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Cited by 84

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Restoration of senescent human diploid fibroblasts by modulation of the extracellular matrix

Choi, Hae Ri, Cho, Kyung A, Kang, Hyun Tae, Lee, Jung Bin, Kaeberlein, Matt, Suh, Yousin, Chung, In Kwon, Park, Sang Chul·2011·Aging Cell
DOI 10.1111/j.1474-9726.2010.00654.x
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Abstract

Summary: Human diploid fibroblasts have the capacity to complete a finite number of cell divisions before entering a state of replicative senescence characterized by growth arrest, changes in morphology, and altered gene expression. Herein, we report that interaction with extracellular matrix (ECM) from young cells is sufficient to restore aged, senescent cells to an apparently youthful state. The identity of the restored cells as having been derived from senescent cells has been confirmed by a variety of methods, including time lapse live cell imaging and DNA finger print analysis. In addition to cell morphology, phenotypic restoration was assessed by resumption of proliferative potential, growth factor responsiveness, reduction of intracellular reactive oxygen species levels, recovery of mitochondrial membrane potential, and increased telomere length. Mechanistically, we find that both Ku and SIRT1 are induced during restoration and are required for senescent cells to return to a youthful phenotype. These observations demonstrate that human cellular senescence is profoundly influenced by cues from the ECM, and that senescent cell plasticity is much greater than that was previously believed to be the case.

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Crossref · 10.1111/j.1474-9726.2010.00654.x

Cites

11 of 11 references verified0 citation errors · 0 not checkable

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  • ECM prepared from young human fibroblasts induces a youthful state in aged senescent cells.

    “Moreover, extracellular matrix prepared from young human fibroblasts induces a youthful state in aged senescent cells 252 .”

    From Hallmarks of aging: An expanding universe (2023) · cites this paper as [252]

  • In human cells, extracellular matrix (ECM) from young fibroblasts rejuvenated aged senescent cells.

    “| Altered intercellular communication | Human cells | ECM from young fibroblasts | Rejuvenation of aged senescent cells | 252”

    From Hallmarks of aging: An expanding universe (2023) · cites this paper as [252]

Citations

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Metadata

Authors
Choi, H. R., Cho, K. A., Kang, H. T., Lee, J. B., Kaeberlein, M., Suh, Y., Chung, I. K., & Park, S. C.
Venue
Aging Cell
Publisher
Wiley
Published
2011-01-12
Volume
10
Issue
1
Pages
148-157
ISSN
  • 1474-9718
  • 1474-9726
DOI
10.1111/j.1474-9726.2010.00654.x
Cited by
84
References
11
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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