Structural Basis for Sorting Mechanism of p62 in Selective Autophagy

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

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p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

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Elimination of FKBP51 attenuates CCl4-induced liver injury via enhancement of mitochondrial function by increased Parkin activityPreprint

Qiu, B., Zhong, Z., Dou, L., Xu, Y., Zou, Y., Weldon, K. S., Wang, J., Zhang, L., Liu, M., Williams, K. E., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2679397/v1 · Cited by 1

Neddylation Regulates Mitochondrial Dynamics and Turnover in the Adult HeartPreprint

Zou, J., Wang, W., Chen, Q., Zhang, L., Zambrano-Carrasco, J., Li, Y., Lu, Y., Zhou, H., Dong, K., Fukai, T., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.03.692150 · Cited by 1

Excess Met1-ubiquitination leads to solid aggregate formationPreprint

Kaypee, S., Miyasaka, M., NAKAJIMA, T., Nishimura, H., Sakamaki, J.-I., Komatsu, M., & Ikeda, F. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.20.700516 · Cited by 1

Regulation of the p62 promoter by oxidative damage in neurodegenerative disease and aging

Du, Y. (2009) · Cited by 1

ROLE OF BILE ACIDS AND FARNESOID X RECEPTOR IN HEPATIC AUTOPHAGY AND ITS IMPLICATIONS IN ETHANOL-INDUCED HEPATOTOXICITY

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XBP1, Unfolded Protein Response, and Endocrine Responsiveness

Clarke, R. C. (2009) · doi:10.21236/ada516632

Mechanism of Cargo Recognition During Selective Autophagy

Watanabe, Y., & Nobuo, N. (2012) · InTech eBooks · doi:10.5772/33894

Autophagy and antigen processing : strategies to enhance T cell recognition of cancer cells

Williams, L. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham)

IDENTIFICATION OF SUMOYLATED PROTEINS AND INVESTIGATION OF PROTEIN UBIQUITINATION IN THE NF-κB PATHWAY

Liu, X. (2012) · UKnowledge (University of Kentucky)

Mechanisms Underlying the Cellular Clearance of Antitrypsin Z

Gelling, C. L., & Brodsky, J. L. (2012) · Proceedings of the American Thoracic Society

The Functions of Autophagy Genes in Lymphocytes and Osteoclasts

Miller, B. C. (2011) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7m043dz

Fibronectin-integrin interaction promotes fibroblast activation (nemosis) and crosstalk with tumor cells

Salmenperä, P. (2012) · Työväentutkimus Vuosikirja

Addicted to Autophagy: Ph+ B-ALL May Acquire Imatinib-resistance and Enhanced Malignancy through a Highly-active Autophagy Pathway

Arkus, N. L. A. (2011)

P R O T E I N FA M I LY R E V I E W

Shpilka, T., Weidberg, H., Pietrokovski, S., & Elazar, Z. (2011)

Analysis of the function and the regulation of autophagy in Arabidopsis thaliana

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REGULATION OF CARDIAC AUTOPHAGY IN RESPONSE TO LIPID OVERLOAD

Jaishy, B. P. (2013)

Atg26 is involved in selective autophagy of the major coat protein Gag of the S. cerevisiae virus L-A

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The Effects of GMS Immunity-Related GTPases on Guanylate-Binding Proteins, Protein

Traver, M. K. (2013)

Defining the role of folliculin and its interacting partners

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Cytotoxic effects of Sideritis scardica extracts against tumor cells in vitro

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The role of autophagy in clearance of protein aggregates

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CROSS-TALK BETWEEN THE UBIQUITIN-PROTEASOME SYSTEM AND MACROAUTOPHAGY

Pankiv, S., & Johansen, T. (2012) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789814350457_0003

AUTOPHAGY IN AMYOTROPHIC LATERAL SCLEROSIS

Gál, J., & Zhu, H. (2012) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789814350457_0009

Activation of mTORC1 Improves Cone Cell Metabolism and Extends Vision in Retinitis Pigmentosa Mice: A Dissertation

Venkatesh, A. (2016) · eScholarship@UMassChan · doi:10.13028/m2nc7g

Autophagy-linked FYVE protein mediates the turnover of mutant huntingtin and modifies pathogenesis in mouse models of Huntington’s disease

Fox, L. M. (2016) · doi:10.7916/d83b60cm

Interactions of L. monocytogenes with Host Cellular Defenses

Lam, G. Y. (2012) · TSpace (University of Toronto)

Examining the Role of Endoplasmic Reticulum Stress in Pancreatic Beta-cell Biology

Teodoro, T. (2012) · TSpace (University of Toronto)

Targeting Selective Autophagy of Insoluble Protein Aggregates

Seneci, P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801944-3.00005-9

Analysis of autophagy in lung cancer

Al‐Ali, R. (2016) · Gredos (University of Salamanca) · doi:10.14201/gredos.132790

Neuroprotective Agents Target Molecular Mechanisms of Programmed Cell Death After Traumatic Brain Injury

Tao, L. (2018) · Springer eBooks · doi:10.1007/978-3-319-77495-4_5

C9orf72 expansions disrupt ATM-mediated DNA repair

Walker, C. (2018) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)

Programmed cell death mechanisms and nanoparticle toxicity

Madkour, L. H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-822481-6.00010-4

Exploring selective autophagy in Drosophila: Methods to identify Atg8-interacting proteins

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Development of new tools to study lipidated mammalian ATG8Preprint

Park, S., Jeon, P., Yamasaki, A., Lee, H., Mun, J. Y., Jun, Y., Park, J.-H., Lee, S.-H., Lee, S.-K., Song, H. K., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-221701/v1

The role of autophagy in Alzheimer disease

Jaeger, P. A. (2011) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-8320

Selective Autophagy

Noda, N. N., & Inagaki, F. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-405877-4.00002-0

Insights into membrane binding of PROPPINs and Reconstitution of mammalian autophagic conjugation systems

Busse, R. A. (2013) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-3900

Faculty Opinions recommendation of p62 links the autophagy pathway and the ubiqutin-proteasome system upon ubiquitinated protein degradation.

Lipton, S. A. (2017) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727653084.793538935

Faculty Opinions recommendation of Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses.

Jenny, A. (2017) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732071110.793538790

GMAP is an Atg8a-Interacting Protein that Regulates Golgi Turnover In DrosophilaPreprint

Rahman, M. A., Lőrincz, P., Juhász, G., Zhang, Y., & Nezis, I. P. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3920639

Faculty Opinions recommendation of Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy.

Diehl, J. A. (2017) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.725967101.793538077

Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein

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LC3

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Peer Review #2 of "Analysis of microRNA expression profiles in exosomes derived from acute myeloid leukemia by p62 knockdown and effect on angiogenesis (v0.2)"

(2022) · PeerJ · doi:10.7287/peerj.13498v0.2/reviews/2

Peer Review #1 of "Analysis of microRNA expression profiles in exosomes derived from acute myeloid leukemia by p62 knockdown and effect on angiogenesis (v0.1)"

(2022) · PeerJ · doi:10.7287/peerj.13498v0.1/reviews/1

Peer Review #2 of "Analysis of microRNA expression profiles in exosomes derived from acute myeloid leukemia by p62 knockdown and effect on angiogenesis (v0.1)"

(2022) · PeerJ · doi:10.7287/peerj.13498v0.1/reviews/2

Peer Review #1 of "Analysis of microRNA expression profiles in exosomes derived from acute myeloid leukemia by p62 knockdown and effect on angiogenesis (v0.2)"

(2022) · PeerJ · doi:10.7287/peerj.13498v0.2/reviews/1

In-cell chemical crosslinking identifies hotspots for p62-IκBα interaction that underscore a critical role of p62 in limiting NF-κB activation through IκBα-stabilizationPreprint

Liu, Y., Trnka, M. J., He, L., Burlingame, A. L., & Correia, M. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.13.512146

Wnt5a-Ror2 signaling activates p62-Nrf2 axis in reactive astrocytes after brain injuryPreprint

Endo, M., Tanaka, Y., Fukuoka, M., Suzuki, H., & Minami, Y. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.19.537450

ATG8 family protein, cargo selection, and autophagy

Mishra, A., & Dhiman, R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90142-0.00006-2

MARCH5 promotes autophagy through interaction with P62 leading to malignant progression of hepatocellular carcinomaPreprint

Xin, C. A. I., Gao, J., Yan, Z., Zhang, H., Zhang, S., & Guo, D. (2023) · Research Square · doi:10.21203/rs.3.rs-3416817/v1

Machine learning approaches for the identification of ligands of the autophagy marker LC3

Soulère, L., & Queneau, Y. (2023) · Artificial Intelligence Chemistry · doi:10.1016/j.aichem.2023.100022

Additional file 3 of A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons

Beckers, J., Tharkeshwar, A. K., Fumagalli, L., Contardo, M., Schoor, E. V., Fazal, R., Thal, D. R., Chandran, S., Mancuso, R., Bosch, L. V. D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24159426

Additional file 2 of A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons

Beckers, J., Tharkeshwar, A. K., Fumagalli, L., Contardo, M., Schoor, E. V., Fazal, R., Thal, D. R., Chandran, S., Mancuso, R., Bosch, L. V. D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24159423

SAP30, a novel autophagy regulatory gene in neuroblastoma

Pathania, A. S., Murugan, A., Zahid, A., Chava, H., Coulter, D. W., Călin, G. A., & Challagundla, K. B. (2024) · Molecular Therapy Oncology · doi:10.1016/j.omton.2024.200916

Noncanonical activation of protease-activated receptor 1 induces autophagy in mammalian breast cancer cellsPreprint

Saha, S., Kumar, R. V., Sarangi, S., Gope, A., Pal, A., Tapader, R., Nag, N., & Pal, A. (2025) · Research Square · doi:10.1101/2025.01.11.632575

Balance between autophagy and apoptosis determines anoikis resistance: a mathematical model on cell fatePreprint

Maiti, S., Chedere, A., Jolly, M. K., Chandra, N. R., & Rangarajan, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.09.658583

Autophagy Receptors Couple Cargo Destined to Be Degraded with the Core Autophagy Machinery

Olsvik, H. L., Lamark, T., & Johansen, T. (2025) · Learning materials in biosciences · doi:10.1007/978-3-031-88121-3_4

The single nucleotide polymorphism rs155787 on the autophagy gene of SQSTM1 is associated with silicosis susceptibility: A multi-stage study

Jiang, L., Wang, F., Huai, M., Zhang, W., Chen, X., Li, C., Zhang, X., Liu, B., Su, Y., Chu, M., et al. (2025) · Toxicology Letters · doi:10.1016/j.toxlet.2025.111744

Additional file 1 of A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons

Beckers, J., Tharkeshwar, A. K., Fumagalli, L., Contardo, M., Schoor, E. V., Fazal, R., Thal, D. R., Chandran, S., Mancuso, R., Bosch, L. V. D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24159420

Additional file 1 of Long noncoding RNA BCRP3 stimulates VPS34 and autophagy activities to promote protein homeostasis and cell survival

Yan, R.-L., Luan, C.-L., Liao, C.-C., Liu, L.-H., Chen, F.-Y., Chen, H.-Y., & Chen, R.-H. (2022) · Figshare · doi:10.6084/m9.figshare.19746434

Additional file 1 of DAP1 regulates osteoblast autophagy via the ATG16L1–LC3 axis in Graves’ disease-induced osteoporosis

Gao, M., Du, Z., Dong, Q., Su, S., & Tian, L. (2024) · Figshare · doi:10.6084/m9.figshare.26618821

Additional file 3 of DAP1 regulates osteoblast autophagy via the ATG16L1–LC3 axis in Graves’ disease-induced osteoporosis

Gao, M., Du, Z., Dong, Q., Su, S., & Tian, L. (2024) · Figshare · doi:10.6084/m9.figshare.26618827

The Effects of GMS Immunity-Related GTPases on Guanylate-Binding Proteins, Protein Aggregate Formation, and Macroautophagy

Traver, M. K. (2013) · DukeSpace (Duke University)

Additional file 2 of Knocking out Fkbp51 decreases CCl4-induced liver injury through enhancement of mitochondrial function and Parkin activity

Qiu, B., Zhong, Z., Dou, L., Xu, Y., Zou, Y., Weldon, K., Wang, J., Zhang, L., Liu, M., Williams, K. E., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26659447

Additional file 1 of Knocking out Fkbp51 decreases CCl4-induced liver injury through enhancement of mitochondrial function and Parkin activity

Qiu, B., Zhong, Z., Dou, L., Xu, Y., Zou, Y., Weldon, K., Wang, J., Zhang, L., Liu, M., Williams, K. E., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26659444

Additional file 2 of DAP1 regulates osteoblast autophagy via the ATG16L1–LC3 axis in Graves’ disease-induced osteoporosis

Gao, M., Du, Z., Dong, Q., Su, S., & Tian, L. (2024) · Figshare · doi:10.6084/m9.figshare.26618824

p62/SQSTM1 selectively supports starvation-induced autophagy in N2a neuroblastoma cellsPreprint

Marimuthu, A., Saha, D., Vengataraghavan, V., Jivin, B. M. M., & Devanathan, V. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.03.697476

Rapid optogenetic blockade of autophagy reveals that nuclear pore complex proteins are robust autophagy substratesPreprint

Mondal, P., Cyril, A., Mamriev, D., Parham, L. R., Wierzbicki, I. H., Shen, C., Doglioni, G., Dufrense, S., Komarla, A., Gonzalez, D. J., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.03.703609

Legionella Lem26 functions as an ATG8-activated effector that inhibits host autophagy

Parducho, K. R., Yang, Z., Guinn, E. J., Choi, D., Nag, S., Melia, T. J., & Roy, C. R. (2026) · mBio · doi:10.1128/mbio.03595-25

A novel lipid-triggered allosteric site modulates LC3-LIR receptor binding activityPreprint

Gahlot, D., Jesu Castin, E., Mathur, S. C., Das, D., Kumar, A., Arun, A., Gain, C., Sharma, M., Pal, R. K., Jain, N., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.10.710726

Effects of diclofenac exposure on myelin organization, autophagy, and cellular proliferation in the rat cerebral cortex and hippocampus

Yakut, S., Akı, R. H., & Mutluay, D. (2026) · Journal of Advances in VetBio Science and Techniques · doi:10.31797/vetbio.1860946

Etude de l’interaction entre la protéine Vif du VIH-1 et la protéine LC3 impliquée dans le processus autophagique

Borel, S. (2012) · theses.fr (ABES) · doi:10.70675/dd21a0adz8f37z4bcezaf0az3e604f81bd73

Interactions VIH/autophagie dans les cellules dendritiques : de la réplication à la présentation des antigènes

Coulon, P.-G. A. (2014) · theses.fr (ABES) · doi:10.70675/35505ce2z6226z4be3z9fc3za30de5ecacdc

Regulation of proteotoxicity through atypical NEDDylation

Maghames, C. M. (2016) · theses.fr (ABES) · doi:10.70675/f67a0612z3cccz46b5zb058zebfbc60f1ac4

Autophagy inhibition in HIV-1-infected CD4 T lymphocytes : the role of Vif and Vpr accessory proteins

Alfaisal, J. (2016) · theses.fr (ABES) · doi:10.70675/912b4531z9f61z4aacz89bez526a9131ecb9

L’autophagie macrophagique protège contre l'atteinte hépatique et la fibrose au cours de la maladie alcoolique du foie

Lodder, J. (2014) · theses.fr (ABES) · doi:10.70675/7a468cf4z8ec3z4e5az9085z099ff24be1f1

Rôles de l’autophagie dans l'homéostasie des cellules souches intestinales

Trentesaux, C. (2018) · theses.fr (ABES) · doi:10.70675/6bad110bz19b1z4cd6z81d0z74d0fb1e27f3

Mechanisms and function of mitophagy in adaptation to heat stress during development of C. elegans

Chen, Y. (2019) · theses.fr (ABES) · doi:10.70675/c8145e7bz8153z43acz8532z3ea5954dd01c

Modulation de l'autophagie neuronale par la sérine protéase tPA en conditions ischémiques

Thiebaut, A. M. (2019) · theses.fr (ABES) · doi:10.70675/6586c0abz9e4cz455fz95ffzc52ec76397f8

Rôle de l’autophagie dans l’ostéosarcome

Camuzard, O. (2019) · theses.fr (ABES) · doi:10.70675/db9b0551zd9a2z4cf6z8dc4zdfbbe6b4e208

Analysis of the proteasome-autophagy crosstalk under proteotoxic stress conditions in acute myeloid leukemia

Lopez-Reyes, R. G. (2020) · theses.fr (ABES) · doi:10.70675/0cf3c9baz63d4z4ebfzb6efza0a5f5a241b2

Mechanisms of C9ORF72 pathogenicity and related autophagy impairment in amyotrophic lateral sclerosis

de Calbiac, H. (2019) · theses.fr (ABES) · doi:10.70675/bafe951fz8332z4b0azb55bzac8a4af1955b

Influence de l’autophagie sur l’activité des inhibiteurs d’angiokinases nintedanib et regorafenib dans le cancer colorectal

Louadj, L. (2021) · theses.fr (ABES) · doi:10.70675/fef4f1f5z422cz4970zaa0ezcc44411339d5

Etude des fonctions des protéines « ubiquitin-like » GABARAP/LGG-1 via l’ingénierie CRISPR-Cas9 au cours de l’autophagie et du développement chez Caenorhabditis elegans

Leboutet, R. (2021) · theses.fr (ABES) · doi:10.70675/1646eccez560bz4f4dza83czfbdc82f013e9

La monoacylglycerol lipase favorise la régénération hépatique en reprogrammant le métabolisme lipidique des macrophages et des hépatocytes

Allaire, M. (2021) · theses.fr (ABES) · doi:10.70675/63c01410z4e9ez41a1za1d1z5413ce87e73c

Prévention de l’obésité alimentaire : impact des acides gras polyinsaturés en n-3 sur le microbiote intestinal et l’intégrité et le processus autophagique en lien avec la sécrétion du mucus colique

Bourragat, A. (2023) · theses.fr (ABES) · doi:10.70675/3b3b969dz44b9z4105z8818z615b5feee249

Analyse des fonctions de la protéine du réticulum endoplasmique, PDZD-8 dans l'autophagie chez Caenorhabditis elegans

Pouget, A. (2024) · doi:10.70675/92766df5z1811z4470z97f3ze6b8287ff2db

Structure-based design of p62-derived peptides that inhibit autophagy-associated readouts and enhance chemotherapy response in breast cancer cells

Mokhles, F., Azimee, S., Cordani, M., Rahmati, M., Fard, N. A., Djavaheri‐Mergny, M., & Moosavi, M. A. (2026) · Cell Death · doi:10.1016/j.celld.2026.100011

Structural insights into the interaction between the BH3-like domain of hepatitis B virus X protein and LC3B

Kusunoki, H., Tanaka, T., Mizukami, T., Wakamatsu, K., & Nagata, T. (2026) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2026.141149

Tissue Factor-inhibited Beclin1-autophagy via BCL2 overexpression suppresses the differentiation of human monocytes into mature osteoclasts

Wu, L., Gao, T., Ke, D., & 刘国明 (2026) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2025-0028

Herb Pair of Aurantii Fructus Immaturus–Atractylodis Macrocephalae Rhizoma Alleviates Slow‐Transit Constipation in Rats by Regulating Mitophagy and Modulating Gut Microbiota

Wang, Y., Zhen, S., Sun, M., Su, L., & Yan, S. (2026) · Neurogastroenterology & Motility · doi:10.1111/nmo.70341

Iterative design leads to a smart probe capable of quantifying autophagic flux with switchable fluorescence via engaging MAP1LC3/LC3

Lu, Y., Wang, N., Liu, M., Lu, Z., Fan, S., Lv, W., Lu, Y., Han, F., & Li, X. (2026) · Autophagy · doi:10.1080/15548627.2026.2674717

A peptide-induced regression of low-grade malignant breast tumor via activation of autophagy in breast cancer cells

Saha, S., Kumar, R., Sarangi, S., Gope, A., Pal, A., Tapader, R., Nag, N., Bhattacharya, S., & Pal, A. (2026) · Molecular Medicine · doi:10.1186/s10020-026-01514-4

Functionalized Fluorescent Nanodiamonds Reveal Therapeutic Protein Clearance Through ENDOTAC Linked to AUTOTAC

Lin, Y., Lai, Y.-H., Pang, J.-Y., Lin, Y., Chang, T., Fang, I., Wang, R.-H., Chang, C., Chiang, I., Wu, S., et al. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.202505913

Programmable Nanobody‐Targeting Chimeras Enable Intracellular Viral Protein Degradation

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