The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Profiling MicroRNA Expression in Hepatocellular Carcinoma Reveals MicroRNA-224 Up-regulation and Apoptosis Inhibitor-5 as a MicroRNA-224-specific Target
Open accessAbstract
Like other cancers, aberrant gene regulation features significantly in hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) were recently found to regulate gene expression at the post-transcriptional/translational levels. The expression profiles of 157 miRNAs were examined in 19 HCC patients, and 19 up-regulated and 3 down-regulated miRNAs were found to be associated with HCC. Putative gene targets of these 22 miRNAs were predicted in silico and were significantly enriched in 34 biological pathways, most of which are frequently dysregulated during carcinogenesis. Further characterization of microRNA-224 (miR-224), the most significantly up-regulated miRNA in HCC patients, revealed that miR-224 increases apoptotic cell death as well as proliferation and targets apoptosis inhibitor-5 (API-5) to inhibit API-5 transcript expression. Significantly, miR-224 expression was found to be inversely correlated with API-5 expression in HCC patients (p < 0.05). Hence, our findings define a true in vivo target of miR-224 and reaffirm the important role of miRNAs in the dysregulation of cellular processes that may ultimately lead to tumorigenesis.
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Cited by
Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification
(2021) · Advances in Cancer Research · doi:10.1016/bs.acr.2020.10.001 · Cited by 851
miR-15a and miR-16-1 in cancer: discovery, function and future perspectives
Aqeilan, R. I., Calin, G. A., & Croce, C. M. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.69 · Cited by 648
Serum exosomal microRNAs as novel biomarkers for hepatocellular carcinoma
Sohn, W., Kim, J., Kang, S. H., Yang, S. R., Cho, J.-Y., Cho, H. C., Shim, S. G., & Paik, Y.-H. (2015) · Experimental & Molecular Medicine · doi:10.1038/emm.2015.68 · Cited by 426
miR221/222 in Cancer: Their Role in Tumor Progression and Response to Therapy
Garofalo, M., Quintavalle, C., Romano, G., M. Croce, C., & Condorelli, G. (2012) · Current Molecular Medicine · doi:10.2174/156652412798376170 · Cited by 331
Molecular Classification and Novel Targets in Hepatocellular Carcinoma: Recent Advancements
Hoshida, Y., Toffanin, S., Lachenmayer, A., Villanueva, A., Minguez, B., & Llovet, J. (2010) · Seminars in Liver Disease · doi:10.1055/s-0030-1247131 · Cited by 310
Metadata
- Authors
- Wang, Y., Lee, A. T. C., Ma, J. Z. I., Wang, J., Ren, J., Yang, Y., Tantoso, E., Li, K.-B., Ooi, L. L. P. J., Tan, P., & Lee, C. G. L.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 283
- Issue
- 19
- Pages
- 13205-13215
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2091651379
- Cited by
- 363
- References
- 8
- FWCI
- 11.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Wang, Y., Lee, A. T. C., Ma, J. Z. I., Wang, J., Ren, J., Yang, Y., Tantoso, E., Li, K.-B., Ooi, L. L. P. J., Tan, P., & Lee, C. G. L. (2008). Profiling MicroRNA Expression in Hepatocellular Carcinoma Reveals MicroRNA-224 Up-regulation and Apoptosis Inhibitor-5 as a MicroRNA-224-specific Target. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m707629200
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