The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Obesity‐induced insulin resistance and hepatic steatosis are alleviated by ω‐3 fatty acids: a role for resolvins and protectins
Open accessAbstract
Omega‐3‐polyunsaturated fatty acids (w‐3‐PUFAs) have well‐documented protective effects that are attributed not only to eicosanoid inhibition but also to the formation of novel biologically active lipid mediators (i.e ., resolvins and protectins). In this study, we examined their effects on ob/ob mice, an obesity model of insulin resistance and fatty liver disease. Dietary intake ofw‐3‐PUFAs had insulin‐sensitizing actions in adipose tissue and liver and improved insulin tolerance in obese mice. Genes involved in insulin sensitivity (PPAR/γ), glucose transport (GLUT‐2/GLUT–4), and insulin receptor signaling (IRS‐1/IRS–2) were up‐regulated byw‐3‐PUFAs. Moreover,w‐3‐PUFAs increased adiponectin, an anti‐inflammatory and insulin‐sensitizing adipokine, and induced AMPK phosphorylation, a fuel‐sensing enzyme and a gatekeeper of the energy balance. Concomitantly, hepatic steatosis was alleviated byw‐3‐PUFAs. A lipidomic analysis with liquid chromatography/mass spectrome‐try/mass spectrometry revealed that w‐3‐PUFAs inhibited the formation of w‐6‐PUFA‐derived eicosanoids, while triggering the formation of w‐3‐PUFA‐derived resolvins and protectins. Moreover, representative members of these lipid mediators, namely resolvin E1 and protectin D1, mimicked the insulin‐sensitizing and antisteatotic effects of w‐3‐PUFAs and induced adiponectin expression to a similar extent that of rosigli‐tazone, a member of the thiazolidinedione family of antidiabetic drugs. Taken together, these findings uncover beneficial actions of w‐3‐PUFAs and their bioactive lipid autacoids in preventing obesity‐induced insulin resistance and hepatic steatosis.—Gonzalez‐Periz, A.,Horrillo, R., Ferre, N., Gronert, K., Dong, B., Moran‐Salvador, E.,Titos, E., Martinez‐Clemente, M.,Lopez‐Parra, M.,Arroyo, V., Claria, J. Obesity‐induced insulin resistance and hepatic steatosis are alleviated byw‐3 fatty acids: a role for resolvins and protectins. FASEB J. 23, 1946–1957 (2009)
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Cites
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Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
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n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases
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Cited by
Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., & Olefsky, J. M. (2010) · Cell · doi:10.1016/j.cell.2010.07.041 · Cited by 2,428
“Recent studies have also indicated that metabolic products derived from u-3 FAs, such as 17S-hydroxy-DHA, resolvins, and protectins may play a role in the long term resolution of inflammation and this might attenuate insulin resistance in the context of obesity (González-Périz et al., 2009).”
Omega-3 Fatty Acids and Cardiovascular Disease
Mozaffarian, D., & Wu, J. H. Y. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.06.063 · Cited by 1,771
Resolvins and protectins in inflammation resolution
Serhan, C. N., & Petasis, N. A. (2011) · Chemical Reviews · doi:10.1021/cr100396c · Cited by 996
Serhan, C. N. (2017) · The FASEB Journal · doi:10.1096/fj.201601222r · Cited by 555
Serhan, C. N., Dalli, J., Colas, R. A., Winkler, J. W., & Chiang, N. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.08.006 · Cited by 492
Metadata
- Authors
- González-Périz, A., Horrillo, R., Ferré, N., Gronert, K., Dong, B., Morán-Salvador, E., Titos, E., Martínez-Clemente, M., López-Parra, M., Arroyo, V., & Clária, J.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2009-02-11
- Volume
- 23
- Issue
- 6
- Pages
- 1946-1957
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2163837156
- Cited by
- 555
- References
- 58
- FWCI
- 36.87
- Type
- journal article
- Language
- en
- Open access
- green
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- González-Périz, A., Horrillo, R., Ferré, N., Gronert, K., Dong, B., Morán-Salvador, E., Titos, E., Martínez-Clemente, M., López-Parra, M., Arroyo, V., & Clária, J. (2009). Obesity‐induced insulin resistance and hepatic steatosis are alleviated by ω‐3 fatty acids: a role for resolvins and protectins. The FASEB Journal. https://doi.org/10.1096/fj.08-125674
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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