Cited by 2,606Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

Adipose tissue, adipokines, and inflammation

Fantuzzi, Giamila·2005·Journal of Allergy and Clinical Immunology

Abstract

White adipose tissue is no longer considered an inert tissue mainly devoted to energy storage but is emerging as an active participant in regulating physiologic and pathologic processes, including immunity and inflammation. Macrophages are components of adipose tissue and actively participate in its activities. Furthermore, cross-talk between lymphocytes and adipocytes can lead to immune regulation. Adipose tissue produces and releases a variety of proinflammatory and anti-inflammatory factors, including the adipokines leptin, adiponectin, resistin, and visfatin, as well as cytokines and chemokines, such as TNF-alpha, IL-6, monocyte chemoattractant protein 1, and others. Proinflammatory molecules produced by adipose tissue have been implicated as active participants in the development of insulin resistance and the increased risk of cardiovascular disease associated with obesity. In contrast, reduced leptin levels might predispose to increased susceptibility to infection caused by reduced T-cell responses in malnourished individuals. Altered adipokine levels have been observed in a variety of inflammatory conditions, although their pathogenic role has not been completely clarified.

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Crossref · 10.1016/j.jaci.2005.02.023

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Authors
Fantuzzi, G.
Affiliations
University of Illinois Chicago (US)
Corresponding author
Fantuzzi, Giamila
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2005-05
Volume
115
Issue
5
Pages
911-919
ISSN
0091-6749 (ISSN-L)
OpenAlex
W2158079900
Cited by
2,606
References
89
Citations by year
2026: 45 · 2025: 67 · 2024: 96 · 2023: 117 · 2022: 119 · 2021: 127 · 2020: 112 · 2019: 121 · 2018: 123 · 2017: 145 · 2016: 112 · 2015: 132 · 2014: 139 · 2013: 184 · 2012: 148
FWCI
16.18
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Allergy and Clinical Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK061483, DK-061483)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
white adipose tissue, adipokines, inflammation, adipose tissue macrophages, leptin, adiponectin, resistin, visfatin, TNF-α, interleukin-6, MCP-1, insulin resistance, obesity, cardiovascular disease, infection susceptibility, T cell response, malnutrition
MeSH terms
Adipose Tissue, Animals, Autoimmune Diseases, Hormones, Ectopic, Humans, Inflammation, Insulin Resistance, Macrophages, Obesity, Complement Factor D, Serine Endopeptidases, Cytokines, Adipocytes, Leptin, Intercellular Signaling Peptides and Proteins, Adiponectin, Resistin, Nicotinamide Phosphoribosyltransferase

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