Suppression of Diacylglycerol Acyltransferase-2 (DGAT2), but Not DGAT1, with Antisense Oligonucleotides Reverses Diet-induced Hepatic Steatosis and Insulin Resistance

Cited by (384)

Items 201–300 of 384

  1. The pathogenesis of hepatic steatosis in MASLD: a lipid droplet perspective
    Natalie Krahmer, Tobias C. Walther, Robert V. Farese · 2025 · Journal of Clinical Investigation
  2. Role of the N-terminal hydrophobic residues of DGKε in targeting the endoplasmic reticulum
    Hirooki Matsui, Yasukazu Hozumi, Toshiaki Tanaka, Masashi Okada, Tomoyuki Nakano, Yusuke Suzuki, Ken Iseki, Seiji Kakehata, Matthew K. Topham, Kaoru Goto · 2014 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  3. Emerging targets for therapy in ALD: Lessons from NASH
    Ashwani Kumar Singal, Vijay H. Shah, Harmeet Malhi · 2023 · Hepatology
  4. Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors
    Jason E. Imbriglio, Dong‐Ming Shen, Rui Liang, Ken Marby, Ming You, Hye Won Youm, Zhe Feng, Clare London, Yusheng Xiong, Jim Tata et al. · 2015 · Journal of Medicinal Chemistry
  5. Hepatic VLDL secretion: DGAT1 determines particle size but not particle number, which can be supported entirely by DGAT2
    Zehra Irshad, Nikola Paul Chmel, Raghu Adya, Victor A. Zammit · 2018 · Journal of Lipid Research
  6. Neuroprotective effects of Myricetin on Epoxiconazole-induced toxicity in F98 cells
    Hiba Hamdi, Salwa Abid‐Essefi, Joël Eyer · 2021 · Free Radical Biology and Medicine
  7. ЭФФЕКТИВНОСТЬ УПРАЖНЕНИЙ КЕГЕЛЯ В ТЕРАПИИ ПРОЛАПСА ТАЗОВЫХ ОРГАНОВ 1-2 СТЕПЕНИ У ЖЕНЩИН В ПОСТМЕНОПАУЗАЛЬНОМ ПЕРИОДЕ
    Вадим Гельевич Мозес, Olesiya Korotkevich, Ющенко Марина Анатольевна, Елгина Светлана Ивановна, Рудаева Елена Владимировна, Мозес Кира Борисовна, Помыткина Татьяна Евгеньевна · 2025 · Matʹ i ditâ v Kuzbasse
  8. Shrimp Oil Extracted from Shrimp Processing By-Product Is a Rich Source of Omega-3 Fatty Acids and Astaxanthin-Esters, and Reveals Potential Anti-Adipogenic Effects in 3T3-L1 Adipocytes
    Indrayani Phadtare, Hitesh B. Vaidya, Kelly Hawboldt, Sukhinder Kaur Cheema · 2021 · Marine Drugs
  9. Basal re-esterification finetunes mitochondrial fatty acid utilization
    Anand Kumar Sharma, Tongtong Wang, Alaa Othman, Radhika Khandelwal, Miroslav Baláž, Salvatore Modica, Nicola Zamboni, Christian Wolfrum · 2023 · Molecular Metabolism
  10. Hepatoprotective effect of tamoxifen on steatosis and non-alcoholic steatohepatitis in mouse models
    Taishi Miyashita, Yasuyuki Toyoda, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, Tsuyoshi Yokoi · 2012 · The Journal of Toxicological Sciences
  11. Rose hip exerts antidiabetic effects via a mechanism involving downregulation of the hepatic lipogenic program
    Ulrika Andersson, Emma Henriksson, Kristoffer Ström, Jan Alenfall, Olga Göransson, Cecilia Holm · 2010 · American Journal of Physiology-Endocrinology and Metabolism
  12. Nonalcoholic Fatty Liver Disease and Staging of Hepatic Fibrosis
    Atilla Engin · 2024 · Advances in experimental medicine and biology
  13. Fatty liver and insulin resistance: not always linked.
    Gustav Schonfeld, Pin Yue, Xiaobo Lin, Zhouji Chen · 2008 · PubMed Central
  14. Mechanisms coupling lipid droplets to MASLD pathophysiology
    Mari V. Reid, Gavin Fredrickson, Douglas G. Mashek · 2024 · Hepatology
  15. Nicotinic Acid Decreases Apolipoprotein B100-Containing Lipoprotein Levels by Reducing Hepatic Very Low Density Lipoprotein Secretion through a Possible Diacylglycerol Acyltransferase 2 Inhibition in Obese Dogs
    Jérôme Le Bloc’h, Véronique Leray, Maud Chétiveaux, Benjamin Freuchet, Thierry Magot, Michel Krempf, Patrick Nguyen, Khadija Ouguerram · 2010 · Journal of Pharmacology and Experimental Therapeutics
  16. LA and ALA prevent glucose intolerance in obese male rats without reducing reactive lipid content, but cause tissue-specific changes in fatty acid composition
    Sarthak Matravadia, Piotr Zabielski, Adrian Chabowski, David M. Mutch, Graham P. Holloway · 2016 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
  17. Genes involved in the establishment of hepatic steatosis in Muscovy, Pekin and mule ducks
    Annabelle Tavernier, Stéphane Davail, Karine Ricaud, Marie-Dominique Bernadet, Karine Gontier · 2016 · Molecular and Cellular Biochemistry
  18. Nonalcohol fatty liver disease: balancing supply and utilization of triglycerides
    Leinys S. Santos‐Báez, Henry N. Ginsberg · 2021 · Current Opinion in Lipidology
  19. High-content assays for evaluating cellular and hepatic diacylglycerol acyltransferase activity
    Jenson Qi, Wensheng Lang, Edward C. Giardino, Gary W. Caldwell, Charles Smith, Lisa K. Minor, Andrew L. Darrow, G. Willemsens, Katharina DeWaepenaert, Peter W. M. Roevens et al. · 2010 · Journal of Lipid Research
  20. Second‐generation antisense oligonucleotides against β‐catenin protect mice against diet‐induced hepatic steatosis and hepatic and peripheral insulin resistance
    Violeta Popov, François R. Jornayvaz, Emin Özgür Akgül, Shoichi Kanda, Michael J. Jurczak, Dongyan Zhang, Abudukadier Abulizi, Sachin K. Majumdar, Blas A. Guigni, Kitt Falk Petersen et al. · 2015 · The FASEB Journal
  21. Selective suppression of adipose tissue apoE expression impacts systemic metabolic phenotype and adipose tissue inflammation
    Zhihua Huang, Catherine A. Reardon, Godfrey S. Getz, Nobuyo Maeda, Theodore Mazzone · 2014 · Journal of Lipid Research
  22. Chitooligosaccharide supplementation prevents the development of high fat diet-induced non-alcoholic fatty liver disease (NAFLD) in mice via the inhibition of cluster of differentiation 36 (CD36)
    Mengyao Zhao, Xin Shen, Xiaodan Li, Baoli Chen, Liqiang Fan, Quanming Xia, Liming Zhao · 2019 · Journal of Functional Foods
  23. JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 inhibitor, improves glucose metabolism in diet-induced obesity and genetic T2DM mice
    Daisuke Tomimoto, Chihiro Okuma, Yukihito Ishii, Akio Kobayashi, Takeshi Ohta, Makoto Kakutani, Tsuneo Imanaka, Nobuya Ogawa · 2015 · Journal of Pharmacological Sciences
  24. Resveratrol protects against hepatic insulin resistance in a rat's model of non‐alcoholic fatty liver disease by down‐regulation of GPAT ‐1 and DGAT 2 expression and inhibition of PKC membranous translocation
    Rehab Mustafa Badi, Dalia G. Mostafa, Eman F. Khaleel, Huda H. Satti · 2019 · Clinical and Experimental Pharmacology and Physiology
  25. Cytochrome P450 2E1 and hyperglycemia-induced liver injury
    Aparajita Dey, Smita Kumar · 2011 · Cell Biology and Toxicology
  26. Targeting energy expenditure via fuel switching and beyond
    John G. Geisler · 2010 · Diabetologia
  27. Therapeutic Potential of the Natural Product Mangiferin in Metabolic Syndrome
    Raihan H. Mirza, Nan Chi, Yuling Chi · 2013 · Journal of Nutritional Therapeutics
  28. Increased Subcutaneous Adipose Tissue Expression of Genes Involved in Glycerolipid-Fatty Acid Cycling in Obese Insulin-Resistant Versus -Sensitive Individuals
    Marie‐Soleil Gauthier, Joëlle R. Pérusse, Marie-Ève Lavoie, ROBERT M. SLADEK, S.R. Murthy Madiraju, Neil B. Ruderman, Benoit Coulombe, Marc Prentki, RÉMI P.R. RABASA-LHORET · 2014 · The Journal of Clinical Endocrinology & Metabolism
  29. α-Linolenic acid supplementation and exercise training reveal independent and additive responses on hepatic lipid accumulation in obese rats
    Paula Michelle Miotto, Meaghan Horbatuk, Ross Proudfoot, Sarthak Matravadia, Marica Bakovic, Adrian Chabowski, Graham P. Holloway · 2017 · American Journal of Physiology-Endocrinology and Metabolism
  30. Dual extraction of mRNA and lipids from a single biological sample
    Normand Podechard, Simon Ducheix, Arnaud Polizzi, Frédéric Lasserre, Alexandra Montagner, Vincent Legagneux, Edwin Fouché, Fabrice Saez, Jean‐Marc A. Lobaccaro, Laïla Lakhal et al. · 2018 · Scientific Reports
  31. Differential capability of metabolic substrates to promote hepatocellular lipid accumulation
    Ngoc Anh Hoang, Friederike Richter, M. Schubert, Stefan Lorkowski, Lars‐Oliver Klotz, Holger Steinbrenner · 2018 · European Journal of Nutrition
  32. Anthropometric and Biochemical Characteristics of Patients with Nonalcoholic Fatty Liver Diagnosed by Non-Invasive Diagnostic Methods
    T. Novaković, Mevludin Mekić, Ljiljana Smilic, Tanja N. Smilic, Biljana Ini, Kostic Kostic, Ljiljana Jovićević, Zlatica Mirković, Srbislava Milinić · 2014 · Medical Archives
  33. Hepatic Mediators of Lipid Metabolism and Ketogenesis: Focus on Fatty Liver and Diabetes
    Gustavo Werpel Fernandes, Bárbara M. L. C. Bocco · 2020 · Current Diabetes Reviews
  34. Hydroxy Selenomethionine Alleviates Hepatic Lipid Metabolism Disorder of Pigs Induced by Dietary Oxidative Stress via Relieving the Endoplasmic Reticulum Stress
    Jinzhong Jing, Shenggang Yin, Yan Liu, Yonggang Liu, Longqiong Wang, Jiayong Tang, Gang Jia, Guangmang Liu, Gang Tian, Xiaoling Chen et al. · 2022 · Antioxidants
  35. Ameliorative role of bioactive phytoconstituents targeting obesity associated NAFLD by modulation of inflammation and lipogenesis pathways: a comprehensive review
    Pervej Alom Barbhuiya, Saikat Sen, Manash Pratim Pathak · 2023 · Phytochemistry Reviews
  36. Changes in the levels of endothelium-derived coagulation parameters in nonalcoholic fatty liver disease
    Oktay Bilgir, Ferda Bilgir, Giray Bozkaya, Mehmet Çalan · 2013 · Blood Coagulation & Fibrinolysis
  37. Deletion of diacylglycerol kinase ε confers susceptibility to obesity via reduced lipolytic activity in murine adipocytes
    Tomoyuki Nakano, Keiko Seino, Ichiro Wakabayashi, Diana M. Stafforini, Matthew K. Topham, Kaoru Goto · 2018 · The FASEB Journal
  38. ER stress mediated degradation of diacylglycerol acyltransferase impairs mitochondrial functions in TMCO1 deficient cells
    Xi Wang, Qiao-Chu Wang, Zhongshuai Sun, Tingting Li, Keyan Yang, Chaoqiang An, Caixia Guo, Tie-Shan Tang · 2019 · Biochemical and Biophysical Research Communications
  39. Impact of leptin deficiency compared with neuronal-specific leptin receptor deletion on cardiometabolic regulation
    Jussara Marcia do Carmo, Alexandre A. da Silva, Fábio Nelson Gava, Sydney P. Moak, Xuemei Dai, John Edward Hall · 2019 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
  40. Peroxisome proliferator‐activated receptor gamma regulates genes involved in milk fat synthesis in mammary epithelial cells of water buffalo
    Fangting Zhou, Yina Ouyang, Yongwang Miao · 2021 · Animal Science Journal
  41. Pathogenesis of insulin resistance
    Cheol Soo Choi · 2009 · The Korean Journal of Internal Medicine
  42. Quantification of Mangiferin by High Pressure Liquid Chromatography; Physicochemical and Sensory Evaluation of Functional Mangiferin Drink
    Muhammad Imran, Masood Sadiq Butt, Saeed Akhtar, Muhammad Riaz, Muhammad Jawad Iqbal, Hafiz Ansar Rasul Suleria · 2015 · Journal of Food Processing and Preservation
  43. Identification of DGAT2 Inhibitors Using Mass Spectrometry
    Xuelei Sherry Song, Jiaping Zhang, Xun Chen, Oksana C. Palyha, Christine Chung, Lisa M. Sonatore, Larissa C. Wilsie, Steven J. Stout, David G. McLaren, Andrew K.P. Taggart et al. · 2015 · SLAS DISCOVERY
  44. Antisense oligonucleotide is a promising intervention for liver diseases
    Kailing Lu, Qijing Fan, Xiaoju Zou · 2022 · Frontiers in Pharmacology
  45. Tangduqing Granules Attenuate Insulin Resistance and Abnormal Lipid Metabolism through the Coordinated Regulation of PPARγ and DGAT2 in Type 2 Diabetic Rats
    Qinghua Zhang, Yingying Huang, Xiaojin Li, Hongyi Liu, Baichuan He, Bin Wang, Yuntao Ma, Xiang Dong Zhou, Yaqin Liu, Shentao Wu · 2019 · Journal of Diabetes Research
  46. Triglyceride-Rich Lipoproteins
    Maaike Kockx, Leonard Kritharides · 2018 · Cardiology Clinics
  47. Nonalcoholic fatty liver disease: emerging mechanisms and consequences
    Aaron R. Turkish · 2008 · Current Opinion in Clinical Nutrition & Metabolic Care
  48. Reduced adiposity and improved insulin sensitivity in obese mice with antisense suppression of 4E-BP2 expression
    Xing Xian Yu, Sanjay Pandey, Sheri L. Booten, Susan F. Murray, Brett P. Monia, Sanjay Bhanot · 2008 · American Journal of Physiology-Endocrinology and Metabolism
  49. Trivalent chromium alleviates oleic acid induced steatosis in SMMC-7721 cells by decreasing fatty acid uptake and triglyceride synthesis
    Song Wang, Jian Wang, Xiaonan Zhang, Linlin Hu, Zhijia Fang, Zhiwei Huang, Ping Shi · 2016 · BioMetals
  50. Gene expression profile-based drug screen identifies SAHA as a novel treatment for NAFLD
    Zhujun Cheng, Yusong Wen, Bowen Liang, Siyang Chen, Yujun Liu, Zang Wang, Jiayu Cheng, Xiaoli Tang, Hongbo Xin, Libin Deng · 2019 · Molecular Omics
  51. The protective effect of curcumin on carbon tetrachloride induced liver damage
    Şahver Ege Hişmioğulları, Fatma Bahar Sunay, Serpil Paksoy, Hasan Akşit · 2014
  52. Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3
    Kim Huard, Allyn T. Londregan, Gregory J. Tesz, Kevin B. Bahnck, Thomas V. Magee, David Hepworth, Jana Polívková, Steven B. Coffey, Brandon A. Pabst, James R. Gosset et al. · 2015 · Journal of Medicinal Chemistry
  53. Long-term fructose consumption prolongs hepatic stearoyl-CoA desaturase 1 activity independent of upstream regulation in rats
    Li Liu, Shang Wang, Ling Yao, Jinxiu Li, Peng Ma, Lirong Jiang, Dazhi Ke, Yongquan Pan, Jianwei Wang · 2016 · Biochemical and Biophysical Research Communications
  54. Antisense technology for the prevention or the treatment of cardiovascular disease: The next blockbuster?
    Vasilios Gabriel Athyros, Anna I. Kakafika, Κωνσταντίνος Τζιόμαλος, Asterios I. Karagiannis, Dimitri P. Mikhailidis · 2008 · Expert Opinion on Investigational Drugs
  55. Patent landscape for discovery of promising acyltransferase DGAT and MGAT inhibitors
    Vishal Prakash Zambre, Shamali M. Khamkar, Dnyaneshwar D. Gavhane, Sagar C. Khedkar, Monali R. Chavan, Madhuri M. Pandey, Sonali B. Sanap, Rajesh B. Patil, Sanjay Dinkar Sawant · 2020 · Expert Opinion on Therapeutic Patents
  56. Evolution of Spatial and Temporalcis-Regulatory Divergence in Sticklebacks
    Katya L. Mack, Tyler A. Square, Bin Zhao, Craig T. Miller, Hunter B. Fraser · 2023 · Molecular Biology and Evolution
  57. Effect of diacylglycerol acyltransferase 2 overexpression in 3T3-L1 is associated to an increase in mono-unsaturated fatty acid accumulation
    Zhi‐Qi Zhang, Gang Shu, Xiaotong Zhu, Junming Guo, Han Cai, Songbo Wang, Lina Wang, Ping Gao, Qianyun Xi, Yongliang Zhang et al. · 2014 · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
  58. Antisense and small-molecule modulation of diacylglycerol acyltransferase
    Brian K. Hubbard, Istvan J. Enyedy, Thomas A. Gilmore, Michael H. Serrano‐Wu · 2007 · Expert Opinion on Therapeutic Patents
  59. Pre- and post-prandial expression of genes involved in lipid metabolism at the end of the overfeeding period of mule ducks
    Annabelle Tavernier, Karine Ricaud, Marie-Dominique Bernadet, Karine Gontier, Stéphane Davail · 2017 · Molecular and Cellular Biochemistry
  60. Maraviroc improves hepatic triglyceride content but not inflammation in a murine nonalcoholic fatty liver disease model induced by a chronic exposure to high-fat diet
    Laura Pérez‐Martínez, Laura Ochoa‐Callejero, Susana Rubio-Mediavilla, Judit Narro-Íñiguez, Iván Bernardo, José Antonio Oteo, José Ramón Blanco · 2018 · Translational research
  61. Short-Term Physical Inactivity Induces Diacylglycerol Accumulation and Insulin Resistance in Muscle via Lipin1 Activation
    Saori Kakehi, Yoshifumi Tamura, Shin‐ichi Ikeda, Naoko Kaga, Hikari Taka, Noriko Ueno, Tetsuya Shiuchi, Atsushi Kubota, Keishoku Sakuraba, Ryuzo Kawamori et al. · 2019 · American Journal of Physiology-Endocrinology and Metabolism
  62. The Epidemic of Type 2 Diabetes Mellitus: Its Links to Obesity, Insulin Resistance, and Lipotoxicity
    Kenneth J. Cusi · 2009 · Humana Press eBooks
  63. Perinatal exposure to di-(2-ethylhexyl) phthalate induces hepatic lipid accumulation mediated by diacylglycerol acyltransferase 1
    SJ An, E J Lee, Jeong Sh, Y-p Hong, So Yoon Ahn, Y-J Yang · 2021 · Human & Experimental Toxicology
  64. The many pathways driving liver inflammation in MASH
    Herbert Tilg, Timon Erik Adolph, Stefano Romeo, Rohit Seth Loomba · 2026 · Cell Metabolism
  65. An aqueous olive leaf extract (OLE) ameliorates parameters of oxidative stress associated with lipid accumulation and induces lipophagy in human hepatic cells
    Stefano Tacconi, Savino Longo, Flora Guerra, C. Moliteni, Marzia Friuli, Adele Romano, Silvana Gaetani, Vito Michele Paradiso, Graziana Difonzo, Francesco Caponio et al. · 2023 · Food & Function
  66. Preferential lipolysis of DGAT1 over DGAT2 generated triacylglycerol in Huh7 hepatocytes
    Rajakumar Selvaraj, Sarah V. Zehnder, Russell Watts, Jihong Lian, Chinmayee Das, Randal Nelson, Richard S. Lehner · 2023 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  67. Z-ligustilide and n-Butylidenephthalide Isolated from the Aerial Parts of Angelica tenuissima Inhibit Lipid Accumulation In Vitro and In Vivo
    Wonseok Lee, Hye Ryoung Koo, You‐Jin Choi, Jin Gyu Choi, Myung Sook Oh, Xing Yu Jin, Munki Choo, Sunghyouk Park, Yoo‐Seong Jeong, Suk‐Jae Chung et al. · 2019 · Planta Medica
  68. Brief daily access to cafeteria‐style diet impairs hepatic metabolism even in the absence of excessive body weight gain in rats
    Anna Maria Giudetti, Maria Vittoria Micioni Di Bonaventura, Alessandra Ferramosca, Serena Longo, Emanuela Micioni Di Bonaventura, Marzia Friuli, Adele Romano, Silvana Gaetani, Carlo Cifani · 2020 · The FASEB Journal
  69. Regulation of p53 and NF-κB transactivation activities by DGKζ in catalytic activity-dependent and -independent manners
    Toshiaki Tanaka, Tomoyuki Nakano, Yasukazu Hozumi, Alberto Maria Martelli, Kaoru Goto · 2021 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  70. Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits
    Benjamin Scott Glicksberg, Letizia Amadori, Nicholas K. Akers, Katyayani Sukhavasi, Oscar Franzén, Li Li, Gillian M. Belbin, Kristin L. Akers, Khader Shameer, Marcus A. Badgeley et al. · 2019 · BMC Medical Genomics
  71. The Role of Bone Morphogenetic Protein Signaling in Non-Alcoholic Fatty Liver Disease
    Timothy E. Thayer, Christian Lacks Lino Cardenas, Trejeeve Martyn, Christopher Nicholson, Lisa Traeger, Florian Wunderer, Charles L. Slocum, Haakon H. Sigurslid, Hannah R. Shakartzi, Caitlin O’Rourke et al. · 2020 · Scientific Reports
  72. Treatment of rats with Jiangzhi Capsule improves liquid fructose-induced fatty liver: modulation of hepatic expression of SREBP-1c and DGAT-2
    Yuanyang Zhao, Yongquan Pan, Yifan Yang, Robert Gordon Batey, Jianwei Wang, Yuhao Li · 2015 · Journal of Translational Medicine
  73. Discovery of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors with a 1H-Pyrrolo[2,3-b]pyridine Core
    Mun Ock Kim, Su‐Ui Lee, Kwangman Choi, Sangku Lee, Hyeongki Kim, Hyunju Kang, Miri Choi, Eun Bin Kwon, Myung Ji Kang, Sunhong Kim et al. · 2014 · Biological and Pharmaceutical Bulletin
  74. A simple homogeneous scintillation proximity assay for acyl-coenzyme A:diacylglycerol acyltransferase
    Ramakrishna Seethala, Tara L. Peterson, Jessica Dong, Ching-Hsuen Chu, Luping Chen, Rajasree Golla, Zhengping Ma, Reshma Panemangalore, R. Michael Lawrence, Dong Cheng · 2008 · Analytical Biochemistry
  75. Gut microbiome and metabolism alterations in schizophrenia with metabolic syndrome severity
    Hongxia Zhao, Guangcan Zhu, Tong Zhu, Binbin Ding, Ahong Xu, Songyan Gao, Yufan Chao, Na Li, Yongchun Chen, Zuowei Wang et al. · 2024 · BMC Psychiatry
  76. Therapeutic potential of antisense oligonucleotides for the management of dyslipidemia
    Rosanne M. Crooke, Mark J. Graham · 2011 · Clinical Lipidology
  77. Mechanistic Characterization of Long Residence Time Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)
    Brandon A. Pabst, Kentaro Futatsugi, Qifang Li, Kay Ahn · 2018 · Biochemistry
  78. Investigating dual inhibition of ACC and CD36 for the treatment of nonalcoholic fatty liver disease in mice
    Camille J. Devereux, Jacqueline A. Bayliss, Stacey N. Keenan, Magdalene K. Montgomery, Matthew J. Watt · 2023 · American Journal of Physiology-Endocrinology and Metabolism
  79. Small structural changes of the imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitors produce an improved safety profile
    Kentaro Futatsugi, Kim Huard, Daniel W. Kung, John C. Pettersen, Declan A. Flynn, J. R. Gosset, Gary E. Aspnes, R. J. Barnes, Shawn Cabral, Matthew Dowling et al. · 2016 · MedChemComm
  80. Serum amylase levels are decreased in Chinese non-alcoholic fatty liver disease patients
    Jinmei Yao, Ying Y. Zhao, Juanwen Zhang, Yani Hong, Huanle Lu, Jianping Wu · 2014 · Lipids in Health and Disease
  81. In-depth metabolic phenotyping of genetically engineered mouse models in obesity and diabetes
    Hui‐Young Lee, Kyeong‐Hoon Jeong, Cheol Soo Choi · 2014 · Mammalian Genome
  82. Exercise and Dairy Protein have Distinct Effects on Indices of Liver and Systemic Lipid Metabolism
    Logan K. Townsend, Shivam Gandhi, Hesham Shamshoum, Sarah K. Trottier, David M. Mutch, Raylene A. Reimer, Jane Shearer, Paul J. LeBlanc, David Charles Wright · 2019 · Obesity
  83. Diet-Induced Physiological Responses in the Liver of Atlantic Salmon (Salmo salar) Inferred Using Multiplex PCR Platforms
    Albert Caballero‐Solares, Xi Xue, Beth M. Cleveland, Maryam Beheshti Foroutani, Christopher Charles Parrish, Richard G. Taylor, Matthew L. Rise · 2020 · Marine Biotechnology
  84. Detection of differentially expressed candidate genes for a fatty liver QTL on mouse chromosome 12
    Misato Kobayashi, Miyako Suzuki, Tamio Ohno, Kana Tsuzuki, Chie Taguchi, Soushi Tateishi, Teruo Kawada, Young‐Il Kim, Atsushi Murai, Fumihiko Horio · 2016 · BMC Genetics
  85. Role of Dgat2 in Glucose Uptake and Fatty Acid Metabolism in C2C12 Skeletal Myotubes
    S. Bu · 2023 · Journal of Microbiology and Biotechnology
  86. Differences in diacylglycerol acyltransferases expression patterns and regulation cause distinct hepatic triglyceride deposition in fish
    Xiaojun Xiang, Renlei Ji, Shangzhe Han, Xiang Xu, Si Zhu, Yongnan Li, Jianlong Du, Kangsen Mai, Qinghui Ai · 2024 · Communications Biology
  87. Next generation risk assessment of hair dye HC yellow no. 13: Ensuring protection from liver steatogenic effects
    Sara Sepehri, Dinja De Win, Anja Heymans, Freddy Van Goethem, Robim Marcelino Rodrigues, Vera Rogiers, Tamara Vanhaecke · 2025 · Regulatory Toxicology and Pharmacology
  88. Lrp6 Genotype affects Individual Susceptibility to Nonalcoholic Fatty Liver Disease and Silibinin Therapeutic Response via Wnt/β-catenin-Cyp2e1 Signaling
    Lijie Chen, Xiu‐Xian Lin, Jìng Guo, Ying Xu, Song-Xia Zhang, Dan Chen, Qing Zhao, Jian Xiao, Guanghui Lian, Shifang Peng et al. · 2021 · International Journal of Biological Sciences
  89. A Study on How Methionine Restriction Decreases the Body’s Hepatic and Lipid Deposition in Rice Field Eel (Monopterus albus)
    Yajun Hu, Minglang Cai, Huan Zhong, Wuying Chu, Wuying Chu · 2021 · International Journal of Molecular Sciences
  90. Profiling Gene Programs in the Blood During Liver Regeneration in Living Liver Donors
    Michael C. Lawrence, Carly M. Darden, Srividya Vasu, Kenjiro Kumano, Jinghua Gu, Xuan Wang, Jinyan Chan, Zhaohui Xu, Benjamin Lemoine, Phuong Nguyen et al. · 2019 · Liver Transplantation
  91. Roux-en-Y Gastric Bypass in Obese Diabetic Rats Promotes Autophagy to Improve Lipid Metabolism through mTOR/p70S6K Signaling Pathway
    Nanxi Ma, Rui Ma, Kaixin Tang, Xuesong Li, Bing He · 2020 · Journal of Diabetes Research
  92. Targeting Hepatic Glycerolipid Synthesis and Turnover to Treat Fatty Liver Disease
    George G. Schweitzer, Brian N. Finck · 2014 · Advances in Hepatology
  93. New mechanisms contributing to hepatic steatosis: glucose, insulin, and lipid signaling
    Yoo Jeong Lee, Jung Hwan Yu, Won–Ho Kim, Jae Woo Kim · 2014 · Animal Cells and Systems
  94. Trivalent Chromium Supplementation Ameliorates Oleic Acid-Induced Hepatic Steatosis in Mice
    Song Wang, Jian Wang, Yajing Liu, Hui Li, Qiao Wang, Zhiwei Huang, Wenbin Liu, Ping Shi · 2018 · Biological Trace Element Research
  95. Hepatic DGAT2 gene expression is regulated by the synergistic action of ChREBP and SP1 in HepG2 cells
    Eunji Shin, Jin-Sik Bae, Jung‐Youn Han, Junghoon Lee, Yun-Seung Jeong, Ho-Jae Lee, Yong‐Ho Ahn, Ji-Young Cha · 2016 · Animal Cells and Systems
  96. Tetrahydroisoquinolines
    Larry Yet · 2018
  97. Methionine supplemented in a high fat-diet: Effects of growth performance and lipid metabolism in rice field eel (Monopterus albus)
    Yajun Hu, Minglang Cai, Junzhi Zhang, Jihong Dai, Huan Zhong, Wuying Chu, Wencheng Xu, Yi Hu, Kaijian Chen · 2023 · Aquaculture Reports
  98. A PNPLA3-Deficient iPSC-Derived Hepatocyte Screen Identifies Pathways to Potentially Reduce Steatosis in Metabolic Dysfunction-Associated Fatty Liver Disease
    Caren Doueiry, Christiana S. Kappler, Carla Martinez-Morant, Stephen A. Duncan · 2024 · International Journal of Molecular Sciences
  99. Beyond PPARs and Metformin
    Philip A. Carpino, David Hepworth · 2012 · Annual reports in medicinal chemistry
  100. Urokinase-type plasminogen activator (uPA) stimulates triglyceride synthesis in Huh7 hepatoma cells via p38-dependent upregulation of DGAT2
    Nicole Paland, Aviva Gamliel-Lazarovich, Raymond Coleman, Bianca Fuhrman · 2014 · Atherosclerosis