A peptide-gated ion channel from the freshwater polyp Hydra
Open accessAbstract
Chemical transmitters are either low molecular weight molecules or neuropeptides. As a general rule, neuropeptides activate only slow metabotropic receptors. To date, only one exception to this rule is known, the FMRFamide-activated Na(+) channel (FaNaC) from snails. Until now FaNaC has been regarded as a curiosity, and it was not known whether peptide-gated ionotropic receptors are also present in other animal groups. Nervous systems first evolved in cnidarians, which extensively use neuropeptides. Here we report cloning from the freshwater cnidarian Hydra of a novel ion channel (Hydra sodium channel, HyNaC) that is directly gated by the neuropeptides Hydra-RFamides I and II and is related to FaNaC. The cells expressing HyNaC localize to the base of the tentacles, adjacent to the neurons producing the Hydra-RFamides, suggesting that the peptides are the natural ligands for this channel. Our results suggest that neuropeptides were already used for fast transmission in ancient nervous systems.
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Neuropeptide signaling in Hydra is mediated not only by GPCRs but also by ion channel receptors.
“neuropeptide signaling in Hydra is mediated not only by GPCRs, but also by ion channel receptors [38,40,56]”
From Back to the Basics: Cnidarians Start to Fire (2017) · cites this paper as [38]
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- Authors
- Golubovic, A., Kuhn, A., Williamson, M., Kalbacher, H., Holstein, T. W., Grimmelikhuijzen, C. J. P., & Gründer, S.
- Affiliations
- University of Würzburg (DE)
- University of Copenhagen (DK)
- University of Tübingen (DE)
- Corresponding author
- Gründer, Stefan
- ORCID
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 282
- Issue
- 48
- Pages
- 35098-35103
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2023710681
- Cited by
- 101
- References
- 27
- Citations by year
- 2025: 6 · 2024: 3 · 2023: 8 · 2022: 9 · 2021: 6 · 2020: 6 · 2019: 6 · 2018: 7 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 5 · 2013: 7 · 2012: 4
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- Hydra, neuropeptides, ligand-gated ion channels, cnidarian nervous system, nervous system evolution, fast synaptic transmission
- MeSH terms
- Amino Acid Sequence, Animals, Cloning, Molecular, Hydra, Ions, Ligands, Membrane Proteins, Molecular Sequence Data, Nerve Tissue Proteins, Peptides, Phylogeny, Sodium Channels, Sequence Homology, Amino Acid, In Situ Hybridization, Rats, Acid Sensing Ion Channels
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