The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Up-regulation of Caveolin Attenuates Epidermal Growth Factor Signaling in Senescent Cells
Open accessAbstract
Senescent human diploid fibroblasts do not respond to growth factors like epidermal growth factor (EGF), although they have a normal level of receptors and downstream signaling molecules. To examine the mechanism of signaling attenuation, we investigated Erk activation after EGF stimulation in senescent cells. Senescent cells did not phosphorylate Erk-1/2 after EGF stimulation, whereas young cells did. In those senescent cells, we found an increased level of caveolin proteins and strong interactions between caveolin-1 and EGF receptor. Electron microscopic analysis demonstrated an increased number of caveolae structures in senescent cells. More interestingly, brain, spleen, and lung from 26-month-old rats showed substantial increases of caveolin proteins. However, in the case of p53-induced senescence, caveolin-1 was not induced, and EGF stimulation phosphorylated Erk-1/2 as much as young control cells. Finally, we overexpressed caveolin-1 in young human diploid fibroblasts in which the activation of Erk-1/2 upon EGF stimulation was significantly suppressed. These results suggest that the unresponsiveness of senescent fibroblasts to EGF stimulation may be due to the overexpression of caveolins, which seems to be independent of growth arrest and other aging phenotypes.
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Cites
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
Dissecting the Interaction between Nitric Oxide Synthase (NOS) and Caveolin
Garcı́a-Cardeña, G., Martasek, P., Masters, B. S. S., Skidd, P. M., Couet, J., Li, S., Lisanti, M. P., & Sessa, W. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.41.25437 · Cited by 821
Cited by
Doherty, G. J., & McMahon, H. T. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.081307.110540 · Cited by 3,075
CO AS A CELLULAR SIGNALING MOLECULE
Kim, H. P., Ryter, S. W., & Choi, A. M. K. (2006) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.46.120604.141053 · Cited by 426
Increased caveolin-1 expression in Alzheimer’s disease brain
Gaudreault, S. B., Dea, D., & Poirier, J. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.07.004 · Cited by 120
Caveolin-1, cellular senescence and age-related diseases
Zou, H., Stoppani, E., Volonte, D., & Galbiati, F. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.11.001 · Cited by 112
Restoration of senescent human diploid fibroblasts by modulation of the extracellular matrix
Choi, H. R., Cho, K. A., Kang, H. T., Lee, J. B., Kaeberlein, M., Suh, Y., Chung, I. K., & Park, S. C. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2010.00654.x · Cited by 84
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Metadata
- Authors
- Park, W.-Y., Park, J.-S., Cho, K.-A., Kim, D.-I., Ko, Y.-G., Seo, J.-S., & Park, S. C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-07
- Volume
- 275
- Issue
- 27
- Pages
- 20847-20852
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2023179617
- Cited by
- 229
- References
- 3
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Park, W.-Y., Park, J.-S., Cho, K.-A., Kim, D.-I., Ko, Y.-G., Seo, J.-S., & Park, S. C. (2000). Up-regulation of Caveolin Attenuates Epidermal Growth Factor Signaling in Senescent Cells. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m908162199
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