · doi:10.1038/nn770 · Cited by 611 · see citing works

SIRT3, a human SIR2 homologue, is an NAD- dependent deacetylase localized to mitochondria

Onyango, P. O., Celic, I., McCaffery, J. M., Boeke, J. D., & Feinberg, A. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222538099 · Cited by 573 · see citing works

Identification of a Class of Small Molecule Inhibitors of the Sirtuin Family of NAD-dependent Deacetylases by Phenotypic Screening

Grozinger, C. M., Chao, E. D., Blackwell, H. E., Moazed, D., & Schreiber, S. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106779200 · Cited by 533 · see citing works

Connexin 43 hemichannels mediate Ca2+‐regulated transmembrane NAD+ fluxes in intact cells

Bruzzone, S., Guida, L., Zocchi, E., Franco, L., & FLORA, A. D. (2000) · The FASEB Journal · doi:10.1096/fj.00-0566fje · Cited by 464 · see citing works

Axon pathology in neurological disease: a neglected therapeutic target

Coleman, M. P., & Perry, V. H. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02255-5 · Cited by 383 · see citing works

Manipulation of a Nuclear NAD+ Salvage Pathway Delays Aging without Altering Steady-state NAD+ Levels

Anderson, R. M., Bitterman, K. J., Wood, J. G., Medvedik, O., Cohen, H. Y., Lin, S., Manchester, J. K., Gordon, J. I., & Sinclair, D. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111773200 · Cited by 295 · see citing works

Enzymology of NAD+ homeostasis in man

Magni, G., Amici, A., Emanuelli, M., Orsomando, G., Raffaelli, N., & Ruggieri, S. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3161-1 · Cited by 289 · see citing works

A <i>Ufd2/D4Cole1e</i> chimeric protein and overexpression of <i>Rbp7</i> in the slow Wallerian degeneration ( <i>Wld</i> ^S ) mouse

Conforti, L., Tarlton, A., Mack, T. G. A., Mi, W., Buckmaster, E. A., Wagner, D., Perry, V. H., & Coleman, M. P. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11377 · Cited by 251 · see citing works

Poly(ADP-Ribose) Polymerase Inhibitors

Southan, G. J., & Szabó, C. (2003) · Current Medicinal Chemistry · doi:10.2174/0929867033368376 · Cited by 180 · see citing works

Mechanisms of cerebral cortical patterning in mice and humans

Monuki, E. S., & Walsh, C. A. (2001) · Nature Neuroscience · doi:10.1038/nn752 · Cited by 145 · see citing works

Wlds-Mediated Protection of Dopaminergic Fibers in an Animal Model of Parkinson Disease

Sajadi, A., Schneider, B. L., & Aebischer, P. (2004) · Current Biology · doi:10.1016/j.cub.2004.01.053 · Cited by 142 · see citing works

Diversity in the Sir2 family of protein deacetylases

Buck, S. W., Gallo, C. M., & Smith, J. S. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0903424 · Cited by 93 · see citing works

Structure of Human Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase

Zhou, T., Kurnasov, O. V., Tomchick, D. R., Binns, D. D., Grishin, N. V., Márquez, V. E., Osterman, A. L., & Zhang, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111469200 · Cited by 86 · see citing works

Poly(ADP‐Ribose) Polymerase‐1 in Acute Neuronal Death and Inflammation

Skaper, S. D. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07532.x · Cited by 72 · see citing works

Neuroprotection after Transient Global Cerebral Ischemia in Wld ^s Mutant Mice

Gillingwater, T. H., Haley, J. E., Ribchester, R. R., & Horsburgh, K. (2004) · Journal of Cerebral Blood Flow &amp; Metabolism · doi:10.1097/01.wcb.0000095798.98378.34 · Cited by 68 · see citing works

The Rate of Wallerian Degeneration in Cultured Neurons from Wild Type and C57BL/WldS Mice Depends on Time in Culture and may be Extended in the Presence of Elevated K+ Levels

Buckmaster, E. A., Perry, V. H., & Brown, M. C. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01155.x · Cited by 61 · see citing works

Chemosensitization and Radiosensitization of Human Cancer by Antisense Anti‐MDM2 Oligonucleotides

Wang, H., Oliver, P. G., Zhang, Z., Agrawal, S., & Zhang, R. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1281.025 · Cited by 50 · see citing works

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057 · see citing works

Therapeutic potential of resveratrol: the in vivo evidence

Baur, J. A., & Sinclair, D. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2060 · Cited by 3,958 · see citing works

Oxidative stress and neurodegeneration: where are we now?

Halliwell, B. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03907.x · Cited by 2,614 · see citing works

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

Cantó, C., Menzies, K. J., & Auwerx, J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.023 · Cited by 1,648 · see citing works

NAD+ metabolism and its roles in cellular processes during ageing

Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00313-x · Cited by 1,617 · see citing works

NAD ⁺ /NADH and NADP ⁺ /NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences

Ying, W. (2008) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2007.1672 · Cited by 1,494 · see citing works

Neural mechanisms of ageing and cognitive decline

Bishop, N. A., Lu, T., & Yankner, B. A. (2010) · Nature · doi:10.1038/nature08983 · Cited by 1,323 · see citing works

NAD ⁺ in aging, metabolism, and neurodegeneration

Verdin, E. (2015) · Science · doi:10.1126/science.aac4854 · Cited by 1,319 · see citing works

The plasticity of aging: insights from long-lived mutants

Kenyon, C. (2005) · Cell · doi:10.1016/j.cell.2005.02.002 · Cited by 1,338 · see citing works

Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction

Haigis, M. C., & Guarente, L. P. (2006) · Genes &amp; Development · doi:10.1101/gad.1467506 · Cited by 1,295 · see citing works

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

Kim, D., Nguyen, M. D., Dobbin, M. M., Fischer, A., Sananbenesi, F., Rodgers, J. T., Delalle, I., Baur, J. A., Sui, G., Armour, S. M., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601758 · Cited by 1,074 · see citing works

Mechanism of Human SIRT1 Activation by Resveratrol

Borra, M. T., Smith, B. C., & Denu, J. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501250200 · Cited by 1,065 · see citing works

Clinical progression in Parkinson disease and the neurobiology of axons

Cheng, H., Ulane, C. M., & Burke, R. E. (2010) · Annals of Neurology · doi:10.1002/ana.21995 · Cited by 1,012 · see citing works

The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells

Revollo, J. R., Grimm, A. A., & Imai, S.-I. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408388200 · Cited by 1,010 · see citing works

Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival

Yang, H., Yang, T., Baur, J. A., Perez, E., Matsui, T., Carmona, J. J., Lamming, D. W., Souza-Pinto, N. C., Bohr, V. A., Rosenzweig, A., et al. (2007) · Cell · doi:10.1016/j.cell.2007.07.035 · Cited by 950 · see citing works

The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways

Houtkooper, R. H., Cantó, C., Wanders, R. J., & Auwerx, J. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0026 · Cited by 899 · see citing works

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

Rajman, L., Chwalek, K., & Sinclair, D. A. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.011 · Cited by 865 · see citing works

SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging

Oberdoerffer, P., Michan, S., McVay, M., Mostoslavsky, R., Vann, J., Park, S.-K., Hartlerode, A., Stegmuller, J., Hafner, A., Loerch, P., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.025 · Cited by 852 · see citing works

Axon degeneration mechanisms: Commonality amid diversity

Coleman, M. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1788 · Cited by 819 · see citing works

Calorie restriction–the SIR2 connection

Guarente, L., & Picard, F. (2005) · Cell · doi:10.1016/j.cell.2005.01.029 · Cited by 793 · see citing works

The biochemistry of sirtuins

Sauve, A. A., Wolberger, C., Schramm, V. L., & Boeke, J. D. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133500 · Cited by 763 · see citing works

Substrate-specific activation of sirtuins by resveratrol

Kaeberlein, M., McDonagh, T., Heltweg, B., Hixon, J., Westman, E. A., Caldwell, S. D., Napper, A., Curtis, R., DiStefano, P. S., Fields, S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500655200 · Cited by 745 · see citing works

SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling

Chen, J., Zhou, Y., Mueller-Steiner, S., Chen, L.-F., Kwon, H., Yi, S., Mucke, L., & Gan, L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509329200 · Cited by 740 · see citing works

Resveratrol stimulates AMP kinase activity in neurons

Dasgupta, B., & Milbrandt, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610068104 · Cited by 723 · see citing works

PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes

Gupte, R., Liu, Z., & Kraus, W. L. (2017) · Genes &amp; Development · doi:10.1101/gad.291518.116 · Cited by 681 · see citing works

Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD ⁺ Precursor Vitamins in Human Nutrition

Bogan, K. L., & Brenner, C. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155443 · Cited by 707 · see citing works

The Aging Brain

Yankner, B. A., Lu, T., & Loerch, P. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.2.010506.092044 · Cited by 677 · see citing works

The SARM1 toll/interleukin-1 receptor domain possesses intrinsic NAD(+) cleavage activity that promotes pathological axonal degeneration

Essuman, K., Summers, D. W., Sasaki, Y., Mao, X., DiAntonio, A., & Milbrandt, J. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.022 · Cited by 619 · see citing works

NAD+ homeostasis in health and disease

Katsyuba, E., Romani, M., Hofer, D., & Auwerx, J. (2020) · Nature Metabolism · doi:10.1038/s42255-019-0161-5 · Cited by 627 · see citing works

SARM1 activation triggers axon degeneration locally via NAD ⁺ destruction

Gerdts, J., Brace, E. J., Sasaki, Y., DiAntonio, A., & Milbrandt, J. (2015) · Science · doi:10.1126/science.1258366 · Cited by 593 · see citing works

Sirtuins in aging and age-related disease

Longo, V. D., & Kennedy, B. K. (2006) · Cell · doi:10.1016/j.cell.2006.07.002 · Cited by 628 · see citing works

Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction

Qin, W., Yang, T., Ho, L., Zhao, Z., Wang, J., Chen, L., Zhao, W., Thiyagarajan, M., MacGrogan, D., Rodgers, J. T., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602909200 · Cited by 626 · see citing works

Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms

Berger, F., Lau, C., Dahlmann, M., & Ziegler, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508660200 · Cited by 508 · see citing works

Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

Gilley, J., & Coleman, M. P. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000300 · Cited by 472 · see citing works

Sirtuin Functions in Health and Disease

Yamamoto, H., Schoonjans, K., & Auwerx, J. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0079 · Cited by 480 · see citing works

NAD ⁺ Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death

Alano, C. C., Garnier, P., Ying, W., Higashi, Y., Kauppinen, T. M., & Swanson, R. A. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5552-09.2010 · Cited by 439 · see citing works

Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD+?

Cantó, C., & Auwerx, J. (2012) · Pharmacological Reviews · doi:10.1124/pr.110.003905 · Cited by 433 · see citing works

Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+

Belenky, P., Racette, F. G., Bogan, K. L., McClure, J. M., Smith, J. S., & Brenner, C. (2007) · Cell · doi:10.1016/j.cell.2007.03.024 · Cited by 411 · see citing works

SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

Ghosh, H. S., McBurney, M., & Robbins, P. D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009199 · Cited by 397 · see citing works

Sirtuins: The ‘ <i>magnificent seven</i> ’, function, metabolism and longevity

Dali‐Youcef, N., Lagouge, M., Froelich, S., Koehl, C., Schoonjans, K., & Auwerx, J. (2007) · Annals of Medicine · doi:10.1080/07853890701408194 · Cited by 402 · see citing works

Adherence to a Mediterranean-type dietary pattern and cognitive decline in a community population

Tangney, C. C., Kwasny, M. J., Li, H., Wilson, R. S., Evans, D. A., & Morris, M. C. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.007369 · Cited by 397 · see citing works

The epigenetics of aging and neurodegeneration

Lardenoije, R., Iatrou, A., Kenis, G., Kompotis, K., Steinbusch, H. W. M., Mastroeni, D., Coleman, P., Lemere, C. A., Hof, P. R., van den Hove, D. L. A., et al. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.05.002 · Cited by 381 · see citing works

Sirtuin functions and modulation: from chemistry to the clinic

Carafa, V., Rotili, D., Forgione, M., Cuomo, F., Serretiello, E., Hailu, G. S., Jarho, E., Lahtela-Kakkonen, M., Mai, A., & Altucci, L. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0224-3 · Cited by 387 · see citing works

Mammalian Sirt1: insights on its biological functions

Rahman, S., & Islam, R. (2011) · Cell Communication and Signaling · doi:10.1186/1478-811x-9-11 · Cited by 362 · see citing works

Protein acetylation in metabolism – metabolites and cofactors

Menzies, K. J., Zhang, H., Katsyuba, E., & Auwerx, J. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.181 · Cited by 331 · see citing works

The Sir2 family of protein deacetylases

Denu, J. M. (2005) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2005.08.010 · Cited by 325 · see citing works

Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice

Trammell, S. A. J., Weidemann, B. J., Chadda, A., Yorek, M. S., Holmes, A., Coppey, L. J., Obrosov, A., Kardon, R. H., Yorek, M. A., & Brenner, C. (2016) · Scientific Reports · doi:10.1038/srep26933 · Cited by 301 · see citing works

Histone Deacetylases Inhibitors in Neurodegenerative Diseases, Neuroprotection and Neuronal Differentiation

Shukla, S., & Tekwani, B. L. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00537 · Cited by 314 · see citing works

Activation of SIRT3 by the NAD(+) precursor nicotinamide riboside protects from noise-induced hearing loss

Brown, K. D., Maqsood, S., Huang, J.-Y., Pan, Y., Harkcom, W., Li, W., Sauve, A., Verdin, E., & Jaffrey, S. R. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.11.003 · Cited by 277 · see citing works

Stimulation of Nicotinamide Adenine Dinucleotide Biosynthetic Pathways Delays Axonal Degeneration after Axotomy

Sasaki, Y., Araki, T., & Milbrandt, J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2320-06.2006 · Cited by 269 · see citing works

Axon pruning: An essential step underlying the developmental plasticity of neuronal connections

Low, L. K., & Cheng, H.-J. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1883 · Cited by 258 · see citing works

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

Di Stefano, M., Nascimento-Ferreira, I., Orsomando, G., Mori, V, Gilley, J., Brown, R., Janeckova, L., Vargas, M. E., Worrell, L. A., Loreto, A., et al. (2015) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2014.164 · Cited by 246 · see citing works

P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage

Wang, G., Han, T., Nijhawan, D., Theodoropoulos, P., Naidoo, J., Yadavalli, S., Mirzaei, H., Pieper, A. A., Ready, J. M., & McKnight, S. L. (2014) · Cell · doi:10.1016/j.cell.2014.07.040 · Cited by 243 · see citing works

Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation

Mirbaha, H., Holmes, B. B., Sanders, D. W., Bieschke, J., & Diamond, M. I. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.652693 · Cited by 215 · see citing works

Radical medicine: treating ageing to cure disease

Finkel, T. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1763 · Cited by 234 · see citing works

Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses

Cho, H., Proll, S. C., Szretter, K. J., Katze, M. G., Gale, M., & Diamond, M. S. (2013) · Nature Medicine · doi:10.1038/nm.3108 · Cited by 228 · see citing works

Sirtuin regulation in aging and injury

Poulose, N., & Raju, R. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.08.017 · Cited by 236 · see citing works

Insulin/IGF-like signalling, the central nervous system and aging

Broughton, S., & Partridge, L. (2009) · Biochemical Journal · doi:10.1042/bj20082102 · Cited by 228 · see citing works

Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells

Hara, N., Yamada, K., Shibata, T., Osago, H., Hashimoto, T., & Tsuchiya, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610357200 · Cited by 205 · see citing works

Protective effects and mechanisms of sirtuins in the nervous system

Zhang, F., Wang, S., Gan, L., Vosler, P. S., Gao, Y., Zigmond, M. J., & Chen, J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.09.001 · Cited by 211 · see citing works

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion

Sasaki, Y., Nakagawa, T., Mao, X., DiAntonio, A., & Milbrandt, J. (2016) · eLife · doi:10.7554/elife.19749 · Cited by 192 · see citing works

Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders

Salvadores, N., Sanhueza, M., Manque, P., & Court, F. A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00451 · Cited by 182 · see citing works

High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions

Elibol, B., & Kilic, U. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00614 · Cited by 171 · see citing works

PGC-1α in aging and anti-aging interventions

Anderson, R., & Prolla, T. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.04.005 · Cited by 162 · see citing works

NAD⁺metabolism and oxidative stress: the golden nucleotide on a crown of thorns

Massudi, H., Grant, R., Guillemin, G. J., & Braidy, N. (2012) · Redox Report · doi:10.1179/1351000212y.0000000001 · Cited by 158 · see citing works

Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degeneration

Yahata, N., Yuasa, S., & Araki, T. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4304-08.2009 · Cited by 154 · see citing works

Histone deacetylases (HDACs) and brain function

Volmar, C.-H., & Wahlestedt, C. (2015) · Neuroepigenetics · doi:10.1016/j.nepig.2014.10.002 · Cited by 151 · see citing works

Feeding the brain and nurturing the mind: linking nutrition and the gut microbiota to brain development

Goyal, M. S., Venkatesh, S., Milbrandt, J., Gordon, J. I., & Raichle, M. E. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1511465112 · Cited by 141 · see citing works

Gene therapy targeting SARM1 blocks pathological axon degeneration in mice

Geisler, S., Huang, S. X., Strickland, A., Doan, R. A., Summers, D. W., Mao, X., Park, J., DiAntonio, A., & Milbrandt, J. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20181040 · Cited by 145 · see citing works

Sirtuin activators

Alcaín, F. J., & Villalba, J. M. (2009) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543770902762893 · Cited by 137 · see citing works

Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress

Press, C., & Milbrandt, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0525-08.2008 · Cited by 137 · see citing works

Senescence-associated beta-galactosidase activity expression in aging hippocampal neurons

Geng, Y.-Q., Guan, J.-T., Xu, X.-H., & Fu, Y.-C. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.05.011 · Cited by 129 · see citing works

A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration

Gräff, J., Kahn, M., Samiei, A., Gao, J., Ota, K. T., Rei, D., & Tsai, L.-H. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.5657-12.2013 · Cited by 124 · see citing works

Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration

Kitaoka, Y., Munemasa, Y., Kojima, K., Hirano, A., Ueno, S., & Takagi, H. (2013) · Cell Death &amp; Disease · doi:10.1038/cddis.2013.391 · Cited by 108 · see citing works

CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy

Ljungberg, M. C., Ali, Y. O., Zhu, J., Wu, C.-S., Oka, K., Zhai, R. G., & Lu, H.-C. (2012) · Human Molecular Genetics · doi:10.1093/hmg/ddr492 · Cited by 107 · see citing works

Neuroprotective effects of dietary restriction: Evidence and mechanisms

Pani, G. (2015) · Seminars in Cell &amp; Developmental Biology · doi:10.1016/j.semcdb.2015.03.004 · Cited by 103 · see citing works

NMNATs, evolutionarily conserved neuronal maintenance factors

Ali, Y. O., Li-Kroeger, D., Bellen, H. J., Zhai, R. G., & Lu, H.-C. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.07.002 · Cited by 91 · see citing works

Metabolic Vulnerability in the Neurodegenerative Disease Glaucoma

Inman, D. M., & Harun-Or-Rashid, M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00146 · Cited by 88 · see citing works

Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity

Yan, T., Feng, Y., Zheng, J., Ge, X., Zhang, Y., Wu, D., Zhao, J., & Zhai, Q. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2009.09.007 · Cited by 92 · see citing works

NAD+ metabolite levels as a function of vitamins and calorie restriction: evidence for different mechanisms of longevity

Evans, C., Bogan, K. L., Song, P., Burant, C. F., Kennedy, R. T., & Brenner, C. (2010) · BMC Chemical Biology · doi:10.1186/1472-6769-10-2 · Cited by 81 · see citing works

Assimilation of Endogenous Nicotinamide Riboside Is Essential for Calorie Restriction-mediated Life Span Extension in Saccharomyces cerevisiae

Lu, S.-P., Kato, M., & Lin, S.-J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.004010 · Cited by 75 · see citing works

Implications of NAD metabolism in pathophysiology and therapeutics for neurodegenerative diseases

Hikosaka, K., Yaku, K., Okabe, K., & Nakagawa, T. (2021) · Nutritional Neuroscience · doi:10.1080/1028415x.2019.1637504 · Cited by 62 · see citing works

Region-specific changes in the immunoreactivity of SIRT1 expression in the central nervous system of SOD1G93A transgenic mice as an in vivo model of amyotrophic lateral sclerosis

Lee, J. C., Shin, J.-H., Park, B.-W., Kim, G. S., Kim, J. C., Kang, K.-S., & Cha, C. I. (2012) · Brain Research · doi:10.1016/j.brainres.2011.11.019 · Cited by 32 · see citing works

Deletion of CD38 and supplementation of NAD+ attenuate axon degeneration in a mouse facial nerve axotomy model

Takaso, Y., Noda, M., Hattori, T., Roboon, J., Hatano, M., Sugimoto, H., Brenner, C., Yamamoto, Y., Okamoto, H., Higashida, H., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-73984-3 · Cited by 17 · see citing works

Effects of NAD+ in Caenorhabditis elegans Models of Neuronal Damage

Lee, Y., Jeong, H., Park, K. H., & Kim, K. W. (2020) · Biomolecules · doi:10.3390/biom10070993 · Cited by 8 · see citing works

The influence of peripheral connections on wallerian degeneration

Delgado‐Lezama, R., & ́nez, E. J. M. ̃.-M. (1990) · Brain Research · doi:10.1016/0006-8993(90)91332-b · Cited by 4 · see citing works

WALLERIAN DEGENERATION: A SEQUENTIAL PROCESS

Simón, R., Wade, R. R., Delarco, J. E., et al. (1969) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1969.tb09895.x · Cited by 8 · see citing works

Wallerian Degeneration and Myelin Loss Secondary to Neuronal and Axonal Degeneration

(2005) · Springer eBooks · doi:10.1007/3-540-27660-2_105 · Cited by 6 · see citing works

Two Different Methods of Quantification of Oxidized Nicotinamide Adenine Dinucleotide (NAD+) and Reduced Nicotinamide Adenine Dinucleotide (NADH) Intracellular Levels: Enzymatic Coupled Cycling Assay and Ultra-performance Liquid Chromatography (UPLC)-Mass Spectrometry

Kanamori, K. S., de Oliveira, G. C., Auxiliadora‐Martins, M., Schoon, R. A., Reid, J. M., & Chini, E. N. (2018) · BIO-PROTOCOL · doi:10.21769/bioprotoc.2937 · Cited by 28 · see citing works

ON ENHANCING NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD) ACTIVITY IN LIVING SYSTEMS

Kohane, M. J., & Tiller, W. A. (2001) · Subtle energies & energy medicine · Cited by 1 · see citing works