Tanaka, Keiji

Autophagy regulates lipid metabolism

Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature

Autophagy in Disease and TherapyLipid metabolism and biosynthesis

Cited by 3,975

Impairment of starvation-induced and constitutive autophagy in Atg7 -deficient mice

Komatsu, M., Waguri, S., Ueno, T., Iwata, J., Murata, S., Tanida, I., Ezaki, J., Mizushima, N., Ohsumi, Y., Uchiyama, Y., et al. (2005) · The Journal of Cell Biology

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 2,331

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.

Komatsu, M., Waguri, S., Koike, M., Sou, Y.-S., Ueno, T., Hara, T., Mizushima, N., Iwata, J.-I., Ezaki, J., Murata, S., et al. (2007) · Cell

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 2,124

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Shimura, H., Hattori, N., Kubo, S.-I., Mizuno, Y., Asakawa, S., Minoshima, S., Shimizu, N., Iwai, K., Chiba, T., Tanaka, K., et al. (2000) · Nature Genetics

Parkinson's Disease Mechanisms and TreatmentsUbiquitin and proteasome pathways

Cited by 2,024

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

Matsuda, N., Sato, S., Shiba, K., Okatsu, K., Saisho, K., Gautier, C. A., Sou, Y.-S., Saiki, S., Kawajiri, S., Sato, F., et al. (2010) · Journal of Cell Biology

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 1,969

Ubiquitin is phosphorylated by PINK1 to activate parkin

Koyano, F., Okatsu, K., Kosako, H., Tamura, Y., Go, E., Kimura, M., Kimura, Y., Tsuchiya, H., Yoshihara, H., Hirokawa, T., et al. (2014) · Nature

Parkinson's Disease Mechanisms and TreatmentsUbiquitin and proteasome pathways

Cited by 1,477

Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis

Sanjuan, M. A., Dillon, C. P., Tait, S. W. G., Moshiach, S., Dorsey, F., Connell, S., Komatsu, M., Tanaka, K., Cleveland, J. L., Withoff, S., et al. (2007) · Nature

Autophagy in Disease and TherapyImmune Response and Inflammation

Cited by 1,347

The proteasome: overview of structure and functions

TANAKA, K. (2009) · Proceedings of the Japan Academy, Series B

Ubiquitin and proteasome pathwaysHeat shock proteins research

Cited by 862

Structural Basis for Sorting Mechanism of p62 in Selective Autophagy

Ichimura, Y., Kumanomidou, T., Sou, Y.-S., Mizushima, T., Ezaki, J., Ueno, T., Kominami, E., Yamane, T., Tanaka, K., & Komatsu, M. (2008) · Journal of Biological Chemistry

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 803

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

Ebato, C., Uchida, T., Arakawa, M., Komatsu, M., Ueno, T., Komiya, K., Azuma, K., Hirose, T., Tanaka, K., Kominami, E., et al. (2008) · Cell Metabolism

Pancreatic function and diabetesAutophagy in Disease and Therapy

Cited by 774

Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

Jung, H. S., Chung, K. W., Won Kim, J., Kim, J., Komatsu, M., Tanaka, K., Nguyen, Y. H., Kang, T. M., Yoon, K.-H., Kim, J.-W., et al. (2008) · Cell Metabolism

Pancreatic function and diabetesAutophagy in Disease and Therapy

Cited by 647

Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration

Komatsu, M., Wang, Q. J., Holstein, G. R., Friedrich, V. L., Iwata, J.-I., Kominami, E., Chait, B. T., Tanaka, K., & Yue, Z. (2007) · Proceedings of the National Academy of Sciences

Autophagy in Disease and TherapyHereditary Neurological Disorders

Cited by 614

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

Tokunaga, F., Nakagawa, T., Nakahara, M., Saeki, Y., Taniguchi, M., Sakata, S.-I., Tanaka, K., Nakano, H., & Iwai, K. (2011) · Nature

NF-κB Signaling PathwaysUbiquitin and proteasome pathways

Cited by 609

UV-Induced Ubiquitylation of XPC Protein Mediated by UV-DDB-Ubiquitin Ligase Complex

Sugasawa, K., Okuda, Y., Saijo, M., Nishi, R., Matsuda, N., Chu, G., Mori, T., Iwai, S., Tanaka, K., Tanaka, K., et al. (2005) · Cell

DNA Repair MechanismsUbiquitin and proteasome pathways

Cited by 576

CHIP is a chaperone‐dependent E3 ligase that ubiquitylates unfolded protein

Murata, S., Minami, Y., Minami, M., Chiba, T., & Tanaka, K. (2001) · The EMBO Reports

Ubiquitin and proteasome pathwaysHeat shock proteins research

Cited by 574

Molecular mechanisms of proteasome assembly

Murata, S., Yashiroda, H., & Tanaka, K. (2009) · Nature Reviews Molecular Cell Biology

Ubiquitin and proteasome pathwaysHeat shock proteins research

Cited by 546

Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury

Koike, M., Shibata, M., Tadakoshi, M., Gotoh, K., Komatsu, M., Waguri, S., Kawahara, N., Kuida, K., Nagata, S., Kominami, E., et al. (2008) · The American Journal of Pathology

Neonatal and fetal brain pathologyAutophagy in Disease and Therapy

Cited by 486

p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria

Okatsu, K., Saisho, K., Shimanuki, M., Nakada, K., Shitara, H., Sou, Y., Kimura, M., Sato, S., Hattori, N., Komatsu, M., et al. (2010) · Genes to Cells

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 397

Collided ribosomes form a unique structural interface to induce Hel2-driven quality control pathways

Ikeuchi, K., Tesina, P., Matsuo, Y., Sugiyama, T., Cheng, J., Saeki, Y., Tanaka, K., Becker, T., Beckmann, R., & Inada, T. (2019) · The EMBO Journal

RNA and protein synthesis mechanismsUbiquitin and proteasome pathways

Cited by 315

CHIP: a quality-control E3 ligase collaborating with molecular chaperones

Murata, S., Chiba, T., & Tanaka, K. (2003) · The International Journal of Biochemistry & Cell Biology

Heat shock proteins researchUbiquitin and proteasome pathways

Cited by 218

Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones.

Kaneko, T., Hamazaki, J., Iemura, S.-I., Sasaki, K., Furuyama, K., Natsume, T., Tanaka, K., & Murata, S. (2009) · Cell

Ubiquitin and proteasome pathwaysHeat shock proteins research

Cited by 211

Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation

Iguchi, M., Kujuro, Y., Okatsu, K., Koyano, F., Kosako, H., Kimura, M., Suzuki, N., Uchiyama, S., Tanaka, K., & Matsuda, N. (2013) · Journal of Biological Chemistry

Parkinson's Disease Mechanisms and TreatmentsUbiquitin and proteasome pathways

Cited by 209

Critical role of mitochondrial ubiquitination and the OPTN–ATG9A axis in mitophagy

Yamano, K., Kikuchi, R., Kojima, W., Hayashida, R., Koyano, F., Kawawaki, J., Shoda, T., Demizu, Y., Naito, M., Tanaka, K., et al. (2020) · Journal of Cell Biology

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 205

Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis.

Tashiro, Y., Urushitani, M., Inoue, H., Koike, M., Uchiyama, Y., Komatsu, M., Tanaka, K., Yamazaki, M., Abe, M., Misawa, H., et al. (2012) · Journal of Biological Chemistry

Amyotrophic Lateral Sclerosis ResearchGenetic Neurodegenerative Diseases

Cited by 194