The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Lamins A and C but Not Lamin B1 Regulate Nuclear Mechanics
Open accessAbstract
Mutations in the nuclear envelope proteins lamins A and C cause a broad variety of human diseases, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria syndrome. Cells lacking lamins A and C have reduced nuclear stiffness and increased nuclear fragility, leading to increased cell death under mechanical strain and suggesting a potential mechanism for disease. Here, we investigated the contribution of major lamin subtypes (lamins A, C, and B1) to nuclear mechanics by analyzing nuclear shape, nuclear dynamics over time, nuclear deformations under strain, and cell viability under prolonged mechanical stimulation in cells lacking both lamins A and C, cells lacking only lamin A (i.e. "lamin C-only" cells), cells lacking wild-type lamin B1, and wild-type cells. Lamin A/C-deficient cells exhibited increased numbers of misshapen nuclei and had severely reduced nuclear stiffness and decreased cell viability under strain. Lamin C-only cells had slightly abnormal nuclear shape and mildly reduced nuclear stiffness but no decrease in cell viability under strain. Interestingly, lamin B1-deficient cells exhibited normal nuclear mechanics despite having a significantly increased frequency of nuclear blebs. Our study indicates that lamins A and C are important contributors to the mechanical stiffness of nuclei, whereas lamin B1 contributes to nuclear integrity but not stiffness.
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Cites
Loss of a-Type Lamin Expression Compromises Nuclear Envelope Integrity Leading to Muscular Dystrophy
Sullivan, T., Escalante-Alcalde, D., Bhatt, H., Anver, M., Bhat, N., Nagashima, K., Stewart, C. L., & Burke, B. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.5.913 · Cited by 1,211
Self-citationGoldman, R. D., Shumaker, D. K., Erdos, M. R., Eriksson, M., Goldman, A. E., Gordon, L. B., Gruenbaum, Y., Khuon, S., Mendez, M., Varga, R., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402943101 · Cited by 1,103
Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction
Lammerding, J., Schulze, P. C., Takahashi, T., Kozlov, S. V., Sullivan, T. L., Kamm, R. D., Stewart, C. L., & Lee, R. T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19670 · Cited by 1,064
Self-citationThe nuclear lamina comes of age
Gruenbaum, Y., Margalit, A., Goldman, R. D., Shumaker, D. K., & Wilson, K. L. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1550 · Cited by 834
Identification of essential genes in cultured mammalian cells using small interfering RNAs
Harborth, J., Elbashir, S. M., Bechert, K., Tuschl, T., & Weber, K. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.24.4557 · Cited by 829
Nuclear lamins: building blocks of nuclear architecture
Goldman, R. D., Gruenbaum, Y., Moir, R. D., Shumaker, D. K., & Spann, T. P. (2002) · Genes & Development · doi:10.1101/gad.960502 · Cited by 586
Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C–deficient mice
Nikolova-Krstevski, V., Leimena, C., McMahon, A. C., Tan, J. C., Chandar, S., Jogia, D., Kesteven, S. H., Michalicek, J., Otway, R., Verheyen, F., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19448 · Cited by 429
Self-citationLife at the edge: the nuclear envelope and human disease
Burke, B., & Stewart, C. L. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm879 · Cited by 420
Self-citationLamin B1 is required for mouse development and nuclear integrity
Vergnes, L., Péterfy, M., Bergo, M. O., Young, S. G., & Reue, K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401424101 · Cited by 391
Self-citationAbnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells
Lammerding, J., Hsiao, J., Schulze, P. C., Kozlov, S., Stewart, C. L., & Lee, R. T. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200502148 · Cited by 381
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Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus
Wang, N., Tytell, J. D., & Ingber, D. E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2594 · Cited by 1,762
Mechanics and functional consequences of nuclear deformations
Kalukula, Y., Stephens, A. D., Lammerding, J., & Gabriele, S. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00480-z · Cited by 475
Self-citationOrchestrated Intron Retention Regulates Normal Granulocyte Differentiation
Wong, J. J.-L., Ritchie, W., Ebner, O. A., Selbach, M., Wong, J. W. H., Huang, Y., Gao, D., Pinello, N., Gonzalez, M., Baidya, K., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.052 · Cited by 462
Dittmer, T. A., & Misteli, T. (2011) · Genome Biology · doi:10.1186/gb-2011-12-5-222 · Cited by 481
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Haase, K., & Pelling, A. E. (2015) · Journal of The Royal Society Interface · doi:10.1098/rsif.2014.0970 · Cited by 396
Metadata
- Authors
- Lammerding, J., Fong, L. G., Ji, J. Y., Reue, K., Stewart, C. L., Young, S. G., & Lee, R. T.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2006-09
- Volume
- 281
- Issue
- 35
- Pages
- 25768-25780
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2052373675
- Cited by
- 688
- References
- 37
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lammerding, J., Fong, L. G., Ji, J. Y., Reue, K., Stewart, C. L., Young, S. G., & Lee, R. T. (2006). Lamins A and C but Not Lamin B1 Regulate Nuclear Mechanics. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m513511200
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