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Nedd4-2 Catalyzes Ubiquitination and Degradation of Cell Surface ENaC
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Nedd4-2 reduces ENaC expression on the cell surface at two distinct sites in the endocytic pathway.
“Nedd4-2 reduces ENaC expression on the cell surface at two distinct sites in the endocytic pathway.”
From Ubiquitin-specific Peptidase 8 (USP8) Regulates Endosomal Trafficking of the Epithelial Na+ Channel* (2013) · cites this paper as [11]
Previous work indicated that ubiquitination enhances ENaC endocytosis and sorting to lysosomes for degradation.
“Previous work indicated that ubiquitination enhances ENaC endocytosis and sorting to lysosomes for degradation.”
From Ubiquitin-specific Peptidase 8 (USP8) Regulates Endosomal Trafficking of the Epithelial Na+ Channel* (2013) · cites this paper as [11]
Cytoplasmic lysines in all three ENaC subunits are substrates for ubiquitination.
“which are substrates for ubiquitination (10”
From Ubiquitin-specific Peptidase 8 (USP8) Regulates Endosomal Trafficking of the Epithelial Na+ Channel* (2013) · cites this paper as [11]
Nedd4-2-mediated ubiquitination of ENaC promotes lysosomal degradation and reduces recycling.
“This endosomal sorting decision is governed in part by Nedd4-2-mediated ubiquitination of ENaC; ubiquitination promotes lysosomal degradation and reduces recycling (11”
From Ubiquitin-specific Peptidase 8 (USP8) Regulates Endosomal Trafficking of the Epithelial Na+ Channel* (2013) · cites this paper as [11]
Nedd4-2 catalyzes monoubiquitination and polyubiquitination of αENaC.
“Nedd4-2 catalyzed monoubiquitination and polyubiquitination of αENaC, as we reported previously (11”
From Ubiquitin-specific Peptidase 8 (USP8) Regulates Endosomal Trafficking of the Epithelial Na+ Channel* (2013) · cites this paper as [11]
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Research works printed but not linked: 28
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Cited by
Sorted by citations
Ubiquitin-specific Peptidase 8 (USP8) Regulates Endosomal Trafficking of the Epithelial Na+ Channel*
Zhou, R., Tomkovicz, V. R., Butler, P. L., Ochoa, L. A., Peterson, Z. J., & Snyder, P. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.425272 · Cited by 47
Self-citationSun, T., Guo, J., Shallow, H., Yang, T., Xu, J., Li, W., Hanson, C., Wu, J. G., Li, X., Massaeli, H., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.198408 · Cited by 46
Multi-modal quantification of pathway activity with MAYA
Landais, Y., & Vallot, C. (2023) · Nature Communications · doi:10.1038/s41467-023-37410-2 · Cited by 9
“…genes regulating ENaCs and their residence at the apical membrane: SCNN1A encodes a subunit of ENaCs 30 , NEDD4L participates to ENaCs ubiquitination which leads to their retrieval from cell surface 31 and SGK1 is known to phosphorylate NEDD4L product, which decreases its binding to ENaCs 32,33 .”
Background
Metadata
- Authors
- Zhou, R., Patel, S. V., & Snyder, P. M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 282
- Issue
- 28
- Pages
- 20207-20212
- ISSN
- 0021-9258
- Cited by
- 188
- References
- 0
- Language
- en
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