Vangl1 Protein Acts as a Downstream Effector of Intestinal Trefoil Factor (ITF)/TFF3 Signaling and Regulates Wound Healing of Intestinal Epithelium
Open accessAbstract
The intestinal trefoil factor (ITF/TFF3) protects intestinal epithelia from a range of insults and contributes to mucosal repair. However, the signaling events that mediate healing responses are only partially understood. To identify ITF signaling pathways, proteins that were Ser/Thr phosphorylated in response to ITF stimulation were immunoprecipitated from human colon carcinoma cell lines and identified by mass spectrometry. We demonstrated that Van Gogh-like protein 1 (also designated Vang-like 1 or Vangl1), a protein with four transmembrane domains, was Ser/Thr phosphorylated in response to ITF stimulation. Vangl1 was present in normal human colon and all intestinal epithelial cell lines (IEC) tested. In transfected IEC, FLAG-Vangl1 was mostly present in the Nonidet P-40 soluble fraction as detected by Western blotting, corresponding to the localization of endogenous protein in cytoplasmic vesicular structures by confocal microscopy with rabbit polyclonal anti-human Vangl1 antibody (alpha-Vangl1). Vangl1 cell membrane association increased with differentiation, as demonstrated by co-localization with E-cadherin in differentiated IEC. Increased Vangl1 phosphorylation after stimulation with ITF corresponded to decreased cell membrane association with E-cadherin. Functionally, Vangl1 overexpression enhanced ITF unstimulated and stimulated wound closure of IEC, whereas siRNA directed against Vangl1 inhibited the migratory response to ITF. Vangl1 protein may serve as an effector mediating the ITF healing response of the intestinal mucosa.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Lmna G609G/G609G mice receiving A. muciniphila showed an increment in the intestinal trefoil factor Tff3.
“Lmna G609G/G609G mice receiving A. muciniphila also showed an increment in the intestinal trefoil factor Tff3 (Fig. 4b), which might promote wound healing and repair of the mucosa layer 27 .”
From Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice (2019) · cites this paper as [27]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Current protocols in molecular biology
Sargent, T. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90147-9 · Cited by 7,298 · see citing works
Identification of Vangl2 and Scrb1 as planar polarity genes in mammals
Montcouquiol, M., Rachel, R. A., Lanford, P. J., Copeland, N. G., Jenkins, N. A., & Kelley, M. W. (2003) · Nature · doi:10.1038/nature01618 · Cited by 705 · see citing works
Impaired Defense of Intestinal Mucosa in Mice Lacking Intestinal Trefoil Factor
Mashimo, H. L., Wu, D., Podolsky, D. K., & Fishman, M. C. (1996) · Science · doi:10.1126/science.274.5285.262 · Cited by 702 · see citing works
Self-citationTrefoil factors: initiators of mucosal healing
Taupin, D. R., & Podolsky, D. K. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1203 · Cited by 625 · see citing works
Self-citationBoucheix, C., & Rubinstein, E. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000933 · Cited by 577 · see citing works
Kibar, Z., Vogan, K. J., Groulx, N., Justice, M. J., Underhill, D. A., & Gros, P. (2001) · Nature Genetics · doi:10.1038/90081 · Cited by 504 · see citing works
Tebbutt, N. C., Giraud, A. S., Inglese, M., Jenkins, B., Waring, P., Clay, F. J., Malki, S., Alderman, B. M., Grail, D., Hollande, F., et al. (2002) · Nature Medicine · doi:10.1038/nm763 · Cited by 474 · see citing works
Dignass, A. U., Lynch–Devaney, K., Kindon, H., Thim, L., & Podolsky, D. K. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117332 · Cited by 422 · see citing works
Self-citationBinding of APC to the Human Homolog of the Drosophila Discs Large Tumor Suppressor Protein
Matsumine, A., Ogai, A., Senda, T., Okumura, N., Satoh, K., Baeg, G., KAWAHARA, T., Kobayashi, S., Okada, M., Toyoshima, K., et al. (1996) · Science · doi:10.1126/science.272.5264.1020 · Cited by 421 · see citing works
Specific tetraspanin functions
Hemler, M. E. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200108061 · Cited by 395 · see citing works
strabismus, a novel gene that regulates tissue polarity and cell fate decisions in Drosophila
Wolff, T., & Rubin, G. M. (1998) · Development · doi:10.1242/dev.125.6.1149 · Cited by 321 · see citing works
Intestinal trefoil factor confers colonic epithelial resistance to apoptosis
Taupin, D. R., Kinoshita, K., & Podolsky, D. K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.799 · Cited by 280 · see citing works
Self-citationSuemori, S., Lynch–Devaney, K., & Podolsky, D. K. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11017 · Cited by 273 · see citing works
Self-citationPodolsky, D. K., Lynch–Devaney, K., Stow, J. L., Oates, P. S., Murgue, B., deBeaumont, M., Sands, B. E., & Mahida, Y. R. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53305-6 · Cited by 267 · see citing works
Self-citationOral trefoil peptides protect against ethanol- and indomethacin-induced gastric injury in rats
Babyatsky, M. W., deBeaumont, M., Thim, L., & Podolsky, D. K. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8566596 · Cited by 250 · see citing works
Self-citationThe planar polarity gene strabismus regulates convergent extension movements in Xenopus
Darken, R. S., Scola, A. M., Rakeman, A. S., Das, G., Mlodzik, M., & Wilson, P. A. (2002) · The EMBO Journal · doi:10.1093/emboj/21.5.976 · Cited by 239 · see citing works
Thim, L. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)80690-8 · Cited by 238 · see citing works
Goto, T., & Keller, R. E. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0673 · Cited by 229 · see citing works
Wright, N. A., Poulsom, R., Stamp, G. W. H., Hall, P. A., Jeffery, R. E., Longcroft, J. M., Rio, M., Tomasetto, C., & Chambon, P. (1990) · The Journal of Pathology · doi:10.1002/path.1711620402 · Cited by 227 · see citing works
Nakamura, F., Amieva, M. R., & Furthmayr, H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.52.31377 · Cited by 206 · see citing works
Kinoshita, K., Taupin, D. R., Itoh, H., & Podolsky, D. K. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4680-4690.2000 · Cited by 198 · see citing works
Self-citationRho proteins play a critical role in cell migration during the early phase of mucosal restitution.
dos Santos, M. F., McCormack, S. A., Guo, Z., Okolicány, J., Zheng, Y., Johnson, L. R., & Tigyi, G. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119515 · Cited by 161 · see citing works
Migrating fibroblasts perform polarized, microtubule-dependent exocytosis towards the leading edge
Schmoranzer, J., Kreitzer, G. E., & Simon, S. M. (2003) · Journal of Cell Science · doi:10.1242/jcs.00748 · Cited by 151 · see citing works
Taupin, D. R., Wu, D., Jeon, W.-K., Devaney, K., Wang, T. C., & Podolsky, D. K. (1999) · Journal of Clinical Investigation · doi:10.1172/jci3304 · Cited by 147 · see citing works
Self-citationPhosphorylation of beta-catenin and epidermal growth factor receptor by intestinal trefoil factor.
Liu, D., El‐Hariry, I. A., Karayiannakis, A. J., Wilding, J., Chinery, R., Kmiot, W. A., McCrea, P. D., Gullick, W. J., & Pignatelli, M. N. (1997) · PubMed · Cited by 141 · see citing works
Laprise, P., Viel, A., & Rivard, N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309843200 · Cited by 136 · see citing works
Lee, J. H., Park, S. R., Chay, K.-O., Seo, Y.-W., Kook, H. Y., Ahn, K. Y., Kim, Y. J., & Kim, K. K. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0275 · Cited by 107 · see citing works
Discs-Large and Strabismus are functionally linked to plasma membrane formation
Lee, O.-K., Frese, K. K., James, J. S., Chadda, D., Chen, Z., Javier, R. T., & Cho, K.-O. (2003) · Nature Cell Biology · doi:10.1038/ncb1055 · Cited by 89 · see citing works
Chadwick, M. P., Westley, B. R., & May, F. E. B. (1997) · Biochemical Journal · doi:10.1042/bj3270117 · Cited by 74 · see citing works
Muskett, F. W., May, F. E. B., Westley, B. R., & Feeney, J. (2003) · Biochemistry · doi:10.1021/bi030182k · Cited by 49 · see citing works
Iizuka‐Kogo, A., Shimomura, A., & Senda, T. (2004) · Histochemistry and Cell Biology · doi:10.1007/s00418-004-0729-2 · Cited by 37 · see citing works
Intestinal trefoil factor promotes invasion in non-tumorigenic Rat-2 fibroblast cell
Chan, V. Y. W., Chan, M. W. Y., Leung, W. K., Leung, P. S., Sung, J. J. �., & Chan, F. K. L. (2004) · Regulatory Peptides · doi:10.1016/j.regpep.2004.10.016 · Cited by 33 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Suemori, S., Lynch-Devaney, K., and Podolsky, D. K. (1991) Proc. Natl. Acad. Sci.
- Taupin, D. R., Kinoshita, K., and Podolsky, D. K. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 799 -804
Cited by
Sorted by citations
The effect of host genetics on the gut microbiome
Bonder, M. J., Kurilshikov, A., Tigchelaar, E. F., Mujagic, Z., Imhann, F., Vila, A. V., Deelen, P., Vatanen, T., Schirmer, M., Smeekens, S. P., et al. (2016) · Nature Genetics · doi:10.1038/ng.3663 · Cited by 819 · see citing works
Probiotic bacteria and intestinal epithelial barrier function
Ohland, C., & MacNaughton, W. K. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00243.2009 · Cited by 808 · see citing works
Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice
Bárcena, C., Valdés-Mas, R., Mayoral, P., Garabaya, C., Durand, S., Rodríguez, F., Fernández-García, M. T., Salazar, N., Nogacka, A. M., Garatachea, N., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0504-5 · Cited by 661 · see citing works
Intestinal barrier dysfunction in inflammatory bowel diseases
McGuckin, M. A., Eri, R., Simms, L. A., Florin, T. H. J., & Radford-Smith, G. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20539 · Cited by 627 · see citing works
Epidermal Wound Repair Is Regulated by the Planar Cell Polarity Signaling Pathway
Caddy, J., Wilanowski, T., Darido, C., Dworkin, S., Ting, S. B., Zhao, Q., Rank, G., Auden, A., Srivastava, S., Papenfuss, A. T., et al. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.06.008 · Cited by 209 · see citing works
The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis
Joo, J. H., Wang, B., Frankel, E. B., Ge, L., Xu, L., Iyengar, R. V., Li-Harms, X., Wright, C., Shaw, T. I., Lindsten, T., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.04.020 · Cited by 182 · see citing works
MicroRNA-145 Targets YES and STAT1 in Colon Cancer Cells
Gregersen, L. H., Skanderup, A. J., Frankel, L. B., Wen, J., Krogh, A., & Lund, A. H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008836 · Cited by 162 · see citing works
The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis
Yates, L. L., Schnatwinkel, C., Murdoch, J. N., Bogani, D., Formstone, C. J., Townsend, S., Greenfield, A., Niswander, L. A., & Dean, C. H. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq104 · Cited by 160 · see citing works
Akkermansia muciniphila plays critical roles in host health
Zhao, Q., Yu, J., Hao, Y., Zhou, H., Hu, Y., Zhang, C., Zheng, H., Wang, X., Zeng, F., Hu, J., et al. (2022) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2022.2037506 · Cited by 101 · see citing works
Controlling cell surface dynamics and signaling: How CD82/KAI1 suppresses metastasis
Miranti, C. K. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.08.023 · Cited by 100 · see citing works
Dissecting the diverse functions of the metastasis suppressor CD82/KAI1
Tsai, Y. C., & Weissman, A. M. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.08.031 · Cited by 93 · see citing works
Innate and adaptive mechanisms to control of pathological intestinal inflammation
Kelsall, B. L. (2007) · The Journal of Pathology · doi:10.1002/path.2286 · Cited by 77 · see citing works
Intestinal epithelial cells and their role in innate mucosal immunity
Maldonado‐Contreras, A., & McCormick, B. A. (2010) · Cell and Tissue Research · doi:10.1007/s00441-010-1082-5 · Cited by 74 · see citing works
Matrilysin-1 (MMP7) cleaves galectin-3 and inhibits wound healing in intestinal epithelial cells
Puthenedam, M., Wu, F., Shetye, A., Michaels, A. D., Rhee, K.-J., & Kwon, J. H. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21443 · Cited by 73 · see citing works
Muenchau, S., Deutsch, R., de Castro, I. J., Hielscher, T., Heber, N., Niesler, B., Lušić, M., Stanifer, M. L., & Boulant, S. (2019) · Molecular and Cellular Biology · doi:10.1128/mcb.00553-18 · Cited by 62 · see citing works
Müller, T., Beutler, C., Picó, A. H., Otten, M., Dürr, A., Al‐Abadi, H., Guckelberger, O., Büschenfelde, D. M. Z., Jöhrens, K., Volkmann, M., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.055 · Cited by 55 · see citing works
Self-citationHarzallah, D., & Belhadj, H. (2013) · InTech eBooks · doi:10.5772/50732 · Cited by 47 · see citing works
Regulatory Function of Trefoil peptides (TFF) on Intestinal Cell Junctional Complexes
Buda, A., Jepson, M. A., & Pignatelli, M. N. (2012) · Cell Communication & Adhesion · doi:10.3109/15419061.2012.748326 · Cited by 45 · see citing works
Wang, Y., Li, Z., Zhang, P., Poon, E. N.-Y., Kong, C., Boheler, K. R., Huang, Y., Li, R. A., & Yao, X. (2015) · Stem Cells · doi:10.1002/stem.2118 · Cited by 42 · see citing works
Odyssey of trefoil factors in cancer: Diagnostic and therapeutic implications
Jahan, R., Shah, A., Kisling, S. G., Macha, M. A., Thayer, S. P., Batra, S. K., & Kaur, S. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188362 · Cited by 38 · see citing works
Utility Evaluation of Porcine Enteroids as PDCoV Infection Model in vitro
Luo, H., Zheng, J., Chen, Y., Wang, T., Zhang, Z., Shan, Y., Xu, J., Yue, M., Fang, W., & Li, X. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00821 · Cited by 36 · see citing works
Iliescu, A., Gravel, M., Horth, C., & Gros, P. (2014) · Biochemistry · doi:10.1021/bi500400g · Cited by 31 · see citing works
LINDSAY, C. D. (2010) · Human & Experimental Toxicology · doi:10.1177/0960327110376982 · Cited by 30 · see citing works
Shi, H., Yin, X., Song, L., Guo, Q., & Luo, X.-H. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.10.051 · Cited by 29 · see citing works
Calcagno, S. R., Li, S., Shahid, M. W., Wallace, M. B., Leitges, M., Fields, A. P., & Murray, N. R. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21547 · Cited by 29 · see citing works
Nitric oxide and protein kinase G act on TRPC1 to inhibit 11,12-EET-induced vascular relaxation
Zhang, P., Ma, Y., Wang, Y., Ma, X., Huang, Y., Li, R. A., Wan, S., & Yao, X. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu190 · Cited by 27 · see citing works
An Expanding Role of Vangl Proteins in Embryonic Development
Torban, E., Iliescu, A., & Gros, P. (2012) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-394592-1.00005-3 · Cited by 26 · see citing works
Translocation of PKG1α acts on TRPV4-C1 heteromeric channels to inhibit endothelial Ca2+ entry
Zhang, P., Mao, A.-Q., Sun, C., Zhang, X.-D., Pan, Q., Yang, D., Jin, J., Tang, C., Yang, Z., Yao, X., et al. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2016.43 · Cited by 18 · see citing works
Sun, Y. J., Zhu, Y. J., Wang, L., Mao, X., Peng, X., & Peng, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062429 · Cited by 18 · see citing works
Wang, X., Wang, P., Li, Y., Guo, H., Wang, R., Liu, S., Qiu, J., Wang, X., Hao, Y., Zhao, Y., et al. (2024) · Engineering · doi:10.1016/j.eng.2023.10.016 · Cited by 15 · see citing works
Bel, S., Elkis, Y., Lerer‐Goldshtein, T., Nyska, A., Shpungin, S., & Nir, U. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.364786 · Cited by 15 · see citing works
Çetin, G. O., Toylu, A., Atabey, N., Sercan, Z., & Sakızlı, M. (2015) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2015.0014 · Cited by 12 · see citing works
Mirzadzare, N., Blyth, G. A. D., Hannawayya, R., Cirone, K. M., Kilari, G., Lahiri, P., Tan, Y. L., Herik, A., Fu, Y., Gorman, H., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2538696 · Cited by 10 · see citing works
Varlı, M., Kim, E., Oh, S., Pulat, S., Zhou, R., Gamage, C. D. B., Gökalsın, B., Sesal, N. C., Kim, K. K., Paik, M., et al. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03434-x · Cited by 9 · see citing works
Kalabis, J., Li, G., Fukunaga‐Kalabis, M., Rustgi, A. K., & Herlyn, M. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90294.2008 · Cited by 9 · see citing works
Self-citationKinetic Characterization of an Intestinal Trefoil Factor Receptor
Zhang, Y., Lin, W., Sun, Y. J., Guang-ping, L., Wu, D., Lv, S., Wu, W., & Peng, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074669 · Cited by 8 · see citing works
Loss of ERβ in Aging LXRαβ Knockout Mice Leads to Colitis
Song, X., Wu, W., Dai, Y., Warner, M. N., Nalvarte, I., Antonson, P., Varshney, M., & Gustafsson, J.-Α. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512461 · Cited by 7 · see citing works
Kneller, J. M., Ehlen, T. G., Matisic, J. P., Miller, D. M., van Niekerk, D., Lam, W. L., Marra, M. A., Richards-Kortum, R. R., Follen, M., MacAulay, C. E., et al. (2007) · Biomarker Insights · doi:10.1177/117727190700200020 · Cited by 7 · see citing works
Proteomic profiling of platelet signalling
Howes, J. (2013) · Expert Review of Proteomics · doi:10.1586/14789450.2013.820534 · Cited by 5 · see citing works
Shi, H., Ren, J., Xu, H., Pan, J., Hao, X., Barlow, L. L., & Dong, W. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1227-0 · Cited by 4 · see citing works
Feng, Z.-M., Fang, D.-C., Chen, W., & Wang, R. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9711-2 · Cited by 4 · see citing works
The MUC2 mucin -A network in the intestinal protective mucus
Johansson, M. (2009) · Gothenburg University Publications Electronic Archive (Gothenburg University) · Cited by 3 · see citing works
Fu, Z., Wang, K., Zou, W., Gao, S., Liu, H., Hong, H., Tan, Y., & Luo, Y. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107329 · Cited by 2 · see citing works
Mechanisms of maintenance of intestinal homeostasis by autochthonic microbiota and probiotics
Binek, M., Kizerwetter‐Świda, M., Cisek, A. A., Rzewuska, M., Chrobak‐Chmiel, D., & Gieryńska, M. M. (2016) · Medycyna Weterynaryjna · doi:10.21521/mw.5575 · Cited by 2 · see citing works
Siddique, M. R., Shynder, S., Ashraf, M. A., Yusoff, I., & Wajid, A. (2012) · Chemistry Central Journal · doi:10.1186/1752-153x-6-69 · Cited by 1 · see citing works
RetractedThe interplay between genetics, the microbiome, DNA‐methylation & gene‐expression
Bonder, M. J. (2017) · Cited by 1 · see citing works
Jensen, D. (2010) · eScholarship (California Digital Library) · Cited by 1 · see citing works
Siddique, M. R., Shynder, S., Ashraf, M. A., Yusoff, I., & Wajid, A. (2012) · Chemistry Central Journal · doi:10.1186/1752-153x-6-121
RetractedA network in the intestinal protective mucus
Johansson, M. (2009)
Loos, M. (2007) · Ghent University Academic Bibliography (Ghent University)
Niessen, C. M. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.4449971.5307054
Varlı, M., Kim, E., Oh, S., Pulat, S., Zhou, R., Gamage, C. D. B., Gökalsın, B., Sesal, N. C., Kim, K. K., Paik, M.-J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26751961
Caractérisation du récepteur de la polarité planaire Vangl2 dans les cancers du sein
Belotti, E. (2010) · theses.fr (ABES) · doi:10.70675/2525bca2zb0d0z410cz8836zb2aa0c54a387
- Authors
- Kalabis, J., Rosenberg, I., & Podolsky, D. K.
- Affiliations
- Harvard University (US)
- Corresponding author
- Podolsky, Daniel K.
- ORCID
- Podolsky, Daniel K.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2006-03
- Volume
- 281
- Issue
- 10
- Pages
- 6434-6441
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2047747244
- Cited by
- 55
- References
- 32
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 2 · 2017: 1 · 2016: 5 · 2015: 2 · 2014: 2 · 2013: 5 · 2012: 5
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Massachusetts General Hospital
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK046906, P30DK043351)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Digestive system and related health
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Vangl1, TFF3, mucosal healing, E-cadherin, cell membrane association, cell migration, intestinal epithelial differentiation, colon cancer cell lines
- MeSH terms
- Trefoil Factor-2, Trefoil Factor-3, Animals, Carrier Proteins, Cell Movement, Chlorocebus aethiops, Humans, Intestinal Mucosa, Membrane Proteins, Peptides, Phosphorylation, RNA, Messenger, Serine, Threonine, Wound Healing, Signal Transduction, DNA, Complementary, Caco-2 Cells, HT29 Cells, COS Cells, HCT116 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review