Mechanics and functional consequences of nuclear deformations

Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

Eriksson, M., Brown, W. T., Gordon, L. B., Glynn, M. W., Singer, J. I., Scott, L. J., Erdos, M. R., Robbins, C. M., Moses, T. Y., Berglund, P., et al. (2003) · Nature · doi:10.1038/nature01629 · Cited by 2,217 · see citing works

Tau-mediated neurodegeneration in Alzheimer’s disease and related disorders

Ballatore, C., Lee, V. M.-Y., & Trojanowski, J. Q. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2194 · Cited by 2,174 · see citing works

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

Swift, J., Ivanovska, I. L., Buxboim, A., Harada, T., Dingal, P. C. D. P., Pinter, J., Pajerowski, J. D., Spinler, K. R., Shin, J., Tewari, M., et al. (2013) · Science · doi:10.1126/science.1240104 · Cited by 1,998 · see citing works

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

Aragona, M., Panciera, T., Manfrin, A., Giulitti, S., Michielin, F., Elvassore, N., Dupont, S., & Piccolo, S. (2013) · Cell · doi:10.1016/j.cell.2013.07.042 · Cited by 1,651 · see citing works

Chromosomal instability drives metastasis through a cytosolic DNA response

Bakhoum, S. F., Ngo, B., Laughney, A. M., Cavallo, J.-A., Murphy, C. J., Ly, P., Shah, P., Sriram, R. K., Watkins, T. B. K., Taunk, N. K., et al. (2018) · Nature · doi:10.1038/nature25432 · Cited by 1,638 · see citing works

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

Larson, A. G., Elnatan, D., Keenen, M. M., Trnka, M., Johnston, J. B., Burlingame, A., Agard, D., Redding, S., & Narlikar, G. J. (2017) · Nature · doi:10.1038/nature22822 · Cited by 1,554 · see citing works

Force triggers YAP nuclear entry by regulating transport across nuclear pores

Elosegui-Artola, A., Andreu, I., Beedle, A. E. M., Lezamiz, A., Uroz, M., Kosmalska, A. J., Oria, R., Kechagia, J. Z., Rico-Lastres, P., Le Roux, A.-L., et al. (2017) · Cell · doi:10.1016/j.cell.2017.10.008 · Cited by 1,491 · see citing works

Lamin A Truncation in Hutchinson-Gilford Progeria

Sandre‐Giovannoli, A. D., Bernard, R., Cau, P., Navarro, C. L., Amiel, J., Boccaccio, I., Lyonnet, S., Stewart, C. L., Münnich, A., Merrer, M. F. L., et al. (2003) · Science · doi:10.1126/science.1084125 · Cited by 1,472 · see citing works

Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction force

Wolf, K., te Lindert, M., Krause, M., Alexander, S., te Riet, J., Willis, A. L., Hoffman, R. M., Figdor, C. G., Weiss, S. J., & Friedl, P. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201210152 · Cited by 1,375 · see citing works

Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy

Bonne, G., di Barletta, M. R., Varnous, S., Bécane, H. M., Hammouda, E.-H., Merlini, L., Francesco Muntoni, A., Greenberg, C. R., Gary, F., Urtizberea, J. A., et al. (1999) · Nature Genetics · doi:10.1038/6799 · Cited by 1,353 · see citing works

Coupling of the nucleus and cytoplasm: Role of the LINC complex

Crisp, M., Liu, Q., Roux, K. J., Rattner, J. B., Shanahan, C. M., Burke, B. E., Stahl, P. D., & Hodzic, D. M. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200509124 · Cited by 1,339 · see citing works

Nuclear envelope rupture and repair during cancer cell migration

Denais, C. M., Gilbert, R. M., Isermann, P., McGregor, A. L., te Lindert, M., Weigelin, B., Davidson, P. M., Friedl, P., Wolf, K., & Lammerding, J. (2016) · Science · doi:10.1126/science.aad7297 · Cited by 1,318 · see citing works

Subdiffraction Multicolor Imaging of the Nuclear Periphery with 3D Structured Illumination Microscopy

Schermelleh, L., Carlton, P. M., Haase, S., Shao, L., Winoto, L., Kner, P., Burke, B. E., Cardoso, M. C., Agard, D. A., Gustafsson, M. G. L., et al. (2008) · Science · doi:10.1126/science.1156947 · Cited by 1,126 · see citing works

Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson–Gilford progeria syndrome

Goldman, R. D., Shumaker, D. K., Erdos, M. R., Eriksson, M., Goldman, A. E., Gordon, L. B., Gruenbaum, Y., Khuon, S., Mendez, M., Varga, R., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402943101 · Cited by 1,103 · see citing works

Nuclear structure in cancer cells

Zink, D., Fischer, A. H., & Nickerson, J. A. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1430 · Cited by 1,070 · see citing works

Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction

Lammerding, J., Schulze, P. C., Takahashi, T., Kozlov, S. V., Sullivan, T. L., Kamm, R. D., Stewart, C. L., & Lee, R. T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419670 · Cited by 1,068 · see citing works

Organization of Chromatin by Intrinsic and Regulated Phase Separation

Gibson, B. A., Doolittle, L. K., Schneider, M. W. G., Jensen, L. E., Gamarra, N. I., Henry, L., Gerlich, D. W., Redding, S., & Rosen, M. K. (2019) · Cell · doi:10.1016/j.cell.2019.08.037 · Cited by 1,045 · see citing works

Dilated cardiomyopathy: the complexity of a diverse genetic architecture

Hershberger, R. E., Hedges, D. J., & Morales, A. (2013) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2013.105 · Cited by 1,023 · see citing works

Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine

Moya, I. M., & Halder, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0086-y · Cited by 981 · see citing works

Spatiotemporal Control of Intracellular Phase Transitions Using Light-Activated optoDroplets

Shin, Y., Berry, J. M., Pannucci, N. L., Haataja, M., Toettcher, J. E., & Brangwynne, C. P. (2016) · Cell · doi:10.1016/j.cell.2016.11.054 · Cited by 972 · see citing works

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

Raab, M., Gentili, M., Belly, H. D., Thiam, H. R., Vargas, P., Jiménez, A. J., Lautenschläger, F., Voituriez, R., Lennon‐Duménil, A., Manel, N., et al. (2016) · Science · doi:10.1126/science.aad7611 · Cited by 910 · see citing works

Timing of the brain events underlying access to consciousness during the attentional blink

Sergent, C., Baillet, S., & Dehaene, S. (2005) · Nature Neuroscience · doi:10.1038/nn1549 · Cited by 888 · see citing works

Mechanisms of 3D cell migration

Yamada, K. M., & Sixt, M. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0172-9 · Cited by 868 · see citing works

Physical plasticity of the nucleus in stem cell differentiation

Pajerowski, J. D., Dahl, K. N., Zhong, F. L., Sammak, P. J., & Discher, D. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702576104 · Cited by 834 · see citing works

LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation

Solovei, I., Wang, A. S., Thanisch, K., Schmidt, C. S., Krebs, S., Zwerger, M., Cohen, T. V., Devys, D., Foisner, R., Peichl, L., et al. (2013) · Cell · doi:10.1016/j.cell.2013.01.009 · Cited by 809 · see citing works

Lamins A and C but Not Lamin B1 Regulate Nuclear Mechanics

Lammerding, J., Fong, L. G., Ji, J. Y., Reue, K., Stewart, C. L., Young, S. G., & Lee, R. T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513511200 · Cited by 689 · see citing works

Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome

Shin, Y., Chang, Y.-C., Lee, D. S. W., Berry, J., Sanders, D. W., Ronceray, P., Wingreen, N. S., Haataja, M., & Brangwynne, C. P. (2018) · Cell · doi:10.1016/j.cell.2018.10.057 · Cited by 676 · see citing works

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

Nava, M. M., Miroshnikova, Y. A., Biggs, L. C., Whitefield, D. B., Metge, F., Bouças, J., Vihinen, H., Jokitalo, E., Li, X., ARCOS, J. M. G., et al. (2020) · Cell · doi:10.1016/j.cell.2020.03.052 · Cited by 652 · see citing works

Collagen-based cell migration models in vitro and in vivo

Wolf, K., Alexander, S., Schacht, V., Coussens, L. M., von Andrian, U. H., van Rheenen, J., Deryugina, E., & Friedl, P. (2009) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2009.08.005 · Cited by 637 · see citing works

Transcription upregulation via force-induced direct stretching of chromatin

Tajik, A., Zhang, Y., Wei, F., Sun, J., Jia, Q., Zhou, W., Singh, R., Khanna, N., Belmont, A. S., & Wang, N. (2016) · Nature Materials · doi:10.1038/nmat4729 · Cited by 633 · see citing works

Spatial coordination between cell and nuclear shape within micropatterned endothelial cells

Versaevel, M., Grevesse, T., & Gabriele, S. (2012) · Nature Communications · doi:10.1038/ncomms1668 · Cited by 623 · see citing works

Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus

Guilluy, C., Osborne, L. D., Landeghem, L. V., Sharek, L., Superfine, R., García‐Mata, R., & Burridge, K. (2014) · Nature Cell Biology · doi:10.1038/ncb2927 · Cited by 613 · see citing works

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

Harada, T., Swift, J., Irianto, J., Shin, J., Spinler, K. R., Athirasala, A., Diegmiller, R., Dingal, P. C. D. P., Ivanovska, I. L., & Discher, D. E. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201308029 · Cited by 611 · see citing works

The nucleus acts as a ruler tailoring cell responses to spatial constraints

Lomakin, A. J., Cattin, C. J., Cuvelier, D., Alraies, Z., Molina-Jordán, M., Nader, G. P. F., Srivastava, N., Sáez, P. J., ARCOS, J. M. G., Zhitnyak, I. Y., et al. (2020) · Science · doi:10.1126/science.aba2894 · Cited by 611 · see citing works

A perinuclear actin cap regulates nuclear shape

Khatau, S. B., Hale, C. M., Stewart-Hutchinson, P. J., Patel, M. S., Stewart, C. L., Searson, P. C., Hodzic, D. M., & Wirtz, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908686106 · Cited by 607 · see citing works

Viscoelastic Properties of the Cell Nucleus

Guilak, F., Tedrow, J. R., & Burgkart, R. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2360 · Cited by 590 · see citing works

Emerging views of the nucleus as a cellular mechanosensor

Kirby, T. J., & Lammerding, J. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0038-y · Cited by 560 · see citing works

The Interaction between Nesprins and Sun Proteins at the Nuclear Envelope Is Critical for Force Transmission between the Nucleus and Cytoskeleton

Lombardi, M. L., Jaalouk, D. E., Shanahan, C. M., Burke, B. E., Roux, K. J., & Lammerding, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.233700 · Cited by 554 · see citing works

Engineering gene expression and protein synthesis by modulation of nuclear shape

Thomas, C. H., Collier, J. H., Sfeir, C. S., & Healy, K. E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032668799 · Cited by 483 · see citing works

Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin

Wilhelmsen, K., Litjens, S. H. M., Kuikman, I., Tshimbalanga, N., Janssen, H., van den Bout, I., Raymond, K., & Sonnenberg, A. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200506083 · Cited by 483 · see citing works

Nuclear Positioning

Gundersen, G. G., & Worman, H. J. (2013) · Cell · doi:10.1016/j.cell.2013.02.031 · Cited by 483 · see citing works

Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment

Le, H. Q., Ghatak, S., Yeung, C. C., Tellkamp, F., Günschmann, C., Dieterich, C., Yeroslaviz, A., Habermann, B. H., Pombo, A., Niessen, C. M., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3387 · Cited by 477 · see citing works

Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus

Stephens, A. D., Banigan, E. J., Adam, S. A., Goldman, R. D., & Marko, J. F. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-09-0653 · Cited by 476 · see citing works

The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior

Venturini, V., Pezzano, F., Català-Castro, F., Häkkinen, H.-M., Jiménez‐Delgado, S., Colomer-Rosell, M., Marro, M., Tolosa-Ramon, Q., Paz-López, S., Valverde, M. A., et al. (2020) · Science · doi:10.1126/science.aba2644 · Cited by 470 · see citing works

Mapping Local and Global Liquid Phase Behavior in Living Cells Using Photo-Oligomerizable Seeds

Bracha, D., Walls, M. T., Wei, M.-T., Zhu, L., Kurian, M., Avalos, J. L., Toettcher, J. E., & Brangwynne, C. P. (2018) · Cell · doi:10.1016/j.cell.2018.10.048 · Cited by 462 · see citing works

Lamin A/C and emerin regulate MKL1–SRF activity by modulating actin dynamics

Ho, C. Y., Jaalouk, D. E., Vartiainen, M. K., & Lammerding, J. (2013) · Nature · doi:10.1038/nature12105 · Cited by 456 · see citing works

Nucleoporins Directly Stimulate Expression of Developmental and Cell-Cycle Genes Inside the Nucleoplasm

Kalverda, B., Pickersgill, H., Shloma, V. V., & Fornerod, M. W. J. (2010) · Cell · doi:10.1016/j.cell.2010.01.011 · Cited by 442 · see citing works

Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C–deficient mice

Nikolova-Krstevski, V., Leimena, C., McMahon, A. C., Tan, J. C., Chandar, S., Jogia, D., Kesteven, S. H., Michalicek, J., Otway, R., Verheyen, F., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19448 · Cited by 428 · see citing works

The molecular architecture of lamins in somatic cells

Turgay, Y., Eibauer, M., Goldman, A. E., Shimi, T., Khayat, M., Ben‐Harush, K., Dubrovsky-Gaupp, A., Sapra, K. T., Goldman, R. D., & Medalia, O. (2017) · Nature · doi:10.1038/nature21382 · Cited by 428 · see citing works

Lamin B1 duplications cause autosomal dominant leukodystrophy

Padiath, Q. S., Saigoh, K., Schiffmann, R., Asahara, H., Yamada, T., Koeppen, A. H., Hogan, K. J., Ptáček, L. J., & Fu, Y. (2006) · Nature Genetics · doi:10.1038/ng1872 · Cited by 407 · see citing works

LINC Complexes Form by Binding of Three KASH Peptides to Domain Interfaces of Trimeric SUN Proteins

Sosa, B. A., Rothballer, A., Kutay, U., & Schwartz, T. (2012) · Cell · doi:10.1016/j.cell.2012.03.046 · Cited by 404 · see citing works

Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments

Thiam, H. R., Vargas, P., Carpi, N., Crespo, C. L., Raab, M., Terriac, E., King, M. C., Jacobelli, J., Alberts, A. S., Stradal, T. E. B., et al. (2016) · Nature Communications · doi:10.1038/ncomms10997 · Cited by 393 · see citing works

Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells

Lammerding, J., Hsiao, J., Schulze, P. C., Kozlov, S. V., Stewart, C. L., & Lee, R. T. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200502148 · Cited by 381 · see citing works

Distinct structural and mechanical properties of the nuclear lamina in Hutchinson–Gilford progeria syndrome

Dahl, K. N., Scaffidi, P., Islam, M. F., Yodh, A. G., Wilson, K. L., & Misteli, T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601058103 · Cited by 378 · see citing works

Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C–deficient mice

Nikolova, V., Leimena, C., McMahon, A. C., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419448 · Cited by 370 · see citing works

Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix

Petrie, R. J., Koo, H., & Yamada, K. M. (2014) · Science · doi:10.1126/science.1256965 · Cited by 367 · see citing works

Mechanosensing by the nucleus: From pathways to scaling relationships

Cho, S., Irianto, J., & Discher, D. E. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201610042 · Cited by 363 · see citing works

Matrix Elasticity Regulates Lamin-A,C Phosphorylation and Turnover with Feedback to Actomyosin

Buxboim, A., Swift, J., Irianto, J., Spinler, K. R., Dingal, P. C. D. P., Athirasala, A., Kao, Y.-R., Cho, S., Harada, T., Shin, J., et al. (2014) · Current Biology · doi:10.1016/j.cub.2014.07.001 · Cited by 359 · see citing works

Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization

Roux, K. J., Crisp, M., Liu, Q., Kim, D., Козлов, С. В., Stewart, C. L., & Burke, B. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808602106 · Cited by 358 · see citing works

Nucleokinesis in Neuronal Migration

Tsai, L., & Gleeson, J. G. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.013 · Cited by 357 · see citing works

Mechanochemical Feedback Loops in Development and Disease

Hannezo, É., & Heisenberg, C. (2019) · Cell · doi:10.1016/j.cell.2019.05.052 · Cited by 357 · see citing works

Power-Law Rheology of Isolated Nuclei with Deformation Mapping of Nuclear Substructures

Dahl, K. N., Engler, A. J., Pajerowski, J. D., & Discher, D. E. (2005) · Biophysical Journal · doi:10.1529/biophysj.105.062554 · Cited by 340 · see citing works

Bicaudal D2, Dynein, and Kinesin-1 Associate with Nuclear Pore Complexes and Regulate Centrosome and Nuclear Positioning during Mitotic Entry

Splinter, D., Tanenbaum, M. E., Lindqvist, A., Jaarsma, D., Flotho, A., Yu, K. L., Grigoriev, I., Engelsma, D., Haasdijk, E. D., Keijzer, N., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000350 · Cited by 327 · see citing works

The nuclear envelope and the architecture of the nuclear periphery.

Franke, W. W., Scheer, U., Krohne, G., & Jarasch, E. D. (1981) · The Journal of Cell Biology · doi:10.1083/jcb.91.3.39s · Cited by 324 · see citing works

Cytoskeletal to Nuclear Strain Transfer Regulates YAP Signaling in Mesenchymal Stem Cells

Driscoll, T. P., Cosgrove, B. D., Heo, S., Shurden, Z. E., & Mauck, R. L. (2015) · Biophysical Journal · doi:10.1016/j.bpj.2015.05.010 · Cited by 322 · see citing works

Nuclear Envelope Composition Determines the Ability of Neutrophil-type Cells to Passage through Micron-scale Constrictions

Rowat, A. C., Jaalouk, D. E., Zwerger, M., Ung, W. L., Eydelnant, I. A., Olins, D. E., Olins, A. L., Herrmann, H. O., Weitz, D. A., & Lammerding, J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.441535 · Cited by 321 · see citing works

Nuclear Deformability Constitutes a Rate-Limiting Step During Cell Migration in 3-D Environments

Davidson, P. M., Denais, C., Bakshi, M. C., & Lammerding, J. (2014) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-014-0342-y · Cited by 320 · see citing works

Nuclear pores dilate and constrict in cellulo

Zimmerli, C. E., Allegretti, M., Rantos, V., Goetz, S. K., Obarska-Kosińska, A., Zagoriy, I., Halavatyi, A. A., Hummer, G., Mahamid, J., Kosiński, J., et al. (2021) · Science · doi:10.1126/science.abd9776 · Cited by 320 · see citing works

Nuclear positioning facilitates amoeboid migration along the path of least resistance

Renkawitz, J., Kopf, A., Stopp, J., de Vries, I., Driscoll, M., Merrin, J., Hauschild, R., Welf, E. S., Danuser, G. M., Fiolka, R. P., et al. (2019) · Nature · doi:10.1038/s41586-019-1087-5 · Cited by 307 · see citing works

Loss of lamin A function increases chromatin dynamics in the nuclear interior

Bronshtein, I., Kepten, E., Kanter, I., Berezin, S., Lindner, M., Redwood, A. B., Mai, S., Gonzalo, S., Foisner, R., Shav‐Tal, Y., et al. (2015) · Nature Communications · doi:10.1038/ncomms9044 · Cited by 302 · see citing works

Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest

Cho, S., Vashisth, M., Abbas, A. K., Majkut, S., Vogel, K., Xia, Y., Ivanovska, I. L., Irianto, J., Tewari, M., Zhu, K., et al. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.04.020 · Cited by 301 · see citing works

Nuclear Lamins: Thin Filaments with Major Functions

de Leeuw, R., Gruenbaum, Y., & Medalia, O. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.08.004 · Cited by 300 · see citing works

Adaptive rheology and ordering of cell cytoskeleton govern matrix rigidity sensing

Gupta, M., Sarangi, B. R., Deschamps, J. R., Nematbakhsh, Y., Callan-Jones, A., Margadant, F., Mège, R., Lim, C. T., Voituriez, R., & Ladoux, B. (2015) · Nature Communications · doi:10.1038/ncomms8525 · Cited by 294 · see citing works

DNA Damage Follows Repair Factor Depletion and Portends Genome Variation in Cancer Cells after Pore Migration

Irianto, J., Xia, Y., Pfeifer, C. R., Athirasala, A., Ji, J., Alvey, C. M., Tewari, M., Bennett, R. R., Harding, S. M., Liu, A. J., et al. (2016) · Current Biology · doi:10.1016/j.cub.2016.11.049 · Cited by 280 · see citing works

Dynamic Disruptions in Nuclear Envelope Architecture and Integrity Induced by HIV-1 Vpr

de Noronha, C. M. C., Sherman, M. P., Lin, H. W., Cavrois, M., Moir, R. D., Goldman, R. D., & Greene, W. C. (2001) · Science · doi:10.1126/science.1063957 · Cited by 275 · see citing works

The Cell Nucleus Serves as a Mechanotransducer of Tissue Damage-Induced Inflammation

Enyedi, B., Jelcic, M., & Niethammer, P. (2016) · Cell · doi:10.1016/j.cell.2016.04.016 · Cited by 274 · see citing works

Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies

Vos, W. H. D., Houben, F., Kamps, M. A. F., Malhas, A. N., Verheyen, F., Cox, J., Manders, E. M. M., Verstraeten, V. L. R. M., Steensel, M. A. M. V., Marcelis, C., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr344 · Cited by 271 · see citing works

Spatial confinement downsizes the inflammatory response of macrophages

Jain, N., & Vogel, V. (2018) · Nature Materials · doi:10.1038/s41563-018-0190-6 · Cited by 271 · see citing works

Nuclear envelope rupture is induced by actin-based nucleus confinement

Hatch, E. M., & Hetzer, M. W. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201603053 · Cited by 270 · see citing works

Lamina-associated domains: peripheral matters and internal affairs

Briand, N., & Collas, P. (2020) · Genome biology · doi:10.1186/s13059-020-02003-5 · Cited by 269 · see citing works

Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion

Nader, G. P. F., Agüera‐González, S., Routet, F., Gratia, M., Maurin, M., Cancila, V., Cadart, C., Palamidessi, A., Ramos, R. N., Jouve, M. J., et al. (2021) · Cell · doi:10.1016/j.cell.2021.08.035 · Cited by 267 · see citing works

Transient nuclear envelope rupturing during interphase in human cancer cells

Vargas, J. D., Hatch, E. M., Anderson, D. J., & Hetzer, M. W. (2012) · Nucleus · doi:10.4161/nucl.18954 · Cited by 263 · see citing works

Mechanical Properties of the Cell Nucleus and the Effect of Emerin Deficiency

Rowat, A. C., Lammerding, J., & Ipsen, J. H. (2006) · Biophysical Journal · doi:10.1529/biophysj.106.086454 · Cited by 257 · see citing works

Actomyosin Is the Main Driver of Interkinetic Nuclear Migration in the Retina

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Mammalian nucleophagy: process and function

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Lamin A/C and Vimentin as a Coordinated Regulator during Amoeboid Migration in Microscale Confined Microenvironments

Wang, Y., Hong, L., Liu, Y., Bao, Q., Yang, S., Xu, X., Chen, Y., Liu, W., Shi, X., Shi, Y., et al. (2023) · Nano Letters · doi:10.1021/acs.nanolett.3c02096 · Cited by 22 · see citing works

Sensing the squeeze: nuclear mechanotransduction in health and disease

Srivastava, L. K., & Ehrlicher, A. J. (2024) · Nucleus · doi:10.1080/19491034.2024.2374854 · Cited by 21 · see citing works

Molecular biology needs a map: spatial in situ approaches in plant science

Pasternak, T. P., & Yaroshko, О. M. (2026) · Plant Biology · doi:10.1111/plb.70178 · Cited by 21 · see citing works

A Versatile Micromanipulation Apparatus for Biophysical Assays of the Cell Nucleus

Currey, M. L., Kandula, V., Biggs, R. J., Marko, J. F., & Stephens, A. D. (2022) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-022-00734-y · Cited by 21 · see citing works

Nuclear shapes are geometrically determined by the excess surface area of the nuclear lamina

Dickinson, R. B., & Lele, T. P. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1058727 · Cited by 21 · see citing works

Molecular Mechanisms for the Regulation of Nuclear Membrane Integrity

Lee, G.-E., Byun, J., Lee, C., & Cho, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015497 · Cited by 22 · see citing works

The mechanobiology of NK cells- ‘Forcing NK to Sense’ target cells

Wong, D. C. P., & Ding, J. L. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188860 · Cited by 20 · see citing works

Chromatin phase separation and nuclear shape fluctuations are correlated in a polymer model of the nucleus

Attar, A. G., Paturej, J., Banigan, E. J., & Erbaş, A. (2024) · Nucleus · doi:10.1080/19491034.2024.2351957 · Cited by 21 · see citing works

Nuclear envelope proteins, mechanotransduction, and their contribution to breast cancer progression

Henretta, S., & Lammerding, J. (2025) · npj Biological Physics and Mechanics · doi:10.1038/s44341-025-00018-2 · Cited by 19 · see citing works

Mechanical memory based on chromatin and metabolism remodeling promotes proliferation and smooth muscle differentiation in mesenchymal stem cells

Na, J., Shi, Q., Yang, Z., Liu, Y., Chen, X., Wang, Z., Zheng, L., & Fan, Y. (2024) · The FASEB Journal · doi:10.1096/fj.202302178r · Cited by 19 · see citing works

Heterogeneous force response of chromatin in isolated nuclei

Bergamaschi, G., Biebricher, A. S., Witt, H., Byfield, F. J., Seymonson, X. M. R., Storm, C., Janmey, P. A., & Wuite, G. J. L. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114852 · Cited by 19 · see citing works

Rebalancing redox homeostasis: A pivotal regulator of the cGAS-STING pathway in autoimmune diseases

Zhao, Y., Xu, T., Wu, Z., Li, N., & Liang, Q. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103823 · Cited by 20 · see citing works

Cytoskeletal safeguards: Protecting the nucleus from mechanical perturbations

Kechagia, Z., & Roca‐Cusachs, P. (2023) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2023.100494 · Cited by 19 · see citing works

The dynamic nuclear envelope: resilience in health and dysfunction in disease

Turkmen, A. M., Saik, N. O., & Ullman, K. S. (2023) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2023.102230 · Cited by 19 · see citing works

Coordinated in confined migration: crosstalk between the nucleus and ion channel-mediated mechanosensation

Mistriotis, P., Wisniewski, E. O., Bishwa, R., Kaláb, P., & Κωνσταντόπουλος, Κ. (2024) · Trends in Cell Biology · doi:10.1016/j.tcb.2024.01.001 · Cited by 19 · see citing works

N2FXm, a method for joint nuclear and cytoplasmic volume measurements, unravels the osmo-mechanical regulation of nuclear volume in mammalian cells

Pennacchio, F. A., Poli, A., Pramotton, F. M., Lavore, S., Rancati, I., Cinquanta, M., Vorselen, D., Prina, E., Romano, O. M., Ferrari, A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45168-4 · Cited by 19 · see citing works

Principles of organelle positioning in motile and non-motile cells

Kroll, J., & Renkawitz, J. (2024) · EMBO Reports · doi:10.1038/s44319-024-00135-4 · Cited by 19 · see citing works

Exocrine gland–resident memory CD8 + T cells use mechanosensing for tissue surveillance

Ruef, N., Magdaleno, J. M., Ficht, X., Purvanov, V., Palayret, M., Wissmann, S., Pfenninger, P., Stolp, B., Thelen, F., de Albuquerque, J. B., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.add5724 · Cited by 16 · see citing works

Neural Tissue‐Like, not Supraphysiological, Electrical Conductivity Stimulates Neuronal Lineage Specification through Calcium Signaling and Epigenetic Modification

Li, Y., Ji, Y., Meng, Y., Kim, Y., Lee, H., Kurian, A. G., Park, J., Yoon, J., Knowles, J. C., Choi, Y., et al. (2024) · Advanced Science · doi:10.1002/advs.202400586 · Cited by 18 · see citing works

Constitutive heterochromatin controls nuclear mechanics, morphology, and integrity through H3K9me3 mediated chromocenter compaction

Manning, G., Li, A., Eskndir, N., Currey, M. L., & Stephens, A. D. (2025) · Nucleus · doi:10.1080/19491034.2025.2486816 · Cited by 18 · see citing works

The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate

Marin, H. C., Allen, C., Simental, E., Martin, E. W., Panning, B., Al‐Sady, B., & Buchwalter, A. L. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01703-z · Cited by 20 · see citing works

AKT2-mediated nuclear deformation leads to genome instability during epithelial-mesenchymal transition

Fan, J. C., Chang, S.-N., Chu, C., & Chen, H. (2023) · iScience · doi:10.1016/j.isci.2023.106992 · Cited by 18 · see citing works

Mechanoresponse of Curved Epithelial Monolayers Lining Bowl‐Shaped 3D Microwells

Luciano, M., Versaevel, M., Kalukula, Y., & Gabriele, S. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202203377 · Cited by 18 · see citing works

ECM and epithelial stem cells: the scaffold of destiny

Estrach, S., Vivier, C.-M., & Féral, C. C. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1359585 · Cited by 22 · see citing works

DNA damage causes ATM-dependent heterochromatin loss leading to nuclear softening, blebbing, and rupture

Eskndir, N., Hossain, M., Currey, M. L., Pho, M., Berrada, Y., Lin, K. Y., Manning, G., Prince, K., & Stephens, A. D. (2024) · Molecular Biology of the Cell · doi:10.1091/mbc.e24-05-0232 · Cited by 19 · see citing works

Polarity-JaM: an image analysis toolbox for cell polarity, junction and morphology quantification

Giese, W., Albrecht, J. P., Oppenheim, O., Akmeriç, E. B., Kraxner, J., Schmidt, D., Harrington, K., & Gerhardt, H. (2025) · Nature Communications · doi:10.1038/s41467-025-56643-x · Cited by 18 · see citing works

Mechanobiology of the cell nucleus

Lammerding, J., Engler, A. J., & Kamm, R. D. (2022) · APL Bioengineering · doi:10.1063/5.0135299 · Cited by 17 · see citing works

Lamins as structural nuclear elements through evolution

Odell, J., & Lammerding, J. (2023) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2023.102267 · Cited by 17 · see citing works

Coupling of Perinuclear Actin Cap and Nuclear Mechanics in Regulating Flow‐Induced Yap Spatiotemporal Nucleocytoplasmic Transport

Ma, T., Liu, X., Su, H., Shi, Q., He, Y., Wu, F., Gao, C., Li, K., Liang, Z., Zhang, D., et al. (2023) · Advanced Science · doi:10.1002/advs.202305867 · Cited by 17 · see citing works

Insights into the mechanobiology of cancer metastasis via microfluidic technologies

Liang, L., Song, X., Zhao, H., & Lim, C. T. (2024) · APL Bioengineering · doi:10.1063/5.0195389 · Cited by 19 · see citing works

Confined Migration Drives Stem Cell Differentiation

Gao, X., Li, Y., Lee, J. W. N., Zhou, J., Rangaraj, V., Marlena, J., & Holle, A. W. (2025) · Advanced Science · doi:10.1002/advs.202415407 · Cited by 17 · see citing works

Viscoelastic mechanics of living cells

Zhou, H., Liu, R., Xu, Y., Fan, J., Liu, X., Chen, L., & Wei, Q. (2025) · Physics of Life Reviews · doi:10.1016/j.plrev.2025.02.004 · Cited by 17 · see citing works

A Dock8-dependent mechanosensitive central actin pool maintains T cell shape and protects the nucleus during migration

Shen, C., Cerf, A., Postat, J., Bhagrath, A., Merino, M., Mingarelli, A., Barnes, G., Patel, D., Rogers, D., Luo, V. M., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.adt9239 · Cited by 16 · see citing works

Lamin B loss in nuclear blebs is rupture dependent whereas increased DNA damage is rupture independent

Chu, C. G., Lang, N., Walsh, E., Zheng, M., Manning, G., Shalin, K., Cunha, L. M., Faucon, K. E., Kam, N., Folan, S. N., et al. (2025) · Journal of Cell Science · doi:10.1242/jcs.263945 · Cited by 16 · see citing works

Mechanistic studies in Drosophila and chicken give new insights into functions of DVL1 in dominant Robinow syndrome

Gignac, S. J., MacCharles, K. R., Fu, K., Bonaparte, K., Akarsu, G., Barrett, T. W., Verheyen, E. M., & Richman, J. M. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.049844 · Cited by 12 · see citing works

Biomimetic Alveoli System with Vivid Mechanical Response and Cell–Cell Interface

Niu, M., Zhu, Y., Ding, X., Zu, Y., Zhao, Y., & Wang, Y. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300850 · Cited by 16 · see citing works

Fluid and Bubble Flow Detach Adherent Cancer Cells to Form Spheroids on a Random Positioning Machine

Cortés-Sánchez, J. L., Melnik, D., Sandt, V., Kahlert, S., Marchal, S., Johnson, I. R. D., Calvaruso, M., Liemersdorf, C., Wüest, S. L., Grimm, D. G., et al. (2023) · Cells · doi:10.3390/cells12222665 · Cited by 16 · see citing works

Stretch-injury promotes microglia activation with enhanced phagocytic and synaptic stripping activities

Procès, A., Alpizar, Y. A., Halliez, S., Brône, B., Saudou, F., Ris, L., & Gabriele, S. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122426 · Cited by 16 · see citing works

N-terminal tags impair the ability of lamin A to provide structural support to the nucleus

Odell, J., & Lammerding, J. (2024) · Journal of Cell Science · doi:10.1242/jcs.262207 · Cited by 16 · see citing works

Micropillars in Cell Mechanobiology: Design, Fabrication, Characterization, and Biosensing Applications

Saram, P. D., Nguyen, N., Jamali, S. S., & Kashaninejad, N. (2024) · Small Science · doi:10.1002/smsc.202400410 · Cited by 16 · see citing works

Matrix‐Rigidity Cooperates With Biochemical Cues in M2 Macrophage Activation Through Increased Nuclear Deformation and Chromatin Accessibility

Shin, S. J., Bayarkhangai, B., Tsogtbaatar, K., Yuxuan, M., Kim, S., Kim, Y., Taghizadeh, A., Kim, D., Kim, D., Lee, J., et al. (2025) · Advanced Science · doi:10.1002/advs.202403409 · Cited by 15 · see citing works

The emerging roles of the endoplasmic reticulum in mechanosensing and mechanotransduction

Townson, J., & Progida, C. (2025) · Journal of Cell Science · doi:10.1242/jcs.263503 · Cited by 15 · see citing works

Emerging mechanobiology techniques to probe intracellular mechanics

Molnar, K., & Manneville, J. (2025) · npj Biological Physics and Mechanics. · doi:10.1038/s44341-025-00016-4 · Cited by 15 · see citing works

Mechanical Forces in Nuclear OrganizationPreprint

Miroshnikova, Y. A., & Wickström, S. A. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a039685 · Cited by 121 · see citing works

Nuclear envelope mechanobiology: linking the nuclear structure and function

Goelzer, M. H., Goelzer, J., Ferguson, M., Neu, C. P., & Uzer, G. (2021) · Nucleus · doi:10.1080/19491034.2021.1962610 · Cited by 33 · see citing works

Novel contribution of epigenetic changes to nuclear dynamics

Dreger, M., Madrazo, E., Hurlstone, A. F. L., & Redondo-Muñóz, J. (2019) · Nucleus · doi:10.1080/19491034.2019.1580100 · Cited by 9 · see citing works

The mechanobiology of the nucleus

Damato, M., & Maffia, M. (2020) · Università del Salento · doi:10.1285/i25327518v4i2p7

The nucleus feels the force, LINCed in or not!

Jahed, Z., & Mofrad, M. R. (2019) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2019.02.012 · Cited by 48 · see citing works