The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Identification of a Pool of Non-pumping Na/K-ATPase
Open accessAbstract
Recent studies have ascribed many non-pumping functions to the Na/K-ATPase. Here, we present experimental evidence demonstrating that over half of the plasma membrane Na/K-ATPase in LLC-PK1 cells is performing cellular functions other than ion pumping. This "non-pumping" pool of Na/K-ATPase, like the pumping pump, binds ouabain. Depletion of either cholesterol or caveolin-1 moves some of the "non-pumping" Na/K-ATPase into the pumping pool. Graded knock-down of the alpha1 subunit of the Na/K-ATPase eventually results in loss of this "non-pumping" pool while preserving the pumping pool. Our prior studies indicate that a loss of the non-pumping pool is associated with a loss of receptor function as evidenced by the failure of ouabain administration to induce the activation of Src and/or ERK. Therefore, our new findings suggest that a substantial amount of surface-expressed Na/K-ATPase, at least in some types of cells, may function as non-canonical ouabain-binding receptors.
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Cites
Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 Å resolution
Toyoshima, C., Nakasako, M., Nomura, H., & Ogawa, H. (2000) · Nature · doi:10.1038/35015017 · Cited by 1,798
Kaplan, J. H. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.102201.141218 · Cited by 1,181
Lingrel, J. B., & Kuntzweiler, T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32067-7 · Cited by 744
Nelson, W. J., & Veshnock, P. J. (1987) · Nature · doi:10.1038/328533a0 · Cited by 476
Liu, J., Tian, J., Haas, M., Shapiro, J. I., Askari, A., & Xie, Z. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002950200 · Cited by 391
Self-citationBinding of Src to Na+/K+-ATPase Forms a Functional Signaling Complex
Tian, J., Cai, T., Yuan, Z., Wang, H., Liu, L., Haas, M., Maksimova, E., Huang, X.-Y., & Xie, Z.-J. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-08-0735 · Cited by 358
Self-citationOuabain, a steroid hormone that signals with slow calcium oscillations
Aizman, O., Uhlén, P., Lal, M., Brismar, H., & Aperia, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221315298 · Cited by 321
Phosphorylation of the catalytic subunit of Na+,K(+)-ATPase inhibits the activity of the enzyme.
Bertorello, A. M., Aperia, A., Walaas, S. I., Nairn, A. C., & Greengard, P. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11359 · Cited by 312
Multiple Signal Transduction Pathways Link Na+/K+-ATPase to Growth-related Genes in Cardiac Myocytes
Kometiani, P., Li, J., Gnudi, L., Kahn, B. B., Askari, A., & Xie, Z. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.24.15249 · Cited by 305
Self-citationOuabain Assembles Signaling Cascades through the Caveolar Na+/K+-ATPase
Wang, H., Haas, M., Liang, M., Cai, T., Tian, J., Li, S., & Xie, Z. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313239200 · Cited by 278
Self-citation
Cited by
Endogenous Cardiotonic Steroids: Physiology, Pharmacology, and Novel Therapeutic Targets
Bagrov, A. Y., Shapiro, J. I., & Fedorova, O. V. (2009) · Pharmacological Reviews · doi:10.1124/pr.108.000711 · Cited by 532
Self-citationRole of Ion Channels and Transporters in Cell Migration
Schwab, A., Fabian, A., Hanley, P. J., & Stock, C. (2012) · Physiological Reviews · doi:10.1152/physrev.00018.2011 · Cited by 420
P4-ATPases as Phospholipid Flippases—Structure, Function, and Enigmas
Andersen, J. P., Vestergaard, A. L., Mikkelsen, S. A., Mogensen, L. S., Chalat, M., & Molday, R. S. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00275 · Cited by 317
Glutamate Transporter Coupling to Na,K-ATPase
Rose, E. M., Koo, J. C. P., Antflick, J. E., Ahmed, S. M., Angers, S., & Hampson, D. R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1081-09.2009 · Cited by 311
Metadata
- Authors
- Liang, M., Tian, J., Liu, L., Pierre, S., Liu, J., Shapiro, J., & Xie, Z.-J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 282
- Issue
- 14
- Pages
- 10585-10593
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2122252852
- Cited by
- 263
- References
- 34
- FWCI
- 8.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Liang, M., Tian, J., Liu, L., Pierre, S., Liu, J., Shapiro, J., & Xie, Z.-J. (2007). Identification of a Pool of Non-pumping Na/K-ATPase. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m609181200
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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