Cysteine Cathepsins Trigger Caspase-dependent Cell Death through Cleavage of Bid and Antiapoptotic Bcl-2 Homologues

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Synergistic apoptotic response between valproic acid and fludarabine in chronic lymphocytic leukaemia (CLL) cells involves the lysosomal protease cathepsin B

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The Potential Role of Cathepsin K in Non-Small Cell Lung Cancer

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Cathepsin proteases mediate photoreceptor cell degeneration in Drosophila

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Intrinsically Connected: Therapeutically Targeting the Cathepsin Proteases and the Bcl-2 Family of Protein Substrates as Co-regulators of Apoptosis

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Lysosomal Serine Protease CLN2 Regulates Tumor Necrosis Factor-α-mediated Apoptosis in a Bid-dependent Manner

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Proteomic characterization of EL4 lymphoma‐derived tumors upon chemotherapy treatment reveals potential roles for lysosomes and caspase‐6 during tumor cell death in vivo

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Deficiency for the Cysteine Protease Cathepsin L Impairs Myc-Induced Tumorigenesis in a Mouse Model of Pancreatic Neuroendocrine Cancer

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Nitidine chloride represses Mcl‐1 protein via lysosomal degradation in oral squamous cell carcinoma

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Human cathepsin X/Z is a biologically active homodimer

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RNA-Seq and 16S rRNA Analysis Revealed the Effect of Deltamethrin on Channel Catfish in the Early Stage of Acute Exposure

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Making Connections: p53 and the Cathepsin Proteases as Co-Regulators of Cancer and Apoptosis

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Behind every smile there's teeth: Cathepsin B's function in health and disease with a kidney view

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Cathepsin S Cleaves BAX as a Novel and Therapeutically Important Regulatory Mechanism for Apoptosis

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Candidate gene identification of ovulation-inducing genes by RNA sequencing with an in vivo assay in zebrafish

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A predicted unstructured C-terminal loop domain in SIRT1 is required for cathepsin B cleavage

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Pathophysiological Implications of Urinary Peptides in Hepatocellular Carcinoma

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Cathepsin H Knockdown Reverses Radioresistance of Hepatocellular Carcinoma via Metabolic Switch Followed by Apoptosis

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Cathepsin B maturation plays a critical role in leptin-induced hepatic cancer cell growth through activation of NLRP3 inflammasomes

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Characterization of cathepsin S exosites that govern its elastolytic activity

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Comprehensive analysis of regulated cell death pathways: intrinsic disorder, protein–protein interactions, and cross-pathway communication

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Programmed cell revival from imminent cell death enhances tissue repair and regeneration

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Cathepsin H and cathepsin B of Cynoglossus semilaevis are involved in anti-bacterial immunity against Edwardsiella tarda

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Secreted cystatins decrease proliferation and enhance apoptosis of human leukemic cells

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Marine Cyanobacteria Compounds with Anticancer Properties: Implication of Apoptosis

Martins, M. D. R., & Costa, M. (2014) · Springer eBooks · doi:10.1007/978-3-319-07145-9_29 · Cited by 9

Lysosomal membrane-permeabilization (LMP) and -rupture (LMR) are distinct for cell death

Yamashima, T. (2025) · Frontiers in Cell Death · doi:10.3389/fceld.2025.1669955 · Cited by 11

The impact of cycling hypoxia on the phenotype of HPV‐positive cervical cancer cells

Heber, N., Kuhn, B. J., Strobel, T. D., Lohrey, C., Krijgsveld, J., Hoppe‐Seyler, K., & Hoppe‐Seyler, F. (2023) · Journal of Medical Virology · doi:10.1002/jmv.29280 · Cited by 9

The influence of uremic high cystatin C concentration on neutrophil apoptosis and selected neutrophil functions isolated from healthy subjects

Majewska, E., Wittek, N., Rysz, J., & Baj, Z. (2012) · Medical Science Monitor · doi:10.12659/msm.883545 · Cited by 8

Alterations in cathepsin L expression in lung cancers

Okudela, K., Mitsui, H., Woo, T., Arai, H., Suzuki, T., Matsumura, M., Kojima, Y., Umeda, S., Tateishi, Y., Masuda, M., et al. (2016) · Pathology International · doi:10.1111/pin.12424 · Cited by 8

Expression of genes for enzymes synthesizing lysophosphatidic acid, its receptors and follicle developmental factors derived from the cumulus-oocyte complex is dependent on the ovarian follicle type in cows

Sinderewicz, E., Grycmacher, K., Boruszewska, D., Kowalczyk‐Zieba, I., Staszkiewicz‐Chodor, J., Łukaszuk, K., & Wocławek-Potocka, I. (2018) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2018.03.018 · Cited by 8

Cysteine cathepsins: structure, physiological functions and their role in carcinogenesis

Gureeva, T. A., Timoshenko, O. S., Kugaevskaya, E. V., & Solovyova, N. I. (2021) · Biomeditsinskaya Khimiya · doi:10.18097/pbmc20216706453 · Cited by 8

Immune complex-mediated co-ligation of the BCR with FcγRIIB results in homeostatic apoptosis of B cells involving Fas signalling that is defective in the MRL/Lpr model of systemic lupus erythematosus

Paunović, V., Carter, N. A., Thalhamer, T., Blair, D., Gordon, B., Lacey, E., Michie, A. M., & Harnett, M. M. (2012) · Journal of Autoimmunity · doi:10.1016/j.jaut.2012.04.006 · Cited by 8

Induction of apoptosis by the Amsacta moorei entomopoxvirus

Perera, S. C., Krell, P. J., Demirbağ, Z., Nalçacıoğlu, R., & Arif, B. M. (2013) · Journal of General Virology · doi:10.1099/vir.0.051888-0 · Cited by 8

CTSL2 is a pro-apoptotic target of E2F1 and a modulator of histone deacetylase inhibitor and DNA damage-induced apoptosis

Wong, C., Wu, Z., & Yu, Q. (2013) · Oncogene · doi:10.1038/onc.2013.72 · Cited by 8

Cysteine cathepsins are not critical for TNF-α-induced cell death in T98G and U937 cells

Klarić, M., Sun, T., Stoka, V., Turk, B., & Türk, V. (2009) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2009.04.011 · Cited by 8

Strategies for Assaying Lysosomal Membrane PermeabilizationPreprint

Repnik, U., Česen, M. H., & Turk, B. (2016) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top077479 · Cited by 8

Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy

Halaby, R. (2021) · Medicines · doi:10.3390/medicines8110069 · Cited by 7

The human antibacterial factor APOL3 couples lysosomal damage to mitochondrial DNA efflux and type I IFN induction

Ritacco, D. A., Shahnawaz, H., Oduguwa, A., Hawk, J., Vizcaino, B., Färber, D. L., & Gaudet, R. G. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.01.029 · Cited by 11

Progressive mitochondrial dysfunction in cerebellar synaptosomes of cystatin B-deficient mice

Gorski, K., Jackson, C. B., Nyman, T. A., Rezov, V., Battersby, B. J., & Lehesjoki, A. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1175851 · Cited by 7

Virus-vectoring thrips regulate the excessive multiplication of tomato spotted wilt virus using their antiviral immune responses

Mandal, E., Khan, F., Kil, E., & Kim, Y. (2024) · Journal of General Virology · doi:10.1099/jgv.0.001984 · Cited by 7

Non-Canonical, Extralysosomal Activities of Lysosomal Peptidases in Physiological and Pathological Conditions: New Clinical Opportunities for Cancer Therapy

Conesa-Bakkali, R., Morillo‐Huesca, M., & Martínez‐Fábregas, J. (2025) · Cells · doi:10.3390/cells14020068 · Cited by 7

The anticancer drug imatinib induces autophagy in Schistosoma mansoni

Mughal, M. N., Grevelding, C. G., & Haeberlein, S. (2021) · International Journal for Parasitology · doi:10.1016/j.ijpara.2021.10.008 · Cited by 7

Insight into crustacean cathepsins: Structure-evolutionary relationships and functional roles in physiological processes

Gul, I., Abbas, M. N., Kausar, S., Luo, J., Gao, X., Mu, Y., Fan, W., & Cui, H. (2023) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2023.108852 · Cited by 7

Spatially Confined Intervention of Cellular Senescence by a Lysosomal Metabolism Targeting Molecular Prodrug for Broad‐Spectrum Senotherapy

Xia, Y., Li, J., Wang, L., Luo, X., Xie, Y., & Liu, Y. (2022) · Angewandte Chemie · doi:10.1002/ange.202115764 · Cited by 7

Selective Disruption of Lysosomes in HeLa Cells Triggers Apoptosis Mediated by Cleavage of Bid by Multiple Papain-like Lysosomal Cathepsins

Cirman, T., Bender, K. O., Droga-Mazovec, G., Türk, V., Reed, J. C., Myers, R., Salvesen, G. S., & Turk, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308347200 · Cited by 484

Cathepsin B launches an apoptotic exit effort upon cell death-associated disruption of lysosomes

de Castro, M., Bunt, G., & Wouters, F. S. (2016) · Cell Death Discovery · doi:10.1038/cddiscovery.2016.12 · Cited by 112

Lysosome-mediated apoptosis is associated with cathepsin D-specific processing of bid at Phe24, Trp48, and Phe183.

Appelqvist, H., Johansson, A., Linderoth, E., Johansson, U., Antonsson, B. E., Steinfeld, R., Kågedal, K., & Öllinger, K. M. (2012) · PubMed · Cited by 66

Apoptosis caused by cathepsins does not require Bid signaling in an in vivo model of progressive myoclonus epilepsy (EPM1)

Houseweart, M. K., Vilaythong, A., Yin, X.-M., Turk, B., Noebels, J. L., & Myers, R. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401309 · Cited by 65

Lysosome-mediated apoptosis is associated with cathepsin D-specific processing of bid at

Johansson, A.-C., Linderoth, E., Johansson, U., Antonsson, B. E., Steinfeld, R., Kågedal, K., & Öllinger, K. M. (2012)