The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ
Abstract
TAZ (transcriptional coactivator with PDZ-binding motif), also called WWTR1 (WW domain containing transcription regulator 1), is a 14-3-3-binding molecule homologous to Yes-associated protein. TAZ acts as a coactivator for several transcription factors as well as a modulator of membrane-associated PDZ domain-containing proteins, but its (patho)physiological roles remain unknown. Here we show that gene inactivation of TAZ in mice resulted in pathological changes in the kidney and lung that resemble the common human diseases polycystic kidney disease and pulmonary emphysema. Taz-null/ lacZ knockin mutant homozygotes demonstrated renal cyst formation as early as embryonic day 15.5 with dilatation of Bowman's capsules and proximal tubules, followed by pelvic dilatation and hydronephrosis. After birth, only one-fifth of TAZ-deficient homozygotes grew to adulthood and demonstrated multicystic kidneys with severe urinary concentrating defects and polyuria. Furthermore, adult TAZ-deficient homozygotes exhibited diffuse emphysematous changes in the lung. Thus TAZ is essential for developmental mechanisms involved in kidney and lung organogenesis, whose disturbance may lead to the pathogenesis of common human diseases.
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Cites
Manipulating the mouse embryo: A laboratory manual
Hogan, B. L. M., Costantini, F. D., & Lacy, E. (1986) · Cited by 4,460
PKD2 , a Gene for Polycystic Kidney Disease That Encodes an Integral Membrane Protein
Mochizuki, T., Wu, G., Hayashi, T., Xenophontos, S. L., Veldhuisen, B., Saris, J. J., Reynolds, D. M., Cai, Y., Gabow, P. A., Pierides, A., et al. (1996) · Science · doi:10.1126/science.272.5266.1339 · Cited by 1,406
Pathophysiology of airflow limitation in chronic obstructive pulmonary disease
Hogg, J. C. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16900-6 · Cited by 1,294
Aquaporins in the Kidney: From Molecules to Medicine
Nielsen, S., Frøkiær, J., Marples, D., Kwon, T.-H., Agre, P., & Knepper, M. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00024.2001 · Cited by 1,251
TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation
Hong, J.-H., Hwang, E. S., McManus, M. T., Amsterdam, A., Tian, Y., Kalmukova, R., Mueller, E., Benjamin, T., Spiegelman, B. M., Sharp, P. A., et al. (2005) · Science · doi:10.1126/science.1110955 · Cited by 1,009
Dise, T. E. P. K. (1994) · Cell · doi:10.1016/0092-8674(94)90137-6 · Cited by 903
Ward, C. J., Hogan, M. C., Rossetti, S., Walker, D., Sneddon, T., Wang, X., Kubly, V., Cunningham, J. M., Bacallao, R., Ishibashi, M., et al. (2002) · Nature Genetics · doi:10.1038/ng833 · Cited by 765
Kanai, F., Marignani, P. A., Sarbassova, D., Yagi, R., Hall, R. A., Donowitz, M., Hisaminato, A., Fujiwara, T., Ito, Y., Cantley, L. C., et al. (2000) · The EMBO Journal · doi:10.1093/emboj/19.24.6778 · Cited by 756
Polycystic kidney disease: The complete structure of the PKD1 gene and its protein
The International Polycystic Kidney Disease Consortium (1995) · Cell · doi:10.1016/0092-8674(95)90339-9 · Cited by 625
A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma
Winandy, S., Wu, P., & Georgopoulos, K. (1995) · Cell · doi:10.1016/0092-8674(95)90170-1 · Cited by 527
Cited by
Role of YAP/TAZ in mechanotransduction
Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979
Hippo pathway in organ size control, tissue homeostasis, and cancer
Yu, F.-X., Zhao, B., & Guan, K.-L. (2015) · Cell · doi:10.1016/j.cell.2015.10.044 · Cited by 2,206
YAP/TAZ upstream signals and downstream responses
Totaro, A., Panciera, T., & Piccolo, S. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0142-z · Cited by 1,086
Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine
Moya, I. M., & Halder, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0086-y · Cited by 981
The Hippo Signaling Pathway in Development and Disease
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Metadata
- Authors
- Makita, R., Uchijima, Y., Nishiyama, K., Amano, T., Chen, Q., Takeuchi, T., Mitani, A., Nagase, T., Yatomi, Y., Aburatani, H., Nakagawa, O., Small, E. V., Cobo-Stark, P., Igarashi, P., Murakami, M., Tominaga, J., Sato, T., Asano, T., Kurihara, Y., & Kurihara, H.
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 2008-03
- Volume
- 294
- Issue
- 3
- Pages
- F542-F553
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W2160674488
- Cited by
- 293
- References
- 37
- FWCI
- 5.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Makita, R., Uchijima, Y., Nishiyama, K., Amano, T., Chen, Q., Takeuchi, T., Mitani, A., Nagase, T., Yatomi, Y., Aburatani, H., Nakagawa, O., Small, E. V., Cobo-Stark, P., Igarashi, P., Murakami, M., Tominaga, J., Sato, T., Asano, T., Kurihara, Y., & Kurihara, H. (2008). Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ. American Journal of Physiology-Renal Physiology. https://doi.org/10.1152/ajprenal.00201.2007
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