An Overview of Autophagy: Morphology, Mechanism, and Regulation

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

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Regulation mechanisms and signaling pathways of autophagy

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Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy

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Hereditary Early-Onset Parkinson's Disease Caused by Mutations in <i>PINK1</i>

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Induction of autophagy and inhibition of tumorigenesis by beclin 1

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p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

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Mechanisms of mitophagy

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The Role of Atg Proteins in Autophagosome Formation

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The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

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AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

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Eaten alive: a history of macroautophagy

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Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

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A ubiquitin-like system mediates protein lipidation

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ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

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Mammalian autophagy: core molecular machinery and signaling regulation

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Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

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ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

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Selective degradation of mitochondria by mitophagy

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Autophagy: molecular machinery for self-eating

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Growth factor regulation of autophagy and cell survival in the absence of apoptosis

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Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks

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Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling.

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Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

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LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

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Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

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Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells

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Regulation of TORC1 by Rag GTPases in nutrient response

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The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

Itakura, E., Kishi‐Itakura, C., & Mizushima, N. (2012) · Cell · doi:10.1016/j.cell.2012.11.001 · Cited by 1,327 · see citing works

Phosphorylation of the Autophagy Receptor Optineurin Restricts <i>Salmonella</i> Growth

Wild, P., Farhan, H., McEwan, D. G., Wagner, S., Rogov, V. V., Brady, N. R., Richter, B., Korac, J., Waidmann, O., Choudhary, C., et al. (2011) · Science · doi:10.1126/science.1205405 · Cited by 1,298 · see citing works

Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction.

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Molecular dissection of autophagy: two ubiquitin-like systems

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Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

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A Role for Ubiquitin in Selective Autophagy

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Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

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A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

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Protection against Fatal Sindbis Virus Encephalitis by Beclin, a Novel Bcl-2-Interacting Protein

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The Atg12-Atg5 Conjugate Has a Novel E3-like Activity for Protein Lipidation in Autophagy

Hanada, T., Noda, N. N., Satomi, Y., Ichimura, Y., Fujioka, Y., Takao, T., Inagaki, F., & Ohsumi, Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c700195200 · Cited by 1,123 · cited 1× · see citing works

Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy

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The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy

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Control of Macroautophagy by Calcium, Calmodulin-Dependent Kinase Kinase-β, and Bcl-2

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A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

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Ambra1 regulates autophagy and development of the nervous system

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Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

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Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

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Two Distinct Vps34 Phosphatidylinositol 3–Kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting in <i>Saccharomyces cerevisiae</i>

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The Reversible Modification Regulates the Membrane-Binding State of Apg8/Aut7 Essential for Autophagy and the Cytoplasm to Vacuole Targeting Pathway

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A Role for a 70-Kilodalton Heat Shock Protein in Lysosomal Degradation of Intracellular Proteins

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A Receptor for the Selective Uptake and Degradation of Proteins by Lysosomes

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FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

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NIX is required for programmed mitochondrial clearance during reticulocyte maturation

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Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

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Role for Rab7 in maturation of late autophagic vacuoles

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Microautophagy of Cytosolic Proteins by Late Endosomes

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Plasma membrane contributes to the formation of pre-autophagosomal structures

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Formation Process of Autophagosome Is Traced with Apg8/Aut7p in Yeast

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Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

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An Overview of the Molecular Mechanism of Autophagy

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Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes

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Protein Turnover Via Autophagy: Implications for Metabolism

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Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking

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Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

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The Atg8 and Atg12 ubiquitin‐like conjugation systems in macroautophagy

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LC3 and GATE‐16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis

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Peptide sequences that target cytosolic proteins for lysosomal proteolysis

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Atg8 Controls Phagophore Expansion during Autophagosome Formation

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Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation

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3D tomography reveals connections between the phagophore and endoplasmic reticulum

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Activation of Chaperone-mediated Autophagy during Oxidative Stress

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The regulation of autophagy – unanswered questions

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The Adaptor Protein p62/SQSTM1 Targets Invading Bacteria to the Autophagy Pathway

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Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation

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The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane

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Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum

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TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways

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Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK

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Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase

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An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis

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Atg101, a novel mammalian autophagy protein interacting with Atg13

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The Association of AMPK with ULK1 Regulates Autophagy

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Differential Effects of Endoplasmic Reticulum Stress-induced Autophagy on Cell Survival

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The Atg1-Atg13 Complex Regulates Atg9 and Atg23 Retrieval Transport from the Pre-Autophagosomal Structure

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Autophagy: for better or for worse

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