The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Differential Effects of Endoplasmic Reticulum Stress-induced Autophagy on Cell Survival
Open accessAbstract
Autophagy is a cellular response to adverse environment and stress, but its significance in cell survival is not always clear. Here we show that autophagy could be induced in the mammalian cells by chemicals, such as A23187, tunicamycin, thapsigargin, and brefeldin A, that cause endoplasmic reticulum stress. Endoplasmic reticulum stress-induced autophagy is important for clearing polyubiquitinated protein aggregates and for reducing cellular vacuolization in HCT116 colon cancer cells and DU145 prostate cancer cells, thus mitigating endoplasmic reticulum stress and protecting against cell death. In contrast, autophagy induced by the same chemicals does not confer protection in a normal human colon cell line and in the non-transformed murine embryonic fibroblasts but rather contributes to cell death. Thus the impact of autophagy on cell survival during endoplasmic reticulum stress is likely contingent on the status of cells, which could be explored for tumor-specific therapy.
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Cites
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Cited by
Regulation mechanisms and signaling pathways of autophagy
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An Overview of Autophagy: Morphology, Mechanism, and Regulation
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Crosstalk between apoptosis.; necrosis and autophagy
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“non-transformed murine embryonic fibroblasts, autophagy does not alleviate ER stress but rather contributes to ER-induced apoptosis [82].”
BackgroundAutophagy at the crossroads of catabolism and anabolism
Kaur, J., & Debnath, J. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4024 · Cited by 991
Metadata
- Authors
- Ding, W.-X., Ni, H.-M., Gao, W., Hou, Y.-F., Melan, M. A., Chen, X., Stolz, D. B., Shao, Z.-M., & Yin, X.-M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 282
- Issue
- 7
- Pages
- 4702-4710
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2117875646
- Cited by
- 486
- References
- 38
- FWCI
- 11.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ding, W.-X., Ni, H.-M., Gao, W., Hou, Y.-F., Melan, M. A., Chen, X., Stolz, D. B., Shao, Z.-M., & Yin, X.-M. (2007). Differential Effects of Endoplasmic Reticulum Stress-induced Autophagy on Cell Survival. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m609267200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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