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TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition
Open accessAbstract
The TAZ transcription co-activator has been shown to promote cell proliferation and to induce epithelial-mesenchymal transition. Recently we have demonstrated that TAZ is phosphorylated and inhibited by the Hippo tumor suppressor pathway, which is altered in human cancer. The mechanism of TAZ-mediated transcription is unclear. We demonstrate here that TEAD is a key downstream transcription factor mediating the function of TAZ. Disruption of TEAD-TAZ binding or silencing of TEAD expression blocked the function of TAZ to promote cell proliferation and to induce epithelial-mesenchymal transition, demonstrating TEAD as a key downstream effector of TAZ. We also identified CTGF, a gene that regulates cell adhesion, proliferation, and migration, as a direct target of TAZ and TEAD. Our study establishes a functional partnership between TAZ and TEAD under negative regulation by the Hippo signaling pathway.
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Research works printed but not linked: 23
- Kanai, 2000, EMBO J., 19, 6778, 10.1093/emboj/19.24.6778 · DOI · Paper page
- Hong, 2006, Cell Cycle, 5, 176, 10.4161/cc.5.2.2362 · DOI
- Hong, 2005, Science, 309, 1074, 10.1126/science.1110955 · DOI · Paper page
- Murakami, 2006, Biochem. Biophys. Res. Commun., 339, 533, 10.1016/j.bbrc.2005.10.214 · DOI
- Murakami, 2005, Proc. Natl. Acad. Sci. U. S. A., 102, 18034, 10.1073/pnas.0509109102 · DOI · Paper page
- Makita, 2008, Am. J. Physiol. Renal Physiol., 294, 542, 10.1152/ajprenal.00201.2007 · DOI · Paper page
- Hossain, 2007, Proc. Natl. Acad. Sci. U. S. A., 104, 1631, 10.1073/pnas.0605266104 · DOI · Paper page
- Lei, 2008, Mol. Cell. Biol., 28, 2426, 10.1128/MCB.01874-07 · DOI · Paper page
- Zhao, 2008, Genes Dev., 22, 1962, 10.1101/gad.1664408 · DOI · Paper page
- McClatchey, 2005, Genes Dev., 19, 2265, 10.1101/gad.1335605 · DOI · Paper page
- Hamaratoglu, 2006, Nat. Cell Biol., 8, 27, 10.1038/ncb1339 · DOI · Paper page
- Lai, 2005, Cell, 120, 675, 10.1016/j.cell.2004.12.036 · DOI · Paper page
- Tapon, 2002, Cell, 110, 467, 10.1016/S0092-8674(02)00824-3 · DOI · Paper page
- Chan, 2008, Cancer Res., 68, 2592, 10.1158/0008-5472.CAN-07-2696 · DOI · Paper page
- Park, 2004, J. Biol. Chem., 279, 17384, 10.1074/jbc.M312569200 · DOI
- Chu, 2008, J. Biomed. Sci., 15, 675, 10.1007/s11373-008-9264-9 · DOI
- Sala-Torra, 2007, Blood, 109, 3080, 10.1182/blood-2006-06-031096 · doi:10.1182/blood-2006-06-031096
- Hinestrosa, 2007, Nat. Rev. Cancer, 7, 309, 10.1038/nrc2113 · DOI
- Mani, 2008, Cell, 133, 704, 10.1016/j.cell.2008.03.027 · DOI · Paper page
- Varelas, 2008, Nat. Cell Biol., 10, 837, 10.1038/ncb1748 · DOI · Paper page
- Dornhöfer, 2006, Cancer Res., 66, 5816, 10.1158/0008-5472.CAN-06-0081 · DOI
- Rybak, 2005, Nat. Methods, 2, 291, 10.1038/nmeth745 · DOI
- Wang, 2005, Mol. Cell, 17, 683, 10.1016/j.molcel.2005.02.010 · DOI
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The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells
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Self-citationGenome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth
Zanconato, F., Forcato, M., Battilana, G., Azzolin, L., Quaranta, E., Bodega, B., Rosato, A., Bicciato, S., Cordenonsi, M., & Piccolo, S. (2015) · Nature Cell Biology · doi:10.1038/ncb3216 · Cited by 1,219
Metadata
- Authors
- Zhang, H., Liu, C.-Y., Zha, Z.-Y., Zhao, B., Yao, J., Zhao, S., Xiong, Y., Lei, Q.-Y., & Guan, K.-L.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 284
- Issue
- 20
- Pages
- 13355-13362
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2126712555
- Cited by
- 569
- References
- 0
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Update notices
- correction (2019-04-12)
- Open access
- hybrid
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- creativecommons.org/licenses/by/4.0/ (vor, 4253 d)
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- Zhang, H., Liu, C.-Y., Zha, Z.-Y., Zhao, B., Yao, J., Zhao, S., Xiong, Y., Lei, Q.-Y., & Guan, K.-L. (2009). TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m900843200
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