The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Chemerin, a Novel Adipokine That Regulates Adipogenesis and Adipocyte Metabolism
Open accessAbstract
Obesity is an alarming primary health problem and is an independent risk factor for type II diabetes, cardiovascular diseases, and hypertension. Although the pathologic mechanisms linking obesity with these co-morbidities are most likely multifactorial, increasing evidence indicates that altered secretion of adipose-derived signaling molecules (adipokines; e.g. adiponectin, leptin, and tumor necrosis factor alpha) and local inflammatory responses are contributing factors. Chemerin (RARRES2 or TIG2) is a recently discovered chemoattractant protein that serves as a ligand for the G protein-coupled receptor CMKLR1 (ChemR23 or DEZ) and has a role in adaptive and innate immunity. Here we show an unexpected, high level expression of chemerin and its cognate receptor CMKLR1 in mouse and human adipocytes. Cultured 3T3-L1 adipocytes secrete chemerin protein, which triggers CMKLR1 signaling in adipocytes and other cell types and stimulates chemotaxis of CMKLR1-expressing cells. Adenoviral small hairpin RNA targeted knockdown of chemerin or CMKLR1 expression impairs differentiation of 3T3-L1 cells into adipocytes, reduces the expression of adipocyte genes involved in glucose and lipid homeostasis, and alters metabolic functions in mature adipocytes. We conclude that chemerin is a novel adipose-derived signaling molecule that regulates adipogenesis and adipocyte metabolism.
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Cites
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Cited by
González-Périz, A., Horrillo, R., Ferré, N., Gronert, K., Dong, B., Morán-Salvador, E., Titos, E., Martínez-Clemente, M., López-Parra, M., Arroyo, V., et al. (2009) · The FASEB Journal · doi:10.1096/fj.08-125674 · Cited by 555
Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages
Chen, D., Zhang, X., Li, Z., & Zhu, B. (2021) · Theranostics · doi:10.7150/thno.51777 · Cited by 390
IL-17 regulates adipogenesis, glucose homeostasis, and obesity
Zúñiga, L. A., Shen, W.-J., Joyce-Shaikh, B., Pyatnova, E. A., Richards, A. G., Thom, C., Andrade, S. M., Cua, D. J., Kraemer, F. B., & Butcher, E. C. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001269 · Cited by 394
Michalakis, K., Mintziori, G., Kaprara, A., Tarlatzis, B. C., & Goulis, D. G. (2013) · Metabolism · doi:10.1016/j.metabol.2012.08.012 · Cited by 321
Lehrke, M., Becker, A., Greif, M., Stark, R., Laubender, R. P., von Ziegler, F., Lebherz, C., Tittus, J., Reiser, M., Becker, C., et al. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0380 · Cited by 299
Metadata
- Authors
- Goralski, K. B., McCarthy, T. C., Hanniman, E. A., Zabel, B. A., Butcher, E. C., Parlee, S. D., Muruganandan, S., & Sinal, C. J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2007-09
- Volume
- 282
- Issue
- 38
- Pages
- 28175-28188
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1986082361
- Cited by
- 857
- References
- 12
- FWCI
- 14.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Goralski, K. B., McCarthy, T. C., Hanniman, E. A., Zabel, B. A., Butcher, E. C., Parlee, S. D., Muruganandan, S., & Sinal, C. J. (2007). Chemerin, a Novel Adipokine That Regulates Adipogenesis and Adipocyte Metabolism. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m700793200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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